Ras history: The saga continues

A genetic model for colorectal tumorigenesis

Fearon, E. R., & Vogelstein, B. (1990) · Cell · doi:10.1016/0092-8674(90)90186-i · Cited by 12,132

Mutations of the BRAF gene in human cancer

Davies, H., Bignell, G. R., Cox, C., Stephens, P., Edkins, S., Clegg, S., Teague, J., Woffendin, H., Garnett, M. J., Bottomley, W., et al. (2002) · Nature · doi:10.1038/nature00766 · Cited by 10,674

Cancer statistics, 2009

Jemal, A., Siegel, R., Ward, E., Hao, Y., Xu, J., & Thun, M. J. (2009) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.20006 · Cited by 9,709

An Integrated Genomic Analysis of Human Glioblastoma Multiforme

Parsons, D. W., Jones, S., Zhang, X., Lin, J. C.-H., Leary, R. J., Angenendt, P., Mankoo, P., Carter, H., Siu, I.-M., Gallia, G. L., et al. (2008) · Science · doi:10.1126/science.1164382 · Cited by 5,857

IDH1 and IDH2 Mutations in Gliomas

Yan, H., Parsons, D. W., Jin, G., McLendon, R., Rasheed, B. A., Yuan, W., Kos, I., Batinic-Haberle, I., Jones, S., Riggins, G. J., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808710 · Cited by 5,847

BAY 43-9006 Exhibits Broad Spectrum Oral Antitumor Activity and Targets the RAF/MEK/ERK Pathway and Receptor Tyrosine Kinases Involved in Tumor Progression and Angiogenesis

Wilhelm, S. M., Carter, C., Tang, L., Wilkie, D. P., McNabola, A., Rong, H., Chen, C., Zhang, X., Vincent, P. W., McHugh, M., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1443 · Cited by 4,060

Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

Jones, S., Zhang, X., Parsons, D. W., Lin, J. C.-H., Leary, R. J., Angenendt, P., Mankoo, P., Carter, H., Kamiyama, H., Jimeno, A., et al. (2008) · Science · doi:10.1126/science.1164368 · Cited by 3,969

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

Barbie, D. A., Tamayo, P., Boehm, J. S., Kim, S. Y., Moody, S. E., Dunn, I. F., Schinzel, A. C., Sandy, P., Meylan, E., Scholl, C., et al. (2009) · Nature · doi:10.1038/nature08460 · Cited by 3,922

Rab GTPases as coordinators of vesicle traffic

Stenmark, H. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2728 · Cited by 3,413

The Consensus Coding Sequences of Human Breast and Colorectal Cancers

Sjöblom, T., Jones, S., Wood, L. D., Parsons, D. W., Lin, J., Barber, T. D., Mandelker, D. L., Leary, R. J., Ptak, J., Silliman, N., et al. (2006) · Science · doi:10.1126/science.1133427 · Cited by 3,161

Augmin is a Ran-regulated spindle assembly factor

Kraus, J., Travis, S. M., King, M. R., & Petry, S. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.104736 · Cited by 21

In Silico Prediction of New Inhibitors for Kirsten Rat Sarcoma G12D Cancer Drug Target Using Machine Learning-Based Virtual Screening, Molecular Docking, and Molecular Dynamic Simulation Approaches

Ajmal, A., Danial, M., Zulfat, M., Numan, M., Zakir, S., Hayat, C., Alabbosh, K. F., Zaki, M. E. A., Ali, A., & Wei, D. (2024) · Pharmaceuticals · doi:10.3390/ph17050551 · Cited by 21

Redox state influence on human galectin-1 function

Yu, X., Scott, S. A., Pritchard, R., Houston, T. A., Ralph, S. J., & Blanchard, H. (2015) · Biochimie · doi:10.1016/j.biochi.2015.06.013 · Cited by 21

Computational characterization of the chemical step in the GTP hydrolysis by Ras-GAP for the wild-type and G13V mutated Ras

Mironov, V. A., Khrenova, M. G., Lychko, L. A., & Nemukhin, A. V. (2015) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.24802 · Cited by 21

The small GTPases Ras and Rheb studied by multidimensional NMR spectroscopy: structure and function

Schöpel, M., Potheraveedu, V. N., Al-Harthy, T. S., Abdel-Jalil, R. J., Heumann, R., & Stoll, R. (2017) · Biological Chemistry · doi:10.1515/hsz-2016-0276 · Cited by 21

