The Dual Role of Mesenchymal Stem Cells in Cancer Pathophysiology: Pro-Tumorigenic Effects versus Therapeutic Potential
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Mesenchymal stem/stromal cells (MSCs) are multipotent cells involved in numerous physiological events, including organogenesis, the maintenance of tissue homeostasis, regeneration, or tissue repair. MSCs are increasingly recognized as playing a major, dual, and complex role in cancer pathophysiology through their ability to limit or promote tumor progression. Indeed, these cells are known to interact with the tumor microenvironment, modulate the behavior of tumor cells, influence their functions, and promote distant metastasis formation through the secretion of mediators, the regulation of cell–cell interactions, and the modulation of the immune response. This dynamic network can lead to the establishment of immunoprivileged tissue niches or the formation of new tumors through the proliferation/differentiation of MSCs into cancer-associated fibroblasts as well as cancer stem cells. However, MSCs exhibit also therapeutic effects including anti-tumor, anti-proliferative, anti-inflammatory, or anti-oxidative effects. The therapeutic interest in MSCs is currently growing, mainly due to their ability to selectively migrate and penetrate tumor sites, which would make them relevant as vectors for advanced therapies. Therefore, this review aims to provide an overview of the double-edged sword implications of MSCs in tumor processes. The therapeutic potential of MSCs will be reviewed in melanoma and lung cancers.
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The migration of mesenchymal stem cells to the tumor microenvironment is regulated by numerous factors, including adhesion molecules (VCAM), chemokines (CCL2, CCL5, CCL22, CXCL8, and SDF-1/CXCL12), cytokines (IL-1, IL-6, TGF-β, and TNF-α), IGF-1, PDGF, HIF-1, reactive oxygen species, and many more.
“The migration of MSC to the TME is regulated by numerous factors, including adhesion molecules (VCAM), chemokines (CCL2, CCL5, CCL22, CXCL8, and SDF-1/CXCL12), cytokines (IL-1, IL-6, TGF-β, and TNF-α), insulin GF (IGF-1), PDGF, hypoxia-inducible factor (HIF-1), reactive oxygen species (ROS), and many more [77].”
From Mesenchymal stromal cells in bone marrow niche of patients with multiple myeloma: a double-edged sword (2025) · cites this paper as [77]
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Flagged first, then by citations
1 of the 356 references couldn’t be matched to a known paper.
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Stem Cell for Cancer Immunotherapy: Current Approaches and Challenges
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Biophysical Properties of the Extracellular Matrix in Cancer: Insights Into Immunotherapy
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CD248 Cleaved Form in Human Colorectal Cancer Stroma: Implications for Tumor Behavior and Prognosis
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Nano-phyto formulations for overcoming drug resistance in brain cancer: A translational roadmap
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Mesenchymal Stem Cells and Reticulated Platelets: New Horizons in Multiple Myeloma
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Potential Use of Human Mesenchymal Stem Cells (hMSCs) in Pancreatic Damage/Cancer
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Mesenchymal Stem Cells in Cancer Therapy
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Chemical proteomics decrypts the kinases that shape the dynamic human phosphoproteomePreprint
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A method for inducing a senescence trend in mesenchymal stem cells using D-galactose 1Preprint
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Phenotypic and functional similar ities between mesenchymal stem cells and fibroblasts in cancer
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- Authors
- Slama, Y., Ah-Pine, F., Khettab, M., Arcambal, A., Begue, M., Dutheil, F., & Gasque, P.
- Affiliations
- University of Reunion Island (RE)
- Laboratoire Interdisciplinaire de Recherche en Santé (LIRS), RunResearch, Clinique Sainte-Clotilde, 127 Route de Bois de Nèfles, 97400 Saint-Denis, La Réunion, France
- Clinifutur (RE)
- Corresponding author
- Slama, Youssef
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2023-08-31
- Volume
- 24
- Issue
- 17
- Pages
- 13511
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC10488262
- OpenAlex
- W4386331467
- Cited by
- 57
- References
- 356
- Citations by year
- 2026: 13 · 2025: 22 · 2024: 21 · 2023: 1
- FWCI
- 2.67
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- EPIGEN project research (CPER FEDER 2019221-0022768)
- Topics
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Keywords
- mesenchymal stem cells, tumor microenvironment, tumor progression, metastasis, cancer-associated fibroblasts, cancer stem cells, tumor immunomodulation, melanoma, lung cancer, cell-cell interactions
- MeSH terms
- Humans, Lung Neoplasms, Melanoma, Multipotent Stem Cells, Tumor Microenvironment, Mesenchymal Stem Cells, Carcinogenesis
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