Ras history: The saga continues

Cox, Adrienne D., Der, Channing J.·2010·Small GTPases

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Items 501–600 of 712

  1. The glycolysis regulator PFKFB4 interacts with ICMT and activates RAS/AKT signaling-dependent cell migration in melanoma
    Méghane Sittewelle, Vincent Kappès, Déborah Lécuyer, Anne Helene Monsoro-Burq · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  2. Design, synthesis and biological evaluation of new Myo-inositol derivatives as potential RAS inhibitors
    Javeena Hussain, Dimple Chhabria, Sivapriya Kirubakaran · 2020 · Bioorganic & Medicinal Chemistry Letters
  3. Argonaute 2 modulates EGFR–RAS signaling to promote mutantHRASandNRAS-driven malignancies
    Ronald F. Siebenaler, Seema Chugh, Jessica J. Waninger, Vijaya L. Dommeti, Carson Kenum, Malay K. Mody, Anudeeta Gautam, Nidhi Patel, Alec Chu, Pushpinder Bawa et al. · 2022 · PNAS Nexus
  4. MEK inhibitors and DA ‐Raf, a dominant‐negative antagonist of the Ras– ERK pathway, prevent the migration and invasion of KRAS ‐mutant cancer cells
    Aoi Matsuda, Ryuichi Masuzawa, Kazuya Takahashi, Kazunori Takano, Takeshi Endo · 2024 · Cytoskeleton
  5. KRas4b–Calmodulin Interaction with Membrane Surfaces: Role of Headgroup, Acyl Chain, and Electrostatics
    Shweta Shree, Mark A. McLean, Andrew G. Stephen, Stephen G. Sligar · 2024 · Biochemistry
  6. Regulation of nucleotide excision repair by wild-type HRAS signaling in head and neck cancer
    Lorena Hoxhallari, Konstantinos Katsikis, Antigoni Makri, Marialena Pouliou, Zoi Kanaki, Giannis Vatsellas, Christina Sonou, Dimitrios Telios, Evangelos I Giotakis, Aris Ι. Giotakis et al. · 2025 · Cancer Gene Therapy
  7. Targeting KRASG12C Mutation: Development of effective strategies to overcome drug resistance and limited efficacy
    Rui Li, Xu Huang, Rui Wang, Zhenhua Ren, Yong Lian Zhu, Tao Lu, Yan Sun, Cui Hao · 2025 · European Journal of Medicinal Chemistry
  8. A regulatory role of membrane by direct modulation of the catalytic kinase domain
    Priyanka Prakash · 2020 · Small GTPases
  9. Outcomes and prognostic contributors in patients with KRAS mutated non-small cell pulmonary adenocarcinomas: a single institution experience
    Ethan Alexander Burns, Joe Ensor, Jim Wei-Chun Hsu, Jessica S. Thomas, Randall J. Olsen, Eric Bernicker · 2021 · Journal of Thoracic Disease
  10. KRAS4b:RAF-1 Homogenous Time-Resolved Fluorescence Resonance Energy Transfer Assay for Drug Discovery
    Erik K. Larsen, Maria Abreu Blanco, Dana Rabara, Andrew G. Stephen · 2024 · Methods in molecular biology
  11. Simultaneous targeted delivery of doxorubicin and KRAS suppression by a hybrid molecule containing miR-143 and AS1411 aptamer
    Khanittha Laowichuwakonnukul, Boonchoy Soontornworajit, Jiraporn Arunpanichlert, Pichayanoot Rotkrua · 2025 · Scientific Reports
  12. Synthesis and in vitro biological evaluation of farnesylthiosalicylic acid derivatives as anti-tumor carcinoma agents
    Yong Ling, You Xiao, Guang Tong Chen, Dong Geng Wang, Yu Qin Li, Xin Yang Wang, Heng Zheng · 2012 · Chinese Chemical Letters
  13. Rasosomes originate from the Golgi to dispense Ras signals
    Assaf Grunwald, Irit Gottfried, Adrienne D. Cox, Ronit Haklai, Yoel Kloog, Uri Ashery · 2013 · Cell Death and Disease
  14. Recent Advances in Developing K-Ras Plasma Membrane Localization Inhibitors
    Na Ye, Qingfeng Xu, Wanwan Li, Pingyuan Wang, Jia Zhou · 2019 · Current Topics in Medicinal Chemistry
  15. The interplay between Ras, Autophagy and cancer
    Eran Schmukler, Ronit Pinkas‐Kramarski · 2021 · Advances in Cancer Biology - Metastasis
