Toward an integrative view of Optineurin functions

p62/SQSTM1 Binds Directly to Atg8/LC3 to Facilitate Degradation of Ubiquitinated Protein Aggregates by Autophagy

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Pathogen Recognition by the Innate Immune System

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Phosphorylation of the Autophagy Receptor Optineurin Restricts <i>Salmonella</i> Growth

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Mutations of optineurin in amyotrophic lateral sclerosis

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Interferons at age 50: past, current and future impact on biomedicine

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Adult-Onset Primary Open-Angle Glaucoma Caused by Mutations in Optineurin

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Primary Open-Angle Glaucoma

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The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria

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Salmonellae interplay with host cells

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Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery

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Selective autophagy: ubiquitin-mediated recognition and beyond

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Bora and the Kinase Aurora A Cooperatively Activate the Kinase Plk1 and Control Mitotic Entry

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Polo-like kinases: conservation and divergence in their functions and regulation

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Huntingtin–protein interactions and the pathogenesis of Huntington's disease

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The hunt for huntingtin function: interaction partners tell many different stories

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Optineurin links myosin VI to the Golgi complex and is involved in Golgi organization and exocytosis

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Ubiquitination in signaling to and activation of IKK

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Huntingtin interacts with a family of WW domain proteins

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CYLD: a tumor suppressor deubiquitinase regulating NF-κB activation and diverse biological processes

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Huntingtin facilitates dynein/dynactin-mediated vesicle transport

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Recognition of Bacteria in the Cytosol of Mammalian Cells by the Ubiquitin System

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Regulation of immunity and oncogenesis by the IRF transcription factor family

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Optineurin Negatively Regulates TNFα- Induced NF-κB Activation by Competing with NEMO for Ubiquitinated RIP

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Genome-wide association study identifies variants at CSF1, OPTN and TNFRSF11A as genetic risk factors for Paget's disease of bone

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The Receptor of the Type I Interferon Family

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Huntingtin as an essential integrator of intracellular vesicular trafficking

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Endocytic transport of integrins during cell migration and invasion

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Convergence of the NF-κB and IRF pathways in the regulation of the innate antiviral response

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The genetics of primary open-angle glaucoma: A review

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FIP-2, a coiled-coil protein, links Huntingtin to Rab8 and modulates cellular morphogenesis

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RIG-I-like receptors: Sensing and responding to RNA virus infection

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Interaction of an Adenovirus E3 14.7-Kilodalton Protein with a Novel Tumor Necrosis Factor Alpha-Inducible Cellular Protein Containing Leucine Zipper Domains

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Regulation of NF-κB signaling by the A20 deubiquitinase

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The ubiquitin-binding adaptor proteins p62/SQSTM1 and NDP52 are recruited independently to bacteria-associated microdomains to target Salmonella to the autophagy pathway

Cemma, M., Kim, P. K., & Brumell, J. H. (2011) · Autophagy · doi:10.4161/auto.7.3.14046 · Cited by 203 · see citing works

NEMO specifically recognizes K63‐linked poly‐ubiquitin chains through a new bipartite ubiquitin‐binding domain

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Mutant Huntingtin Impairs Post-Golgi Trafficking to Lysosomes by Delocalizing Optineurin/Rab8 Complex from the Golgi Apparatus

del Toro, D., Alberch, J., Lázaro‐Diéguez, F., Martín‐Ibáñez, R., Xifró, X., Egea, G., & Canals, J. M. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-07-0726 · Cited by 185 · see citing works

Enhanced binding of TBK1 by an optineurin mutant that causes a familial form of primary open angle glaucoma

Morton, S., Hesson, L. B., Peggie, M. W., & Cohen, P. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.02.047 · Cited by 180 · see citing works

Polyubiquitin Binding to Optineurin Is Required for Optimal Activation of TANK-binding Kinase 1 and Production of Interferon β

Gleason, C. E., Ordureau, A., Gourlay, R., Arthur, J. S. C., & Cohen, P. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.267567 · Cited by 173 · see citing works

Inhibition of Autophagy in Mitotic Animal Cells

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A tumor necrosis factor-α–mediated pathway promoting autosomal dominant polycystic kidney disease

Li, X., Magenheimer, B. S., Xia, S., Johnson, T. J., Wallace, D. P., Calvet, J. P., & Li, R. (2008) · Nature Medicine · doi:10.1038/nm1783 · Cited by 170 · see citing works

Myosin Phosphatase-Targeting Subunit 1 Regulates Mitosis by Antagonizing Polo-like Kinase 1

