Altered glucose metabolism in the hippocampal head in memory impairment
Abstract
OBJECTIVE: To evaluate the relevance of hypometabolism in the hippocampal head to the pathophysiology of memory impairment. BACKGROUND: Neurofunctional imaging studies with an image reslicing technique provided by using software suggest that dysfunction of the amygdalohippocampal system causes memory impairment. However, metabolic and morphologic profiles of the whole hippocampal formation have not been evaluated in detail. METHODS: By tilting the gantry of a high-resolution PET scanner in a plane parallel to the hippocampal longitudinal axis determined beforehand by MRI, we performed quantitative measurement of glucose metabolism in the subdivisions of the hippocampal formation (head, body, tail) in 10 patients of normal intelligence with pure amnesia, in eight patients with AD, and in eight normal subjects. RESULTS: Although the volumes of the amygdala and hippocampal formation in pure amnesics were not different significantly from those of normal subjects, glucose metabolism in the head of the hippocampus was significantly lower in pure amnesics. In patients with AD, marked hypometabolism was found extending to the amygdala, the hippocampal head, and the parietotemporal cortex, along with amygdalohippocampal atrophy. CONCLUSION: Hippocampal head dysfunction plays an important role in memory impairment in amnesic patients. Further metabolic impairment over the amygdalohippocampal system and the surrounding association cortex reflects the pathophysiology of AD.
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Reduced size or glucose metabolism (METglu) in the EC, Hip, temporal neocortex, and posterior cingulate gyrus have been shown to predict the MCI conversion to Alzheimer's disease.
“Reduced size or glucose metabolism (METglu) in the EC (10), Hip (11–16), temporal neocortex (17–20), and posterior cingulate gyrus (16) have been shown to predict the MCI conversion to AD.”
Cites
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915 · see citing works
A differential neural response in the human amygdala to fearful and happy facial expressions
Morris, J. S., Frith, C. D., Perrett, D. I., Rowland, D., Young, A. W., Calder, A. J., & Dolan, R. J. (1996) · Nature · doi:10.1038/383812a0 · Cited by 2,013 · see citing works
Zola-Morgan, S., Squire, L., & Amaral, D. (1986) · The Journal of Neuroscience · doi:10.1523/jneurosci.06-10-02950.1986 · Cited by 1,997 · see citing works
Metabolic reduction in the posterior cingulate cortex in very early Alzheimer's disease
Minoshima, S., Giordani, B., Berent, S., Frey, K. A., Foster, N. L., & Kuhl, D. E. (1997) · Annals of Neurology · doi:10.1002/ana.410420114 · Cited by 1,802 · see citing works
Squire, L. R. (1986) · Science · doi:10.1126/science.3086978 · Cited by 1,278 · see citing works
Mishkin, M. (1978) · Nature · doi:10.1038/273297a0 · Cited by 1,207 · see citing works
Noninvasive determination of local cerebral metabolic rate of glucose in man
Huang, S. C., Phelps, M. E., Hoffman, E. J., Sideris, K., Selin, C. J., & Kuhl, D. E. (1980) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1980.238.1.e69 · Cited by 926 · see citing works
Rempel-Clower, N., Zola, S. M., Squire, L. R., & Amaral, D. G. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-16-05233.1996 · Cited by 815 · see citing works
