Expression of Kinase-defective Mutants of c-Src in Human Metastatic Colon Cancer Cells Decreases Bcl-xL and Increases Oxaliplatin- and Fas-induced Apoptosis

Griffiths, Gareth J.; Koh, Mei Yee; Brunton, Valerie G.; Cawthorne, Christopher; Reeves, Natalie A.; Greaves, Martin; Tilby, Michael J.; Pearson, D. Graham; Ottley, Christopher J.; Workman, Paul; Frame, Margaret C.; Dive, Caroline

doi:10.1074/jbc.m408550200

Expression of Kinase-defective Mutants of c-Src in Human Metastatic Colon Cancer Cells Decreases Bcl-xL and Increases Oxaliplatin- and Fas-induced Apoptosis

Tumor resistance to current drugs prevents curative treatment of human colon cancer. A pressing need for effective, tumor-specific chemotherapies exists. The non-receptor-tyrosine kinase c-Src is overexpressed in >70% of human colon cancers and represents a tractable drug target. KM12L4A human me…