  16. Engineering SHP2 Phosphatase for Optical Control.
    Amy Ryan, Chasity P. Janosko, T. Courtney, A. Deiters · 2022 · Biochemistry
  17. Targeting the Raf-MEK-ERK Mitogen-Activated Protein Kinase Cascade for the Treatment of RAS Mutant Cancers
    Tikvah K. Hayes, Channing J. Der · 2014 · Springer eBooks
  18. Discovery of RMC-6291, a potent, orally bioavailable, covalent RAS(ON) G12C selective inhibitor
    James Cregg, Kristof Pota, Adrian L. Gill, Elena S. Koltun · 2024 · Elsevier eBooks
  19. RAS–membrane interaction and oligomerization: there is more than meets the eye
    Abraham C. Sianoya, Vijay Kumar Bhardwaj, Alemayehu Abebe Gorfe · 2025 · Biochemical Society Transactions
  20. Identification of Small-Molecule Inhibitors that Block the GTP-Binding Pocket of K-Ras and Other Members of the Ras Superfamily of Small GTPases
    Luca Carta, Rebecca Hutcheson, Carolina L. Bigarella, Sufang Zhang, Simon A. Davis, Michael J. Rudolph, Charles H. Reynolds, Matthias Quick, Theresa M. Williams, Michael Schmertzler et al. · 2025 · Molecular Cancer Therapeutics
  21. Discovery and Optimization of a Potent, Efficacious, and Brain-Penetrant Inhibitor of KRAS G12C
    Matthew L. Landry, Sushant Malhotra, Maureen H. Beresini, Connie C.C. Chan, Emily Chan, Cecile C. de la Cruz, Nicholas Endres, Marie Evangelista, Amy E. Gustafson, Dennis X. Hu et al. · 2026 · Journal of Medicinal Chemistry
  22. Revisiting RAS family GTPase signaling: effector selectivity and oncogenic bypass
    Dhirendra K. Simanshu, Frank P. McCormick · 2026 · Biochemical Journal
  23. Novel druggable space in human KRAS G13D discovered using structural bioinformatics and a P-loop targeting monoclonal antibody
    Oscar Jungholm, Carolina L. Trkulja, Martin Moche, Sreesha P. Srinivasa, Maria-Nefeli Christakopoulou, Max Davidson, Anna Reymer, Kent E. Jardemark, Rafaela L Fogaça, Anaswara Ashok et al. · 2024 · Scientific Reports
  24. The RAS Signaling Network and Cancer
    Priya S. Hibshman, Channing J. Der · 2024 · Springer eBooks
  25. Optimized conditions for GTP loading of Ras
    Kimberly J. Vish, Maxum E. Paul, Asha P. Rollins, Titus J. Boggon · 2025 · Journal of Biological Chemistry
  26. Photocontrol of the GTPase activity of the small G protein K-Ras by using an azobenzene derivative
    Seigo Iwata, Shinsaku Maruta · 2015 · Biochemistry and Biophysics Reports
  27. Membrane anchoring of the DIRAS3 N-terminal extension permits tumor suppressor function
    Xiaowen Liang, Sung Yun Jung, Lon Wolf R. Fong, Gamze Bildik, Joshua P. Gray, Weiqun Mao, Shuxing Zhang, Steven W. Millward, Alemayehu Abebe Gorfe, Yong Zhou et al. · 2023 · iScience
  28. Catalytically Competent Non-transforming H-RASG12P Mutant Provides Insight into Molecular Switch Function and GAP-independent GTPase Activity of RAS
    Metehan Ilter, Özge Şensoy · 2019 · Scientific Reports
  29. Novel FTS-diamine/cinnamic acid hybrids inhibit tumor cell proliferation and migration and promote apoptosis via blocking Ras-related signaling in vitro
    Yong Ling, Xinmei Zhao, Xianghua Li, Xuemin Wang, Yang Yang, Zhiqiang Wang, Xinyang Wang, Jie Zhang, Yihua Zhang · 2014 · Cancer Chemotherapy and Pharmacology
  30. Change of Ras and its guanosine triphosphatases (GTPases) during development and regression in bovine corpus luteum
    Sang‐Hee Lee, S. Lee · 2019 · Theriogenology
  31. Protein Farnesylation on Nasopharyngeal Carcinoma, Molecular Background and Its Potential as a Therapeutic Target
