Towards a Circuit-Level Understanding of Hippocampal CA1 Dysfunction in Alzheimer's Disease Across Anatomical Axes
Open accessAbstract
The hippocampus has been a primary region of study with regards to synaptic and functional changes in Alzheimer’s disease (AD) due to its involvement in early stages, specifically area CA1. However, most work in this area has treated CA1 as a homogeneous structure comprised of uniform neural circuits. Yet, there is a plethora of evidence that CA1 varies in its structure and function across anatomical axes. Here I review the heterogeneity of the functional and circuit architecture of hippocampal area CA1 across three primary anatomical axes. I also summarize evidence that AD differentially affects these subregions, as well as hypotheses as to why this may occur.
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The distal part of the CA1 region appears to be mainly involved in non-spatial memory, while the proximal part is supposed to play a more important role in tasks depending on spatial information.
“While the distal part of the CA1 region appears to be mainly involved in non-spatial memory, the proximal part is supposed to play a more important role in tasks depending on spatial information [39,40].”
From Characterization of a Mouse Model of Alzheimer’s Disease Expressing Aβ4-42 and Human Mutant Tau (2021) · cites this paper as [39]
The CA1 region of the hippocampus is one of the most susceptible regions of the brain in AD.
“as it has been shown to be one of the most susceptible regions of the brain in AD [29, 30].”
From Control of the temporal development of Alzheimer’s disease pathology by the MR1/MAIT cell axis (2023) · cites this paper as [30]
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“S3), as it has been shown to be one of the most susceptible regions of the brain in AD [29, 30].”
BackgroundCharacterization of a Mouse Model of Alzheimer’s Disease Expressing Aβ4-42 and Human Mutant Tau
Zampar, S., & Wirths, O. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105191 · Cited by 18 · see citing works
- Authors
- Masurkar, A. V.
- Affiliations
- NYU Langone Health (US)
- Corresponding author
- Masurkar, Arjun V
- ORCID
- Masurkar, Arjun V
- Venue
- Journal of Alzheimer’s Disease & Parkinsonism
- Publisher
- OMICS Publishing Group
- Published
- 2018
- Volume
- 08
- Issue
- 01
- ISSN
- 2161-0460 (ISSN-L)
- PMC
- PMC6005196
- OpenAlex
- W2789789438
- Cited by
- 68
- References
- 11
- Citations by year
- 2026: 7 · 2025: 12 · 2024: 11 · 2023: 6 · 2022: 5 · 2021: 10 · 2020: 10 · 2019: 6 · 2018: 1
- FWCI
- 4.02
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- Journal of Alzheimer’s Disease & Parkinsonism (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Leon Levy Foundation
- Blas Frangione Foundation
- National Institute on Aging (P30AG008051)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- Alzheimer's disease, hippocampal CA1, hippocampal subfields, neural circuit architecture, regional heterogeneity, circuit dysfunction, synaptic dysfunction
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