Introduction to Skin Aging

Tobin, Desmond J.

doi:10.1016/j.jtv.2016.03.002

Cited by 701Skin Protection and AgingHair Growth and DisordersWound Healing and Treatments

Introduction to Skin Aging

Open access

Tobin, Desmond J.·2017·Journal of Tissue Viability

DOI 10.1016/j.jtv.2016.03.002

Open this paper in CoChat — free account

Abstract

Cutaneous science has seen considerable development in the last 25 years, in part due to the Omics revolution, and the appreciation that this organ is hardwired into the body's key neuro-immuno-endocrine axes. Moreover, there is greater appreciation of how stratification of skin disorders will permit more targeted and more effective treatments. Against this has been how the remarkable extension in the average human life-span, though in the West at least, this parallels worrying increases in lifestyle-associated conditions like diabetes, skin cancer etc. These demographic trends bring greater urgency to finding clinical solutions for numerous age-related deficits in skin function caused by extrinsic and intrinsic factors. Mechanisms for aging skin include the actions of reactive oxygen species (ROS), mtDNA mutations, and telomere shortening, as well as hormonal changes. We have also significantly improved our understanding of how to harness the skin's considerable regenerative capacity e.g., via its remarkable investment of stem cell subpopulations. In this way we hope to develop new strategies to selectively target the skin's capacity to undergo optimal wound repair and regeneration. Here, the unsung hero of the skin regenerative power may be the humble hair follicle, replete with its compliment of epithelial, mesenchymal, neural and other stem cells. This review introduces the topic of human skin aging, with a focus on how maintenance of function in this complex multi-cell type organ is key for retaining quality of life into old age.

Integrity signals

Registry

Crossref · 10.1016/j.jtv.2016.03.002

Cites

121 of 121 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

HSFs can synthesize and maintain the extracellular matrix of skin and reduce skin photoaging.
“HSFs, which can synthesize and maintain the extracellular matrix of skin and reduce skin photoaging, are a very critical cell type in skin photoaging (Tobin, 2017).”
From A Frog Peptide Ameliorates Skin Photoaging Through Scavenging Reactive Oxygen Species (2022) · cites this paper as Tobin, 2017
UV radiation induces production of ROS, which breaks the dynamic balance between oxidation and antioxidant systems in the skin and reduces its ability to remove ROS.
“UV radiation induces the production of ROS, which breaks the dynamic balance between oxidation and antioxidant systems in the skin [58] and reduces its ability to remove ROS.”
From Boosting the Photoaged Skin: The Potential Role of Dietary Components (2021) · cites this paper as [58]

