Src family kinases and paclitaxel sensitivity
Open accessAbstract
Src-family Kinases (SFKs) participate in the regulation of proliferation, differentiation, apoptosis, autophagy, adhesion, migration, invasion and angiogenesis in normal and cancer cells. Abnormal expression of SFKs has been documented in cancers that arise in breast, colon, ovary, melanocyte, gastric mucosa, head and neck, pancreas, lung, and brain. Targeting SFKs in cancer cells has been shown to be a promising therapeutic strategy in solid tumors, particularly in ovarian, colon and breast cancers. Paclitaxel is one of most widely used chemotherapeutic agents for the management of ovarian, breast, lung and head/neck cancers. As a microtubule-stabilizing agent, paclitaxel possesses both mitosis-dependent and mitosis-independent activities against cancer cells. A variety of mechanisms such as deregulation of P-glycoprotein, alteration of tubulin isotypes, alteration of microtubule-regulatory proteins, deregulation of apoptotic signaling pathways, mutation of tubulins and overexpression of copper transporters have been implicated in the development of primary or secondary resistance to paclitaxel. By affecting cancer cell survival, proliferation, autophagy, microtubule stability, motility, and/or angiogenesis, SFKs interact with mechanisms that regulate paclitaxel sensitivity. Inhibition of SFKs can potentiate the anti-tumor activity of paclitaxel by enhancing apoptosis, autophagy and microtubule stability. Based on pre-clinical observations, administration of SFK inhibitors in combination with paclitaxel could improve treatment for ovarian, breast, lung and head/neck cancers. Identification and validation of predictive biomarkers could also permit personalization of the therapy.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Preclinical evidence in sarcoma and ovarian cancer cell lines suggests that activation of Src reduces sensitivity to various chemotherapeutic drugs, including platinum agents, and that this resistance can be reversed by pharmacological inhibition.
“In addition, evidence from preclinical studies in sarcoma and ovarian cancer cell lines suggests that activation of Src reduces sensitivity to various chemotherapeutic drugs, including platinum agents, and that this resistance can be reversed by pharmacological inhibition [19, 20][21–23][24].”
From Dasatinib, a Src inhibitor, sensitizes liver metastatic colorectal carcinoma to oxaliplatin in tumors with high levels of phospho-Src (2016) · cites this paper as [19]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Hallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590 · see citing works
Autophagy in the Pathogenesis of Disease
Levine, B., & Kroemer, G. (2008) · Cell · doi:10.1016/j.cell.2007.12.018 · Cited by 7,069 · see citing works
Microtubules as a target for anticancer drugs
Jordan, M. A., & Wilson, L. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1317 · Cited by 4,534 · see citing works
Promotion of microtubule assembly in vitro by taxol
SCHIFF, P. B., FANT, J., & HORWITZ, S. B. (1979) · Nature · doi:10.1038/277665a0 · Cited by 3,600 · see citing works
Cellular functions regulated by Src family kinases.
Thomas, S. M., & Brugge, J. (1997) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.13.1.513 · Cited by 2,610 · see citing works
Taxol stabilizes microtubules in mouse fibroblast cells.
Schiff, P. B., & Horwitz, S. B. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.3.1561 · Cited by 1,971 · see citing works
SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins
Koch, C. A., Anderson, D. H., Moran, M. F., Ellis, C. A., & Pawson, T. J. (1991) · Science · doi:10.1126/science.1708916 · Cited by 1,868 · see citing works
Cell death by mitotic catastrophe: a molecular definition
Castedo, M., Perfettini, J.-L., Roumier, T., Andreau, K., Medema, R., & Kroemer, G. (2004) · Oncogene · doi:10.1038/sj.onc.1207528 · Cited by 1,269 · see citing works
The Double-Edged Sword of Autophagy Modulation in Cancer
White, E., & DiPaola, R. S. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-5023 · Cited by 1,137 · see citing works
Microtubules and resistance to tubulin-binding agents
Kavallaris, M. (2010) · Nature reviews. Cancer · doi:10.1038/nrc2803 · Cited by 1,134 · see citing works
Identification of a transformation-specific antigen induced by an avian sarcoma virus
Brugge, J. S., & Erikson, R. L. (1977) · Nature · doi:10.1038/269346a0 · Cited by 889 · see citing works
Src family kinases in tumor progression and metastasis
Summy, J. M., & Gallick, G. E. (2003) · Cancer and Metastasis Reviews · doi:10.1023/a:1023772912750 · Cited by 827 · see citing works
Mechanisms of Taxol resistance related to microtubules
Orr, G. A., Verdier-Pinard, P., McDaid, H., & Horwitz, S. B. (2003) · Oncogene · doi:10.1038/sj.onc.1206934 · Cited by 727 · see citing works
Src kinases as therapeutic targets for cancer
Kim, L. C., Song, L., & Haura, E. B. (2009) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2009.129 · Cited by 700 · see citing works
Mechanisms of Multidrug Resistance in Cancer
Gillet, J., & Gottesman, M. M. (2009) · Methods in molecular biology · doi:10.1007/978-1-60761-416-6_4 · Cited by 696 · see citing works
Giannakakou, P., Sackett, D. L., Kang, Y., Zhan, Z., Buters, J., Fojo, T., & Poruchynsky, M. S. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.27.17118 · Cited by 682 · see citing works
Levinson, A. D., Oppermann, H., Levintow, L., VARMUS, H. E., & Bishop, J. M. (1978) · Cell · doi:10.1016/0092-8674(78)90024-7 · Cited by 653 · see citing works
The microtubule-affecting drug paclitaxel has antiangiogenic activity.