Zola-Morgan, S. M., Squire, L., Amaral, D., & Suzuki, W. (1989) · Journal of Neuroscience · doi:10.1523/jneurosci.09-12-04355.1989 · Cited by 766 · see citing works
Frackowiak, R. S. J., Pozzilli, C., Legg, N. J., du Boulay, G. H., MARSHALL, J., Lenzi, G. L., & Jones, T. (1981) · Brain · doi:10.1093/brain/104.4.753 · Cited by 685 · see citing works
Perforant pathway changes and the memory impairment of Alzheimer's disease
Hyman, B. T., Van Hoesen, G. W., Kromer, L. J., & Damasio, A. R. (1986) · Annals of Neurology · doi:10.1002/ana.410200406 · Cited by 672 · see citing works
Anatomic basis of amygdaloid and hippocampal volume measurement by magnetic resonance imaging
Watson, C. E., Andermann, F., GLOOR, P., Jones‐Gotman, M., Peters, T. M., Evans, A. C., Olivier, A., Melanson, D., & Leroux, G. (1992) · Neurology · doi:10.1212/wnl.42.9.1743 · Cited by 665 · see citing works
Foster, N. L., Chase, T. N., Fedio, P., Patronas, N. J., Brooks, R. A., & Chiro, G. D. (1983) · Neurology · doi:10.1212/wnl.33.8.961 · Cited by 540 · see citing works
Impaired auditory recognition of fear and anger following bilateral amygdala lesions
Scott, S. K., Young, A. W., Calder, A. J., Hellawell, D. J., Aggleton, J. P., & Johnsons, M. (1997) · Nature · doi:10.1038/385254a0 · Cited by 523 · see citing works
Memory‐related neural systems in Alzheimer's disease: An anatomic study
Hyman, B. T., Hoesen, G. W. V., & Damasio, A. R. (1990) · Neurology · doi:10.1212/wnl.40.11.1721 · Cited by 449 · see citing works
The Alzheimer's disease assessment scale: an instrument for assessing treatment efficacy.
Mohs, R. C., Rosen, W. G., & Davis, K. L. (1983) · PubMed · Cited by 420 · see citing works
The Fluorodeoxyglucose 18F Scan in Alzheimer's Disease and Multi-infarct Dementia
Benson, D. F., Kuhl, D. E., Hawkins, R. A., Phelps, M. E., Cummings, J. L., & Tsai, S. Y. (1983) · Archives of Neurology · doi:10.1001/archneur.1983.04050110029003 · Cited by 393 · see citing works
Temporal neocortical afferent connections to the amygdala in the rhesus monkey
Herzog, A. G., & Hoesen, G. W. V. (1976) · Brain Research · doi:10.1016/0006-8993(76)90822-2 · Cited by 294 · see citing works
Human brain glucose utilization and cognitive function in relation to age
Duara, R., PhD, C. G., PhD, J. H., Ingvar, D. H., Sokoloff, L., Margolin, R. A., PhD, R. G. M., Cutler, N. R., & Рапопорт, С. И. (1984) · Annals of Neurology · doi:10.1002/ana.410160613 · Cited by 262 · see citing works
Soininen, H. S., Partanen, K. P. L., Pitkänen, A., Vainio, P. A., Hänninen, T., Hallikainen, M., Koivisto, K. J., & Riekkinen, P. J. (1994) · Neurology · doi:10.1212/wnl.44.9.1660 · Cited by 259 · see citing works
Meltzer, C. C., Zubieta, J.-K., Brandt, J., Tune, L. E., Mayberg, H., & Frost, J. J. (1996) · Neurology · doi:10.1212/wnl.47.2.454 · Cited by 182 · see citing works
Duvernoy, H. M. (1988) · J.F. Bergmann-Verlag eBooks · doi:10.1007/978-3-642-54195-7 · Cited by 172 · see citing works
Uncus and Amygdala Lesions: Effects on Social Behavior in the Free-Ranging Rhesus Monkey
Dicks, D., Myers, R. E., & Kling, A. (1969) · Science · doi:10.1126/science.165.3888.69 · Cited by 132 · see citing works
Ridley, R. M., Timothy, C., Maclean, C. J., & Baker, H. F. (1995) · Neuroscience · doi:10.1016/0306-4522(95)00063-o · Cited by 126 · see citing works
Metabolic Impairment in Human Amnesia: A PET Study of Memory Networks
