The Quaking family of RNA-binding proteins: Coordinators of the cell cycle and differentiation
Open accessAbstract
Transcriptional and epigenetic control of gene expression is critical for cell fate specification, commitment and terminal differentiation during development. However, also regulatory RNAs and RNA-binding proteins have emerged as critical developmental regulators. They control various aspects of mRNA metabolism such as stability, translation, and localization, and similar to some transcriptional regulators, such as PAX5 and MYC, they can affect gene expression on a massive scale. Consistently, defects in many mRNA regulators have been implicated in a number of human disorders, including cancer. Quaking-related (QR) proteins are conserved RNA-binding proteins of the STAR (signal transduction and activation of RNA) family. QR proteins regulate expression of diverse mRNA targets by various mechanisms, play essential roles in a whole host of developmental decisions, and function as tumor suppressors. This review discusses several best-studied members of the QR family, their developmental functions, molecular mechanisms, representative mRNA targets, and their intriguing ability to coordinately control the cell cycle and a wide range of differentiation pathways.
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Dual roles for RBPs in the control of splicing and stability are emerging.
“dual roles for RBPs in the control of splicing and stability are emerging28–30.”
From A compendium of RNA-binding motifs for decoding gene regulation (2013) · cites this paper as [29]
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- Authors
- Biedermann, B., Hotz, H.-R., & Ciosk, R.
- Affiliations
- Friedrich Miescher Institute (CH)
- Corresponding author
- Ciosk, Rafal
- Venue
- Cell Cycle
- Publisher
- Informa UK Limited
- Published
- 2010-05-15
- Volume
- 9
- Issue
- 10
- Pages
- 1929-1933
- ISSN
- 1538-4101 (ISSN-L)
- 1551-4005
- OpenAlex
- W1996787489
- Cited by
- 37
- References
- 50
- Citations by year
- 2023: 2 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 4 · 2016: 4 · 2015: 2 · 2014: 4 · 2013: 7 · 2012: 4
- FWCI
- 0.34
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- Cell Cycle (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Keywords
- RNA-binding proteins, cell cycle regulation, cell differentiation, developmental regulation, mRNA stability, mRNA localization, translational regulation, tumor suppressor, cancer, epigenetic regulation, gene expression regulation
- MeSH terms
- Animals, Cell Cycle, Cell Differentiation, Humans, Models, Biological, Phylogeny, RNA-Binding Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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