Belotti, D., Vergani, V., Drudis, T., Borsotti, P., Pitelli, M. R., Viale, G., Giavazzi, R., & Taraboletti, G. (1996) · PubMed · Cited by 643 · see citing works
Migliaccio, A., Piccolo, D., Castoria, G., Domenico, M. D., Bilancio, A., Lombardi, M., Gong, W., Beato, M., & Auricchio, F. (1998) · The EMBO Journal · doi:10.1093/emboj/17.7.2008 · Cited by 627 · see citing works
c-Src and cooperating partners in human cancer
Ishizawar, R., & Parsons, S. J. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.09.001 · Cited by 617 · see citing works
Kavallaris, M., Kuo, D. Y., Burkhart, C. A., et al. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119642 · Cited by 605 · see citing works
Src kinase regulation by phosphorylation and dephosphorylation
Roskoski, R. J. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.03.012 · Cited by 577 · see citing works
Dumontet, C., & Sikic, B. I. (1999) · Journal of Clinical Oncology · doi:10.1200/jco.1999.17.3.1061 · Cited by 572 · see citing works
Taxol Suppresses Dynamics of Individual Microtubules in Living Human Tumor Cells
Yvon, A.-M. C., Wadsworth, P., & Jordan, M. A. (1999) · Molecular Biology of the Cell · doi:10.1091/mbc.10.4.947 · Cited by 550 · see citing works
Abramsson, A., Lindblom, P., & Betsholtz, C. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200318549 · Cited by 479 · see citing works
Abramsson, A., Lindblom, P., & Betsholtz, C. (2003) · Journal of Clinical Investigation · doi:10.1172/jci18549 · Cited by 478 · see citing works
Weis, S. M., Cui, J., Barnes, L. A., & Cheresh, D. A. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200408130 · Cited by 477 · see citing works
The tumor suppressor gene ARHI regulates autophagy and tumor dormancy in human ovarian cancer cells
Lü, Z., Luo, R. Z.-T., Lu, Y., Zhang, X., Yu, Q., Khare, S., Kondo, S., Kondo, Y., Yu, Y., Mills, G. B., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci35512 · Cited by 466 · see citing works
Zhou, M., Liu, Z., Zhao, Y., Ding, Y., Liu, H., Xi, Y., Xiong, W., Li, G., Lu, J., Fodstad, Ø., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.083337 · Cited by 424 · see citing works
Taxol (paclitaxel): mechanisms of action.
Horwitz, S. B. (1994) · PubMed · Cited by 420 · see citing works
Taxol: Mechanisms of Action and Resistancea
Horwitz, S. B., Lothstein, L., Manfredi, J. J., et al. (1986) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1986.tb38455.x · Cited by 417 · see citing works
Microtubule-associated protein tau: A marker of paclitaxel sensitivity in breast cancer
Rouzier, R., Rajan, R., Wagner, P., Hess, K. R., Gold, D. L., Stec, J. J., Ayers, M., Ross, J. S., Zhang, P. G. Y., Buchholz, T. A., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408974102 · Cited by 413 · see citing works
Finn, R. S., Dering, J., Ginther, C., Wilson, C., Glaspy, P., Tchekmedyian, N., & Slamon, D. J. (2007) · Breast Cancer Research and Treatment · doi:10.1007/s10549-006-9463-x · Cited by 410 · see citing works
Constitutive activation of Src family kinases in mouse embryos that lack Csk
Nada, S., Yagi, T., Takeda, H., Tokunaga, T., Nakagawa, H., Ikawa, Y., Okada, M., & Aizawa, S. (1993) · Cell · doi:10.1016/0092-8674(93)90642-4 · Cited by 402 · see citing works
Imamoto, A., & Soriano, P. M. (1993) · Cell · doi:10.1016/0092-8674(93)90641-3 · Cited by 400 · see citing works
Microtubule dynamics in vitro are regulated by the tubulin isotype composition.