    Eiji Kobayashi, Satoru Kondo, Hirotomo Dochi, Makiko Moriyama‐Kita, Nobuyuki Hirai, Takeshi Komori, Takayoshi Ueno, Yosuke Nakanishi, Miyako Hatano, Kazuhira Endo et al. · 2022 · Cancers
  32. Differential Activity of the KRAS Oncogene by Method of Activation: Implications for Signaling and Therapeutic Intervention
    Nathan T. Ihle · 2012 · Digital Commons-TMC (Texas Medical Center)
  33. How KRAS Mutations Impair Intrinsic GTP Hydrolysis: Experimental and Computational Investigations
    Lin Frank Song, Dana Rabara, Semiha Kevser Bali, Jun Pei, Edmond Y. Lau, Daniel A. Kirshner, Felice C. Lightstone, Frank McCormick, Andrew G. Stephen, Yue Yang · 2025 · Journal of Chemical Information and Modeling
  34. Molecular Dynamics Investigation into the Stability of KRas and CRaf Multimeric Complexes
    Chongli Geng, Juan Zeng, Xianming Deng, Fei Xia, Xin Xu · 2025 · The Journal of Physical Chemistry B
  35. Pan-Cancer Analysis Identifies a Ras-Related GTPase as a Potential Modulator of Cancer
    Hsiang‐Yin Hsueh, Kristyn Gumpper, Jelmer W. Poelstra, Kenneth L. Pitter, Zobeida Cruz‐Monserrate · 2025 · International Journal of Molecular Sciences
  36. Tobacco Smoke and Ras Mutations Among Latino and Non-Latino Children with Acute Lymphoblastic Leukemia
    Maneet Kaur, Adam J. de Smith, Steve Selvin, Luoping Zhang, Marc J. Cunningham, Michelle W. Kang, Helen M. Hansen, Robert Michael Cooper, Roberta McKean‐Cowdin, Joseph Leo Wiemels et al. · 2016 · Archives of Medical Research
  37. KRAS: Structure, function, and development of anticancer drugs
    Dolly A. Parasrampuria, Alex Yu, Nahor Haddish‐Berhane · 2020 · Elsevier eBooks
  38. Impaired contextual fear conditioning in RasGRF2 mutant mice is likely Ras-ERK-dependent
    Anastasia Olevska, Rainer Spanagel, Rick Eugene Bernardi · 2021 · Neurobiology of Learning and Memory
  39. Identification and Characterization of a QTL for Growth of Fusarium circinatum on Pine-Based Medium
    Benedicta S. Swalarsk-Parry, Emma Theodora Steenkamp, Stephanie van Wyk, Quentin C. Santana, Magriet A. van der Nest, Almuth Hammerbacher, Brenda Diana Wingfield, Lieschen De Vos · 2022 · Journal of Fungi
  40. Polyisoprenylated cysteinyl amide inhibitors deplete singly polyisoprenylated monomeric G-proteins in lung and breast cancer cell lines
    Nada Tawfeeq, Jassy Mary S. Lazarte, Yonghao Jin, Matthew D. Gregory, Nazarius Saah Lamango · 2023 · Oncotarget
  41. Dissecting mechanisms of ligand binding and conformational changes in the glutamine-binding protein
    Zhongying Han, Sabrina Panhans, Sophie Brameyer, Ecenaz Bilgen, Marija Ram, Anna Herr, Alessandra Narducci, Michael Isselstein, Paul David Harris, Oliver Brix et al. · 2026 · eLife
  42. Emerging Therapies in Kirsten Rat Sarcoma Virus (+) Non-Small-Cell Lung Cancer
    Anastasia Karachaliou, Elias Alexandros Kotteas, Oraianthi Fiste, Konstantinos Syrigos · 2024 · Cancers
  43. Probing the Electrostatic Effects of H-Ras Tyrosine 32 Mutations on Intrinsic GTP Hydrolysis Using Vibrational Stark Effect Spectroscopy of a Thiocyanate Probe
    Jackson C. Fink, Danielle Landry, Lauren J. Webb · 2024 · Biochemistry
  44. Prevalence of KRAS amplification in patients with metastatic cancer: Real-world next-generation sequencing analysis
    Dae-Ho Choi, Hye‐Lim Jang, Sung Hee Lim, Seung Tae Kim, Jung Yong Hong, Se Hoon Park, Joon Oh Park, Deok geun Kim, Kyoung‐Mee Kim, Jeeyun Lee · 2024 · Pathology - Research and Practice
