Cited by 57Mesenchymal stem cell researchCancer Cells and MetastasisImmune cells in cancer

The Dual Role of Mesenchymal Stem Cells in Cancer Pathophysiology: Pro-Tumorigenic Effects versus Therapeutic Potential

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Slama, Youssef, Ah-Pine, Franck, Khettab, Mohamed, Arcambal, Angelique, Begue, Mickael, Dutheil, Fabien, Gasque, Philippe·2023·International Journal of Molecular Sciences

Abstract

Mesenchymal stem/stromal cells (MSCs) are multipotent cells involved in numerous physiological events, including organogenesis, the maintenance of tissue homeostasis, regeneration, or tissue repair. MSCs are increasingly recognized as playing a major, dual, and complex role in cancer pathophysiology through their ability to limit or promote tumor progression. Indeed, these cells are known to interact with the tumor microenvironment, modulate the behavior of tumor cells, influence their functions, and promote distant metastasis formation through the secretion of mediators, the regulation of cell–cell interactions, and the modulation of the immune response. This dynamic network can lead to the establishment of immunoprivileged tissue niches or the formation of new tumors through the proliferation/differentiation of MSCs into cancer-associated fibroblasts as well as cancer stem cells. However, MSCs exhibit also therapeutic effects including anti-tumor, anti-proliferative, anti-inflammatory, or anti-oxidative effects. The therapeutic interest in MSCs is currently growing, mainly due to their ability to selectively migrate and penetrate tumor sites, which would make them relevant as vectors for advanced therapies. Therefore, this review aims to provide an overview of the double-edged sword implications of MSCs in tumor processes. The therapeutic potential of MSCs will be reviewed in melanoma and lung cancers.

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  • The migration of mesenchymal stem cells to the tumor microenvironment is regulated by numerous factors, including adhesion molecules (VCAM), chemokines (CCL2, CCL5, CCL22, CXCL8, and SDF-1/CXCL12), cytokines (IL-1, IL-6, TGF-β, and TNF-α), IGF-1, PDGF, HIF-1, reactive oxygen species, and many more.

    “The migration of MSC to the TME is regulated by numerous factors, including adhesion molecules (VCAM), chemokines (CCL2, CCL5, CCL22, CXCL8, and SDF-1/CXCL12), cytokines (IL-1, IL-6, TGF-β, and TNF-α), insulin GF (IGF-1), PDGF, hypoxia-inducible factor (HIF-1), reactive oxygen species (ROS), and many more [77].”

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Authors
Slama, Y., Ah-Pine, F., Khettab, M., Arcambal, A., Begue, M., Dutheil, F., & Gasque, P.
Affiliations
  • University of Reunion Island (RE)
  • Laboratoire Interdisciplinaire de Recherche en Santé (LIRS), RunResearch, Clinique Sainte-Clotilde, 127 Route de Bois de Nèfles, 97400 Saint-Denis, La Réunion, France
  • Clinifutur (RE)
Corresponding author
Slama, Youssef
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2023-08-31
Volume
24
Issue
17
Pages
13511
ISSN
1422-0067 (ISSN-L)
OpenAlex
W4386331467
Cited by
57
References
356
Citations by year
2026: 13 · 2025: 22 · 2024: 21 · 2023: 1
FWCI
2.67
Type
journal article
Language
en
Open access
Locations
  • International Journal of Molecular Sciences (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
EPIGEN project research (CPER FEDER 2019221-0022768)
Topics
  • Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
  • Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
  • Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Keywords
mesenchymal stem cells, tumor microenvironment, tumor progression, metastasis, cancer-associated fibroblasts, cancer stem cells, tumor immunomodulation, melanoma, lung cancer, cell-cell interactions
MeSH terms
Humans, Lung Neoplasms, Melanoma, Multipotent Stem Cells, Tumor Microenvironment, Mesenchymal Stem Cells, Carcinogenesis

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