Ageing populations: the challenges ahead
Christensen, K., Doblhammer, G., Rau, R., & Vaupel, J. W. (2009) · The Lancet · doi:10.1016/s0140-6736(09)61460-4 · Cited by 3,764 · see citing works
The Global Burden of Skin Disease in 2010: An Analysis of the Prevalence and Impact of Skin Conditions
Hay, R. J., Johns, N. E., Williams, H. C., Bolliger, I. W., Dellavalle, R. P., Margolis, D. J., Marks, R., Naldi, L., Weinstock, M. A., Wulf, S. K., et al. (2014) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.446 · Cited by 1,706 · see citing works
Rook's Textbook of Dermatology
(2004) · Wiley eBooks · doi:10.1002/9780470750520 · Cited by 1,662 · see citing works
UV-light-induced signal cascades and skin aging
Rittié, L. (2002) · Ageing Research Reviews · doi:10.1016/s1568-1637(02)00024-7 · Cited by 987 · see citing works
Photoageing: mechanism, prevention and therapy
Yaar, M., & Gilchrest, B. A. (2007) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2007.08108.x · Cited by 755 · see citing works
Mechanisms of hair graying: incomplete melanocyte stem cell maintenance in the niche
Nishimura, E. K., Granter, S. R., & Fisher, D. E. (2005) · Science · doi:10.1126/science.1099593 · Cited by 750 · see citing works
Epidermal thickness at different body sites: Relationship to age, gender, pigmentation, blood content, skin type and smoking habits
Sandby-Møller, J., Poulsen, T., & Wulf, H. C. (2003) · Acta Dermato-Venereologica · doi:10.1080/00015550310015419 · Cited by 737 · see citing works
Skin ageing and its treatment
Baumann, L. (2007) · The Journal of Pathology · doi:10.1002/path.2098 · Cited by 675 · see citing works
The influence of age and sex on skin thickness, skin collagen and density
SHUSTER, S., BLACK, M. M., & McVITIE, E. (1975) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1975.tb05113.x · Cited by 640 · see citing works
Estrogen accelerates cutaneous wound healing associated with an increase in TGF-β1 levels
Ashcroft, G. S., Dodsworth, J., Boxtel, E. V., Tarnuzzer, R. W., Horan, M. A., Schultz, G. S., & Ferguson, M. W. J. (1997) · Nature Medicine · doi:10.1038/nm1197-1209 · Cited by 573 · see citing works
The aged epidermal permeability barrier. Structural, functional, and lipid biochemical abnormalities in humans and a senescent murine model.
Ghadially, R., Brown, B. E., Sequeira‐Martin, S. M., Kr, F., & Elias, P. M. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117919 · Cited by 561 · see citing works
Structural and functional changes of normal aging skin
Fenske, N. A., & Lober, C. W. (1986) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(86)70208-9 · Cited by 535 · see citing works
pH Directly Regulates Epidermal Permeability Barrier Homeostasis, and Stratum Corneum Integrity/Cohesion
Hachem, J. P., Crumrine, D. A., Fluhr, J. W., Brown, B. E., Feingold, K. R., & Elias, P. M. (2003) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2003.12365.x · Cited by 526 · see citing works
Studies in Cutaneous Aging: I. The Elastic Fiber Network
Braverman, I. M., & Fonferko, E. (1982) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12507866 · Cited by 507 · see citing works
Age-Related Mechanical Properties of Human Skin: An In Vivo Study.
Escoffier, C., de Rigal, J., Rochefort, A., Vasselet, R., Lévêque, J.-L., & Agache, P. G. (1989) · Journal of Investigative Dermatology · doi:10.1016/0022-202x(89)90058-4 · Cited by 492 · see citing works
Photoaging of the skin from phenotype to mechanisms
Scharffetter‐Kochanek, K., Brenneisen, P., Wenk, J., Herrmann, G., Ma, W., Kuhr, L., Meewes, C., & Wlaschek, M. (2000) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00098-x · Cited by 487 · see citing works
Structural Alterations in Exposed and Unexposed Aged Skin
Lavker, R. M. (1979) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12532763 · Cited by 464 · see citing works
Innate immunity in aging: impact on macrophage function
Plowden, J., Renshaw‐Hoelscher, M., Engleman, C., Katz, J. M., & Sambhara, S. R. (2004) · Aging Cell · doi:10.1111/j.1474-9728.2004.00102.x · Cited by 430 · see citing works
Age and skin structure and function, a quantitative approach (I): blood flow, pH, thickness, and ultrasound echogenicity
Waller, J. M., & Maïbach, H. I. (2005) · Skin Research and Technology · doi:10.1111/j.0909-725x.2005.00151.x · Cited by 392 · see citing works
