The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Bone grafts, bone substitutes and orthobiologics: The bridge between basic science and clinical advancements in fracture healing
Open accessAbstract
The biology of fracture healing is better understood than ever before, with advancements such as the locking screw leading to more predictable and less eventful osseous healing. However, at times one's intrinsic biological response, and even concurrent surgical stabilization, is inadequate. In hopes of facilitating osseous union, bone grafts, bone substitutes and orthobiologics are being relied on more than ever before. The osteoinductive, osteoconductive and osteogenic properties of these substrates have been elucidated in the basic science literature and validated in clinical orthopaedic practice. Furthermore, an industry built around these items is more successful and in demand than ever before. This review provides a comprehensive overview of the basic science, clinical utility and economics of bone grafts, bone substitutes and orthobiologics.
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National Center for Biotechnology Information
(2019) · Springer Reference Medizin · doi:10.1007/978-3-662-48986-4_301184 · Cited by 1,400
Friedlaender, G. E., Perry, C. R., Cole, J. D., Cook, S. D., Cierny, G., Muschler, G. F., Zych, G. A., Calhoun, J. H., LaForte, A. J., & Yin, S. (2001) · The Journal of Bone and Joint Surgery-American Volume · doi:10.2106/00004623-200100002-00010 · Cited by 957
Khan, S. N., Cammisa, F. P., Sandhu, H. S., Diwan, A. D., Girardi, F. P., & Lane, J. M. (2005) · Journal of the American Academy of Orthopaedic Surgeons · doi:10.5435/00124635-200501000-00010 · Cited by 857
Laurencin, C., Khan, Y., & El-Amin, S. F. (2006) · Expert Review of Medical Devices · doi:10.1586/17434440.3.1.49 · Cited by 716
Cahill, K. S. (2009) · JAMA · doi:10.1001/jama.2009.956 · Cited by 489
Design of ceramic-based cements and putties for bone graft substitution
RMS Foundation, C.-2. B., & Bohner, M. (2010) · European Cells and Materials · doi:10.22203/ecm.v020a01 · Cited by 327
Psychosocial Aspects of Disabling Musculoskeletal Pain
Vranceanu, A.-M., Barsky, A., & Ring, D. (2009) · The Journal of Bone and Joint Surgery-American Volume · doi:10.2106/jbjs.h.01512 · Cited by 304
Complications of Thermal Capsulorrhaphy of the Shoulder
Wong, K. L., & Williams, G. R. (2001) · The Journal of Bone and Joint Surgery-American Volume · doi:10.2106/00004623-200100022-00013 · Cited by 282
The Use of Osteoconductive Bone Graft Substitutes in Orthopaedic Trauma
Hak, D. J. (2007) · Journal of the American Academy of Orthopaedic Surgeons · doi:10.5435/00124635-200709000-00003 · Cited by 244
Milano, F., van Baal, J. W. P. M., Buttar, N. S., Rygiel, A. M., de Kort, F., DeMars, C. J., Rosmolen, W. D., Bergman, J. J. G. H. M., van Marle, J., Wang, K. K., et al. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.026 · Cited by 169
The Bone Morphogenetic Protein Pathway Is Inactivated in the Majority of Sporadic Colorectal Cancers
Kodach, L. L., Wiercinska, E., de Miranda, N. F. C. C., Bleuming, S. A., Musler, A. R., Peppelenbosch, M. P., Dekker, E., van den Brink, G. R., van Noesel, C. J. M., Morreau, H., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.02.059 · Cited by 168
The role of stem cells in fracture healing and nonunion
Fayaz, H. C., Giannoudis, P. V., Vrahas, M. S., Smith, R. M., Moran, C., Pape, H. C., Krettek, C., & Jupiter, J. B. (2011) · International Orthopaedics · doi:10.1007/s00264-011-1338-z · Cited by 160
Bostrom, M. P., & Seigerman, D. A. (2005) · HSS Journal® The Musculoskeletal Journal of Hospital for Special Surgery · doi:10.1007/s11420-005-0111-5 · Cited by 158
Kan, L., Hu, M., Gomes, W. A., & Kessler, J. A. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63372-x · Cited by 153