RASAL1 induces to downregulate the SCD1, leading to suppression of cell proliferation in colon cancer via LXRα/SREBP1c pathway

Wang, G., Li, Z., Li, X., Zhang, C., & Peng, L. (2019) · Biological Research · doi:10.1186/s40659-019-0268-x · Cited by 21

Understanding the Biological Activities of Vitamin D in Type 1 Neurofibromatosis: New Insights into Disease Pathogenesis and Therapeutic Design

Riccardi, C., Perrone, L., Napolitano, F., Sampaolo, S., & Melone, M. A. B. (2020) · Cancers · doi:10.3390/cancers12102965 · Cited by 22

Control of Ras-Mediated Signaling in Aspergillus fumigatus

Norton, T. S., & Fortwendel, J. R. (2014) · Mycopathologia · doi:10.1007/s11046-014-9765-1 · Cited by 21

PX-FERM proteins

Ghai, R., & Collins, B. M. (2011) · Small GTPases · doi:10.4161/sgtp.2.5.17276 · Cited by 21

A H-REV107 Peptide Inhibits Tumor Growth and Interacts Directly with Oncogenic KRAS Mutants

Han, C. W., Jeong, M. S., Ha, S. C., & Jang, S. B. (2020) · Cancers · doi:10.3390/cancers12061412 · Cited by 20

The Role of Fast-Cycling Atypical RHO GTPases in Cancer

Aspenström, P. (2022) · Cancers · doi:10.3390/cancers14081961 · Cited by 21

Upregulation of YKL-40 Promotes Metastatic Phenotype and Correlates with Poor Prognosis and Therapy Response in Patients with Colorectal Cancer

Robertis, M. D., Greco, M. R., Cardone, R. A., Mazza, T., Marzano, F., Mehterov, N. H., Kazakova, M., Belev, N., Tullo, A., Pesole, G., et al. (2022) · Cells · doi:10.3390/cells11223568 · Cited by 21

Ras inhibition by FTS attenuates brain tumor growth in mice directly and by enhancing reactivity of cytotoxic lymphocytes

Aizman, E., Mor, A., Levy, A., George, J., & Kloog, Y. (2012) · Oncotarget · doi:10.18632/oncotarget.420 · Cited by 20

A High-Throughput Assay for Small Molecule Destabilizers of the KRAS Oncoprotein

Carver, J. O., Dexheimer, T. S., Hsu, D. J., Weng, M., Smith, J. L., Guha, R., Jadhav, A., Simeonov, A. M., & Luo, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103836 · Cited by 20

N-Arachidonoyl Dopamine Inhibits NRAS Neoplastic Transformation by Suppressing Its Plasma Membrane Translocation

Wu, M. H., Huang, J., Zhang, J., Benes, C. H., Jiao, B., & Ren, R. (2016) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-16-0419 · Cited by 20

Insights into optic pathway glioma vision loss from mouse models of neurofibromatosis type 1

Freret, M. E., & Gutmann, D. H. (2018) · Journal of Neuroscience Research · doi:10.1002/jnr.24250 · Cited by 20

Complex karyotype in myelodysplastic syndromes: Diagnostic procedure and prognostic susceptibility

Shahjahani, M., Hadad, E. H., Azizidoost, S., Nezhad, K. C., & Shahrabi, S. (2019) · Oncology Reviews · doi:10.4081/oncol.2019.389 · Cited by 20

The chaperone SmgGDS-607 has a dual role, both activating and inhibiting farnesylation of small GTPases

García-Torres, D., & Fierke, C. A. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.007438 · Cited by 20

Inhibition of RAS: proven and potential vulnerabilities

Zuberi, M., Khan, I., & O’Bryan, J. P. (2020) · Biochemical Society Transactions · doi:10.1042/bst20190023 · Cited by 20

Insights into the GTP/GDP Cycle of RabX3, a Novel GTPase from Entamoeba histolytica with Tandem G-Domains

Chandra, M., Mukherjee, M., Srivastava, V. K., Saito‐Nakano, Y., Nozaki, T., & Datta, S. (2014) · Biochemistry · doi:10.1021/bi401428f · Cited by 20

The Genetic Landscape of Pheochromocytomas and Paragangliomas: Somatic Mutations Take Center Stage

