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Cited by 52Nutrition and Health in AgingMuscle metabolism and nutritionMuscle Physiology and Disorders

The effectiveness of protein supplementation combined with resistance exercise programs among community-dwelling older adults with sarcopenia: a systematic review and meta-analysis

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Whaikid, Phatcharaphon, Piaseu, Noppawan·2024·Epidemiology and Health
DOI 10.4178/epih.e2024030PMC PMC11369567
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Abstract

OBJECTIVES: The combination of protein supplementation and resistance exercise shows promise for improving and maintaining muscle mass, strength, and performance in older adults with sarcopenia. This systematic review aimed to evaluate the effects of this combination on muscle mass, muscle strength, and physical performance in community-dwelling older adults with sarcopenia.METHODS: We conducted a comprehensive search of 4 electronic databases: PubMed, Scopus, Embase, and the MEDLINE Library. The search covered literature from January 2013 to January 2023 and followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Two independent reviewers assessed the methodological quality of each study using the standard critical appraisal tool from the Joanna Briggs Institute (JBI). Meta-analysis was performed with the JBI Sumari program.RESULTS: The review included 7 randomized controlled trials and 1 quasi-experimental study, encompassing a total of 854 participants aged 60 years and above. The study durations ranged from 10 weeks to 24 weeks. An analysis of standardized mean differences (SMDs) showed that protein supplementation combined with resistance exercise significantly increased muscle mass (SMD, 0.95; 95% confidence interval [CI], 0.13 to 1.78; p<0.05) and muscle strength (SMD, 0.32; 95% CI, 0.08 to 0.56; p<0.05).CONCLUSIONS: Although the limited number of randomized controlled trials restricts the robustness of our conclusions, the evidence suggests that protein supplementation combined with resistance exercise is effective in enhancing muscle mass and strength in community-dwelling older adults with sarcopenia.

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  • In populations with sarcopenia, interventions combining protein supplementation with resistance exercise have resulted in increases in muscle mass and muscle strength.

    “In populations with sarcopenia, interventions combining protein supplementation with resistance exercise have resulted in increases in muscle mass and muscle strength”

    From 13. Older Adults: Standards of Care in Diabetes—2026 (2026) · cites this paper as [89]

  • The risk for sarcopenia can be mitigated with adequate protein intake and resistance or strength training.

    “The risk for sarcopenia can be mitigated with adequate protein intake and resistance or strength training”

    From 13. Older Adults: Standards of Care in Diabetes—2026 (2026) · cites this paper as [89]

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Authors
Whaikid, P., & Piaseu, N.
Affiliations
Mahidol University (TH)
Corresponding author
Piaseu, Noppawan
ORCID
Venue
Epidemiology and Health
Publisher
Korean Society of Epidemiology
Published
2024-02-14
Volume
46
Pages
e2024030
ISSN
  • 1225-3596 (ISSN-L)
  • 2092-7193
DOI
10.4178/epih.e2024030
PMC
PMC11369567
OpenAlex
W4391909845
Cited by
52
References
56
Citations by year
2026: 30 · 2025: 19 · 2024: 3
FWCI
2.97
Type
journal article
Language
en
Open access
Licence
Locations
  • Epidemiology and Health (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Center of Health Promotion and Well-Being and Ramathibodi School of Nursing
  • Faculty of Medicine Ramathibodi Hospital, Mahidol University
Topics
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Keywords
sarcopenia, protein supplementation, resistance training, older adults, muscle mass, muscle strength, physical performance, community-dwelling older adults
MeSH terms
Aged, Combined Modality Therapy, Dietary Proteins, Humans, Middle Aged, Dietary Supplements, Muscle Strength, Resistance Training, Sarcopenia, Independent Living

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