Cited by 85Dementia and Cognitive Impairment ResearchMemory and Neural MechanismsAlzheimer's disease research and treatments

Altered glucose metabolism in the hippocampal head in memory impairment

Ouchi, Y., Nobezawa, S., Okada, H., Yoshikawa, E., Futatsubashi, M., Kaneko, M.·1998·Neurology

Abstract

OBJECTIVE: To evaluate the relevance of hypometabolism in the hippocampal head to the pathophysiology of memory impairment. BACKGROUND: Neurofunctional imaging studies with an image reslicing technique provided by using software suggest that dysfunction of the amygdalohippocampal system causes memory impairment. However, metabolic and morphologic profiles of the whole hippocampal formation have not been evaluated in detail. METHODS: By tilting the gantry of a high-resolution PET scanner in a plane parallel to the hippocampal longitudinal axis determined beforehand by MRI, we performed quantitative measurement of glucose metabolism in the subdivisions of the hippocampal formation (head, body, tail) in 10 patients of normal intelligence with pure amnesia, in eight patients with AD, and in eight normal subjects. RESULTS: Although the volumes of the amygdala and hippocampal formation in pure amnesics were not different significantly from those of normal subjects, glucose metabolism in the head of the hippocampus was significantly lower in pure amnesics. In patients with AD, marked hypometabolism was found extending to the amygdala, the hippocampal head, and the parietotemporal cortex, along with amygdalohippocampal atrophy. CONCLUSION: Hippocampal head dysfunction plays an important role in memory impairment in amnesic patients. Further metabolic impairment over the amygdalohippocampal system and the surrounding association cortex reflects the pathophysiology of AD.

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Crossref · 10.1212/wnl.51.1.136

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Authors
Ouchi, Y., Nobezawa, S., Okada, H., Yoshikawa, E., Futatsubashi, M., & Kaneko, M.
Affiliations
Hamamatsu Photonics (Japan) (JP)
Venue
Neurology
Published
1998-07
Volume
51
Issue
1
Pages
136-142
ISSN
  • 0028-3878 (ISSN-L)
  • 1526-632X
OpenAlex
W1973705001
Cited by
85
References
32
Citations by year
2026: 1 · 2022: 3 · 2021: 1 · 2020: 2 · 2019: 3 · 2018: 2 · 2016: 2 · 2014: 2 · 2013: 2 · 2012: 6
FWCI
4.72
Type
journal article
Language
en
Open access
closed
Locations
  • Neurology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords
hippocampal head, glucose metabolism, hypometabolism, memory impairment, Alzheimer's disease, amygdala, hippocampal formation, temporoparietal cortex, positron emission tomography
MeSH terms
Adult, Aged, Amnesia, Female, Glucose, Hippocampus, Humans, Intelligence Tests, Magnetic Resonance Imaging, Male, Middle Aged, Temporal Lobe, Tomography, Emission-Computed

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