Dahia, P. L. M. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-2191 · Cited by 20

MUC1-C represses the RASSF1A tumor suppressor in human carcinoma cells

Rajabi, H. N., Hata, T., Li, W., Long, M. D., Hu, Q., Liu, S., Raina, D. B., Kui, L., Yasumizu, Y., Hong, D., et al. (2019) · Oncogene · doi:10.1038/s41388-019-0940-1 · Cited by 19

Concomitant KRAS mutations attenuate sensitivity of non-small cell lung cancer cells to KRAS G12C inhibition

Vaclová, T., Chakraborty, A., Sherwood, J. L., Ross, S. J., Carroll, D. K., Barrett, J. C., Downward, J., & de Bruin, E. C. (2022) · Scientific Reports · doi:10.1038/s41598-022-06369-3 · Cited by 20

Binding modes of GDP, GTP and GNP to NRAS deciphered by using Gaussian accelerated molecular dynamics simulations

Bao, H., Wang, W., Sun, H. B., & Chen, J. Z. (2023) · SAR and QSAR in environmental research · doi:10.1080/1062936x.2023.2165542 · Cited by 18

Bridging the gap: A regulator of NF-κB linking inflammation and cancer

Postler, T. S., & Ghosh, S. (2015) · Journal of Oral Biosciences · doi:10.1016/j.job.2015.05.001 · Cited by 19

Plant Rabs and the role in fruit ripening

Lawson, T., Mayes, S., Lycett, G. W., & Chin, C. F. (2018) · Biotechnology and Genetic Engineering Reviews · doi:10.1080/02648725.2018.1482092 · Cited by 19

Exon-4 Mutations in KRAS Affect MEK/ERK and PI3K/AKT Signaling in Human Multiple Myeloma Cell Lines

Weißbach, S., Heredia-Guerrero, S. C., Barnsteiner, S., Großhans, L., Bodem, J., Starz, H., Langer, C., Appenzeller, S., Knop, S. T., Steinbrunn, T., et al. (2020) · Cancers · doi:10.3390/cancers12020455 · Cited by 18

Ras2 is important for growth and pathogenicity in Fusarium circinatum

Phasha, M. M., Wingfield, M. J., Wingfield, B. D., Coetzee, M. P. A., Hallen‐Adams, H. E., Fru, F. F., Swalarsk-Parry, B. S., Yılmaz, N., Duong, T. A., & Steenkamp, E. T. (2021) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2021.103541 · Cited by 18

Targeting the ERK mitogen-activated protein kinase cascade for the treatment of KRAS-mutant pancreatic cancer

Diehl, J. N., Hibshman, P. S., Ozkan‐Dagliyan, I., Goodwin, C. M., Howard, S. V., Cox, A. D., & Der, C. J. (2022) · Advances in cancer research · doi:10.1016/bs.acr.2021.07.008 · Cited by 18

Rho GTPase Signaling in Platelet Regulation and Implication for Antiplatelet Therapies

Dandamudi, A., Akbar, H., Cancelas, J. A., & Zheng, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032519 · Cited by 19

Selective Targeting of the KRAS Codon 12 Mutation Sequence by Pyrrole–Imidazole Polyamide seco ‐CBI Conjugates

Taylor, R. D., Chandran, A., Kashiwazaki, G., Hashiya, K., Bando, T., Nagase, H., & Sugiyama, H. (2015) · Chemistry - A European Journal · doi:10.1002/chem.201501870 · Cited by 17

Aphanin, a triterpenoid from Amoora rohituka inhibits K-Ras mutant activity and STAT3 in pancreatic carcinoma cells

Rabi, T., & Catapano, C. V. (2016) · Tumor Biology · doi:10.1007/s13277-016-5102-2 · Cited by 17

Discovery of direct inhibitor of KRAS oncogenic protein by natural products: a combination of pharmacophore search, molecular docking, and molecular dynamic studies

Amanlou, M., Hashemi, S., Sharifi, A., Zareei, S., Mohamedi, G., & Biglar, M. (2020) · Research in Pharmaceutical Sciences · doi:10.4103/1735-5362.288425 · Cited by 17

Proteins moonlighting in tumor metabolism and epigenetics

Lv, L., & Lei, Q. (2021) · Frontiers of Medicine · doi:10.1007/s11684-020-0818-1 · Cited by 18

