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Autophagy Is a Defense Mechanism Inhibiting BCG and Mycobacterium tuberculosis Survival in Infected Macrophages

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Autophagy Defends Cells Against Invading Group A Streptococcus

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The Reversible Modification Regulates the Membrane-Binding State of Apg8/Aut7 Essential for Autophagy and the Cytoplasm to Vacuole Targeting Pathway

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Matrix Protein 2 of Influenza A Virus Blocks Autophagosome Fusion with Lysosomes

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Microtubules Facilitate Autophagosome Formation and Fusion of Autophagosomes with Endosomes

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Autophagy induction by the pathogen receptor CD46.

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Modification of Cellular Autophagy Protein LC3 by Poliovirus

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Utilizing flow cytometry to monitor autophagy in living mammalian cells

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Identification of novel autophagy regulators by a luciferase-based assay for the kinetics of autophagic flux

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Non-Autophagic GFP-LC3 Puncta Induced by Saponin and Other Detergents

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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) ¹

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Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

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LC3-Associated Endocytosis Facilitates β-Amyloid Clearance and Mitigates Neurodegeneration in Murine Alzheimer’s Disease

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Copper is an essential regulator of the autophagic kinases ULK1/2 to drive lung adenocarcinoma

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A Bacterial Effector Reveals the V-ATPase-ATG16L1 Axis that Initiates Xenophagy

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Vitamin D Inhibits Human Immunodeficiency Virus Type 1 and Mycobacterium tuberculosis Infection in Macrophages through the Induction of Autophagy

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Autophagy variation within a cell population determines cell fate through selective degradation of Fap-1

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Autophagy is required for endothelial cell alignment and atheroprotection under physiological blood flow

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Acidic extracellular pH neutralizes the autophagy-inhibiting activity of chloroquine

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Human STING is a proton channel

Liu, B., Carlson, R. J., Pires, I. S., Gentili, M., Feng, E., Hellier, Q., Schwartz, M. A., Blainey, P. C., Irvine, D. J., & Hacohen, N. (2023) · Science · doi:10.1126/science.adf8974 · Cited by 221 · see citing works

Untangling Autophagy Measurements

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Receptor usage dictates HIV-1 restriction by human TRIM5α in dendritic cell subsets

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Biosynthesis of copper oxide nanoparticles mediated Annona muricata as cytotoxic and apoptosis inducer factor in breast cancer cell lines

Mahmood, R. I., Kadhim, A. A., IBRAHEEM, S. A., Albukhaty, S., Mohammed-Salih, H. S., Abbas, R. H., Jabir, M. S., Mohammed, M. K. A., Nayef, U. M., AlMalki, F. A., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-20360-y · Cited by 165 · see citing works

Mitochondrial damage contributes toPseudomonas aeruginosaactivation of the inflammasome and is downregulated by autophagy

Jabir, M. S., Hopkins, L., Ritchie, N. D., Ullah, I., Bayes, H. K., Li, D., Tourlomousis, P., Lupton, A., Puleston, D. J., Simon, A. K., et al. (2015) · Autophagy · doi:10.4161/15548627.2014.981915 · Cited by 163 · see citing works

A novel method for autophagy detection in primary cells: Impaired levels of macroautophagy in immunosenescent T cells

Phadwal, K., Alegre-Abarrategui, J., Watson, A. S., Pike, L., Anbalagan, S., Hammond, E. M., Wade-Martins, R., McMichael, A., Klenerman, P., & Simon, A. K. (2012) · Autophagy · doi:10.4161/auto.18935 · Cited by 155 · see citing works

Human Immunodeficiency Virus Type 1 Nef Inhibits Autophagy through Transcription Factor EB Sequestration

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Characterization of macroautophagic flux in vivo using a leupeptin-based assay

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Hormonally Active Vitamin D3 (1α,25-Dihydroxycholecalciferol) Triggers Autophagy in Human Macrophages That Inhibits HIV-1 Infection*

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B1a B cells require autophagy for metabolic homeostasis and self-renewal

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Targeting NAD+ salvage pathway induces autophagy in multiple myeloma cells via mTORC1 and extracellular signal-regulated kinase (ERK1/2) inhibition

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Bioanalysis of Eukaryotic Organelles

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Green Synthesis of Silver Nanoparticles Using Annona muricata Extract as an Inducer of Apoptosis in Cancer Cells and Inhibitor for NLRP3 Inflammasome via Enhanced Autophagy

Jabir, M. S., Saleh, Y. M., Sulaiman, G. M., Yaseen, N. Y., Sahib, U. I., Dewir, Y. H., Alwahibi, M. S., & Soliman, D. A. (2021) · Nanomaterials · doi:10.3390/nano11020384 · Cited by 143 · see citing works

Hepatitis C virus inhibits AKT-tuberous sclerosis complex (TSC), the mechanistic target of rapamycin (MTOR) pathway, through endoplasmic reticulum stress to induce autophagy

Huang, H., Kang, R., Wang, J., Luo, G. G., Yang, W. Z., & Zhao, Z. (2012) · Autophagy · doi:10.4161/auto.22791 · Cited by 133 · see citing works

