The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Hypervirulent (hypermucoviscous)Klebsiella pneumoniae: A new and dangerous breed
Open accessAbstract
A new hypervirulent (hypermucoviscous) variant of Klebsiella pneumoniae has emerged. First described in the Asian Pacific Rim, it now increasingly recognized in Western countries. Defining clinical features are the ability to cause serious, life-threatening community-acquired infection in younger healthy hosts, including liver abscess, pneumonia, meningitis and endophthalmitis and the ability to metastatically spread, an unusual feature for enteric Gram-negative bacilli in the non-immunocompromised. Despite infecting a healthier population, significant morbidity and mortality occurs. Although epidemiologic features are still being defined, colonization, particularly intestinal colonization, appears to be a critical step leading to infection. However the route of entry remains unclear. The majority of cases described to date are in Asians, raising the issue of a genetic predisposition vs. geospecific strain acquisition. The traits that enhance its virulence when compared with "classical" K. pneumoniae are the ability to more efficiently acquire iron and perhaps an increase in capsule production, which confers the hypermucoviscous phenotype. An objective diagnostic test suitable for routine use in the clinical microbiology laboratory is needed. If/when these strains become increasingly resistant to antimicrobials, we will be faced with a frightening clinical scenario.
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Cites
Acute Bacterial Meningitis in Adults -- A Review of 493 Episodes
Durand, M. L., Calderwood, S. B., Weber, D. J., Miller, S. I., Southwick, F. S., Caviness, V. S., & Swartz, M. N. (1993) · New England Journal of Medicine · doi:10.1056/nejm199301073280104 · Cited by 1,344
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Sequencing and analysis of the large virulence plasmid pLVPK of Klebsiella pneumoniae CG43
Chen, Y.-T., Chang, H.-Y., Lai, Y.-C., Pan, C.-C., Tsai, S.-F., & Peng, H.-L. (2004) · Gene · doi:10.1016/j.gene.2004.05.008 · Cited by 351
Russo, T. A., Shon, A. S., Beanan, J. M., Olson, R., MacDonald, U., Pomakov, A. O., & Visitacion, M. P. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026734 · Cited by 153
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Hypervirulent Klebsiella pneumoniae
Russo, T. A., & Marr, C. M. (2019) · Clinical Microbiology Reviews · doi:10.1128/cmr.00001-19 · Cited by 1,311
Self-citationRusso, T. A., Olson, R., Fang, C.-T., Stoesser, N., Miller, M., MacDonald, U., Hutson, A., Barker, J. H., La Hoz, R. M., Johnson, J. R., et al. (2018) · Journal of Clinical Microbiology · doi:10.1128/jcm.00776-18 · Cited by 783
Self-citationGenomic Definition of Hypervirulent and Multidrug-Resistant Klebsiella pneumoniae Clonal Groups
Bialek-Davenet, S., Criscuolo, A., Ailloud, F., Passet, V., Jones, L., Delannoy-Vieillard, A.-S., Garin, B., Le Hello, S., Arlet, G., Nicolas-Chanoine, M.-H., et al. (2014) · Emerging Infectious Diseases · doi:10.3201/eid2011.140206 · Cited by 481
Molecular Pathogenesis of Klebsiella Pneumoniae
Li, B., Zhao, Y., Liu, C., Chen, Z., & Zhou, D. (2014) · Future Microbiology · doi:10.2217/fmb.14.48 · Cited by 364
Lam, M. M. C., Wyres, K. L., Duchêne, S., Wick, R. R., Judd, L. M., Gan, Y.-H., Hoh, C.-H., Archuleta, S., Molton, J. S., Kalimuddin, S., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05114-7 · Cited by 348
Metadata
- Authors
- Shon, A. S., Bajwa, R. P. S., & Russo, T. A.
- Venue
- Virulence
- Publisher
- Informa UK Limited
- Published
- 2013-02-15
- Volume
- 4
- Issue
- 2
- Pages
- 107-118
- ISSN
- 2150-5594 (ISSN-L)
- 2150-5608
- OpenAlex
- W1991331030
- Cited by
- 1,171
- References
- 4
- FWCI
- 16.19
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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