RASAL3 Is a Putative RasGAP Modulating Inflammatory Response by Neutrophils

Saito, S., Cao, D., Victor, A. R., Peng, Z., Wu, H.-Y., & Okwan-Duodu, D. K. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.744300 · Cited by 17

Chemically modified MIR143-3p exhibited anti-cancer effects by impairing the KRAS network in colorectal cancer cells

Sugito, N., Heishima, K., & Akao, Y. (2022) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2022.09.001 · Cited by 17

PPDPF Promotes the Development of Mutant KRAS‐Driven Pancreatic Ductal Adenocarcinoma by Regulating the GEF Activity of SOS1

Ni, Q., Zhu, B., Ji, Y., Zheng, Q., Liang, X., Ma, N., Jiang, H., Zhang, F., Shang, Y., Wang, Y., et al. (2022) · Advanced Science · doi:10.1002/advs.202202448 · Cited by 17

Targeting KRAS for the potential treatment of pancreatic ductal adenocarcinoma: Recent advancements provide hope (Review)

Zhang, J. H., Darman, L., Hassan, M. S., von Holzen, U. W., & Awasthi, N. (2023) · Oncology Reports · doi:10.3892/or.2023.8643 · Cited by 19

Multiple medicinal chemistry strategies of targeting KRAS: State-of-the art and future directions

Shang, Y., Fu, S., Hao, Q., Ying, H., Wang, J., & Shen, T. (2024) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2023.107092 · Cited by 17

Natural products targeting RAS by multiple mechanisms and its therapeutic potential in cancer: An update since 2020

Liu, Y., Chen, J., Li, X., Fan, Y., Peng, C. Y., Ye, X., Wang, Y. A., & Xie, X. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107577 · Cited by 17

A novel terpenoid class for prevention and treatment of KRAS‐driven cancers: Comprehensive analysis using in situ, in vitro, and in vivo model systems

Ganaie, A. A., Siddique, H. R., SHEIKH, I. A., Parray, A., Wang, L., Panyam, J., Villalta, P. W., Deng, Y., Konety, B. R., & Saleem, M. (2020) · Molecular Carcinogenesis · doi:10.1002/mc.23200 · Cited by 17

De novo sequence redesign of a functional Ras‐binding domain globally inverted the surface charge distribution and led to extreme thermostability

Liu, R., Wang, J., Xiong, P., Chen, Q., & Liu, H. (2021) · Biotechnology and Bioengineering · doi:10.1002/bit.27716 · Cited by 18

Correlation of O2 transport on the micro and macro scale.

Honig, C. R., & Gayeski, T. E. (1982) · PubMed · Cited by 17

ERF deletion rescues RAS deficiency in mouse embryonic stem cellsPreprint

Mayor‐Ruiz, C., Olbrich, T., Drosten, M., Lecona, E., Vega-Sendino, M., Ortega, S., Domı́nguez, O., Barbacid, M., Ruiz, S., & Fernández-Capetillo, Ó. (2018) · Genes & Development · doi:10.1101/gad.310086.117 · Cited by 17

An allele-agnostic mutant-KRAS inhibitor suppresses tumor maintenance signals and reprograms tumor immunity in pancreatic cancer

McAndrews, K. M., Paradiso, F., Stalnecker, C. A., Selvanesan, B. C., Thege, F. I., Peng, D. H., Diaz, B. A. M., Sugimoto, H., Patel, S. I., Mahadevan, K. K., et al. (2025) · Science Translational Medicine · doi:10.1126/scitranslmed.adt5511 · Cited by 17

Modeling receptor flexibility in the structure-based design of KRASG12C inhibitors

Zhu, K., Li, C., Wu, K. Y., Mohr, C., Li, X., & Lanman, B. A. (2022) · Journal of Computer-Aided Molecular Design · doi:10.1007/s10822-022-00467-0 · Cited by 17

SOS1-inspired hydrocarbon-stapled peptide as a pan-Ras inhibitor

Li, A., Li, X., Zou, J., Zhuo, X., Chen, S., Chai, X., Gai, C., Xu, W., Zhao, Q., & Zou, Y. (2023) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2023.106500 · Cited by 16

Markov State Models Reconcile Conformational Plasticity of GTPase with Its Substrate Binding Event

Dandekar, B. R., Ahalawat, N., Sinha, S., & Mondal, J. (2023) · JACS Au · doi:10.1021/jacsau.3c00151 · Cited by 16

