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Hypervirulent (hypermucoviscous)Klebsiella pneumoniae: A new and dangerous breed

Open access
Shon, Alyssa S., Bajwa, Rajinder P.S., Russo, Thomas A.·2013·Virulence

Abstract

A new hypervirulent (hypermucoviscous) variant of Klebsiella pneumoniae has emerged. First described in the Asian Pacific Rim, it now increasingly recognized in Western countries. Defining clinical features are the ability to cause serious, life-threatening community-acquired infection in younger healthy hosts, including liver abscess, pneumonia, meningitis and endophthalmitis and the ability to metastatically spread, an unusual feature for enteric Gram-negative bacilli in the non-immunocompromised. Despite infecting a healthier population, significant morbidity and mortality occurs. Although epidemiologic features are still being defined, colonization, particularly intestinal colonization, appears to be a critical step leading to infection. However the route of entry remains unclear. The majority of cases described to date are in Asians, raising the issue of a genetic predisposition vs. geospecific strain acquisition. The traits that enhance its virulence when compared with "classical" K. pneumoniae are the ability to more efficiently acquire iron and perhaps an increase in capsule production, which confers the hypermucoviscous phenotype. An objective diagnostic test suitable for routine use in the clinical microbiology laboratory is needed. If/when these strains become increasingly resistant to antimicrobials, we will be faced with a frightening clinical scenario.

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Metadata

Authors
Shon, A. S., Bajwa, R. P. S., & Russo, T. A.
Venue
Virulence
Published
2013-02-15
Volume
4
Issue
2
Pages
107-118
ISSN
  • 2150-5594 (ISSN-L)
  • 2150-5608
OpenAlex
W1991331030
Cited by
1,171
References
4
FWCI
16.19
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Hypervirulent (hypermucoviscous)Klebsiella pneumoniae: A new and dangerous breed. https://app.cochat.ai/papers/10.4161/viru.22718
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Shon, A. S., Bajwa, R. P. S., & Russo, T. A. (2013). Hypervirulent (hypermucoviscous)Klebsiella pneumoniae: A new and dangerous breed. Virulence. https://doi.org/10.4161/viru.22718

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