Parvalbumin-Positive Basket Cells Differentiate among Hippocampal Pyramidal Cells
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CA1 pyramidal cells (PCs) are not homogeneous but rather can be grouped by molecular, morphological, and functional properties. However, less is known about synaptic sources differentiating PCs. Using paired recordings in vitro, two-photon Ca(2+) imaging in vivo, and computational modeling, we found that parvalbumin-expressing basket cells (PVBCs) evoked greater inhibition in CA1 PCs located in the deep compared to superficial layer of stratum pyramidale. In turn, analysis of reciprocal connectivity revealed more frequent excitatory inputs to PVBCs by superficial PCs, demonstrating bias in target selection by both the excitatory and inhibitory local connections in CA1. Additionally, PVBCs further segregated among deep PCs, preferentially innervating the amygdala-projecting PCs but receiving preferential excitation from the prefrontal cortex-projecting PCs, thus revealing distinct perisomatic inhibitory interactions between separate output channels. These results demonstrate the presence of heterogeneous PVBC-PC microcircuits, potentially contributing to the sparse and distributed structure of hippocampal network activity.
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Multiple studies strongly suggest that subtype specific microcircuits indeed exist, even among PVBCs.
“However, multiple studies have challenged this view and strongly suggest that subtype specific microcircuits indeed exist, even among PVBCs (650, 656, 1230, 1252).”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [656]
In the hippocampus, PVBCs evoke larger amplitude IPSCs in PCs located near s.o. than those near s.r. (deep vs. superficial).
“Furthermore, in the hippocampus, PVBCs evoke larger amplitude IPSCs in PCs located near s.o. than those near s.r. (i.e., deep vs. superficial) (656) (FIGURE 8A).”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [656]
In CA1 of the hippocampus, PVBCs are more likely to be innervated by and receive the largest excitatory drive from prefrontal cortex projecting PCs.
“Finally, in CA1 of the hippocampus, PVBCs evoke larger IPSCs in PCs that project to the amygdala than those that project to the prefrontal cortex; conversely, PVBCs are more likely to be innervated by and receive the largest excitatory drive from prefrontal cortex projecting PCs (656) (FIGURE 8E).”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [656]
In CA1 of the hippocampus, PVBCs evoke larger IPSCs in PCs that project to the amygdala than those that project to the prefrontal cortex.
“Finally, in CA1 of the hippocampus, PVBCs evoke larger IPSCs in PCs that project to the amygdala than those that project to the prefrontal cortex; conversely, PVBCs are more likely to be innervated by and receive the largest excitatory drive from prefrontal cortex projecting PCs (656) (FIGURE 8E).”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [656]
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- Authors
- Lee, S.-H., Marchionni, I., Bezaire, M., Varga, C., Danielson, N., Lovett-Barron, M., Losonczy, A., & Soltesz, I.
- Affiliations
- University of California, Irvine (US)
- Columbia University (US)
- Corresponding author
- Lee, Sang-Hun
- ORCID
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2014-06
- Volume
- 82
- Issue
- 5
- Pages
- 1129-1144
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC4076442
- OpenAlex
- W2033044289
- Cited by
- 358
- References
- 44
- Citations by year
- 2026: 18 · 2025: 34 · 2024: 42 · 2023: 29 · 2022: 26 · 2021: 31 · 2020: 23 · 2019: 26 · 2018: 37 · 2017: 28 · 2016: 27 · 2015: 30 · 2014: 6
- FWCI
- 13.86
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Padua Research Archive (University of Padova) (submittedVersion, other-oa)
- Funders
- Natural Sciences and Engineering Research Council of Canada
- National Science Foundation (DGE-0808392, TG-IBN130022, TG-IBN100011)
- McKnight Foundation
- National Institutes of Health (NS74432)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- parvalbumin basket cells, CA1 pyramidal neurons, perisomatic inhibition, synaptic connectivity, reciprocal connections, stratum pyramidale, paired recordings, two-photon calcium imaging, computational modeling
- MeSH terms
- Amygdala, Animals, Calcium, Female, Male, Mice, Inbred C57BL, Nerve Net, Parvalbumins, Physical Conditioning, Animal, Prefrontal Cortex, Pyramidal Cells, Entorhinal Cortex, Mice, CA1 Region, Hippocampal
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