Yamashiro, S., Yamakita, Y., Totsukawa, G., Goto, H., Kaibuchi, K., Ito, M., Hartshorne, D. J., & Matsumura, F. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.02.013 · Cited by 169 · see citing works

Pathogenesis of Paget Disease of Bone

Ralston, S. H., & Layfield, R. (2012) · Calcified Tissue International · doi:10.1007/s00223-012-9599-0 · Cited by 169 · see citing works

Overexpression of optineurin E50K disrupts Rab8 interaction and leads to a progressive retinal degeneration in mice

Chi, Z.-L., Akahori, M., Obazawa, M., Minami, M., Noda, T., Nakaya, N., Tomarev, S., Kawase, K., Yamamoto, T., Noda, S., et al. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq146 · Cited by 151 · see citing works

Mitosis controls the Golgi and the Golgi controls mitosis

Colanzi, A., & Corda, D. (2007) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2007.06.002 · Cited by 149 · see citing works

Inhibition of Metabotropic Glutamate Receptor Signaling by the Huntingtin-binding Protein Optineurin

Anborgh, P. H., Godin, C. M., Pampillo, M., Dhami, G. K., Dale, L. B., Cregan, S. P., Truant, R., & Ferguson, S. S. G. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m504508200 · Cited by 141 · see citing works

Loss of myosin VI reduces secretion and the size of the Golgi in fibroblasts from Snell's waltzer mice

Warner, C. L., Stewart, A., Luzio, J. P., Steel, K. P., Libby, R. T., Kendrick‐Jones, J., & Buß, F. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg055 · Cited by 140 · see citing works

Cellular and Molecular Biology of Optineurin

Ying, H., & Yue, B. Y. J. T. (2012) · International review of cytology · doi:10.1016/b978-0-12-394305-7.00005-7 · Cited by 135 · see citing works

Molecular genetics in glaucoma

Liu, Y., & Allingham, R. R. (2011) · Experimental Eye Research · doi:10.1016/j.exer.2011.08.007 · Cited by 134 · see citing works

Optineurin Increases Cell Survival and Translocates to the Nucleus in a Rab8-dependent Manner upon an Apoptotic Stimulus

Marco, N. D., Buono, M., Troise, F., & Diez‐Roux, G. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601467200 · Cited by 132 · see citing works

LUBAC regulates NF‐κB activation upon genotoxic stress by promoting linear ubiquitination of NEMO

Niu, J., Shi, Y., Iwaï, K., & Wu, Z.-H. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.264 · Cited by 129 · see citing works

Optineurin Negatively Regulates the Induction of IFNβ in Response to RNA Virus Infection

Mankouri, J., Fragkoudis, R., Richards, K. H., Wetherill, L. F., Harris, M., Kohl, A., Elliott, R. M., & Macdonald, A. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000778 · Cited by 129 · see citing works

Huntingtin coordinates the dynein-mediated dynamic positioning of endosomes and lysosomes

Caviston, J. P., Zajac, A. L., Tokito, M. K., & Holzbaur, E. L. F. (2010) · Molecular Biology of the Cell · doi:10.1091/mbc.e10-03-0233 · Cited by 123 · see citing works

NF-κB Mediates Tumor Necrosis Factor α-Induced Expression of Optineurin, a Negative Regulator of NF-κB

Sudhakar, C., Nagabhushana, A., Jain, N. S., & Swarup, G. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005114 · Cited by 119 · see citing works

Myosin VI is required for sorting of AP-1B–dependent cargo to the basolateral domain in polarized MDCK cells

Au, J. S.-Y., Puri, C., Ihrke, G., Kendrick‐Jones, J., & Buß, F. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200608126 · Cited by 117 · see citing works

Phorbol Esters and Cytokines Regulate the Expression of theNEMO-related Protein, a Molecule Involved in a NF-κB-independent Pathway

Schwamborn, K., Weil, R., Courtois, G., Whiteside, S. T., & Israël, A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001500200 · Cited by 116 · see citing works

Optineurin Is Required for CYLD-Dependent Inhibition of TNFα-Induced NF-κB Activation

Nagabhushana, A., Bansal, M., & Swarup, G. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017477 · Cited by 111 · see citing works

Regulation of endocytic trafficking of transferrin receptor by optineurin and its impairment by a glaucoma-associated mutant

Nagabhushana, A., Chalasani, M. L. S., Jain, N. S., Radha, V., Rangaraj, N., Balasubramanian, D., & Swarup, G. (2010) · BMC Cell Biology · doi:10.1186/1471-2121-11-4 · Cited by 110 · see citing works

