Ras history: The saga continues
Cox, Adrienne D., Der, Channing J.·2010·Small GTPases
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- In vivo and in vitro expression of the RASAL1 gene in human gastric adenocarcinoma and its clinicopathological significanceHong Chen, Xiaowei Yang, Hui Zhang, Qing Yang, Zhi Wang, Yang Liu, Feng-lin Lu, Baoyi Zhou, CHENG-HUI QIU-XI, SHENG-LIN LU · 2011 · Oncology Letters
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- Inhibitors of the ERK mitogen-activated protein kinase cascade for targeting RAS mutant cancers.Leanna R. Gentry, A. Samatar, C. Der · 2013 · The Enzymes
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- Identification and biochemical characterisation of Acanthamoeba castellanii cysteine protease 3Zhixin Wang, Duo Wu, Hiroshi Tachibana, Meng Feng, Xunjia Cheng · 2020 · Parasites & Vectors
- Clinical characteristics of pancreatic and biliary tract cancers associated with Lynch syndromeShigemasa Takamizawa, Chigusa Morizane, Noriko Tanabe, Yuta Maruki, Shunsuke Kondo, Susumu Hijioka, Hideki Ueno, Kokichi Sugano, Nobuyoshi Hiraoka, Takuji Okusaka · 2021 · Journal of Hepato-Biliary-Pancreatic Sciences
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- MicroRNA‐Based Therapeutic Strategies for Targeting Mutant and Wild Type RAS in CancerSriganesh B. Sharma, John Michael Ruppert · 2015 · Drug Development Research
- DA-Raf, a dominant-negative antagonist of the Ras–ERK pathway, is a putative tumor suppressorEmiri Kanno, Osamu Kawasaki, Kazuya Takahashi, Kazunori Takano, Takeshi Endo · 2017 · Experimental Cell Research
- Synthesis of Ras proteins and their application in biofunctional studiesJun Hu, Pengcheng Zhu, Yanmei Li, Yong‐Xiang Chen · 2018 · Chinese Chemical Letters
- Three distinct regions of cRaf kinase domain interact with membranePriyanka Prakash, John F. Hancock, Alemayehu Abebe Gorfe · 2019 · Scientific Reports
- EPHA2 feedback activation limits the response to PDEδ inhibition in KRAS-dependent cancer cellsYuehong Chen, Hao Lv, Ning Shen, Xiaomin Wang, Shuai Tang, Bing Xiong, Jian Ding, Meiyu Geng, Min Huang · 2019 · Acta Pharmacologica Sinica
- Novel insights into the pathogenesis and treatment of NRAS mutant melanomaJeffrey W. Zhao, Carlos Galvez, Kathryn Eby Beckermann, Douglas Buckner Johnson, Jeffrey Alan Sosman · 2021 · Expert Review of Precision Medicine and Drug Development
- A novel antiproliferative PKCα-Ras-ERK signaling axis in intestinal epithelial cellsNavneet Kaur, Michelle A. Lum, Robert E. Lewis, Adrian R. Black, Jennifer D. Black · 2022 · Journal of Biological Chemistry
- The IQGAP-related protein DGAP1 mediates signaling to the actin cytoskeleton as an effector and a sequestrator of Rac1 GTPasesVedrana Filić, Maja Marinović, Jan Faix, I.T. Weber · 2014 · Cellular and Molecular Life Sciences
- Structural bioinformatics enhances mechanistic interpretation of genomic variation, demonstrated through the analyses of 935 distinct RAS family mutationsSwarnendu Tripathi, Nikita R. Dsouza, Raul A. Urrutia, Michael T. Zimmermann · 2020 · Bioinformatics
- A Narrative Review of RAS Mutations in Early-Stage Colorectal Cancer: Mechanisms and Clinical ImplicationsYildirim, Hasan Cagri, Gunenc, Damla, Almuradova, Elvina, Sutcuoglu, Osman, Yalcin, Suayib · 2025 · Medicina
- The motor-clutch model in mechanobiology and mechanomedicineXu Zhao, Feng Xu, Bo Cheng · 2024 · Mechanobiology in Medicine
- Discovery of RGT-018: A Potent, Selective, and Orally Bioavailable SOS1 Inhibitor for KRAS-Driven CancersFei Xiao, Kailiang Wang, Xinjuan Wang, Huijuan Li, Zhilong Hu, Xiaoming Ren, Wei Huang, Teng Feng, Lili Yao, Jing Lin et al. · 2024 · Molecular Cancer Therapeutics