Panda, D., Miller, H. P., Banerjee, A., Ludueña, R. F., & Wilson, L. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.24.11358 · Cited by 372 · see citing works
Song, Z., Yao, X., & Wu, M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300957200 · Cited by 364 · see citing works
The Role of Src in Solid Tumors
Wheeler, D. L., Iida, M., & Dunn, E. F. (2009) · The Oncologist · doi:10.1634/theoncologist.2009-0009 · Cited by 346 · see citing works
Huang, F., Reeves, K., Han, X., Fairchild, C., Platero, S., Wong, T. W., Lee, F., Shaw, P., & Clark, E. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3633 · Cited by 344 · see citing works
Src family kinases: Regulation of their activities, levels and identification of new pathways
Ingley, E. (2007) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2007.08.012 · Cited by 337 · see citing works
Substoichiometric Binding of Taxol Suppresses Microtubule Dynamics
Derry, W. B., Wilson, L. R., & Jordan, M. A. (1995) · Biochemistry · doi:10.1021/bi00007a014 · Cited by 335 · see citing works
Johnson, F. M., Saigal, B., Talpaz, M., & Donato, N. J. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-0757 · Cited by 330 · see citing works
Mitosis is not a key target of microtubule agents in patient tumors
Komlodi-Pasztor, E., Sackett, D., Wilkerson, J., & Fojo, T. (2011) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2010.228 · Cited by 312 · see citing works
Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension
Lens, S. M. A., Wolthuis, R. M. F., Klompmaker, R., Kauw, J., Agami, R., Brummelkamp, T. R., Kops, G. J. P. L., & Medema, R. H. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg307 · Cited by 310 · see citing works
Ottenhoff-Kalff, A. E., Rijksen, G., van Beurden, E. A., Hennipman, A. H., Michels, A. A., & Staal, G. E. J. (1992) · PubMed · Cited by 306 · see citing works
Knockouts of Src-family kinases: stiff bones, wimpy T cells, and bad memories.Preprint
Lowell, C. A., & Soriano, P. M. (1996) · Genes & Development · doi:10.1101/gad.10.15.1845 · Cited by 285 · see citing works
The roles of copper transporters in cisplatin resistance
Kuo, M. T., Chen, H. H. W., Song, I., Savaraj, N., & Ishikawa, T. (2007) · Cancer and Metastasis Reviews · doi:10.1007/s10555-007-9045-3 · Cited by 282 · see citing works
Zaffaroni, N., Pennati, M., Colella, G., et al. (2002) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-002-8518-3 · Cited by 276 · see citing works
Bourguignon, L., Zhu, H., Shao, L., & Chen, Y. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006498200 · Cited by 262 · see citing works
Targeting Src in breast cancer
Finn, R. S. (2008) · Annals of Oncology · doi:10.1093/annonc/mdn291 · Cited by 248 · see citing works
Ahmed, A. A., Mills, A. D., Ibrahim, A. E. K., Temple, J., Blenkiron, C., Vias, M., Massie, C. E., Iyer, N. G., McGeoch, A. T., Crawford, R., et al. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.11.014 · Cited by 233 · see citing works
Mammary tumors expressing the neu proto-oncogene possess elevated c-Src tyrosine kinase activity.
Muthuswamy, S. K., Siegel, P. M., Dankort, D. L., Webster, M. A., & Muller, W. J. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.1.735 · Cited by 228 · see citing works
Class III β-Tubulin Mediates Sensitivity to Chemotherapeutic Drugs in Non–Small Cell Lung Cancer
Gan, P. P., Pasquier, E., & Kavallaris, M. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0509 · Cited by 222 · see citing works
Taxol: mechanisms of action and resistance.
Horwitz, S. B., Cohen, D., Rao, S., et al. (1993) · PubMed · Cited by 220 · see citing works
SRC: A Century of Science Brought to the Clinic
Aleshin, A. A., & Finn, R. S. (2010) · Neoplasia · doi:10.1593/neo.10328 · Cited by 212 · see citing works
Mechanisms of multidrug resistance: the potential role of microtubule-stabilizing agents
Fojo, T., & Menefee, M. E. (2007) · Annals of Oncology · doi:10.1093/annonc/mdm172 · Cited by 212 · see citing works
Song, L., Morris, M. D., Bagui, T. K., Lee, F. Y., Jove, R., & Haura, E. B. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4620 · Cited by 203 · see citing works
Guy, C. T., Muthuswamy, S. K., Cardiff, R. D., Soriano, P. M., & Muller, W. (1994) · Genes & Development · doi:10.1101/gad.8.1.23 · Cited by 202 · see citing works
Effect of stathmin on the sensitivity to antimicrotubule drugs in human breast cancer.
Alli, E., Bash-Babula, J., Yang, J., & Hait, W. N. (2002) · PubMed · Cited by 187 · see citing works
Antisense oligonucleotides to class III β-tubulin sensitize drug-resistant cells to Taxol
Kavallaris, M., Burkhart, C. A., & Horwitz, S. B. (1999) · British Journal of Cancer · doi:10.1038/sj.bjc.6690507 · Cited by 179 · see citing works
Vispé, S., DeVries, L., Créancier, L., Besse, J., Bréand, S., Hobson, D. J., Svejstrup, J. Q., Annereau, J., Cussac, D., Dumontet, C., et al. (2009) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-09-0549 · Cited by 177 · see citing works
Ling, X., Bernacki, R. J., Brattain, M. G., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m310947200 · Cited by 176 · see citing works
Activated Src Protein Tyrosine Kinase Is Overexpressed in Late-Stage Human Ovarian Cancers
Wiener, J. R., Windham, T. C., Estrella, V. C., Parikh, N. U., Thall, P. F., Deavers, M. T., Bast, R. C., Mills, G. B., & Gallick, G. E. (2002) · Gynecologic Oncology · doi:10.1006/gyno.2002.6851 · Cited by 175 · see citing works