Pathogenesis of Paget's disease of bone

Ralston, S. H. (2008) · Bone · doi:10.1016/j.bone.2008.06.015 · Cited by 104 · see citing works

Polo-like Kinase 1 (PLK1) Regulates Interferon (IFN) Induction by MAVS

Vitour, D., Dabo, S., Pour, M. A., Vilasco, M., Vidalain, P., Jacob, Y., Mesel‐Lemoine, M., Paz, S., Arguello, M., Lin, R., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.018275 · Cited by 101 · see citing works

Studies of Optineurin, a Glaucoma Gene

Park, B., Shen, X., Samaraweera, M., & Yue, B. Y. J. T. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.060400 · Cited by 97 · see citing works

Myosin VI and its binding partner optineurin are involved in secretory vesicle fusion at the plasma membrane

Bond, L. M., Peden, A. A., Kendrick‐Jones, J., Sellers, J. R., & Buß, F. (2010) · Molecular Biology of the Cell · doi:10.1091/mbc.e10-06-0553 · Cited by 92 · see citing works

LUBAC, a novel ubiquitin ligase for linear ubiquitination, is crucial for inflammation and immune responses

Tokunaga, F., & Iwaï, K. (2012) · Microbes and Infection · doi:10.1016/j.micinf.2012.01.011 · Cited by 91 · see citing works

ABIN1 Protein Cooperates with TAX1BP1 and A20 Proteins to Inhibit Antiviral Signaling

Gao, L., Coope, H. J., Grant, S. M., Ma, A. I., Ley, S. C., & Harhaj, E. W. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.283762 · Cited by 88 · see citing works

Processing of Optineurin in Neuronal Cells

Shen, X., Ying, H., Qiu, Y., Park, J., Shyam, R., Chi, Z., Iwata, T., & Yue, B. Y. J. T. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.175810 · Cited by 87 · see citing works

Plk1-Dependent Phosphorylation of Optineurin Provides a Negative Feedback Mechanism for Mitotic Progression

Kachaner, D., Filipe, J. C.-R., Laplantine, E., Bauch, A., Bennett, K. L., Superti‐Furga, G., Israël, A., & Weil, R. (2012) · Molecular Cell · doi:10.1016/j.molcel.2011.12.030 · Cited by 86 · see citing works

NRP/Optineurin Cooperates with TAX1BP1 to Potentiate the Activation of NF-κB by Human T-Lymphotropic Virus Type 1 Tax Protein

Journo, C., Filipe, J. C.-R., About, F., Chevalier, S. A., Afonso, P. V., Brady, J. N., Flynn, D., Tangy, F., Israël, A., Vidalain, P., et al. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000521 · Cited by 84 · see citing works

Screening of OPTN in French familial amyotrophic lateral sclerosis

Millecamps, S., Boillée, S., Chabrol, E., Camu, W., Cazeneuve, C., Salachas, F., Pradat, P., Danel-Brunaud, V., Vandenberghe, N., Corcia, P., et al. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.11.005 · Cited by 84 · see citing works

Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) Associates with Huntingtin Protein and Promotes Its Atypical Ubiquitination to Enhance Aggregate Formation

Zucchelli, S., Marcuzzi, F., Codrich, M., Agostoni, E., Vilotti, S., Biagioli, M., Pinto, M., Carnemolla, A., Santoro, C., Gustincich, S., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.187591 · Cited by 78 · see citing works

TBK1 Protects Vacuolar Integrity during Intracellular Bacterial Infection

Radtke, A. L., Delbridge, L. M., Balachandran, S., Barber, G. N., & O’Riordan, M. X. (2007) · PLoS Pathogens · doi:10.1371/journal.ppat.0030029 · Cited by 75 · see citing works

Impairment of Protein Trafficking upon Overexpression and Mutation of Optineurin

Park, B., Ying, H., Shen, X., Park, J., Qiu, Y., Shyam, R., & Yue, B. Y. J. T. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011547 · Cited by 70 · see citing works

Optineurin is co-localized with FUS in basophilic inclusions of ALS with FUS mutation and in basophilic inclusion body disease

Ito, H., Fujita, K., Nakamura, M., Wate, R., Kaneko, S., Sasaki, S., Yamane, K., Suzuki, N., Aoki, M., Shibata, N., et al. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0809-z · Cited by 61 · see citing works

Identification of a transcription factor IIIA-interacting protein

Moreland, R. J., Dresser, M. E., Rodgers, J. S., Roe, B. A., Conaway, J. W., Conaway, R. C., & Hanas, J. S. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.9.1986 · Cited by 60 · see citing works

Molecular cloning, genomic structure, and protein characterization of mouse optineurin☆