Pharmacological strategies to target oncogenic KRAS signaling in pancreatic cancer

Chuang, H.-C., Huang, P.-H., Kulp, S. K., & Chen, C. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.01.006 · Cited by 16

KRAS-G12C covalent inhibitors: A game changer in the scene of cancer therapies

Naim, N., Moukheiber, S., Daou, S., & Kourié, H. R. (2021) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2021.103524 · Cited by 16

D154Q Mutation does not Alter KRAS Dimerization

Grozavu, I., Stuart, S. E., Lyakisheva, A., Yao, Z., Pathmanathan, S., Ohh, M., & Štagljar, I. (2021) · Journal of Molecular Biology · doi:10.1016/j.jmb.2021.167392 · Cited by 16

Discovery of ARS-1620 analogs as KRas G12C inhibitors with high in vivo antitumor activity

Zhao, H., Li, L., Liu, J., Mai, R., Chen, J., & Chen, J. (2022) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2022.105652 · Cited by 16

Paridis Rhizoma Sapoinins attenuates liver fibrosis in rats by regulating the expression of RASAL1/ERK1/2 signal pathway

Hong, Y., Han, Y., Wang, Y., Gao, J., Li, Y., Liu, Q., & Lun-zhu, X. (2016) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2016.07.010 · Cited by 16

Prospective identification of resistance mechanisms to HSP90 inhibition in KRAS mutant cancer cells

ROUHI, A. M., Miller, C. V., Grasedieck, S., Reinhart, S., Stolze, B., Döhner, H., Kuchenbauer, F. C., Bullinger, L., Fröhling, S., & Scholl, C. (2016) · Oncotarget · doi:10.18632/oncotarget.13841 · Cited by 16

Colorectal Cancer Modeling with Organoids: Discriminating between Oncogenic RAS and BRAF Variants

Post, J. B., Roodhart, J. M. L., & Snippert, H. J. G. (2020) · Trends in cancer · doi:10.1016/j.trecan.2019.12.005 · Cited by 16

Aberrant DNA Methylation of Tumor Suppressor Genes and Oncogenes as Cancer Biomarkers

Alshammari, E. S., Zhang, Y., Sobota, J., & Yang, Z. (2022) · doi:10.1002/9781119807704.ch12 · Cited by 16

Pharmacophoric analogs of sotorasib-entrapped KRAS G12C in its inactive GDP-bound conformation: covalent docking and molecular dynamics investigations

Oyedele, A.-Q. K., Ogunlana, A. T., Boyenle, I. D., Ibrahim, N. O., Gbadebo, I. O., Owolabi, N., Ashiru, M. A., Francis, A. C., Eyinade, O., & Adelusi, T. I. (2022) · Molecular Diversity · doi:10.1007/s11030-022-10534-1 · Cited by 17

The role of molecular testing in pancreatic cancer

Zhen, D. B., Safyan, R. A., Konick, E. Q., Nguyen, R., Pritchard, C. C., & Chiorean, E. G. (2023) · Therapeutic Advances in Gastroenterology · doi:10.1177/17562848231171456 · Cited by 16

Direct Observation of Membrane-Associated H-Ras in the Native Cellular Environment by In-Cell 19F-NMR Spectroscopy

Ikari, M., Yagi, H., Kasai, T., Inomata, K., Ito, M., Higuchi, K., Matsuda, N., Ito, Y., & Kigawa, T. (2023) · JACS Au · doi:10.1021/jacsau.3c00108 · Cited by 15

Regulation of Ras Signaling by S-Nitrosylation

Simão, S., Agostinho, R. R., Martı́nez-Ruiz, A., & Araújo, I. M. (2023) · Antioxidants · doi:10.3390/antiox12081562 · Cited by 15

Cryo-EM Structures of CRAF2/14-3-32 and CRAF2/14-3-32/MEK12 Complexes

Dedden, D., Nitsche, J., Schneider, E. V., Thomsen, M., Schwarz, D. F., Leuthner, B., & Grädler, U. (2024) · Journal of Molecular Biology · doi:10.1016/j.jmb.2024.168483 · Cited by 13

SHANK3 depletion leads to ERK signalling overdose and cell death in KRAS-mutant cancers

