The DOI matches its Crossref record; 126 of the 126 references it cites were found in a registry or an index.
Non-coding RNAs as direct and indirect modulators of epigenetic regulation
Open accessAbstract
Epigenetic regulation of gene expression is an increasingly well-understood concept that explains much of the contribution of an organism's environment and experience to its biology. However, discussion persists as to which mechanisms can be classified as epigenetic. Ongoing research continues to uncover novel pathways, including the important role of non-protein coding RNA transcripts in epigenetic gene regulation. We know that the majority of human and other mammalian transcripts are not translated but that many of these are nonetheless functional. These non-coding RNAs (ncRNAs) can be short (<200 nt) or long (<200 nt) and are further classified by genomic origin and mechanism of action. We discuss examples of ncRNAs that interact with histone modifying complexes or DNA methyltransferases to regulate gene expression, others that are targets of these epigenetic mechanisms, and propose a model in which such transcripts feed back into an epigenetic regulatory network.
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Self-citation
Cited by
Grünewald, T. G. P., Cidre-Aranaz, F., Surdez, D., Tomazou, E. M., de Álava, E., Kovar, H., Sorensen, P. H., Delattre, O., & Dirksen, U. (2018) · Nature Reviews Disease Primers · doi:10.1038/s41572-018-0003-x · Cited by 873
Non-coding RNAs as regulators in epigenetics
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Gene regulation in the immune system by long noncoding RNAs
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Epigenetics of Stress-Related Psychiatric Disorders and Gene × Environment Interactions
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Epigenetic Inheritance: Concepts, Mechanisms and Perspectives
Lacal, I., & Ventura, R. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00292 · Cited by 258
Metadata
- Authors
- Peschansky, V. J., & Wahlestedt, C.
- Venue
- Epigenetics
- Publisher
- Informa UK Limited
- Published
- 2013-12-13
- Volume
- 9
- Issue
- 1
- Pages
- 3-12
- ISSN
- 1559-2294 (ISSN-L)
- 1559-2308
- OpenAlex
- W2038862787
- Cited by
- 516
- References
- 126
- FWCI
- 7.14
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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