- Open pipelines for integrated tumor genome profiles reveal differences between pancreatic cancer tumors and cell linesJeremy Goecks, Bassel F. El‐Rayes, Shishir Kumar Maithel, H. Jean Khoury, James Taylor, Michael R. Rossi · 2015 · Cancer Medicine
- Neuroepithelial cell competition triggers loss of cellular juvenescenceFaidruz Azura Jam, Takao Morimune, Atsushi Tsukamura, Ayami Tano, Yuya Tanaka, Yasuhiro Mori, Takefumi Yamamoto, Masaki Nishimura, Ikuo Tooyama, Masaki Mori · 2020 · Scientific Reports
- Sotorasib – an inhibitor of KRAS p.G12c mutation in advanced non-small cell carcinomaAmit Kumar Agrawal, Ramya Pragya, Amit Choudhary, Anuj Kumar Gupta, Kuraparthy Sambasivaiah, Bal Krishna Mishra, Satvik Khaddar, Akhil Kapoor · 2021 · Cancer Research Statistics and Treatment
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- Unraveling and targeting RAS-driven metabolic signaling for therapeutic gainJonathan M. DeLiberty, Ryan N. Robb, Claire E. Gates, Kirsten L. Bryant · 2022 · Advances in cancer research
- TGFβ-induced changes in membrane curvature influence Ras oncoprotein membrane localizationAlexandros F. Damalas, Ivana Vonkova, Marijonas Tutkus, Dimitrios G. Stamou · 2022 · Scientific Reports
- Molecular Dynamics of Enzyme-Substrate Complexes in Guanosine Trifosphate-Binding ProteinsMaria G. Khrenova, Igor V. Polyakov, Alexander V. Nemukhin · 2022 · Russian Journal of Physical Chemistry B
- Identification of Potential Inhibitors Targeting GTPase-Kirsten RAt Sarcoma Virus (K-Ras) Driven Cancers via E-Pharmacophore-Based Virtual Screening and Drug Repurposing ApproachS. Udhaya Kumar, Rinku Polachirakkal Varghese, V. Anu Preethi, C. George Priya Doss, Hatem Zayed · 2023 · Frontiers in Bioscience-Landmark
- Dominant-negative antagonists of the Ras–ERK pathway: DA-Raf and its related proteins generated by alternative splicing of RafTakeshi Endo · 2019 · Experimental Cell Research
- Light at the end of the tunnel: Clinical features and therapeutic prospects of KRAS mutant subtypes in non-small-cell lung cancerLiyuan Gao, Weizhang Shen · 2022 · Frontiers in Genetics
- Proteomics uncover EPHA2 as a potential novel therapeutic target in colorectal cancer cell lines with acquired cetuximab resistanceLucien Torlot, Anna Jarząb, Johanna Albert, Ágnes Pók-Udvari, Arndt Stahler, Julian Walter Holch, Marco Gerlinger, Volker Heinemann, Frederick Klauschen, Thomas Kirchner et al. · 2022 · Journal of Cancer Research and Clinical Oncology
- Molecular docking and simulation of Curcumin with Geranylgeranyl Transferase1 (GGTase1) and Farnesyl Transferase (FTase)Parasuraman Aiya Subramani, Venkata Ramireddy Narala, Rajamani Dinakaran Michael, Dakshayani Lomada, Madhava C. Reddy · 2015 · Bioinformation
- What drives the clustering of membrane-bound Ras?Zhenlong Li, Alemayehu Abebe Gorfe · 2012 · Small GTPases
- Targeting endogenous K-RAS for degradation through the affinity-directed protein missile systemSascha Röth, Thomas Macartney, Agnieszka Konopacka, Markus A. Queisser, Gopal P. Sapkota · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
- Advances in the Treatment of Rare Mutations in Non-Small Cell Lung CancerYanning Sun, Li Ma, Xiaofei Zhang, Zhaoxia Wang · 2024 · OncoTargets and Therapy
- Melanoma: Pathogenesis and Targeted TherapyYang Fu, Jie Liu, Zeming Mo, Bin Wang, Yaotiao Deng, Y. Jiang · 2026 · MedComm
- Direkte Modulation von Aktivität und Funktion kleiner GTPasenPhilipp M. Cromm, Jochen Spiegel, Tom N. Grossmann, Herbert Waldmann · 2015 · Angewandte Chemie
- Neurofibromatosis as a gateway to better treatment for a variety of malignanciesAnnette C. Bakker, Salvatore La Rosa, Larry S. Sherman, Pamela B. Knight, Hye-Rim Lee, Patrice Pancza, Marco Nievo · 2016 · Progress in Neurobiology
