The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Recombinant bacteriophage lysins as antibacterials
Open accessAbstract
With the increasing worldwide prevalence of antibiotic resistant bacteria, bacteriophage endolysins (lysins) represent a very promising novel alternative class of antibacterial in the fight against infectious disease. Lysins are phage-encoded peptidoglycan hydrolases which, when applied exogenously (as purified recombinant proteins) to Gram-positive bacteria, bring about rapid lysis and death of the bacterial cell. A number of studies have recently demonstrated the strong potential of these enzymes in human and veterinary medicine to control and treat pathogens on mucosal surfaces and in systemic infections. They also have potential in diagnostics and detection, bio-defence, elimination of food pathogens and control of phytopathogens. This review discusses the extensive research on recombinant bacteriophage lysins in the context of antibacterials, and looks forward to future development and potential.
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Cites
Prokaryotes: The unseen majority
Whitman, W. B., Coleman, D. C., & Wiebe, W. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.12.6578 · Cited by 4,871 · cited 1×
“Bacteriophage (phage) are considered ubiquitous and estimated to be the most abundant biological entities on earth.(1,2) Phages are viruses that specifically infect bacteria.”
BackgroundThe crisis in antibiotic resistance
Neu, H. C. (1992) · Science · doi:10.1126/science.257.5073.1064 · Cited by 2,834 · cited 1×
“There is currently an ever-growing concern over the global spread of antibiotic resistance among human and animal pathogens and the need for novel effective antibacterials (like phage lysins) to combat them is well recognised.(23,24) MRSA is now the most commonly reported antibiotic resistant bacterium in clinical set…”
BackgroundBacteriophage lysins as effective antibacterials
Fischetti, V. A. (2008) · Current Opinion in Microbiology · doi:10.1016/j.mib.2008.09.012 · Cited by 477
Eady, E. A., & Cove, J. H. (2003) · Current Opinion in Infectious Diseases · doi:10.1097/00001432-200304000-00007 · Cited by 329
Cited by
Bacteriophage Endolysins as Novel Antimicrobials
Schmelcher, M., Donovan, D. M., & Loessner, M. J. (2012) · Future Microbiology · doi:10.2217/fmb.12.97 · Cited by 785
Antibiotic alternatives: the substitution of antibiotics in animal husbandry?
Cheng, G., Hao, H., Xie, S., Wang, X., Dai, M., Huang, L., & Yuan, Z. (2014) · Frontiers in Microbiology · doi:10.3389/fmicb.2014.00217 · Cited by 622
Nelson, D. C., Schmelcher, M., Rodriguez-Rubio, L., Klumpp, J., Pritchard, D. G., Dong, S., & Donovan, D. M. (2012) · Advances in Virus Research · doi:10.1016/b978-0-12-394438-2.00007-4 · Cited by 372
Vermassen, A., Leroy, S., Talon, R., Provot, C., Popowska, M., & Desvaux, M. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00331 · Cited by 348
Bacteriophage virion-associated peptidoglycan hydrolases: potential new enzybiotics
Rodríguez-Rubio, L., Martínez, B., Donovan, D. M., Rodríguez, A., & García, P. (2013) · Critical Reviews in Microbiology · doi:10.3109/1040841x.2012.723675 · Cited by 173
Metadata
- Authors
- Fenton, M., McAuliffe, O., O’Mahony, J., & Coffey, A.
- Venue
- Bioengineered Bugs
- Publisher
- Informa UK Limited
- Published
- 2010-01
- Volume
- 1
- Issue
- 1
- Pages
- 9-16
- ISSN
- 1949-1018 (ISSN-L)
- 1949-1026
- OpenAlex
- W2047943475
- Cited by
- 225
- References
- 4
- FWCI
- 12.60
- Type
- journal article
- Language
- en
- Open access
- bronze
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