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Antioxidant defense and aging in C. elegans: Is the oxidative damage theory of aging wrong?
Open accessAbstract
The oxidative damage theory of aging once seemed almost proven. Yet recently the buzzards have been assembling in the blue skies above it. New challenges to the theory from work using nematode worms seem set to bring them down to peck at its bones. But is the theory really dead, or does it just need to be modified?
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Citations
Cited by
Kenyon, C. J. (2010) · Nature · doi:10.1038/nature08980 · Cited by 2,739
Achieving the Balance between ROS and Antioxidants: When to Use the Synthetic Antioxidants
Poljsak, B., Šuput, D., & Milisav, I. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/956792 · Cited by 1,301
Free radicals and antioxidants: updating a personal view
Halliwell, B. (2012) · Nutrition Reviews · doi:10.1111/j.1753-4887.2012.00476.x · Cited by 912
Unraveling the biological roles of reactive oxygen species
Murphy, M. P., Holmgren, A., Larsson, N.-G., Halliwell, B., Chang, C. J., Kalyanaraman, B., Rhee, S. G., Thornalley, P. J., Partridge, L., Gems, D., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.03.010 · Cited by 836
Self-citationReactive oxygen species and the free radical theory of aging
Liochev, S. I. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.02.011 · Cited by 768
Metadata
- Authors
- Gems, D., & Doonan, R.
- Venue
- Cell Cycle
- Publisher
- Informa UK Limited
- Published
- 2009-06
- Volume
- 8
- Issue
- 11
- Pages
- 1681-1687
- ISSN
- 1538-4101 (ISSN-L)
- 1551-4005
- OpenAlex
- W2039213813
- Cited by
- 264
- References
- 0
- FWCI
- 8.33
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Gems, D., & Doonan, R. (2009). Antioxidant defense and aging in C. elegans: Is the oxidative damage theory of aging wrong? Cell Cycle. https://doi.org/10.4161/cc.8.11.8595
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