Jacobs, C., & Rübsamen, H. (1983) · PubMed · Cited by 168 · see citing works
Zhang, Q. H., Thomas, S. M., Xi, S., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0504 · Cited by 167 · see citing works
SRC gene expression in human cancer: the role of transcriptional activation
Dehm, S. M., & Bonham, K. (2004) · Biochemistry and Cell Biology · doi:10.1139/o03-077 · Cited by 165 · see citing works
Autophagy Blockade Sensitizes Prostate Cancer Cells towards Src Family Kinase Inhibitors
Wu, Z., Chang, P., Yang, J. C., Chu, C.-Y., Wang, L., Chen, N., Ma, A.-H., Desai, S. J., Lo, S. H., Evans, C. P., et al. (2010) · Genes & Cancer · doi:10.1177/1947601909358324 · Cited by 165 · see citing works
Rosanò, L., Cianfrocca, R., Masi, S., Spinella, F., Castro, V. D., Biroccio, A., Salvati, E., Nicotra, M. R., Natali, P. G., & Bagnato, A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807158106 · Cited by 163 · see citing works
Penson, R. T., Oliva, E., Skates, S. J., et al. (2004) · Gynecologic Oncology · doi:10.1016/j.ygyno.2003.11.053 · Cited by 163 · see citing works
Martello, L. A., Verdier‐Pinard, P., Shen, H. J., He, L., Torres, K. E., Orr, G. A., & Horwitz, S. B. (2003) · PubMed · Cited by 160 · see citing works
Wen, X.-F., Yang, G. S., Mao, W., Thornton, A., Liu, J., Bast, R. C., & Le, X.-F. (2006) · Oncogene · doi:10.1038/sj.onc.1209685 · Cited by 159 · see citing works
Self-citationNilsson, M. B., Armaiz-Peña, G. N., Takahashi, R., Lin, Y. G., Trevino, J. G., Li, Y., Jennings, N., Arevalo, J. M. G., Lutgendorf, S. K., Gallick, G. E., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611539200 · Cited by 158 · see citing works
Zhang, C. C., Yang, J., White, E., et al. (1998) · Oncogene · doi:10.1038/sj.onc.1201658 · Cited by 158 · see citing works
Zhang, J., Kalyankrishna, S., Wislez, M., Thilaganathan, N., Saigal, B., Wei, W., Ma, L., Wistuba, I. I., Johnson, F. M., & Kurie, J. M. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2007.060706 · Cited by 154 · see citing works
Therapeutic Targeting of ATP7B in Ovarian Carcinoma
Mangala, L. S., Zuzel, V., Schmandt, R. E., LeShane, E. S., Halder, J. B., Armaiz-Peña, G. N., Spannuth, W. A., Tanaka, T., Shahzad, M. M. K., Lin, Y. G., et al. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-2306 · Cited by 154 · see citing works
Clinical Overview of the Taxanes
Goldspiel, B. R. (1997) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1002/j.1875-9114.1997.tb03813.x · Cited by 146 · see citing works
p53 status does not affect sensitivity of human ovarian cancer cell lines to paclitaxel.
Debernardis, D., Siré, E. G., de Feudis, P., Vikhanskaya, F., Valenti, M., Russo, P., Parodi, S., D’Incalci, M., & Broggini, M. (1997) · PubMed · Cited by 146 · see citing works
A β-Tubulin Leucine Cluster Involved in Microtubule Assembly and Paclitaxel Resistance
Gonzalez‐Garay, M. L., Chang, L., Cabral, F., Blade, K. L., & Menick, D. R. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.34.23875 · Cited by 146 · see citing works
Efficacy and Antivascular Effects of EphA2 Reduction With an Agonistic Antibody in Ovarian Cancer
Landen, C. N., Lu, C., Han, L. Y., et al. (2006) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djj414 · Cited by 134 · see citing works
Liu, J., Kang, H. K., Raab, M., da Silva, A. J., Kraeft, S., & Rudd, C. E. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.15.8779 · Cited by 133 · see citing works
Targeting SRC in glioblastoma tumors and brain metastases: Rationale and preclinical studies
Ahluwalia, M. S., de Groot, J., Liu, W., & Gladson, C. L. (2010) · Cancer Letters · doi:10.1016/j.canlet.2010.08.014 · Cited by 128 · see citing works
Dasatinib-induced autophagy is enhanced in combination with temozolomide in glioma
Milano, V. C., Piao, Y., LaFortune, T. A., & de Groot, J. (2009) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-08-0669 · Cited by 127 · see citing works
Serrels, A., Macpherson, I. R., Evans, T. R. J., Lee, F. Y., Clark, E. A., Sansom, O. J., Ashton, G. H. S., Frame, M. C., & Brunton, V. G. (2006) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-06-0382 · Cited by 124 · see citing works
Transmembrane Signaling by G Protein-Coupled Receptors
Luttrell, L. M. (2006) · Humana Press eBooks · doi:10.1385/1-59745-048-0:1 · Cited by 123 · see citing works
Src redox regulation: Again in the front line
Giannoni, E., Taddei, M. L., & Chiarugi, P. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.04.025 · Cited by 121 · see citing works
Phase 2 study of dasatinib in the treatment of head and neck squamous cell carcinoma
Brooks, H. D., Glisson, B. S., Bekele, B. N., Ginsberg, L. E., El‐Naggar, A. K., Culotta, K. S., Takebe, N., Wright, J., Tran, H. T., & Papadimitrakopoulou, V. A. (2010) · Cancer · doi:10.1002/cncr.25769 · Cited by 117 · see citing works
The Lipid Raft-Anchored Adaptor Protein Cbp Controls the Oncogenic Potential of c-Src
Oneyama, C., Hikita, T., Enya, K., Dobenecker, M.-W., Saito, K., Nada, S., Tarakhovsky, A., & Okada, M. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.03.026 · Cited by 116 · see citing works
Koppikar, P., Choi, S.-H., Egloff, A. M., Cai, Q., Suzuki, S., Freilino, M. L., Nozawa, H., Thomas, S. M., Gooding, W. E., Siegfried, J. M., et al. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-5226 · Cited by 113 · see citing works
pp60c-src activation in lung adenocarcinoma
