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Cited by 2Skin Protection and AgingAdvancements in Transdermal Drug DeliveryFacial Rejuvenation and Surgery Techniques

In Vivo Evaluations of Emulsion O/W for a New Topical Anti-Aging Formulation: Short-Term and Long-Term Efficacy

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Mazzulla, Sergio, Anile, Dante, Sio, Silvia De, Scaglione, Annalisa, Seta, Marco De, Anile, Adelaide·2018·Journal of Cosmetics, Dermatological Sciences and Applications
DOI 10.4236/jcdsa.2018.83013
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Abstract

This study aims to evaluate the in vivo efficacy in terms of elasticity, hydration and anti-wrinkle enhancement of a new cosmetic cream formulation: Apollinea anti-ageing facial cream. The latter is O/W (oil/water) emulsion with high volume percentages of snail secretion filtrate and donkey milk serum in its composition. The investigation has been performed on (twelve) healthy subjects: 8 (eight) females, and 4 (four) males, all presenting evident skin wrinkles in typical facial areas (e.g. forehead and eye contour). The subjects had to apply about 2 grams of Apollinea anti-ageing facial cream every day. The efficacy of the new cosmetic formulation was assessed before and after the cosmetic treatment, precisely 2 hours, to assess the short-term efficacy, and 40 days after, this to evaluate the product long-term efficacy. Elasticity enhancements have been tested through measurements of the viscoelastic properties of the skin, whereas the hydration parameter through measurements of the skin and subcutaneous tissues dielectric constant. All the latter measurements have been performed with specific instrumentation, as discussed more in detail in the following. To evaluate the anti-wrinkles efficacy instead, we proceeded with digital camera imaging and image analysis processed through ImageJ software. The new Apollinea facial cream cosmetic formulation, based on donkey milk whey and snail secretion filtrate from Helix Aspersa Müller, showed significant enhancement effects on skin elasticity and hydration as well as an important skin-wrinkles-reduction.

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  • Cosmetic products containing snail mucus are being developed to decrease stretch marks, acne, and pigment spots; soothe and moisturize the skin; eliminate signs of photoaging and reduce damage caused by free radicals; fight age-related skin changes; and recover gray hair color.

    “Cosmetic products in different forms containing snail mucus (ampoules, creams, serums, etc.) are being developed that are designed to decrease stretch marks, acne, and pigment spots; to soothe and moisturize the skin; to eliminate signs of photoaging and reduce damage caused by free radicals; to fight age-related skin changes; to recover gray hair color; etc.”

    From Chemical Variability and Biological Potential of Cornu aspersum Mucus as a Source for the Development of New Cosmetic and Pharmaceutical Products (2025) · cites this paper as [54]

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  • The study on the oil/water emulsion Apollinea Anti-Aging Face Cream, with a combination of C. aspersum snail mucus filtrate, donkey milk serum, sweet almond oil, and karite butter, showed a significant improvement in skin elasticity and hydration, as well as a reduction in skin wrinkles.

    “The study on the oil/water emulsion Apollinea Anti-Aging Face Cream, with a combination of C. aspersum snail mucus filtrate, donkey milk serum, sweet almond oil, and karite butter, showed a significant improvement in skin elasticity and hydration, as well as a reduction in skin wrinkles [54].”

    From Chemical Variability and Biological Potential of Cornu aspersum Mucus as a Source for the Development of New Cosmetic and Pharmaceutical Products (2025) · cites this paper as [54]

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Cited by

Sorted by citations

Authors
Mazzulla, S., Anile, D., Sio, S. D., Scaglione, A., Seta, M. D., & Anile, A.
Affiliations
University of Calabria (IT)
ORCID
Venue
Journal of Cosmetics, Dermatological Sciences and Applications
Publisher
Scientific Research Publishing, Inc.
Published
2018
Volume
08
Issue
03
Pages
110-125
ISSN
  • 2161-4105 (ISSN-L)
  • 2161-4512
DOI
10.4236/jcdsa.2018.83013
OpenAlex
W2889024790
Cited by
2
References
1
Citations by year
2023: 1 · 2019: 1
FWCI
0.27
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Cosmetics Dermatological Sciences and Applications (publishedVersion, cc-by)
  • INFM-OAR (INFN Catania) (submittedVersion, cc-by)
Topics
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
  • Health Sciences › Medicine › Dermatology › Facial Rejuvenation and Surgery Techniques
Keywords
oil-water emulsions, Helix aspersa, skin elasticity, skin hydration, wrinkle reduction, dielectric constant

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