Fazio, F., Perani, D., Gilardi, M. C., Colombo, F., Cappa, S. F., Vallar, G., Bettinardi, V., Paulesu, E., Alberoni, M., Bressi, S., et al. (1992) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1992.52 · Cited by 120 · see citing works
Nybäck, H., Nyman, H., Blomqvist, G., Sjogren, I., & Stone‐Elander, S. (1991) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.54.8.672 · Cited by 63 · see citing works
Development of a high resolution PET
Yamashita, T., Uchida, H., Okada, H., Kurono, T., Takemori, T., Watanabe, M., Shimizu, K., Yoshikawa, E., Ohmura, T., Satoh, N., et al. (1990) · IEEE Transactions on Nuclear Science · doi:10.1109/23.106683 · Cited by 45 · see citing works
Self-citationCoronal reconstruction images of glucose metabolism in Alzheimer's disease
Fukuyama, H., Harada, K., Yamauchi, H., Miyoshi, T., Yamaguchi, S., Kimura, J., Kameyama, M., Senda, M., Yonekura, Y., & Konishi, J. (1991) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(91)90249-7 · Cited by 23 · see citing works
Hippocampal formations imaging with axial sections parallel to their longitudinal axis
Beaurain, J., Dormont, D., Semah, F., Hasboun, D., & Baulac, M. (1994) · Magnetic Resonance Imaging · doi:10.1016/0730-725x(94)92361-2 · Cited by 18 · see citing works
Kartsounis, L. D. (1996) · Neurocase · doi:10.1093/neucas/2.4.259-s · Cited by 6 · see citing works
Baron, J., & Miyazawa, H. (1991) · Methods in neurosciences · doi:10.1016/b978-0-12-185263-4.50033-9 · Cited by 6 · see citing works
Bilateral and limited amygdalohippocampal lesions causing a pure amnesic syndrome
Duyckaerts, C. J. (1996) · Neurocase · doi:10.1093/neucas/2.4.259-m · Cited by 2 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Mueller, S. G., Weiner, M. W., Thal, L. J., Petersen, R. C., Jack, C. R., Jagust, W., Trojanowski, J. Q., Toga, A. W., & Beckett, L. (2005) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2005.06.003 · Cited by 1,233 · see citing works
Brain glucose metabolism in the early and specific diagnosis of Alzheimer?s disease
Mosconi, L. (2005) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-005-1762-7 · Cited by 900 · see citing works
de Leon, M. J., Convit, A., Wolf, O. T., Tarshish, C. Y., DeSanti, S., Rusinek, H., Tsui, W., Kandil, E., Scherer, A. J., Roche, A., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.191044198 · Cited by 629 · see citing works
Brain Glucose Hypometabolism and Oxidative Stress in Preclinical Alzheimer's Disease
Mosconi, L., Pupi, A., & de Leon, M. J. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1427.007 · Cited by 599 · see citing works
Hippocampal formation glucose metabolism and volume losses in MCI and AD
De Santi, S., de Leon, M. J., Rusinek, H., Convit, A., Tarshish, C. Y., Roche, A., Tsui, W. H., Kandil, E., Boppana, M., Daisley, K., et al. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00230-5 · Cited by 548 · see citing works
Advances in the early detection of Alzheimer's disease
Nestor, P. J., Scheltens, P., & Hodges, J. R. (2004) · Nature Medicine · doi:10.1038/nrn1433 · Cited by 465 · see citing works
Limbic hypometabolism in Alzheimer's disease and mild cognitive impairment
Nestor, P. J., Fryer, T. D., Smielewski, P. S., & Hodges, J. R. (2003) · Annals of Neurology · doi:10.1002/ana.10669 · Cited by 414 · see citing works
Reduced hippocampal metabolism in MCI and AD