- HRAS Q61L Mutation as a Possible Target for Non-Small Cell Lung Cancer: Case Series and Review of LiteratureLaurent Mathiot, Guillaume Herbreteau, Siméon Robin, Charlotte Fenat, Jaafar Bennouna, Christophe Blanquart, Marc Guillaume Denis, Elvire Pons Tostivint · 2022 · Current Oncology
- Conformational ensemble-dependent lipid recognition and segregation by prenylated intrinsically disordered regions in small GTPasesMussie K. Araya, Alemayehu Abebe Gorfe · 2023 · Communications Biology
- Miro GTPases at the Crossroads of Cytoskeletal Dynamics and Mitochondrial TraffickingPontus Aspenström · 2024 · Cells
- Weighted gene co-expression network analysis and whole genome sequencing identify potential lung cancer biomarkersMireguli Abudereheman, Zhengjun Lian, Baidurula Ainitu · 2024 · Frontiers in Oncology
- Krüppel‐like factor 6 interferes with cellular transformation induced by the H‐ ras oncogeneLucas Daniel Trucco, Verónica Andreoli, Nicolás Gonzalo Núñez, Mariana Maccioni, José Luís Bocco · 2014 · The FASEB Journal
- Why does mutation of G ln61 in Ras by the nitro analog NG ln maintain activity of R as‐ GAP in hydrolysis of guanosine triphosphate?Maria G. Khrenova, Bella L. Grigorenko, Vladimir A. Mironov, Alexander V. Nemukhin · 2015 · Proteins Structure Function and Bioinformatics
- NMR Study to Identify a Ligand-Binding Pocket in RasTill Maurer, Weiru Wang · 2013 · The Enzymes
- The value of genomics in dissecting the RAS-network and in guiding therapeutics for RAS-driven cancersGajendra Shrestha, Shelley M. MacNeil, Jasmine A. McQuerry, David F. Jenkins, Sunil Sharma, Andrea H. Bild · 2016 · Seminars in Cell and Developmental Biology
- Médecine de précision et médecine des systèmes: La médecine personnalisée se trompet-elle de cible ?Marie Darrason · 2017 · Lato Sensu Revue de la Société de philosophie des sciences
- An Application of pET SUMO Protein Expression System in Escherichia coli: Cloning, Expression, Purification, and Characterisation of Native Kras4BG12V OncoproteinMichelle Siying Tan, Yuan Han Teh, Kok Lian Ho, Johnson Stanslas · 2019 · The Protein Journal
- HPLC Method to Resolve, Identify and Quantify Guanine Nucleotides Bound to the GTPase RasJonathan P. Hannan, G. Hayden Swisher, Justin G. Martyr, Nicholas J. Cordaro, Annette H. Erbse, Joseph J. Falke · 2021 · Analytical Biochemistry
- Tipifarnib enhances anti-EGFR activity of cetuximab in non-HRas mutated head and neck squamous cell carcinoma cancer (HNSCC)Lihua Shu, Dongsheng Wang, Sreenivas Nannapaneni, Youzhi Sun, Christopher C Griffith, Xu Wang, Zhengjia Chen, Mihir R. Patel, Mark W. El‐Deiry, Dong Moon Shin et al. · 2021 · Oral Oncology
- Conformational SERS Classification of K‐Ras Point Mutations for Cancer DiagnosticsJudit Morlà‐Folch, Patricia Gisbert‐Quilis, Matteo Masetti, Eduardo García‐Rico, Ramón A. Álvarez‐Puebla, Luca Guerrini · 2017 · Angewandte Chemie
- The discovery of some promising putative binders of KRAS G12D receptor using computer-aided drug discovery approachAbdul-Quddus Kehinde Oyedele, Nurudeen Owolabi, Tope Tunji Odunitan, Abosede Christiana Ajibare, Rukayat Olajumoke Jimoh, Waliu O. Abdulazeez, Maryam Bello-Hassan Titilayo, Abiola Sarah Soares, Adedayo Toluwani Adekola, Teslim Oluwaseyi Abdulkareem et al. · 2023 · Informatics in Medicine Unlocked
- Synthetic Lethal Genetic Screens in Ras Mutant CancersBing Yu, Ji Luo · 2013 · The Enzymes
- Reaction Mechanism of Guanosine Triphosphate Hydrolysis by the Vision-Related Protein Complex Arl3–RP2Maria G. Khrenova, Ekaterina D. Kots, Alexander V. Nemukhin · 2016 · The Journal of Physical Chemistry B