Recent Developments in the Biology of Fracture Repair
Kwong, F. N. K., & Harris, M. B. (2008) · Journal of the American Academy of Orthopaedic Surgeons · doi:10.5435/00124635-200811000-00001 · Cited by 134
Regulation of TMPRSS6 by BMP6 and iron in human cells and mice
Meynard, D., Vaja, V., Sun, C. C., Corradini, E., Chen, S., López-Otín, C., Grgurević, L., Hong, C. C., Stirnberg, M., Gütschow, M., et al. (2011) · Blood · doi:10.1182/blood-2011-04-348698 · Cited by 132
Bone Morphogenetic Protein in Spine Surgery: Current and Future Uses
Even, J. L., Eskander, M. S., & Kang, J. D. (2012) · Journal of the American Academy of Orthopaedic Surgeons · doi:10.5435/00124635-201209000-00001 · Cited by 116
Teriparatide (1‐34 human PTH) regulation of osterix during fracture repair
Kaback, L. A., Soung, D. Y., Naik, A., Geneau, G., Schwarz, E. M., Rosier, R. N., O’Keefe, R. J., & Drissi, H. (2008) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21816 · Cited by 92
Delayed Union and Nonunion of Fractures
Cleveland, K. B. (2008) · Elsevier eBooks · doi:10.1016/b978-0-323-03329-9.50059-3 · Cited by 89
Bone Regeneration: New Findings and Potential Clinical Applications
Einhorn, T. A., & Lee, C. A. (2001) · Journal of the American Academy of Orthopaedic Surgeons · doi:10.5435/00124635-200105000-00002 · Cited by 80
Management of Segmental Bony Defects: The Role of Osteoconductive Orthobiologics
McKee, M. D. (2006) · Journal of the American Academy of Orthopaedic Surgeons · doi:10.5435/00124635-200600001-00036 · Cited by 60
Khan, S. N., Fraser, J. F., Sandhu, H. S., Cammisa, F. P., Girardi, F. P., & Lane, J. M. (2005) · Journal of the American Academy of Orthopaedic Surgeons · doi:10.5435/00124635-200503000-00006 · Cited by 60
Fractures of the Tibia and Fibula
(2006) · Elsevier eBooks · doi:10.1016/b978-0-7216-9214-2.50022-8 · Cited by 16
Symposium: The Introduction of Biologics in Orthopaedics
Obremskey, W. T., Marotta, J. S., Yaszemski, M. J., Churchill, L. R., Boden, S. D., & Dirschl, D. R. (2007) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.f.01185 · Cited by 13
The Introduction of Biologics in Orthopaedics: Issues of Cost, Commercialism, and Ethics*
Obremskey, W. T., Marotta, J. S., Yaszemski, M. J., Churchill, L. R., Boden, S. D., & Dirschl, D. R. (2007) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-200707000-00030 · Cited by 8
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Advancing biomaterials of human origin for tissue engineering
Chen, F.-M., & Liu, X. (2016) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2015.02.004 · Cited by 1,158
Fernandez de Grado, G., Keller, L., Idoux-Gillet, Y., Wagner, Q., Musset, A.-M., Benkirane-Jessel, N., Bornert, F., & Offner, D. (2018) · Journal of Tissue Engineering · doi:10.1177/2041731418776819 · Cited by 912
Bone Grafts and Substitutes in Dentistry: A Review of Current Trends and Developments
Zhao, R., Yang, R., Cooper, P. R., Khurshid, Z., Shavandi, A., & Ratnayake, J. (2021) · Molecules · doi:10.3390/molecules26103007 · Cited by 641
Bone grafts: which is the ideal biomaterial?
Haugen, H. J., Lyngstadaas, S. P., Rossi, F., & Perale, G. (2019) · Journal of Clinical Periodontology · doi:10.1111/jcpe.13058 · Cited by 573
Bone grafts and their substitutes
Fillingham, Y., & Jacobs, J. (2016) · The Bone & Joint Journal · doi:10.1302/0301-620x.98b.36350 · Cited by 420
Metadata
- Authors
- Roberts, T. T., & Rosenbaum, A. J.
- Venue
- Organogenesis
- Publisher
- Informa UK Limited
- Published
- 2012-10
- Volume
- 8
- Issue
- 4
- Pages
- 114-124
- ISSN
- 1547-6278 (ISSN-L)
- 1555-8592
- OpenAlex
- W1998727589
- Cited by
- 773
- References
- 25
- FWCI
- 2.79
- Type
- journal article
- Language
- en
- Open access
- bronze
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