Mosconi, L., Tsui, W. H., Santi, S. D., Li, J., Rusinek, H., Convit, A. J., Li, Y., Boppana, M., & de Leon, M. J. (2005) · Neurology · doi:10.1212/01.wnl.0000163856.13524.08 · Cited by 335 · see citing works
Fellgiebel, A., Wille, P., Müller, M. J., Winterer, G., Scheurich, A., Vucurevic, G., Schmidt, L. G., & Stoeter, P. (2004) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000077817 · Cited by 298 · see citing works
Brain Serotonin Transporter Density and Aggression in Abstinent Methamphetamine Abusers
Sekine, Y., Ouchi, Y., Takei, N., Yoshikawa, E., Nakamura, K., Futatsubashi, M., Okada, H., Minabe, Y., Suzuki, K., Iwata, Y., et al. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.1.90 · Cited by 287 · see citing works
Self-citationOhmae, E., Ouchi, Y., Oda, M., Suzuki, T., Nobesawa, S., Kanno, T., Yoshikawa, E., Futatsubashi, M., Ueda, Y., Okada, H., et al. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.08.008 · Cited by 222 · see citing works
Self-citationHippocampal Head Size Associated with Verbal Memory Performance in Nondemented Elderly
Hackert, V., den Heijer, T., Oudkerk, M., Koudstaal, P. J., Albert Hofman, D., & Breteler, M. M. B. (2002) · NeuroImage · doi:10.1006/nimg.2002.1248 · Cited by 195 · see citing works
Early detection of Alzheimer’s disease using neuroimaging
Mosconi, L., Bryś, M., Głodzik-Sobańska, L., Santi, S. D., Rusinek, H., & de Leon, M. J. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2006.05.016 · Cited by 186 · see citing works
Yokokura, M., Mori, N., Yagi, S., Yoshikawa, E., Kikuchi, M., Yoshihara, Y., Wakuda, T., Sugihara, G., Takebayashi, K., Suda, S., et al. (2011) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-010-1612-0 · Cited by 174 · see citing works
Self-citationOuchi, Y., Yoshikawa, E., Okada, H., Futatsubashi, M., Sekine, Y., Iyo, M., & Sakamoto, M. (1999) · PubMed · Cited by 145 · see citing works
Self-citationOuchi, Y. (2001) · Brain · doi:10.1093/brain/124.4.784 · Cited by 125 · see citing works
Self-citationShimura, H., Hattori, N., Kubo, S., Yoshikawa, M., Kitada, T., Matsumine, H., Asakawa, S., Minoshima, S., Yamamura, Y., Shimizu, N., et al. (1999) · Annals of Neurology · doi:10.1002/1531-8249(199905)45:5 · Cited by 282 · see citing works
Self-citationTeipel, S. J., Pruessner, J. C., Faltraco, F., Born, C., Rocha-Unold, M., Evans, A. C., Möller, H. ‐., & Hampel, H. J. (2006) · Journal of Neurology · doi:10.1007/s00415-006-0120-4 · Cited by 114 · see citing works
The Human Parahippocampal Region: I. Temporal Pole Cytoarchitectonic and MRI Correlation
Blaizot, X., Mansilla, F., Serrano, A. M. I., Constans, J., Salinas-Alaman, A., Pró-Sistiaga, P., Mohedano‐Moriano, A., & Insausti, R. (2010) · Cerebral Cortex · doi:10.1093/cercor/bhp289 · Cited by 103 · see citing works
Application of Cortical Unfolding Techniques to Functional MRI of the Human Hippocampal Region
Zeineh, M., Engel, S. A., & Bookheimer, S. Y. (2000) · NeuroImage · doi:10.1006/nimg.2000.0561 · Cited by 106 · see citing works
Mizuno, K., Wakai, M., Takeda, A., & Sobue, G. (2000) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(99)00289-0 · Cited by 103 · see citing works
Scarmeas, N., Habeck, C. G., Zarahn, E., Anderson, K. E., Park, A., Hilton, J., Pelton, G. H., Tabert, M. H., Honig, L. S., Moeller, J. R., et al. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.04.032 · Cited by 99 · see citing works
The use of a wearable camera improves autobiographical memory in patients with Alzheimer's disease
