Cited by 716Bone Tissue Engineering MaterialsDental Implant Techniques and OutcomesTissue Engineering and Regenerative Medicine

Bone graft substitutes

Laurencin, Cato, Khan, Yusuf, El-Amin, Saadiq F·2006·Expert Review of Medical Devices

Abstract

The current gold standard of bone grafts is the autograft since it possesses all the characteristics necessary for new bone growth, namely osteoconductivity, osteogenicity and osteoinductivity. However, the autograft has its limitations, including donor-site morbidity and supply limitations, hindering this as an option for bone repair. An extensive list of currently available alternatives to bone grafts is provided, along with a classification scheme that divides these bone graft substitutes into five groups depending on the primary material composition: allograft, cell, factor, ceramic and polymer. Of the bone graft substitutes listed, several are discussed in detail. Beyond the current state of the art, attention is paid to what lies ahead in the field of bone graft substitutes. Biodegradable composite structures and various new architectures are discussed, as are newly developed polymeric materials, with tissue engineering providing the platform for future directions within this discipline.

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Registry

Crossref · 10.1586/17434440.3.1.49

Cites

39 of 39 references verified0 citation errors · 0 not checkable

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Authors
Laurencin, C., Khan, Y., & El-Amin, S. F.
Affiliations
University of Virginia (US)
Venue
Expert Review of Medical Devices
Published
2006-01
Volume
3
Issue
1
Pages
49-57
ISSN
  • 1743-4440 (ISSN-L)
  • 1745-2422
OpenAlex
W2040247007
Cited by
716
References
39
Citations by year
2026: 14 · 2025: 17 · 2024: 33 · 2023: 41 · 2022: 43 · 2021: 48 · 2020: 41 · 2019: 51 · 2018: 39 · 2017: 52 · 2016: 48 · 2015: 37 · 2014: 34 · 2013: 43 · 2012: 42
FWCI
1.79
Type
journal article
Language
en
Open access
closed
Locations
  • Expert Review of Medical Devices (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
  • Health Sciences › Dentistry › Oral Surgery › Dental Implant Techniques and Outcomes
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Keywords
bone graft substitutes, allograft, growth factors, ceramic bone substitutes, osteoconductivity, osteoinductivity, donor site morbidity, biodegradable composites, tissue engineering scaffolds, bone regeneration
MeSH terms
Animals, Bone and Bones, Humans, Bone Transplantation, Bone Substitutes

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