- Different molecular recognition by three domains of the full-length GRB2 to SOS1 proline-rich motifs and EGFR phosphorylated sitesKeita Tateno, Takami Ando, Maako Tabata, Haruka Sugasawa, Toshifumi Hayashi, Sangya Yu, Pooppadi Maxin Sayeesh, Kohsuke Inomata, Tsutomu Mikawa, Yutaka Ito et al. · 2024 · Chemical Science
- Antitumor activity of sorafenib plus CDK4/6 inhibitor in pancreatic patient derived cell with KRAS mutationTaehyang Lee, Kyung Kim, Jeeyun Lee, Se Hoon Park, Young Suk Park, Ho Yeong Lim, Won Ki Kang, Joon Oh Park, Seung Tae Kim · 2018 · Journal of Cancer
- KRAS-targeted therapy in the treatment of non-small cell lung cancerJina Yun, Reid Nakagawa, Kenneth W. Tham · 2022 · Journal of Oncology Pharmacy Practice
- CaaX-motif-adjacent residues influence G protein gamma (Gγ) prenylation under suboptimal conditionsMithila Tennakoon, Waruna Thotamune, John L. Payton, Ajith Karunarathne · 2023 · Journal of Biological Chemistry
- RHOAL57Vdrives the development of diffuse gastric cancer through IGF1R-PAK1-YAP1 signalingAntje Schaefer, Richard G. Hodge, Haisheng Zhang, G. Aaron Hobbs, Julien Dilly, Minh V. Huynh, Craig M. Goodwin, Feifei Zhang, J. Nathaniel Diehl, Mariaelena Pierobon et al. · 2023 · Science Signaling
- Ras ChaperonesYoel Kloog, Galit Elad‐Sfadia, Roni Haklai, Adam Mor · 2013 · The Enzymes
- Proteomic changes in a childhood acute lymphoblastic leukemia cell line during the adaptation to vincristineAna Laura Guzmán-Ortiz, Gerardo Aparicio‐Ozores, Ricardo Valle‐Rios, Oscar Medina Contreras, Genaro Patiño‐López, Héctor Quezada · 2017 · Boletín Médico del Hospital Infantil de México
- Targeting the “undruggable” RAS - new strategies - new hope?Britta Mörchen, Oleksandr Shkura, Raphael Stoll, Iris Helfrich · 2019 · Cancer Drug Resistance
- KRAS as Potential Target in Colorectal Cancer TherapyShu-Kee Eng, Teng Hern Tan Loh, Bey Hing Goh, Wai-Leng Lee · 2019 · Springer eBooks
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- K-RAS4A: Lead or Supporting Role in Cancer Biology?Veronica Aran · 2021 · Frontiers in Molecular Biosciences
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- Discovery and Characterization of Divarasib (GDC-6036), a Potent Covalent Inhibitor of KRAS G12CNicholas Endres, Steven Do, Rana M Mroue, Jack A. Terrett, Matt Saabye, Angela Oh, Thomas Hunsaker, Emily Chan, John C. Tran (1471192), Lan K. Nguyen et al. · 2026 · Journal of Medicinal Chemistry
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- Prenylation and Phosphorylation of Ras Superfamily Small GTPasesHeather B. Hodges, Lauren E. Parker, Adrienne D. Cox · 2011 · The Enzymes
- Metabolic profiling of gemcitabine- and paclitaxel-treated immortalized human pancreatic cell lines with K-RASG12DAkiko Todaka, Rina Umehara, Keiko Sasaki, Masakuni Serizawa, Kenichi Urakami, Masatoshi Kusuhara, Ken Yamaguchi, Hirofumi Yasui · 2017 · Biomedical Research
- A combination therapy for KRAS-mutant lung cancer by targeting synthetic lethal partners of mutant KRASXiufeng Pang, Mingyao Liu · 2016 · 癌症:英文版
- A Perspective on Covalent Inhibitors: Research and Development Trends of Warheads and TargetsHaitao Chen, Robert E. Bird, Da-Sheng Wang, Leilani M. Lotti Diaz, Kavita A. Iyer, Gary R. Gustafson, Junko Kato-Weinstein, Qiongqiong Angela Zhou · 2023 · ChemRxiv
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- Posttranslational Modifications of Small G ProteinsBingying Zhou, Adrienne D. Cox · 2014 · Springer eBooks
- Exploring the interactions of the RAS family in the human protein network and their potential implications in RAS-directed therapiesAníbal Bueno, Ian Morilla, Diego Díez, Aurelio A. Moya‐García, José Lozano, Juan A. G. Ranea · 2016 · Oncotarget
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