Woodberry, E., Browne, G., Hodges, S. E., Watson, P., Kapur, N., & Woodberry, K. (2014) · Memory · doi:10.1080/09658211.2014.886703 · Cited by 92 · see citing works
Samuraki, M., Matsunari, I., Chen, W.-P., Yajima, K., Yanase, D., Fujikawa, A., Takeda, N., Nishimura, S., Matsuda, H., & Yamada, M. (2007) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-007-0454-x · Cited by 92 · see citing works
Mevel, K., Desgranges, B., Baron, J., Landeau, B., Sayette, V. D. L., Viader, F., Eustache, F., & Chételat, G. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.04.048 · Cited by 87 · see citing works
Hippocampal perfusion in mild Alzheimer's disease
Rodriguez, G., Vitali, P., Calvini, P., Bordoni, C., Girtler, N. G., Taddei, G. Z., Mariani, G., & Nobili, F. M. (2000) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(00)00071-8 · Cited by 87 · see citing works
Yokokura, M., Terada, T., Bunai, T., Nakaizumi, K., Takebayashi, K., Iwata, Y., Yoshikawa, E., Futatsubashi, M., Suzuki, K., Mori, N., et al. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x16646788 · Cited by 85 · see citing works
Self-citationMosconi, L., Santi, S. D., Li, Y., Li, J., Zhan, J., Tsui, W. H., Boppana, M., Pupi, A., & de Leon, M. J. (2005) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-005-1956-z · Cited by 81 · see citing works
Alterations in α4β2 nicotinic receptors in cognitive decline in Alzheimer’s aetiopathology
Okada, H., Ouchi, Y., Ogawa, M., Futatsubashi, M., Saito, Y., Yoshikawa, E., Terada, T., Oboshi, Y., Tsukada, H., Ueki, T., et al. (2013) · Brain · doi:10.1093/brain/awt195 · Cited by 72 · see citing works
Self-citationYokokura, M., Takebasashi, K., Takao, A., Nakaizumi, K., Yoshikawa, E., Futatsubashi, M., Suzuki, K., Nakamura, K., Yamasue, H., & Ouchi, Y. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0784-7 · Cited by 66 · see citing works
Self-citationVoxel-Based Mapping of Brain Hypometabolism in Permanent Amnesia with PET
Aupée, A., Desgranges, B., Eustache, F., Lalevée, C., Sayette, V. D. L., Viader, F., & Baron, J. (2001) · NeuroImage · doi:10.1006/nimg.2001.0762 · Cited by 69 · see citing works
Masurkar, A. V. (2018) · Journal of Alzheimer’s Disease & Parkinsonism · doi:10.4172/2161-0460.1000412 · Cited by 68 · see citing works
Ouchi, Y., Yoshikawa, E., Futatsubashi, M., Okada, H., Torizuka, T., & Sakamoto, M. (2002) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200206000-00013 · Cited by 65 · see citing works
Self-citationLong-term memory in Alzheimer’s disease
Fleischman, D. A., & Gabrieli, J. D. E. (1999) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(99)80034-8 · Cited by 52 · see citing works
Yagi, S., Yoshikawa, E., Futatsubashi, M., Yokokura, M., Yoshihara, Y., Torizuka, T., & Ouchi, Y. (2010) · Journal of Nuclear Medicine · doi:10.2967/jnumed.110.076802 · Cited by 48 · see citing works
Self-citationA multi‐hit hypothesis for an <i>APOE4</i> ‐dependent pathophysiological state
Steele, O. G., Stuart, A. C., Minkley, L., Shaw, K., Bonnar, O., Anderle, S., Penn, A. C., Rusted, J., Serpell, L., Hall, C., et al. (2022) · European Journal of Neuroscience · doi:10.1111/ejn.15685 · Cited by 44 · see citing works
Deletion of Glucose Transporter GLUT8 in Mice Increases Locomotor Activity