Masaki, T., Igarashi, K., Tokuda, M., Yukimasa, S., Han, F., Jin, Y. J., Li, J. Q., Yoneyama, H., Uchida, N., Fujita, J., et al. (2003) · European Journal of Cancer · doi:10.1016/s0959-8049(03)00276-4 · Cited by 111 · see citing works
Nam, S., Williams, A. H., Vultur, A., List, A. F., Bhalla, K. N., Smith, D. D., Lee, F. Y., & Jove, R. (2007) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-06-0446 · Cited by 109 · see citing works
Pengetnze, Y., Steed, M., Roby, K. F., Terranova, P. F., & Taylor, C. C. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.08.012 · Cited by 107 · see citing works
Tan, M., Li, P., Klos, K. S., Lü, J., Lan, K., Nagata, Y., Fang, D., Jing, T., & Yu, D. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-2353 · Cited by 107 · see citing works
Human Mutations That Confer Paclitaxel Resistance
Yin, S., Bhattacharya, R., & Cabral, F. (2010) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-09-0674 · Cited by 103 · see citing works
Activity of the multikinase inhibitor dasatinib against ovarian cancer cells
Konecny, G. E., Glas, R., Dering, J., Manivong, K., Qi, J., Finn, R. S., Yang, G. R., Hong, K.-L., Ginther, C., Winterhoff, B. J. N., et al. (2009) · British Journal of Cancer · doi:10.1038/sj.bjc.6605381 · Cited by 101 · see citing works
Qian, X., Li, G., Vass, W. C., Papageorge, A. G., Walker, R. C., Asnaghi, L., Steinbach, P. J., Tosato, G., Hunter, K. W., & Lowy, D. R. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.07.031 · Cited by 99 · see citing works
Src as a potential therapeutic target in non-small-cell lung cancer
Giaccone, G., & Zucali, P. A. (2008) · Annals of Oncology · doi:10.1093/annonc/mdn048 · Cited by 99 · see citing works
Src Family Nonreceptor Tyrosine Kinases as Molecular Targets for Cancer Therapy
Johnson, F. M., & Gallick, G. E. (2007) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/187152007784111278 · Cited by 98 · see citing works
Stover, D. R., Furet, P., & Lydon, N. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.21.12481 · Cited by 95 · see citing works
Gan, P. P., McCarroll, J. A., Po’uha, S. T., Kamath, K., Jordan, M. A., & Kavallaris, M. (2010) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-09-0679 · Cited by 95 · see citing works
Targeting Epidermal Growth Factor Receptor and Src Pathways in Head and Neck Cancer
Egloff, A. M., & Grandis, J. R. (2008) · Seminars in Oncology · doi:10.1053/j.seminoncol.2008.03.008 · Cited by 94 · see citing works
Antiangiogenic and Antitumor Effects of Src Inhibition in Ovarian Carcinoma
Han, L. Y., Landen, C. N., Trevino, J. G., Halder, J., Lin, Y. G., Kamat, A. A., Kim, T., Merritt, W. M., Coleman, R. L., Gershenson, D. M., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-1410 · Cited by 94 · see citing works
Chen, T., Pengetnze, Y., & Taylor, C. (2005) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.217.4.2 · Cited by 94 · see citing works
Caveolin Scaffolding Region and the Membrane Binding Region of Src Form Lateral Membrane Domains
Wanaski, S. P., Ng, B. K., & Gläser, M. (2002) · Biochemistry · doi:10.1021/bi012097n · Cited by 93 · see citing works
Phosphorylation of c-Src on Tyrosine 527 by Another Protein Tyrosine Kinase
Thomas, J. E., Soriano, P. M., & Brugge, J. S. (1991) · Science · doi:10.1126/science.1719633 · Cited by 92 · see citing works
Dasatinib induces autophagic cell death in human ovarian cancer
Le, X., Mao, W., Lü, Z., Carter, B. Z., & Bast, R. C. (2010) · Cancer · doi:10.1002/cncr.25426 · Cited by 92 · see citing works
Self-citationWiener, J. R., Nakano, K., Kruzelock, R. P., Bucana, C. D., Bast, R. C., & Gallick, G. E. (1999) · PubMed · Cited by 91 · see citing works
Pusztai, L., Jeong, J., Gong, Y. Y., et al. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2008.21.6887 · Cited by 90 · see citing works
Caveolin-1 Reduces Osteosarcoma Metastases by Inhibiting c-Src Activity and Met Signaling
Cantiani, L., Manara, M. C., Zucchini, C., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-4697 · Cited by 88 · see citing works
Lim, R. W. L., & Halpain, S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001887200 · Cited by 86 · see citing works
Prognostic relevance of P-glycoprotein expression in breast cancer
Linn, S. C., Giaccone, G., van Diest, P. J., et al. (1995) · Annals of Oncology · doi:10.1093/oxfordjournals.annonc.a059284 · Cited by 83 · see citing works
Wang, X.-D., Reeves, K. A., Luo, F. R., Xu, L., Lee, F. Y., Clark, E. A., & Huang, F. (2007) · Genome biology · doi:10.1186/gb-2007-8-11-r255 · Cited by 82 · see citing works
Teneriello, M. G., Tseng, P. C., Crozier, M., et al. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2008.18.9548 · Cited by 80 · see citing works
Šale, S., Sung, R. K., Shen, P., et al. (2002) · PubMed · Cited by 79 · see citing works
Zou, C., Jia, L., Jin, H., et al. (2011) · BMC Cancer · doi:10.1186/1471-2407-11-22 · Cited by 79 · see citing works
Lü, J., Tan, M., Huang, W.-C., et al. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-0954 · Cited by 79 · see citing works
George, J. A., Chen, T., & Taylor, C. C. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1822 · Cited by 78 · see citing works
Oguri, T., Ozasa, H., Uemura, T., Bessho, Y., Miyazaki, M., Maeno, K., 前田, 浩., Sato, S., & Ueda, R. (2008) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-07-2088 · Cited by 76 · see citing works
Activity of pp60c-src in 60 different cell lines derived from human tumors.