Selective autophagy: Xenophagy

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Tightrope act: autophagy in stem cell renewal, differentiation, proliferation, and aging

Phadwal, K., Watson, A., & Simon, A. K. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1032-3 · Cited by 124 · see citing works

Concurrent detection of autolysosome formation and lysosomal degradation by flow cytometry in a high-content screen for inducers of autophagy

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Targeting autophagy by small molecule inhibitors of vacuolar protein sorting 34 (Vps34) improves the sensitivity of breast cancer cells to Sunitinib

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A switch from canonical to noncanonical autophagy shapes B cell responses

Martínez, N., Villavicencio, P. M., Gasparrini, F., Frederico, B., Aggarwal, S., Gaya, M., Tsui, C., Burbage, M., Keppler, S. J., Montaner, B., et al. (2017) · Science · doi:10.1126/science.aal3908 · Cited by 107 · see citing works

Autophagy in Pulmonary Diseases

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Sorting cells for basal and induced autophagic flux by quantitative ratiometric flow cytometry

Gump, J. M., & Thorburn, A. M. (2014) · Autophagy · doi:10.4161/auto.29394 · Cited by 102 · see citing works

Caspase-1 Cleavage of the TLR Adaptor TRIF Inhibits Autophagy and β-Interferon Production during Pseudomonas aeruginosa Infection

Jabir, M. S., Ritchie, N. D., Li, D., Bayes, H. K., Tourlomousis, P., Puleston, D. J., Lupton, A., Hopkins, L., Simon, A. K., Bryant, C. E., et al. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.01.010 · Cited by 101 · see citing works

Cytoprotective effect of kaempferol against palmitic acid-induced pancreatic β-cell death through modulation of autophagy via AMPK/mTOR signaling pathway

Varshney, R., Gupta, S., & Roy, P. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.02.033 · Cited by 100 · see citing works

Chloroquine Autophagic Inhibition Rebalances Th17/Treg-Mediated Immunity and Ameliorates Systemic Lupus Erythematosus

An, N., Chen, Y., Wang, C., Yang, C., Wu, Z., Xue, J., Lin, Y., Wang, S., Liu, J., & Pan, Q. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000484955 · Cited by 99 · see citing works

High-fat diet induces cardiomyocyte apoptosis via the inhibition of autophagy

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Depletion of L -arginine induces autophagy as a cytoprotective response to endoplasmic reticulum stress in human T lymphocytes

García‐Navas, R., Munder, M., & Mollinedo, F. (2012) · Autophagy · doi:10.4161/auto.21315 · Cited by 91 · see citing works

Epigallocatechin-3-gallate opposes HBV-induced incomplete autophagy by enhancing lysosomal acidification, which is unfavorable for HBV replication

Zhong, L., Hu, J., Shu, W., Gao, B., & Xiong, S. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.136 · Cited by 91 · see citing works

CD40 ligand and interferon‐γ induce an antimicrobial response against M ycobacterium tuberculosis in human monocytes

Klug‐Micu, G. M., Stenger, S., Sommer, A., Liu, P. T., Krutzik, S. R., Modlin, R. L., & Fabri, M. (2013) · Immunology · doi:10.1111/imm.12062 · Cited by 89 · see citing works

Asbestos induces mesothelial cell transformation via HMGB1-driven autophagy

Xue, J., Patergnani, S., Giorgi, C., Suarez, J. S., Goto, K., Bononi, A., Tanji, M., Novelli, F., Pastorino, S., Xu, R., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2007622117 · Cited by 86 · see citing works

IRF8 directs stress-induced autophagy in macrophages and promotes clearance of Listeria monocytogenes

Gupta, M., Shin, D.-M., Ramakrishna, L., Goussetis, D. J., Platanias, L. C., Xiong, H., Morse, H. C., & Ozato, K. (2015) · Nature Communications · doi:10.1038/ncomms7379 · Cited by 86 · see citing works

Autophagy in Pulmonary Diseases

Nakahira, K., Pabon Porras, M. A., & Choi, A. M. K. (2016) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201512-2468so · Cited by 78 · see citing works

Human Liver Memory CD8+ T Cells Use Autophagy for Tissue Residence

Swadling, L., Pallett, L., Diniz, M., Baker, J., Amin, O. E., Stegmann, K. A., Burton, A. R., Schmidt, N., Jeffery-Smith, A., Zakeri, N., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2019.12.050 · Cited by 75 · see citing works

Autophagy-inducing peptides from mammalian VSV and fish VHSV rhabdoviral G glycoproteins (G) as models for the development of new therapeutic molecules

García-Valtanen, P., Ortega-Villaizán, M. D. M., Martínez‐López, A., Medina-Gali, R. M., Pérez, L., MacKenzie, S. A., Figueras, A. J., Coll, J. M., & Estepa, A. (2014) · Autophagy · doi:10.4161/auto.29557 · Cited by 76 · see citing works

Immunohistochemical analysis of macroautophagy

Martinet, W., Schrijvers, D. M., Timmermans, J., Bult, H., & Meyer, G. R. Y. D. (2012) · Autophagy · doi:10.4161/auto.22968 · Cited by 76 · see citing works