  45. The Role of RAS in CNS Tumors: A Key Player or an Overlooked Oncogene?
    Isabel de Souza Barbosa, Carlos Pilotto Heming, Vivaldo Moura‐Neto, Veronica Aran · 2025 · International Journal of Molecular Sciences
  46. Immunotherapy in the management of melanoma: current status
    Jerry D. Brewer, Alston · 2013 · ImmunoTargets and Therapy
  47. On fitness: how do mutations shape the biology of cancer?
    Ian J. Majewski · 2019 · Biochemical Society Transactions
  48. The Endeavours in RAS Inhibition - the Past, Present, and Future
    Javeena Hussain, Sivapriya Kirubakaran, Srimadhavi Ravi · 2020 · Current Topics in Medicinal Chemistry
  49. Pheochromocytoma and Paraganglioma
    Mercedes Robledo, María Currás, Alberto Cascón · 2021 · Springer eBooks
  50. Recommendations for the use of biomarkers for head and neck cancer, including salivary gland tumours: A Consensus of the Spanish Society of Medical Oncology and the Spanish Society of Pathology
    Jose Manuel Manuel Trigo Perez, Mónica García‐Cosío, Almudena García‐Castaño, Montserrat Gomà, Ricard Mesı́a, Elena Ruiz‐Bravo, Ainara Soria-Rivas, Paola Castillo, Irene Braña, Margarita Alberola‐Ferranti · 2022 · Revista Española de Patología
  51. Cancer modeling in colorectal organoids reveals intrinsic differences between oncogenic RAS and BRAF variants
    Jasmin B. Post, Nizar Hami, Jeroen O. Lohuis, Marieke van de Ven, Renske de Korte‐Grimmerink, Christina Stangl, Ellen Stelloo, Ingrid Verlaan-Klink, Jacco van Rheenen, Hugo J.G. Snippert · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
  52. Oncogenic KRAS engages an RSK1/NF1 complex in pancreatic cancer
    Derek K. Cheng, Tobiloba E. Oni, Youngkyu Park, Jennifer S. Thalappillil, Hsiu-Chi Ting, Brinda Alagesan, Nadia V. Prasad, Keith D. Rivera, Darryl Pappin, Linda Van Aelst et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  53. RanGTP regulates the augmin complex
    Jodi Kraus, Sophie M. Travis, Matthew R. King, Sabine Petry · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  54. Dissecting mechanisms of ligand binding and conformational changes in the glutamine-binding protein
    Zhongying Han, Sabrina Panhans, Sophie Brameyer, Ecenaz Bilgen, Marija Ram, Anna Herr, Alessandra Narducci, Michael Isselstein, Paul David Harris, Oliver Brix et al. · 2024 · eLife
  55. Methods for Controlling Small GTPase Activity
    Benjamin M. Faulkner, Yuchen He, Daniel Sitrin, Cliff I. Stains · 2025 · ChemBioChem
  56. RESEARCH CHALLENGES IN STAGE III AND IV RAS-ASSOCIATED CANCERS: A Narrative Review of the Complexities and Functions of the Family of RAS Genes and Ras Proteins in Housekeeping and Tumorigenesis
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  57. Development of potent inhibitors against KRAS, its mutant G12R, allosteric and Switch-I/Switch-II site
    Vikas Yadav, Mohammad Kashif, Swati Sharma, Naidu Subbarao · 2025 · In Silico Pharmacology
  58. Single-Cell Genomics and Somatic Variation in Circulating and Cardiac Resident Cells
    Nazia Hilal, Maniteja Arava, Sangita Choudhury · 2026 · Circulation Research
  59. Mechanistic insights on spatiotemporal control of Ras-signaling
    Clotilde Charrier, Sascha Mrachacz, Sabrina Schulze, Michael Lammers · 2026 · Biological Chemistry
  60. Cancer Risk and Spectrum in Individuals with RASopathies
    Mwe Mwe Chao, Martin Zenker, Christian Peter Kratz · 2020 · Springer eBooks
  61. Therapeutic Intervention of Signaling Pathways in Colorectal Cancer
    Vikas Chandra, Ashutosh Tiwari, Rajat Pratap Singh, Kartiki Vasant Desai · 2022 · Springer eBooks
  62. Potent and selective eradication of tumor cells by an EpCAM-targeted Ras-degrading enzyme
    Valentina Palacio-Castañeda, Bas van de Crommert, Elke Verploegen, Mike Overeem, Jenny van Oostrum, Wouter P. R. Verdurmen · 2023 · Molecular Therapy — Oncolytics
  63. RIT1 deficiency alters cerebral lipid metabolism and reduces white matter tract oligodendrocytes and conduction velocities
    Lei Wu, Fang Wang, Carole L. Moncman, Mritunjay Pandey, Harrison A. Clarke, Hilaree N. Frazier, Lyndsay E.A. Young, Matthew S. Gentry, Weikang Cai, Olivier Thibault et al. · 2023 · Heliyon
  64. κ B ‐ R as proteins are fast‐exchanging GTP ases and function via nucleotide‐independent binding of Ral GTP ase‐activating protein complexes
    René Rasche, Lisa Helene Apken, Esther Michalke, Daniel Kümmel, Andrea Oeckinghaus · 2024 · FEBS Letters
  65. Rac1 GTPase Regulates the βTrCP-Mediated Proteolysis of YAP Independently of the LATS1/2 Kinases
    Chitra Palanivel, Tabbatha N. Somers, Bailey M. Gabler, Yuanhong Chen, Yongji Zeng, Jesse L. Cox, Parthasarathy Seshacharyulu, Jixin Dong, Ying Yan, Surinder K. Batra et al. · 2024 · Cancers