Budde, R. J. A., Ke, S., & Levin, V. A. (1994) · PubMed · Cited by 76 · see citing works
Signalling by the p60 family of protein—tyrosine kinases
Kefalas, P., Brown, T. R. P., & Brickell, P. M. (1995) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/1357-2725(95)00024-j · Cited by 75 · see citing works
Targeting pericytes with a PDGF-B aptamer in human ovarian carcinoma models
Lu, C., Shahzad, M. M. K., Moreno‐Smith, M., Lin, Y. G., Jennings, N. B., Allen, J. K., Landen, C. N., Mangala, L. S., Armaiz-Peña, G. N., Schmandt, R. E., et al. (2010) · Cancer Biology & Therapy · doi:10.4161/cbt.9.3.10635 · Cited by 75 · see citing works
Functional Roles of Src and Fgr in Ovarian Carcinoma
Kim, H., Han, H. D., Armaiz-Peña, G. N., Stone, R. L., Nam, E. J., Lee, J., Shahzad, M. M. K., Nick, A. M., Lee, S. J., Roh, J., et al. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-2081 · Cited by 75 · see citing works
Cheung, C. H. A., Chen, H.-H., Kuo, C., et al. (2009) · Molecular Cancer · doi:10.1186/1476-4598-8-43 · Cited by 75 · see citing works
Wilson, G., Cramer, A., Welman, A., Knox, F., Swindell, R., Kawakatsu, H., Clarke, R. B., Dive, C., & Bundred, N. J. (2006) · British Journal of Cancer · doi:10.1038/sj.bjc.6603444 · Cited by 74 · see citing works
Matsuoka (1992) · International Journal of Oncology · doi:10.3892/ijo_00000153 · Cited by 74 · see citing works
Tanaka, Y., Kobayashi, H., Suzuki, M., Kanayama, N., & Terao, T. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m309131200 · Cited by 74 · see citing works
Semba, S., Trapasso, F., Fabbri, M., McCorkell, K. A., Volinia, S., Druck, T., Iliopoulos, D., Pekarsky, Y., Ishii, H., Garrison, P. N., et al. (2005) · Oncogene · doi:10.1038/sj.onc.1209323 · Cited by 73 · see citing works
Martinez‐Balibrea, E., Martínez‐Cardús, A., Musulén, E., et al. (2009) · International Journal of Cancer · doi:10.1002/ijc.24273 · Cited by 73 · see citing works
Copper Transport Systems are Involved in Multidrug Resistance and Drug Transport
Furukawa, T., Komatsu, M., Ikeda, R., et al. (2008) · Current Medicinal Chemistry · doi:10.2174/092986708786848479 · Cited by 71 · see citing works
Caveolin-1 Tyrosine Phosphorylation Enhances Paclitaxel-mediated Cytotoxicity
Shajahan‐Haq, A. N., Wang, A., Decker, M., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m608857200 · Cited by 70 · see citing works
Elsberger, B., Fullerton, R., Zino, S., Jordan, F., Mitchell, T. J., Brunton, V. G., Mallon, E., Shiels, P. G., & Edwards, J. (2010) · British Journal of Cancer · doi:10.1038/sj.bjc.6605829 · Cited by 70 · see citing works
Taxol and anti-stathmin therapy: a synergistic combination that targets the mitotic spindle.
Iancu, C., Mistry, S. J., Arkin, S., et al. (2000) · PubMed · Cited by 68 · see citing works
Owatari, S., Akune, S., Komatsu, M., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3096 · Cited by 65 · see citing works
Le, X., Mao, W., Lu, C., et al. (2008) · Cell Cycle · doi:10.4161/cc.7.23.7212 · Cited by 65 · see citing works
Self-citationA phase I study of dasatinib and weekly paclitaxel for metastatic breast cancer
Fornier, M. N., Morris, P. G., Abbruzzi, A., D’Andrea, G. M., Gilewski, T., Bromberg, J., Dang, C. T., Dickler, M. N., Modi, S., Seidman, A. D., et al. (2011) · Annals of Oncology · doi:10.1093/annonc/mdr018 · Cited by 64 · see citing works
The Tumor Suppressor Protein Fhit
Chaudhuri, A. R., KHAN, I. A., Prasad, V., Robinson, A. K., Ludueña, R. F., & Barnes, L. D. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.34.24378 · Cited by 63 · see citing works
Dual targeting of EphA2 and FAK in ovarian carcinoma
Shahzad, M. M. K., Lu, C., Lee, J.-W., et al. (2009) · Cancer Biology & Therapy · doi:10.4161/cbt.8.11.8523 · Cited by 63 · see citing works
Griffiths, G. J., Koh, M. Y., Brunton, V. G., Cawthorne, C., Reeves, N. A., Greaves, M., Tilby, M. J., Pearson, D. G., Ottley, C. J., Workman, P., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408550200 · Cited by 60 · see citing works
Src Inhibitors in Lung Cancer: Current Status and Future Directions
Rothschild, S. I., Gautschi, O. P., Haura, E. B., & Johnson, F. M. (2010) · Clinical Lung Cancer · doi:10.3816/clc.2010.n.030 · Cited by 59 · see citing works
Jeong, K. J., Park, S. Y., Seo, J. H., et al. (2008) · Experimental & Molecular Medicine · doi:10.3858/emm.2008.40.6.607 · Cited by 58 · see citing works
Larotaxel: broadening the road with new taxanes
Metzger, O., Moulin, C., de Azambuja, E., & Awada, A. H. (2009) · Expert Opinion on Investigational Drugs · doi:10.1517/13543780903119167 · Cited by 57 · see citing works
Mutational analysis of the class I β‐tubulin gene in human breast cancer
Hasegawa, S., Miyoshi, Y., Egawa, C., et al. (2002) · International Journal of Cancer · doi:10.1002/ijc.10575 · Cited by 57 · see citing works
Oijen, M. G. C. T., Rijksen, G., ten Broek, F.-W., & Slootweg, P. J. (2007) · Journal of Oral Pathology and Medicine · doi:10.1111/j.1600-0714.1998.tb01931.x · Cited by 56 · see citing works
Cdc2-mediated modulation of pp60c-src activity.