Rezaie, T., & Sarfarazi, M. (2004) · Genomics · doi:10.1016/j.ygeno.2004.10.011 · Cited by 59 · see citing works

Association of common KIBRA variants with episodic memory and AD risk

Burgess, J. D., Pedraza, O., Graff‐Radford, N. R., Hirpa, M., Zou, F., Miles, R., Nguyen, T., Li, M., Lucas, J. A., Ivnik, R. J., et al. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.11.004 · Cited by 58 · see citing works

Optineurin and Its Mutants: Molecules Associated with Some Forms of Glaucoma

Chalasani, M. L. S., Swarup, G., & Balasubramanian, D. (2009) · Ophthalmic Research · doi:10.1159/000232400 · Cited by 57 · see citing works

Hypothesis: huntingtin may function in membrane association and vesicular traffickingThis paper is one of a selection of papers published in this Special Issue, entitled CSBMCB — Membrane Proteins in Health and Disease.

Truant, R., Atwal, R. S., & Burtnik, A. (2006) · Biochemistry and Cell Biology · doi:10.1139/o06-181 · Cited by 55 · see citing works

Angiopoietin-like 7 Secretion Is Induced by Glaucoma Stimuli and Its Concentration Is Elevated in Glaucomatous Aqueous Humor

Kuchtey, J., Kallberg, M., Gelatt, K. N., Rinkoski, T. A., Komaromy, A. M., & Kuchtey, R. W. (2008) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.07-1347 · Cited by 55 · see citing works

Defining the Pathogenicity of Optineurin in Juvenile Open-Angle Glaucoma

Willoughby, C. E., Chan, L. L. Y., Herd, S., Billingsley, G. D., Noordeh, N., Levin, A. V., Buys, Y. M., Trope, G. E., Sarfarazi, M., & Héon, E. (2004) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.04-0107 · Cited by 55 · see citing works

Analysis of OPTN as a causative gene for amyotrophic lateral sclerosis

Belzil, V., Daoud, H., Desjarlais, A., Bouchard, J.-P., Dupré, N., Camu, W., Dion, P. A., & Rouleau, G. A. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.10.001 · Cited by 51 · see citing works

Founder effect and estimation of the age of the Progranulin Thr272fs mutation in 14 Italian pedigrees with frontotemporal lobar degeneration

Borroni, B., Bonvicini, C., Galimberti, D., Tremolizzo, L., Papetti, A., Archetti, S., Turla, M., Alberici, A., Agosti, C., Premi, E., et al. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.08.009 · Cited by 51 · see citing works

Cell-free cotranslation and selection using in vitro virus for high-throughput analysis of protein–protein interactions and complexesPreprint

Miyamoto‐Sato, E., Ishizaka, M., Horisawa, K., Tateyama, S., Takashima, H., Fuse, S., Sue, K., Hirai, N., Masuoka, K., & Yanagawa, H. (2005) · Genome Research · doi:10.1101/gr.3510505 · Cited by 50 · see citing works

A novel heterozygous nonsense mutation of the OPTN gene segregating in a Danish family with ALS

Tümer, Z., Bertelsen, B., Gredal, O., Magyari, M., Nielsen, K. C., LuCamp, Grønskov, K., & Brøndum‐Nielsen, K. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.07.001 · Cited by 49 · see citing works

Transgenic studies on the role of optineurin in the mouse eye

Kroeber, M., Ohlmann, A., Russell, P., & Tamm, E. R. (2006) · Experimental Eye Research · doi:10.1016/j.exer.2005.11.004 · Cited by 48 · see citing works

Myosin VI and Optineurin Are Required for Polarized EGFR Delivery and Directed Migration

Chibalina, M. V., Poliakov, A. A., Kendrick‐Jones, J., & Buß, F. (2010) · Traffic · doi:10.1111/j.1600-0854.2010.01101.x · Cited by 48 · see citing works

Rab8‐Optineurin‐Myosin VI: Analysis of Interactions and Functions in the Secretory Pathway

Chibalina, M. V., Roberts, R. C., Arden, S. D., Kendrick‐Jones, J., & Buß, F. (2008) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(07)38002-6 · Cited by 46 · see citing works

Depletion of optineurin in RGC-5 cells derived from retinal neurons causes apoptosis and reduces the secretion of neurotrophins

Sippl, C., Bosserhoff, A., Fischer, D., & Tamm, E. R. (2011) · Experimental Eye Research · doi:10.1016/j.exer.2011.08.011 · Cited by 44 · see citing works

“Without Ub I am nothing”: NEMO as a multifunctional player in ubiquitin-mediated control of NF-κB activation

