Stromal galectin-1 expression is associated with long-term survival in resectable pancreatic ductal adenocarcinoma
Open accessAbstract
The overall 5 year survival rate for pancreatic ductal adenocarcinoma (i.e., PDAC) is a dismal 5%, although patients that have undergone surgical resection have a somewhat better survival rate of up to 20%. Very long-term survivors of PDAC (defined as patients with ≥ 10 year survival following apparently curative resection), on the other hand, are considerably less frequent. The molecular characteristics of very long-term survivors (VLTS) are poorly understood, but might provide novel insights into prognostication for this disease. In this study, a panel of five VLTS and stage-matched short-term survivors (STS, defined as disease-specific mortality within 14 months of resection) were identified, and quantitative proteomics was applied to comparatively profile tumor tissues from both cohorts. Differentially expressed proteins were identified in cancers from VLTS vs. STS patients. Specifically, the expression of galectin-1 was 2-fold lower in VLTS compared with STS tumors. Validation studies were performed by immunohistochemistry (IHC) in two additional cohorts of resected PDAC, including: 1) an independent cohort of VLTS and 2) a panel of sporadic PDAC with a considerable range of overall survival following surgery. Immunolabeling analysis confirmed that significantly lower expression of stromal galectin-1 was associated with VLTS (p = 0.02) and also correlated with longer survival in sporadic, surgically-treated PDAC cases (hazard ratio = 4.9, p = 0.002). The results from this study provide new insights to better understand the role of galectin-1 in PDAC survival, and might be useful for rendering prognostic information, and developing more effective therapeutic strategies aimed at improving survival.
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LGALS1 overexpression has been negatively associated with survival in PDAC patients.
“LGALS1 overexpression has also been negatively associated with survival in PDAC patients33”
From Occult polyclonality of preclinical pancreatic cancer models drives in vitro evolution (2022) · cites this paper as [33]
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- Authors
- Chen, R., Pan, S., Ottenhof, N. A., de Wilde, R. F., Wolfgang, C. L., Lane, Z., Post, J., Bronner, M. P., Willmann, J. K., Maitra, A., & Brentnall, T. A.
- Affiliations
- University of Washington (US)
- Johns Hopkins University (US)
- Henry Ford Hospital (US)
- Cleveland Clinic (US)
- University of Utah (US)
- Stanford Medicine (US)
- Corresponding author
- Brentnall, Teresa A.
- ORCID
- Venue
- Cancer Biology & Therapy
- Publisher
- Informa UK Limited
- Published
- 2012-08
- Volume
- 13
- Issue
- 10
- Pages
- 899-907
- ISSN
- 1538-4047 (ISSN-L)
- 1555-8576
- PMC
- PMC3414412
- OpenAlex
- W2040375770
- Cited by
- 62
- References
- 48
- Citations by year
- 2026: 2 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 3 · 2020: 5 · 2019: 8 · 2018: 6 · 2017: 8 · 2016: 4 · 2015: 1 · 2014: 11 · 2013: 5 · 2012: 2
- FWCI
- 3.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cancer Biology & Therapy (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Johns Hopkins University
- National Institutes of Health
- National Cancer Institute (R21CA149772, R01CA113669, P01CA134292, K07CA116296, R21CA161575, K25CA137222, P50CA062924, R01CA107209, P30CA015704)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK081368)
- Topics
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Life Sciences › Immunology and Microbiology › Immunology › Galectins and Cancer Biology
- Health Sciences › Medicine › Surgery › Cholangiocarcinoma and Gallbladder Cancer Studies
- Keywords
- galectin-1, pancreatic ductal adenocarcinoma, tumor stroma, long-term survival, prognostic factors, surgical resection, proteomic profiling, differentially expressed proteins, overall survival
- MeSH terms
- Humans, Neoplasm Staging, Pancreatic Neoplasms, Prognosis, Gene Expression Regulation, Neoplastic, Stromal Cells, Disease Progression, Carcinoma, Pancreatic Ductal, Galectin 1, Tumor Microenvironment
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