Stover, D. R., Liebetanz, J., & Lydon, N. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47102-5 · Cited by 53 · see citing works
Mutational analysis of the β-tubulin gene in lung cancer
Tsurutani, J., Komiya, T., Uejima, H., et al. (2002) · Lung Cancer · doi:10.1016/s0169-5002(01)00291-4 · Cited by 49 · see citing works
Leung, E. L., Tam, I. Y. S., Tin, V. P., Chua, D. T.-T., Sihoe, A. D., Cheng, L., Ho, J., Chung, L.-P., & Wong, M. P. (2009) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-09-0003 · Cited by 48 · see citing works
Role of PELP1/MNAR Signaling in Ovarian Tumorigenesis
Chakravarty, D., Nair, S. S., Rajhans, R., Pitcheswara, P. R., Liu, J., Balasenthil, S., Le, X., Burow, M. E., Auersperg, N., TEKMAL, R. R., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-5698 · Cited by 48 · see citing works
Self-citationC-Src Activation by ErbB2 Leads to Attachment-Independent Growth of Human Breast Epithelial Cells
Sheffield, L. G. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9214 · Cited by 46 · see citing works
Lee, F. Y. F., Covello, K. L., Castaneda, S., et al. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-0025 · Cited by 43 · see citing works
Naramoto, H., Uematsu, T., Uchihashi, T., et al. (2007) · International Journal of Oncology · doi:10.3892/ijo.30.2.393 · Cited by 41 · see citing works
Piacentini, M., Piredda, L., Starace, D., Annicchiarico‐Petruzzelli, M., Mattei, M., Oliverio, S., Farrace, M. G., & Melino, G. (1996) · The Journal of Pathology · doi:10.1002/(sici)1096-9896(199612)180:4 · Cited by 39 · see citing works
Clinical Development of Src Tyrosine Kinase Inhibitors in Lung Cancer
Lee, D. L., & Gautschi, O. P. (2006) · Clinical Lung Cancer · doi:10.3816/clc.2006.n.020 · Cited by 37 · see citing works
Teoh, D. K., Ayeni, T. A., Rubatt, J. M., Adams, D. J., Grace, L. A., Starr, M. D., Barry, W. T., Berchuck, A., Murphy, S. K., & Secord, A. A. (2011) · Gynecologic Oncology · doi:10.1016/j.ygyno.2010.11.017 · Cited by 37 · see citing works
Src inhibitors in breast cancer therapy
Hiscox, S., & Nicholson, R. I. (2008) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.12.6.757 · Cited by 37 · see citing works
The involvement of Fyn kinase in resumption of the first meiotic division in mouse oocytes
Levi, M., Maro, B., & Shalgi, R. (2010) · Cell Cycle · doi:10.4161/cc.9.8.11299 · Cited by 35 · see citing works
Frasson, M., Vitadello, M., Brunati, A. M., Rocca, N. L., Tibaldi, E. V., Pinna, L. A., Gorza, L., & Donella‐Deana, A. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2008.10.001 · Cited by 34 · see citing works
Non-anti-mitotic concentrations of taxol reduce breast cancer cell invasiveness
Tran, T.-A., Gillet, L., Roger, S., Besson, P., White, E., & Guennec, J. L. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.12.073 · Cited by 33 · see citing works
Wiesen, K. M., Xia, S., Yang, C. H., & Horwitz, S. B. (2007) · Cancer Letters · doi:10.1016/j.canlet.2007.07.022 · Cited by 32 · see citing works
Hage‐Sleiman, R., Herveau, S., Matera, E., Laurier, J.-F., & Dumontet, C. (2010) · BMC Cancer · doi:10.1186/1471-2407-10-135 · Cited by 28 · see citing works
Huang, R. Y., Wang, S., Hsieh, C., et al. (2008) · International Journal of Cancer · doi:10.1002/ijc.23579 · Cited by 27 · see citing works
FHIT protein enhances paclitaxel‐induced apoptosis in lung cancer cells
Kim, C. H., Yoo, J. S., Lee, C., et al. (2005) · International Journal of Cancer · doi:10.1002/ijc.21573 · Cited by 22 · see citing works
The role of Fyn kinase in the release from metaphase in mammalian oocytes
Levi, M., & Shalgi, R. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.08.027 · Cited by 20 · see citing works
Pinedo, H. M. (1994) · Annals of Oncology · doi:10.1093/annonc/5.suppl_5.3 · Cited by 20 · see citing works
Zheng, R., Yano, S., Matsumori, Y., Nakataki, E., Muguruma, H., Yoshizumi, M., & Sone, S. (2005) · Clinical & Experimental Metastasis · doi:10.1007/s10585-005-7768-5 · Cited by 19 · see citing works
Amino acid substitutions at proline 220 of β-tubulin confer resistance to paclitaxel and colcemid
