The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
MicroRNA expression analysis in triple-negative (ER, PR and Her2/neu) breast cancer
Open accessAbstract
miRNAs are small, regulatory molecules approximately 21-24 nucleotides in length. They function at the post-transcriptional level by controlling the expression of more than 50% of human protein-coding genes and play an essential role in cell signaling pathways. The objective of the present study was to explore the expression profile of oncomiRs and tumor-suppressor miRs, and to define their possible correlations in triple-negative (ER, PR and Her2/neu) primary breast cancers. Forty-nine primary triple-negative breast cancer cases, along with 34 matched tumor-associated normal samples were investigated for the expression of 9 miRNAs using qPCR. Relationships between the expression of miR-10b, miR-21, miR-122a, miR-145, miR-205, miR-210, miR-221, miR-222 and miR-296 and the pathologic features of the tumors were examined, as were the influences of miR expression on patient overall and cancer-specific survival. miR-21, miR-210 and miR-221 were significantly overexpressed, whereas miR-10b, miR-145, miR-205, miR-122a were significantly underexpressed in the triple-negative primary breast cancers. Significant correlations among all of the studied miRs were scored both in the breast cancer and control tissue. Expression of miR-222 and miR-296 did not exhibit any significant difference between the breast cancer and normal tissue. There was a non-significant trend for high expression levels of the microRNAs, miR-21, miR-210, miR-221 and miR-222, to be associated with worse patient disease-free and overall survival. miR-21, miR-210 and miR-221 expression plays a significant role in triple- negative primary breast cancers.
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Cites
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Cited by
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Loss of microRNA-205 expression is associated with melanoma progression
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Metadata
- Authors
- Radojicic, J., Zaravinos, A., Vrekoussis, T., Kafousi, M., Spandidos, D. A., & Stathopoulos, E. N.
- Venue
- Cell Cycle
- Publisher
- Informa UK Limited
- Published
- 2011-02
- Volume
- 10
- Issue
- 3
- Pages
- 507-517
- ISSN
- 1538-4101 (ISSN-L)
- 1551-4005
- OpenAlex
- W2087660989
- Cited by
- 256
- References
- 50
- FWCI
- 8.64
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: MicroRNA expression analysis in triple-negative (ER, PR and Her2/neu) breast cancer. https://app.cochat.ai/papers/10.4161/cc.10.3.14754
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- Radojicic, J., Zaravinos, A., Vrekoussis, T., Kafousi, M., Spandidos, D. A., & Stathopoulos, E. N. (2011). MicroRNA expression analysis in triple-negative (ER, PR and Her2/neu) breast cancer. Cell Cycle. https://doi.org/10.4161/cc.10.3.14754
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