Schmidt, S., Gawlik, V., Hölter, S. M., Augustin, R., Scheepers, A., Behrens, M., Wurst, W., Gailus‐Durner, V., Fuchs, H., de Angelis, M. H., et al. (2008) · Behavior Genetics · doi:10.1007/s10519-008-9208-1 · Cited by 40 · see citing works
Hippocampal Subregions are Differentially Affected in the Progression to Alzheimer's Disease
Greene, S. J., Killiany, R., & Initiative, T. A. D. N. (2011) · The Anatomical Record · doi:10.1002/ar.21493 · Cited by 40 · see citing works
Investigating temporal pole function by functional imaging
Dupont, S. (2002) · Epileptic Disorders · doi:10.1684/j.1950-6945.2002.tb00513.x · Cited by 38 · see citing works
Alterations in serotonin transporter and body image-related cognition in anorexia nervosa
Yokokura, M., Terada, T., Bunai, T., Nakaizumi, K., Kato, Y., Yoshikawa, E., Futatsubashi, M., Suzuki, K., Yamasue, H., & Ouchi, Y. (2019) · NeuroImage Clinical · doi:10.1016/j.nicl.2019.101928 · Cited by 31 · see citing works
Self-citationKato, Y., Yokokura, M., Iwabuchi, T., Murayama, C., Harada, T., Goto, T., Tamayama, T., Kameno, Y., Wakuda, T., Kuwabara, H., et al. (2022) · American Journal of Psychiatry · doi:10.1176/appi.ajp.22010014 · Cited by 32 · see citing works
Self-citationOboshi, Y., Ouchi, Y., Yagi, S., Kono, S., Nakai, N., Yoshikawa, E., Futatsubashi, M., Terada, T., Kim, K., & Harada, K. (2012) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2011.201 · Cited by 30 · see citing works
Self-citationMillien, I., Blaizot, X., Giffard, C., Mézenge, F., Insausti, R., Baron, J., & Chavoix, C. (2002) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000037997.34930.67 · Cited by 28 · see citing works
Smith, Y. R., Bowen, L., Love, T., Berent‐Spillson, A., Frey, K. A., Persad, C. C., Reame, N. K., Koeppe, R. A., & Zubieta, J. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-0351 · Cited by 28 · see citing works
Chételat, G., Desgranges, B., & Eustache, F. (2006) · Revue Neurologique · doi:10.1016/s0035-3787(06)75104-9 · Cited by 25 · see citing works
Konishi, T., Kono, S., Fujimoto, M., Terada, T., Matsushita, K., Ouchi, Y., & Miyajima, H. (2012) · Journal of Neurology · doi:10.1007/s00415-012-6618-z · Cited by 25 · see citing works
Self-citationWhither the Hippocampus? FDG-PET Hippocampal Hypometabolism in Alzheimer Disease Revisited
Maldjian, J. A., & Whitlow, C. T. (2012) · American Journal of Neuroradiology · doi:10.3174/ajnr.a3113 · Cited by 24 · see citing works
Yang, Z., Yu, R., Cao, Z., Wu, Y., Zhao, X., Xie, Q., Luo, M., & Liu, Y. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.625843 · Cited by 21 · see citing works
Ouchi, Y., Nobezawa, S., Yoshikawa, E., Futatsubashi, M., Kanno, T., Okada, H., Torizuka, T., Nakayama, T., & Tanaka, K. (2001) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200109000-00003 · Cited by 22 · see citing works
Self-citationYakushev, I. Y., Gerhard, A., Müller, M. J., Lorscheider, M., Buchholz, H., Schermuly, I., Weibrich, C., Hammers, A., Stoeter, P., Schreckenberger, M., et al. (2011) · Brain Structure and Function · doi:10.1007/s00429-011-0302-4 · Cited by 21 · see citing works
Høgh, P., Sjö, N. M., Gade, A., & Waldemar, G. (2004) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000077730 · Cited by 20 · see citing works
Kosenko, E. A., Tikhonova, L. A., Alilova, G. A., Urios, A., & Montoliu, C. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9010206 · Cited by 18 · see citing works
Glucose and Oxygen Hypometabolism in Aceruloplasminemia Brains.