Yin, S., Cabral, F., & Veeraraghavan, S. (2007) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-06-0791 · Cited by 19 · see citing works
Src as a Therapeutic Target in Breast Cancer
Morgan, L. D., Nicholson, R. I., & Hiscox, S. (2008) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/187153008786848295 · Cited by 19 · see citing works
Inagaki, K., Kobayashi, H., Yoshida, R., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501406200 · Cited by 18 · see citing works
Fyn Phosphorylates Human MAP-2c on Tyrosine 67
Zamora-León, S. P., Bresnick, A. R., Backer, J., & Shafit‐Zagardo, B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m411380200 · Cited by 16 · see citing works
Bellarosa, D., Binaschi, M., Maggi, C. A., & Goso, C. (2005) · PubMed · Cited by 16 · see citing works
Wakahara, K., Kobayashi, H., Yagyu, T., et al. (2004) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20160 · Cited by 15 · see citing works
Effect of autophagy on paclitaxel-induced CaSki cell death.
Sun, Y., Jin, L. G., Liu, J., et al. (2010) · PubMed · doi:10.3969/j.issn.1672-7347.2010.06.004 · Cited by 12 · see citing works
Gruber, D., Faire, K., & Bulinski, J. C. (2001) · Cell Motility and the Cytoskeleton · doi:10.1002/cm.1026 · Cited by 11 · see citing works
[The detection of the c-src protein gene product in human lung tumors].
Мазуренко, Н. Н., Коган, Е. А., Зборовская, И. Б., et al. (1991) · PubMed · Cited by 6 · see citing works
Genomic structure and alternative splicing of the murine bhk/ctk/ntk gene
Ershler, M. A., Samokhvalov, I. M., Belyavsky, A. V., et al. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)01154-7 · Cited by 3 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Verbeek BS, Vroom TM, Adriaansen-Slot SS, Ottenhoff-Kalff AE, Geertzema JG, Hennipman A, et al. c-Src protein expression is increased in human breast cancer. An immunohistochemical and biochemical analysis. J Pathol 1996; 180:383-8. 0
Cited by
Sorted by citations
Mechanisms of Taxane Resistance
Maloney, S., Spring, C., Morejon-Lasso, L., & Prosperi, J. (2020) · Cancers · doi:10.3390/cancers12113323 · Cited by 198 · see citing works
Simpkins, F., Jang, K., Yoon, H., Hew, K. E., Kim, M., Azzam, D. J., Sun, J., Zhao, D., Ince, T. A., Liu, W., et al. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-3697 · Cited by 67 · see citing works
Perez, M., Lucena-Cacace, A., Marín-Gómez, L. M., Padillo-Ruiz, J., Robles-Frias, M. J., Saez, C., Garcia-Carbonero, R., & Carnero, A. (2016) · Oncotarget · doi:10.18632/oncotarget.8880 · Cited by 34 · see citing works
- Authors
- Le, X.-F., & Bast, Jr.
- Affiliations
- The University of Texas MD Anderson Cancer Center (US)
- University of Texas MD Anderson Cancer Center, Houston, TX USA
- Corresponding author
- Le, Xiao-Feng
- ORCID
- Le, Xiao-Feng
- Venue
- Cancer Biology & Therapy
- Publisher
- Informa UK Limited
- Published
- 2011-08-15
- Volume
- 12
- Issue
- 4
- Pages
- 260-269
- ISSN
- 1538-4047 (ISSN-L)
- 1555-8576
- PMC
- PMC3173729
- OpenAlex
- W2119168587
- Cited by
- 79
- References
- 173
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 5 · 2020: 8 · 2019: 3 · 2018: 5 · 2017: 6 · 2016: 11 · 2015: 10 · 2014: 8 · 2013: 6 · 2012: 4
- FWCI
- 0.53
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cancer Biology & Therapy (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Texas MD Anderson Cancer Center (#CA16672, P50 CA83639, P30CA 16672, NCI P50 CA 83639)
- National Cancer Institute (P30CA16672, NCI P50 CA 83639, CA-16672, CA 83639, P50-CA83639, P50CA083639, P30CA016672)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Treatment and Pharmacology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Keywords
- Src family kinases, paclitaxel, drug sensitivity, drug resistance, microtubule stabilization, apoptosis, autophagy, P-glycoprotein, tubulin, copper transporters, combination therapy, predictive biomarkers, ovarian cancer, breast cancer, lung cancer, head and neck cancer
- MeSH terms
- Antineoplastic Agents, Phytogenic, Enzyme Inhibitors, Humans, Neoplasms, Apoptosis, Paclitaxel, Drug Resistance, Neoplasm, src-Family Kinases, RNA Interference, Cell Line, Tumor
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review