Gautheron, J., & Courtois, G. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0404-9 · Cited by 35 · see citing works

Optineurin with amyotrophic lateral sclerosis-related mutations abrogates inhibition of interferon regulatory factor-3 activation

Sakaguchi, T., Irie, T., Kawabata, R., Yoshida, A., Maruyama, H., & Kawakami, H. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.10.040 · Cited by 32 · see citing works

Genetic determinants of Paget's disease of bone

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Structural insights into the interaction and disease mechanism of neurodegenerative disease-associated optineurin and TBK1 proteins

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Pathobiology of Paget's Disease of Bone

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Cellular Functions of Optineurin in Health and Disease

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Role of Optineurin in the Mitochondrial Dysfunction: Potential Implications in Neurodegenerative Diseases and Cancer

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Optineurin deficiency in mice is associated with increased sensitivity to Salmonella but does not affect proinflammatory NF‐κB signaling

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The Golgi apparatus acts as a platform for TBK1 activation after viral RNA sensing

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Altered Functions and Interactions of Glaucoma-Associated Mutants of Optineurin

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Autophagy and Neurodegeneration: Insights from a Cultured Cell Model of ALS

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E50K-OPTN-Induced Retinal Cell Death Involves the Rab GTPase-Activating Protein, TBC1D17 Mediated Block in Autophagy

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A yeast model of optineurin proteinopathy reveals a unique aggregation pattern associated with cellular toxicity

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Is amyotrophic lateral sclerosis/frontotemporal dementia an autophagy disease?

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Mitophagy Regulates Neurodegenerative Diseases

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Brown Fat Determination and Development from Muscle Precursor Cells by Novel Action of Bone Morphogenetic Protein 6

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Optineurin Regulates the Interferon Response in a Cell Cycle-Dependent Manner

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OPTN 691_692insAG is a founder mutation causing recessive ALS and increased risk in heterozygotes

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A glaucoma‐ and ALS‐associated mutant of OPTN induces neuronal cell death dependent on Tbk1 activity, autophagy and ER stress

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Mitophagy in Huntington's disease

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Autophagy dysregulation and the fate of retinal ganglion cells in glaucomatous optic neuropathy

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The Role of Optineurin in Antiviral Type I Interferon Production

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Optineurin downregulation induces endoplasmic reticulum stress, chaperone-mediated autophagy, and apoptosis in pancreatic cancer cells

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A retrospective review of the progress in amyotrophic lateral sclerosis drug discovery over the last decade and a look at the latest strategies

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TBK1 Mediates Critical Effects of Measles Virus Nucleocapsid Protein (MVNP) on Pagetic Osteoclast Formation

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The Selective Autophagy Receptor Optineurin in Crohn’s Disease

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Aberrant Stress Granule Dynamics and Aggrephagy in ALS Pathogenesis

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Identification of an Alu‐repeat‐mediated deletion of OPTN upstream region in a patient with a complex ocular phenotype

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Identification of a splice variant of optineurin which is defective in autophagy and phosphorylation

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Unraveling the mechanism of quercetin alleviating perfluorooctane sulfonate-induced apoptosis in grass carp (Ctenopharyngodon idellus) hepatocytes: AMPK/mTOR-mediated mitophagy

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Molecular effect of an OPTN common variant associated to Paget's disease of bone

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IRF-1-binding site in the first intron mediates interferon-γ-induced optineurin promoter activation

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Optineurin associates with the podocyte Golgi complex to maintain its structure

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Expression profile analysis to predict potential biomarkers for glaucoma: BMP1, DMD and GEM

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Why do motor neurons degenerate? Actualisation in the pathogenesis of amyotrophic lateral sclerosis

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Molecular Basis of the Recognition of the Active Rab8a by Optineurin

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Adaptation of Proteasomes and Lysosomes to Cellular Environments

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PEX14 acts as a molecular link between optineurin and the autophagic machinery to induce pexophagy

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Amyotrophic Lateral Sclerosis 1 and Many Diseases

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Animal Models of Glaucoma

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Functional Defects Caused by Glaucoma – Associated Mutations in Optineurin

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SUMOylation of optineurin is critical for inhibiting interferon β production

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Optineurin mediates delivery of membrane from transferrin receptor-positive endosomes to autophagosomesPreprint

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Selective Disposal of Insoluble Protein Aggregates

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Autophagy-Related Gene Expression Changes Are Found in Pancreatic Cancer and Neurodegenerative Diseases

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GENETSKI DEJAVNIKI V POVEZAVI Z AMIOTROFIČNO LATERALNO SKLEROZO

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