Miyajima, H., Takahashi, Y., Kono, S., Sugimoto, M., SUZUKI, Y., Hishida, A., Sakamoto, M., & Yasuomi, O. U. C. M. (2002) · Internal Medicine · doi:10.2169/internalmedicine.41.186 · Cited by 18 · see citing works
Zhu, J., Zhang, Z., Jia, J., Wang, L., Yang, Q., Wang, Y., & Chen, C. (2019) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-019-00779-0 · Cited by 17 · see citing works
Nozaki, T., Sugiyama, K., Yagi, S., Yoshikawa, E., Kanno, T., Asakawa, T., Ito, T., Terada, T., Namba, H., & Ouchi, Y. (2012) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2012.183 · Cited by 17 · see citing works
Self-citationOuchi, Y., Yoshikawa, E., Futatsubashi, M., Okada, H., Torizuka, T., & Kaneko, M. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2003.12.035 · Cited by 17 · see citing works
Self-citationTemporoporal metabolic abnormalities in temporal lobe epilepsies
Semah, F. (2002) · Epileptic Disorders · doi:10.1684/j.1950-6945.2002.tb00518.x · Cited by 17 · see citing works
Anteroposterior perfusion heterogeneity in human hippocampus measured by arterial spin labeling MRI
Li, X., Sarkar, S. N., Purdy, D. E., Spence, J. S., Haley, R. W., & Briggs, R. W. (2013) · NMR in Biomedicine · doi:10.1002/nbm.2898 · Cited by 16 · see citing works
Ouchi, Y., Yoshikawa, E., Kanno, T., Futatsubashi, M., Sekine, Y., Okada, H., Torizuka, T., & Tanaka, K. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.07.044 · Cited by 16 · see citing works
Self-citationLes substrats cérébraux des troubles de la mémoire épisodique dans la maladie d’Alzheimer
Desgranges, B., Chételat, G., & Eustache, F. (2004) · Revue Neurologique · doi:10.1016/s0035-3787(04)70943-1 · Cited by 15 · see citing works
(2006) · Wiley eBooks · doi:10.1002/9780470041000.cedt079 · Cited by 15 · see citing works
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Self-citationZong-wen, S., lei, S., Li, Q., Kong, Y., Du, F., Tie-ming, X., Hua, Y., Hu, Q., Chen, X., Yuan-yuan, C., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-23127-6 · Cited by 13 · see citing works
Nebu, A., Ikeda, M., Fukuhara, R., Shigenobu, K., Maki, N., Hokoishi, K., Komori, K., Yasuoka, T., & Tanabe, H. (2001) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000051277 · Cited by 13 · see citing works
Nebu, A., Ikeda, M., Fukuhara, R., Komori, K., Maki, N., Hokoishi, K., Shigenobu, K., Kikuchi, T., & Tanabe, H. (2001) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000051250 · Cited by 13 · see citing works
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Nobili, F., & Morbelli, S. (2010) · The Open Nuclear Medicine Journal · doi:10.2174/1876388x01002010046 · Cited by 13 · see citing works
Glucocorticoids and the Aging Brain: Cause or Consequence?
Lucassen, P. J., & de Kloet, E. R. (2001) · Elsevier eBooks · doi:10.1016/b978-012351830-9/50064-0 · Cited by 10 · see citing works
IgLON5 autoimmune antibodies activate Tau via neuronal hyperactivity
Askin, B., Kilic, C., Gómez, C. C., Duong, S. L.-L., Dominguez‐Baquero, A., Goihl, A., Nalbach, K., Petushi, J., Grundschöttel, P., Wagner, J., et al. (2026) · Science Advances · doi:10.1126/sciadv.aec2042 · Cited by 9 · see citing works
Eguchi, A., Kimura, N., Aso, Y., Yabuuchi, K., Ishibashi, M., Hori, D., Sasaki, Y., Nakamichi, A., Uesugi, S., Jikumaru, M., et al. (2019) · Current Alzheimer Research · doi:10.2174/1567205016666190805155230 · Cited by 8 · see citing works
Oboshi, Y., Kikuchi, M., Terada, T., Yoshikawa, E., Bunai, T., & Ouchi, Y. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-151165 · Cited by 7 · see citing works
