The DOI matches its Crossref record; 127 of the 127 references it cites were found in a registry or an index.
Dynamics of the Rho-family small GTPases in actin regulation and motility
Open accessAbstract
The p21 Rho-family of small GTPases are master regulators of actin cytoskeleton rearrangements. Their functions have been well characterized in terms of their effects toward various actin-modulating protein targets. However, more recent studies have shown that the dynamics of Rho GTPase activities are highly complex and tightly regulated in order to achieve their specific subcellular localization. Furthermore, these localized effects are highly dynamic, often spanning the time-scale of seconds, making the interpretation of traditional biochemical approaches inadequate to fully decipher these rapid mechanisms in vivo. Here, we provide an overview of Rho family GTPase biology, and introduce state-of-the-art approaches to study the dynamics of these important signaling proteins that ultimately coordinate the actin cytoskeleton rearrangements during cell migration.
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Cites
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Dynamic Control of Excitatory Synapse Development by a Rac1 GEF/GAP Regulatory Complex
Um, K., Niu, S., Duman, J. G., Cheng, J. X., Tu, Y.-K., Schwechter, B., Liu, F., Hiles, L., Narayanan, A. S., Ash, R. T., et al. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.05.011 · Cited by 81
Neuropathy-causing TRPV4 mutations disrupt TRPV4-RhoA interactions and impair neurite extension
McCray, B. A., Diehl, E., Sullivan, J. M., Aisenberg, W. H., Zaccor, N. W., Lau, A. R., Rich, D. J., Goretzki, B., Hellmich, U. A., Lloyd, T. E., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-21699-y · Cited by 57
A reverse signaling pathway downstream of Sema4A controls cell migration via Scrib
Sun, T., Yang, L., Kaur, H., Pestel, J., Looso, M., Nolte, H., Krasel, C., Heil, D., Krishnan, R. K., Santoni, M.-J., et al. (2017) · Journal of Cell Biology · doi:10.1083/jcb.201602002 · Cited by 44
RhoA regulation in space and time
de Seze, J., Gatin, J., & Coppey, M. (2023) · FEBS Letters · doi:10.1002/1873-3468.14578 · Cited by 42
D’Incal, C., Broos, J., Torfs, T., Kooy, R. F., & Vanden Berghe, W. (2022) · Cells · doi:10.3390/cells11081325 · Cited by 29
Metadata
- Authors
- Spiering, D., & Hodgson, L.
- Venue
- Cell Adhesion & Migration
- Publisher
- Informa UK Limited
- Published
- 2011-03
- Volume
- 5
- Issue
- 2
- Pages
- 170-180
- ISSN
- 1933-6918 (ISSN-L)
- 1933-6926
- OpenAlex
- W2074798811
- Cited by
- 444
- References
- 127
- FWCI
- 10.82
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