Lilja, J., Kaivola, J., Conway, J. R. W., Vuorio, J., Parkkola, H., Roivas, P., Dibus, M., Chastney, M. R., Varila, T., Jacquemet, G., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-52326-1 · Cited by 14

Advances and Challenges in RAS Signaling Targeted Therapy in Leukemia

Chen, Y., Yin, Z., Westover, K. D., Zhou, Z., & Shu, L. (2024) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-24-0504 · Cited by 15

Design, Structure Optimization, and Preclinical Characterization of JAB-21822, a Covalent Inhibitor of KRAS G12C

Li, A., Li, S., Wang, P. G., Dang, C., Fan, X. M., Chen, M., Liu, D., Li, F., Liu, H., Zhang, W., et al. (2025) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c02939 · Cited by 15

Electron Spin Relaxation and Biochemical Characterization of the Hydrogenase Maturase HydF: Insights into [2Fe-2S] and [4Fe-4S] Cluster Communication and Hydrogenase Activation

Shepard, E. M., Byer, A. S., Aggarwal, P., Betz, J. N., Scott, A. G., Shisler, K. A., Usselman, R. J., Eaton, G. R., Eaton, S. S., & Broderick, J. B. (2017) · Biochemistry · doi:10.1021/acs.biochem.7b00169 · Cited by 15

Integrating Rio1 activities discloses its nutrient-activated network in Saccharomyces cerevisiae

Iacovella, M. G., Bremang, M., Basha, O., Giacò, L., Carotenuto, W., Golfieri, C., Szakál, B., Maschio, M. D., Infantino, V., Beznoussenko, G. V., et al. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky618 · Cited by 17

The frequency of EGFR And KRAS mutations in the Turkish population with non-small cell lung cancer and their response to erlotinib therapy

Demiray, A., Yaren, A., Karagenç, N., Bir, F., Demiray, A. G., Karagür, E. R., Tokgün, O., Elmas, L., & Akça, H. (2018) · Balkan Journal of Medical Genetics · doi:10.2478/bjmg-2018-0022 · Cited by 15

Non-Redundant and Overlapping Oncogenic Readouts of Non-Canonical and Novel Colorectal Cancer KRAS and NRAS Mutants

Alcantara, K. M. M., Malapit, J. R. P., Yu, R. T. D., Garrido, J. A. M. G., Rigor, J. P. T., Angeles, A. K., la Paz, E. M. C., & Garcia, R. L. (2019) · Cells · doi:10.3390/cells8121557 · Cited by 16

Targeting RNA helicase DHX33 blocks Ras‐driven lung tumorigenesis in vivo

Wang, X., Feng, W., Peng, C. M., Chen, S., Ji, H., Zhong, H., Ge, W., & Zhang, Y. (2020) · Cancer Science · doi:10.1111/cas.14601 · Cited by 15

RAS GTPase signalling to alternative effector pathways

Singh, S., & Smith, M. J. (2020) · Biochemical Society Transactions · doi:10.1042/bst20200506 · Cited by 15

Targeting the KRAS α4-α5 allosteric interface inhibits pancreatic cancer tumorigenesis

Khan, I., MarElia, C. B., Lefler, J. E., Zuberi, M., Denbaum, E., Koide, A., Connor, D. M., Broome, A., Pécot, T., Timmers, C. D., et al. (2021) · Small GTPases · doi:10.1080/21541248.2021.1906621 · Cited by 14

Overcoming the Tumor Microenvironmental Barriers of Pancreatic Ductal Adenocarcinomas for Achieving Better Treatment Outcomes

Alzhrani, R. M., Alsaab, H. O., Vanamala, K., Bhise, K., Tatiparti, K., Barari, A., Sau, S., & Iyer, A. K. (2021) · Advanced Therapeutics · doi:10.1002/adtp.202000262 · Cited by 16

Targeting Mutant Kirsten Rat Sarcoma Viral Oncogene Homolog in Non-Small Cell Lung Cancer: Current Difficulties, Integrative Treatments and Future Perspectives

Li, J., Li, R., Ma, L.-R., Wang, P., Xu, D., Huang, J., Li, L.-Q., Tang, L. L., Xie, Y., Leung, E. L., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.875330 · Cited by 17

Two Distinct Structures of Membrane‐Associated Homodimers of GTP‐ and GDP‐Bound KRAS4B Revealed by Paramagnetic Relaxation Enhancement