  66. Could Drug Delivery Systems Be Enhancers for Therapy against KRAS-driven Cancers?
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  67. The Effect of Phosphoserine-Containing Membranes on Electrostatic Fields at the Protein–Protein Interface Measured through Vibrational Stark Effect Spectroscopy
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  68. The effect of sodium nitroprusside on survival and stress signaling in PC12 rat phaeochromocytoma cells expressing a dominant negative RasH mutant protein
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  69. Exploring binding modes of the selected inhibitors to phosphodiesterase delta by all-atom molecular dynamics simulations and free energy calculations
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  73. Constitutively active RAS in S. pombe causes persistent Cdc42 signalling but only transient MAPK activation
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  74. Developing Small Molecules that Inhibit K-Ras/GTP Binding Based on New Affinity Measurements
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  75. Dissecting Mechanisms of Ligand Binding and Conformational Changes in the Glutamine-Binding Protein
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  76. Constitutively active RAS prolongs Cdc42 signalling while attenuating MAPK signalling during fission yeast mating
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  77. ERAS, a Member of the Ras Superfamily, Acts as an Oncoprotein in the Mammary Gland
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  78. RASAL3 predicts overall survival and CD8 + T lymphocyte infiltration in lung adenocarcinoma
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  79. The RRAS2 pathogenic variant (c. 67G> T; p. Gly23Cys ) produces Noonan syndrome with embryonal rhabdomyosarcoma
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  80. Biophysical and Biochemical Characterization of Structurally Diverse Small Molecule Hits for KRAS Inhibition
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  81. RAS gene polymorphisms confer the risk of neuroblastoma in Chinese children from Jiangsu province
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  83. Comprehensive analysis of KRAS aberrations in pan-cancer, with a focus on prognostic and therapeutic implications
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  86. Mechanistic insights into KRAS G12D inhibitor binding revealed by molecular dynamics simulations of multiple crystal structures
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  88. Advances and Challenges in KRAS Mutation Detection and Clinical Implications
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  91. Mutational Activation of KRAS and BRAF in Colorectal Cancer
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  92. Genome-Wide Analysis of RAS/ERK Signaling Targets
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  93. Efficient glycosylation of natural Danshensu and its enantiomer by sugar and 2-deoxy sugar donors
    Katarzyna Sidoryk, Piotr Cmoch, Marta Świtalska, Bartosz Trzaskowski, Joanna Wietrzyk, Marcin Cybulski · 2018 · Carbohydrate Research
  94. Mutant K-Ras-Mediated Oxidative Stress in Pancreatic Cancer
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  95. Inadvertent Transfer of Murine VL30 Retrotransposons to CAR-T Cells
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  96. Clinical and morphological features of thyroid tumors with mutations in the NTRK, RAS, BRAF, RET genes
    M. R. Savchuk, Плакса Игорь Леонидович, N. V. Shved · 2022 · Journal of Anatomy and Histopathology
  97. Case report outcome of cetuximab treatment in a metastatic colorectal cancer patient with novel KRAS P34R
    Ruizhi Chen, Dongmei Yang, Yang Liu, Boquan Wang, Huiting Xu · 2023 · Anti-Cancer Drugs
  98. Insight into molecular basis and dynamics of full-length CRaf kinase in cellular signaling mechanisms
    Van A. Ngo · 2024 · Biophysical Journal
  99. Site-directed antibodies targeting driver mutations of the KRAS protein
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  100. Effector Recruitment Method to Study Spatially Regulated Activation of Ras and Rho GTPases
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