The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Long non-coding RNAs and chromatin modifiers: Their place in the epigenetic code
Open accessAbstract
The emergence of long non-coding RNAs (lncRNAs) has shaken up our conception of gene expression regulation, as lncRNAs take prominent positions as components of cellular networks. Several cellular processes involve lncRNAs, and a significant number of them have been shown to function in cooperation with chromatin modifying enzymes to promote epigenetic activation or silencing of gene expression. Different model mechanisms have been proposed to explain how lncRNAs achieve regulation of gene expression by interacting with the epigenetic machinery. Here we describe these models in light of the current knowledge of lncRNAs, such as Xist and HOTAIR, and discuss recent literature on the role of the three-dimensional structure of the genome in the mechanism of action of lncRNAs and chromatin modifiers.
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Cites
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Capturing Chromosome Conformation
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Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes
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“Moreover, HOTAIR interacts with another chromatin complex, the lysine specific demethylase 1 (LSD1)-CoREST complex, which mediates the removal of mono- and di-methylation of H3K4 in nucleosomes, a histone mark associated with gene activation.(33) It seems therefore that HOTAIR is able to operate not only as a guide ln…”
BackgroundKhalil, A. M., Guttman, M., Huarte, M., Garber, M., Raj, A., Rivea Morales, D., Thomas, K., Presser, A., Bernstein, B. E., van Oudenaarden, A., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904715106 · Cited by 2,872
Self-citationYap, K. L., Li, S., Muñoz-Cabello, A. M., Raguz, S., Zeng, L., Mujtaba, S., Gil, J., Walsh, M. J., & Zhou, M.-M. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.03.021 · Cited by 1,391
Quantitative analysis of chromosome conformation capture assays (3C-qPCR)
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Cited by
The emerging role of lncRNAs in cancer
Huarte, M. (2015) · Nature Medicine · doi:10.1038/nm.3981 · Cited by 2,702
Self-citationThe functional role of long non-coding RNAs and epigenetics
Cao, J. (2014) · Biological Procedures Online · doi:10.1186/1480-9222-16-11 · Cited by 357
Expanding the p53 regulatory network: LncRNAs take up the challenge
Grossi, E., Sánchez, Y., & Huarte, M. (2016) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2015.07.011 · Cited by 78
Self-citationDecoding Crucial LncRNAs Implicated in Neurogenesis and Neurological Disorders
Ayana, R., Singh, S., & Pati, S. (2017) · Stem Cells and Development · doi:10.1089/scd.2016.0290 · Cited by 22
Drosophila as a Model to Gain Insight into the Role of lncRNAs in Neurological Disorders
Lo Piccolo, L. (2018) · Advances in Experimental Medicine and Biology · doi:10.1007/978-981-13-0529-0_8 · Cited by 13
Metadata
- Authors
- Marchese, F. P., & Huarte, M.
- Venue
- Epigenetics
- Publisher
- Informa UK Limited
- Published
- 2013-12-13
- Volume
- 9
- Issue
- 1
- Pages
- 21-26
- ISSN
- 1559-2294 (ISSN-L)
- 1559-2308
- OpenAlex
- W2033778071
- Cited by
- 178
- References
- 6
- FWCI
- 4.35
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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