Lee, K., Fang, Z., Enomoto, M., Gasmi-Seabrook, G. M. C., Zheng, L., Koide, S., Ikura, M., & Marshall, C. B. (2020) · Angewandte Chemie · doi:10.1002/ange.202001758 · Cited by 15

KRAS Inhibitor that Simultaneously Inhibits Nucleotide Exchange Activity and Effector Engagement

Pagba, C. V., Gupta, A. K., Naji, A. K., van der Hoeven, D., Churion, K. A., Liang, X., Jakubec, J. L., Höök, M., Zuo, Y., de Kraatz, M. M., et al. (2022) · ACS Bio & Med Chem Au · doi:10.1021/acsbiomedchemau.2c00045 · Cited by 14

The Inhibition of RasGRF2, But Not RasGRF1, Alters Cocaine Reward in Mice

Bernardi, R. E., Olevska, A., Morella, I., Fasano, S., Santos, E., Brambilla, R., & Spanagel, R. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.1120-18.2019 · Cited by 14

Harmine suppresses hyper-activated Ras–MAPK pathway by selectively targeting oncogenic mutated Ras/Raf in Caenorhabditis elegans

Ji, J., Jiang, Y. G., Guo, X., Ji, R., Quan, Q., Ding, M., Li, X., & Liu, Y. (2019) · Cancer Cell International · doi:10.1186/s12935-019-0880-4 · Cited by 14

RASL11B gene enhances hyaluronic acid-mediated chondrogenic differentiation in human amniotic mesenchymal stem cells via the activation of Sox9/ERK/smad signals

Luo, Y., Wang, A.-T., Zhang, Q., Liu, R., & Xiao, J. (2020) · Experimental Biology and Medicine · doi:10.1177/1535370220944375 · Cited by 14

M-Ras is Muscle-Ras, Moderate-Ras, Mineral-Ras, Migration-Ras, and Many More-Ras

Endo, T. (2020) · Experimental Cell Research · doi:10.1016/j.yexcr.2020.112342 · Cited by 14

Identification of novel peptide inhibitors for oncogenic KRAS G12D as therapeutic options using mutagenesis-based remodeling and MD simulations

Samad, A., Khurshid, B., Mahmood, A., Rehman, A. U., Khalid, A., Abdalla, A. N., Algarni, A. S., & Wadood, A. (2023) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2023.2192298 · Cited by 15

Phosphorylation promotes binding affinity of Rap-Raf complex by allosteric modulation of switch loop dynamics

Devanand, T., Venkatraman, P., & Vemparala, S. (2018) · Scientific Reports · doi:10.1038/s41598-018-31234-7 · Cited by 13

Defeat mutant KRAS with synthetic lethality

Pang, X., & Liu, M. (2016) · Small GTPases · doi:10.1080/21541248.2016.1213783 · Cited by 14

Mutant and wild-type Ras: co-conspirators in cancer

Hayes, T. K., & Der, C. J. (2013) · Cancer Discovery · doi:10.1158/2159-8290.cd-12-0521 · Cited by 13

RAS Pathway Mutations and Therapeutics in Vascular Anomalies

Alharbi, S., Merkle, S., Hammill, A. M., Waters, A. M., & Cras, T. D. L. (2025) · Pediatric Blood & Cancer · doi:10.1002/pbc.31605 · Cited by 14

Targeting Ras with protein engineering

Tomazini, A., & Shifman, J. M. (2023) · Oncotarget · doi:10.18632/oncotarget.28469 · Cited by 14

Weighted gene coexpression network analysis identifies hub genes related to KRAS mutant lung adenocarcinoma

Dai, D., Shi, R., Han, S., Jin, H., & Wang, X. (2020) · Medicine · doi:10.1097/md.0000000000021478 · Cited by 13

Active GTPase Pulldown Protocol

Baker, M. J., & Rubio, I. (2021) · Methods in molecular biology · doi:10.1007/978-1-0716-1190-6_7 · Cited by 13

Reflections on drug resistance to KRAS inhibitors and gene silencing/editing tools for targeting mutant KRAS in cancer treatment

Han, Z., Zhou, D., Wang, J., Jiang, B., & Liu, X. (2022) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2022.188677 · Cited by 13

Millisecond molecular dynamics simulations of KRas-dimer formation and interfaces