Autophagy generates citrullinated peptides in human synoviocytes: a possible trigger for anti-citrullinated peptide antibodies

Sorice, M., Iannuccelli, C., Manganelli, V., Capozzi, A., Alessandri, C., Lococo, E., Garofalo, T., Franco, M. D., Bombardieri, M., Nerviani, A., et al. (2016) · Lara D. Veeken · doi:10.1093/rheumatology/kew178 · Cited by 75 · see citing works

Subtractive CRISPR screen identifies the ATG16L1/vacuolar ATPase axis as required for non-canonical LC3 lipidation

Ulferts, R., Marcassa, E., Timimi, L., Lee, L. C., Daley, A., Montaner, B., Turner, S. D., Florey, O., Baillie, J. K., & Beale, R. C. L. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109899 · Cited by 70 · see citing works

IFNG-mediated immune responses enhance autophagy against<i>Mycobacterium tuberculosis</i>antigens in patients with active tuberculosis

Rovetta, A. I., Peña, D., Hernández Del Pino, R. E., Recalde, G. M., Pellegrini, J., Bigi, F., Musella, R. M., Palmero, D. J., Gutierrez, M., Colombo, M. I., et al. (2014) · Autophagy · doi:10.4161/15548627.2014.981791 · Cited by 71 · see citing works

Human autophagy geneATG16L1is post-transcriptionally regulated byMIR142-3p

Zhai, Z., Wu, F., Dong, F., Chuang, A., Messer, J. S., Boone, D. L., & Kwon, J. H. (2014) · Autophagy · doi:10.4161/auto.27553 · Cited by 71 · see citing works

Atg5 Is Essential for the Development and Survival of Innate Lymphocytes

O’Sullivan, T. E., Geary, C. D., Weizman, O.-E., Geiger, T. L., Rapp, M., Dorn, G. W., Overholtzer, M., & Sun, J. C.-Y. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.04.082 · Cited by 70 · see citing works

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, J., Abeliovich, H., Acevedo‐Arozena, A., Adachi, H., Adams, C. M., Adams, P. D., Adeli, K., et al. (2016) · Kölner Universitäts PublikationsServer (Universität zu Köln) · doi:10.5167/uzh-131237 · Cited by 69 · see citing works

The role of the key autophagy kinase ULK1 in hepatocellular carcinoma and its validation as a treatment target

Xue, S.-T., Li, K., Gao, Y., Zhao, L., Gao, Y., Yi, H., Jiang, J., & Li, Z. (2020) · Autophagy · doi:10.1080/15548627.2019.1709762 · Cited by 68 · see citing works

Assays to Monitor Autophagy Progression in Cell Cultures

Orhon, I., & Reggiori, F. (2017) · Cells · doi:10.3390/cells6030020 · Cited by 67 · see citing works

The fluorescence toolbox for visualizing autophagy

Ding, S., & Hong, Y. (2020) · Chemical Society Reviews · doi:10.1039/d0cs00913j · Cited by 63 · see citing works

Iraqi propolis increases degradation of IL-1β and NLRC4 by autophagy following Pseudomonas aeruginosa infection

Jabir, M. S., Sulaiman, G. M., Taqi, Z. J., & Li, D. (2017) · Microbes and Infection · doi:10.1016/j.micinf.2017.10.007 · Cited by 60 · see citing works

LATS1 but not LATS2 represses autophagy by a kinase-independent scaffold function

Tang, F., Gao, R., Jeevan-Raj, B. P., Wyss, C. B., Kalathur, R. K. R., Piscuoglio, S., Ng, C. K. Y., Hindupur, S. K., Nuciforo, S., Dazert, E., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-13591-7 · Cited by 59 · see citing works

A study of autophagy in hemocytes of the Pacific oyster, Crassostrea gigas

Picot, S., Morga, B., Faury, N., Chollet, B., Dégremont, L., Travers, M., Renault, T., & Arzul, I. (2019) · Autophagy · doi:10.1080/15548627.2019.1596490 · Cited by 59 · see citing works

Coating of Quantum Dots strongly defines their effect on lysosomal health and autophagy

Peynshaert, K., Soenen, S. J., Manshian, B. B., Doak, S. H., Braeckmans, K., Smedt, S. C. D., & Remaut, K. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2016.10.022 · Cited by 53 · see citing works

Effects of an In-Frame Deletion of the 6k Gene Locus from the Genome of Ross River Virus

Taylor, A., Melton, J. V., Herrero, L. J., Thaa, B., Karo-Astover, L., Gage, P. W., Nelson, M. A., Sheng, K., Lidbury, B. A., Ewart, G. D., et al. (2016) · Journal of Virology · doi:10.1128/jvi.03192-15 · Cited by 49 · see citing works

Monitoring of autophagy in Chinese hamster ovary cells using flow cytometry

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IL17A augments autophagy in <i>Mycobacterium tuberculosis</i>-infected monocytes from patients with active tuberculosis in association with the severity of the disease

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Progress and Challenges in the Use of MAP1LC3 as a Legitimate Marker for Measuring Dynamic Autophagy In Vivo

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