Self-citationFDG PET in the Evaluation of Mild Cognitive Impairment and Early Dementia
Mosconi, L., & Silverman, D. H. S. (2009) · Springer eBooks · doi:10.1007/978-0-387-76420-7_3 · Cited by 6 · see citing works
Whitlow, C. T., & Maldjian, J. A. (2012) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2012.05.141 · Cited by 5 · see citing works
Neuroimaging of Alzheimer’s Disease, Mild Cognitive Impairment, and Other Dementias
Risacher, S. L., & Saykin, A. J. (2010) · Springer eBooks · doi:10.1007/978-1-4419-6373-4_19 · Cited by 5 · see citing works
The Functional Neuroimaging of Memory Disorders
Fletcher, P. C. (2000) · Elsevier eBooks · doi:10.1016/b978-012481460-8/50011-1 · Cited by 5 · see citing works
Yakushev, I. Y., & Fellgiebel, A. (2011) · Journal of Nuclear Medicine · doi:10.2967/jnumed.110.085084 · Cited by 3 · see citing works
Sperfeld (1999) · Pure Amsterdam UMC · doi:10.1002/1531-8249(199911)46:5 · Cited by 2 · see citing works
Self-citationIncreased anaerobic glycolysis in mitochondrial trifunctional protein-deficient brain
Miyajima, H., Ouchi, Y., Sakamoto, M., Takahashi, Y., Kono, S., & Suzuki, H. (2001) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(01)00445-2 · Cited by 1 · see citing works
Self-citationPositron Emission Tomography in Alzheimer‘s Disease: Early Prediction and Differentiation
Mistur, R. L., Mosconi, L., Santi, S. D., Li, Y., Tsui, W., & de Leon, M. J. (2008) · Future Neurology · doi:10.2217/14796708.4.1.23 · Cited by 1 · see citing works
Cho, Z., Son, Y., Kim, H.-K., Kim, S., Lee, S., Chi, J.-G., Park, C., & Kim, Y.-B. (2011) · Journal of Nuclear Medicine · doi:10.2967/jnumed.110.085407 · Cited by 1 · see citing works
11 The Early Detection of Alzheimer's Disease with Positron Emission Tomography
Mistur, R. L., Mosconi, L., Switalski, R., Santi, S. D., Li, Y., Glodzik, L., Bryś, M., Tsui, W., Rusinek, H., & de Leon, M. J. (2009) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195328875.003.0011 · Cited by 1 · see citing works
Self-discrepancies, autobiographical memory and emotional distress in mild dementia
Christoforou-Hazelwood, L. (2012) · UEA Digital Repository (University of East Anglia)
The Functional Anatomy of the Amnesic Syndrome Studied with Resting [18F]FDG-PET and SPM
Aupée, A., Desgranges, B., Eustache, F., Lalevée, C., Sayette, V. D. L., Viader, F., & Baron, J. (2001) · Elsevier eBooks · doi:10.1016/b978-012285751-5/50056-9
Ainslie, P. N. (2014) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.718270401.793490776
Friedman (2000) · doi:10.1002/1097-0029(20001001)51:1
- Authors
- Ouchi, Y., Nobezawa, S., Okada, H., Yoshikawa, E., Futatsubashi, M., & Kaneko, M.
- Affiliations
- Hamamatsu Photonics (Japan) (JP)
- Venue
- Neurology
- Published
- 1998-07
- Volume
- 51
- Issue
- 1
- Pages
- 136-142
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W1973705001
- Cited by
- 85
- References
- 32
- Citations by year
- 2026: 1 · 2022: 3 · 2021: 1 · 2020: 2 · 2019: 3 · 2018: 2 · 2016: 2 · 2014: 2 · 2013: 2 · 2012: 6
- FWCI
- 4.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- hippocampal head, glucose metabolism, hypometabolism, memory impairment, Alzheimer's disease, amygdala, hippocampal formation, temporoparietal cortex, positron emission tomography
- MeSH terms
- Adult, Aged, Amnesia, Female, Glucose, Hippocampus, Humans, Intelligence Tests, Magnetic Resonance Imaging, Male, Middle Aged, Temporal Lobe, Tomography, Emission-Computed
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