Cited by 199Pharmacogenetics and Drug MetabolismSex and Gender in HealthcareDrug Transport and Resistance Mechanisms

Sex-specific differences in CYP450 isoforms in humans

Scandlyn, Marissa J, Stuart, Emma C, Rosengren, Rhonda J·2008·Expert Opinion on Drug Metabolism & Toxicology

Abstract

BACKGROUND: The activity of various CYP isoforms is critical for maintaining the clinical effectiveness of many medications. Therefore, determining the sex-dependent activity of clinically relevant CYP families is highly important for optimal therapeutic effectiveness. OBJECTIVE: This review examined the sex-dependent activity of CYP3A, CYP1A2, CYP2D6, CYP2C9, CYP2C19 and CYP2E1. METHODS: This review searched for studies performed in humans and hormonal status was not a limiting factor. RESULTS/CONCLUSIONS: The current evidence suggests that CYP2E1 and CYP1A2 activity is higher in males than females, while CYP3A, one of the most clinically relevant CYP isoforms, appears to have greater activity in females. Overall, more studies are needed to fully support these conclusions as there are many factors that influence drug metabolism and thus it is very difficult to isolate gender as a sole modulator of CYP activity.

Integrity signals

Registry

Crossref · 10.1517/17425255.4.4.413

Cites

144 of 144 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Scandlyn, M. J., Stuart, E. C., & Rosengren, R. J.
Affiliations
University of Otago (NZ)
Venue
Expert Opinion on Drug Metabolism & Toxicology
Published
2008-04
Volume
4
Issue
4
Pages
413-424
ISSN
  • 1742-5255 (ISSN-L)
  • 1744-7607
OpenAlex
W2133866312
Cited by
199
References
144
Citations by year
2026: 13 · 2025: 21 · 2024: 18 · 2023: 7 · 2022: 4 · 2021: 11 · 2020: 11 · 2019: 9 · 2018: 6 · 2017: 5 · 2016: 7 · 2015: 7 · 2014: 8 · 2013: 11 · 2012: 23
FWCI
1.79
Type
journal article
Language
en
Open access
closed
Locations
  • Expert Opinion on Drug Metabolism & Toxicology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Sex and Gender in Healthcare
  • Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Keywords
sex differences, CYP450 isoforms, cytochrome P450, CYP3A, CYP1A2, CYP2D6, CYP2C9, CYP2C19, CYP2E1, drug metabolism
MeSH terms
Cytochrome P-450 Enzyme System, Pharmaceutical Preparations, Female, Hormones, Humans, Isoenzymes, Male, Sex Factors, Polymorphism, Single Nucleotide

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review