Ngo, V. A., & Garcı́a, A. E. (2022) · Biophysical Journal · doi:10.1016/j.bpj.2022.04.026 · Cited by 13

KRAS Mutation: Characterization and Its Impact on Survival Outcome of Patients with Metastatic Colorectal Cancer

Damit, D., Patnaik, R. S., Chaw, L., Lu, S. K., Telisinghe, P. U., Lu, Z. H., Kok, K. Y. Y., Ming, L. C., & Lim, Y. C. (2022) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2707213 · Cited by 14

PFKFB4 interacts with ICMT and activates RAS/AKT signaling-dependent cell migration in melanoma

Sittewelle, M., Kappès, V., Zhou, C., Lécuyer, D., & Monsoro-Burq, A. H. (2022) · Life Science Alliance · doi:10.26508/lsa.202201377 · Cited by 13

Proximal Protein Interaction Landscape of RAS Paralogs

Béganton, B., Coyaud, É., Laurent, E. M. N., Mangé, A., Jacquemetton, J., Romancer, M. L., Raught, B., & Solassol, J. (2020) · Cancers · doi:10.3390/cancers12113326 · Cited by 13

Synthetic Vulnerabilities in the KRAS Pathway

Román, M., Hwang, E. E., & Sweet-Cordero, A. (2022) · Cancers · doi:10.3390/cancers14122837 · Cited by 14

Single-cell sensor analyses reveal signaling programs enabling Ras-G12C drug resistance

Zhang, J. Z., Ong, S., Baker, D. A., & Maly, D. J. (2024) · Nature Chemical Biology · doi:10.1038/s41589-024-01684-4 · Cited by 11

Genomic classification of the RAS network identifies a personalized treatment strategy for lung cancer

El-Chaar, N. N., Piccolo, S., Boucher, K. M., Cohen, A. L., Chang, J. T., Moos, P. J., & Bild, A. H. (2014) · Molecular Oncology · doi:10.1016/j.molonc.2014.05.005 · Cited by 12

Recommendations for the use of biomarkers for head and neck cancer, including salivary gland tumours: a consensus of the Spanish Society of Medical Oncology and the Spanish Society of Pathology

Trigo, J. M., García‐Cosío, M., García‐Castaño, A., Gomà, M., Mesía, R., Ruiz‐Bravo, E., Soria-Rivas, A., Castillo, P., Braña, I., & Alberola‐Ferranti, M. (2022) · Clinical & Translational Oncology · doi:10.1007/s12094-022-02856-1 · Cited by 12

A systematic review of genetic ancestry as a risk factor for incidence of non-small cell lung cancer in the US

James, B. A., Williams, J. L., & Nemesure, B. B. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2023.1141058 · Cited by 13

Current advances and development strategies of targeting son of sevenless 1 (SOS1) in drug discovery

Wu, J., Li, X., Wu, C., Wang, D., & Zhang, J. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2024.116282 · Cited by 13

Are all KRAS mutations created equal?

Stinchcombe, T. E., & Der, C. J. (2011) · The Lancet Oncology · doi:10.1016/s1470-2045(11)70200-5 · Cited by 12

Peroxisome Proliferator-Activated Receptor Gamma and Regulations by the Ubiquitin-Proteasome System in Pancreatic Cancer

Stravodimou, A., Mazzoccoli, G., & Voutsadakis, I. A. (2012) · PPAR Research · doi:10.1155/2012/367450 · Cited by 12

Flashback in the history of Ras research

Chaldaiopoulou, G., Γουλιελμάκη, Μ., Khoury, N., Ζουμπουρλής, Β., & Zoumpourlis (2017) · National Hellenic Research Foundation Helios Repository (National Hellenic Research Foundation)

Ras Stories: The State of the Art

Roberts, P. J., & Der, C. J. (2006) · Springer eBooks · doi:10.1007/1-4020-4708-8_1

The Ras Superfamily of Small GTPases: The Unlocked Secrets

Goitre, L., Trapani, E., Trabalzini, L., & Retta, S. F. (2013) · Methods in molecular biology · doi:10.1007/978-1-62703-791-4_1 · Cited by 195

40 Years of RAS—A Historic Overview

Fernández‐Medarde, A., Rivas, J. D. L., & Santos, E. (2021) · Genes · doi:10.3390/genes12050681 · Cited by 57

Ras Proteins☆

George, S., & Der, C. J. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.98756-7