Age-related Changes in Sebaceous Gland Activity
Pochi, P. E., Strauss, J. S., & Downing, D. T. (1979) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12532792 · Cited by 365 · see citing works
Graying: gerontobiology of the hair follicle pigmentary unit
Tobin, D. J., & Paus, R. (2001) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00210-2 · Cited by 362 · see citing works
Self-citation
Biochemistry of human skin—our brain on the outside
Tobin, D. J. (2005) · Chemical Society Reviews · doi:10.1039/b505793k · Cited by 354 · see citing works
Self-citation
Structure of Water, Proteins, and Lipids in Intact Human Skin, Hair, and Nail
Gniadecka, M., Nielsen, O. F., Christensen, D. H., & Wulf, H. C. (1998) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.1998.00146.x · Cited by 351 · see citing works
Inhibition of Type I Procollagen Synthesis by Damaged Collagen in Photoaged Skin and by Collagenase-Degraded Collagen in Vitro
Varani, J., Spearman, D., Perone, P., Fligiel, S., Datta, S. C., Wang, Z. Q., Shao, Y., Kang, S., Fisher, G. J., & Voorhees, J. J. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64040-0 · Cited by 333 · see citing works
Estrogen and skin: The effects of estrogen, menopause, and hormone replacement therapy on the skin
Hall, G. K., & Phillips, T. J. (2005) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2004.08.039 · Cited by 327 · see citing works
Type I and III collagen content and fibre distribution in normal human skin during ageing
Lovell, C. R., Smolenski, K. A., Duance, V. C., Light, N. D., Young, S. R., & DYSON, M. L. (1987) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1987.tb04921.x · Cited by 299 · see citing works
Contoversies in Experimental Dermatology
Chuong, C., Nickoloff, B. J., Elias, P. M., Goldsmith, L. A., Macher, E., Maderson, P. A., Sundberg, J. P., Tagami, H., Plonka, P. M., Thestrup-Pederson, K., et al. (2002) · Experimental Dermatology · doi:10.1034/j.1600-0625.2002.00112.x · Cited by 288 · see citing works
Androgenetic alopecia: pathogenesis and potential for therapy
Ellis, J. A., Sinclair, R. D., & Harrap, S. B. (2002) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399402005112 · Cited by 288 · see citing works
Perspectives and Problems in Cutaneous Gerontology
Kligman, A. M. (1979) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12532758 · Cited by 284 · see citing works
Estrogens and aging skin
Thornton, M. J. (2013) · Dermato-Endocrinology · doi:10.4161/derm.23872 · Cited by 279 · see citing works
Evaluation and treatment of male and female pattern hair loss
Olsen, E. A., Messenger, A. G., Shapiro, J., Bergfeld, W. F., Hordinsky, M. K., Roberts, J. L., Stough, D. B., Washenik, K., & Whiting, D. A. (2004) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2004.04.008 · Cited by 277 · see citing works
Connective Tissue Biochemistry of the Aging Dermis
Uitto, J. (1986) · Dermatologic Clinics · doi:10.1016/s0733-8635(18)30806-4 · Cited by 276 · see citing works
Aged Skin: A Study by Light, Transmission Electron, and Scanning Electron Microscopy.
Lavker, R. M., Zheng, P., & Dong, G. (1987) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12468934 · Cited by 274 · see citing works
Acute effects of UVR on human eyes and skin
Young, A. R. (2006) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2006.02.005 · Cited by 267 · see citing works
Structural Characteristics of the Aging Skin: A Review
Farage, M. A., Miller, K. W., Elsner, P. U., & Maibach, H. I. (2007) · Cutaneous and Ocular Toxicology · doi:10.1080/15569520701622951 · Cited by 266 · see citing works
Long‐term effects of the menopause and sex hormones on skin thickness
Brincat, M., Moniz, C., Studd, J. W. W., Darby, A. J., Magos, A. L., EMBUREY, G., & Versi, E. (1985) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1985.tb01091.x · Cited by 259 · see citing works
Skin Thickness Changes in Normal Aging Skin
Branchet, M., Boisnic, S., Francès, C., & Robert, A. M. (2009) · Gerontology · doi:10.1159/000213172 · Cited by 255 · see citing works
Cigarette Smoking: Risk Factor for Premature Facial Wrinkling
Kadunce, D. P., Burr, R., Gress, R. E., Kanner, R. E., Lyon, J. L., & Zone, J. J. (1991) · Annals of Internal Medicine · doi:10.7326/0003-4819-114-10-840 · Cited by 253 · see citing works
Age-associated Changes in Human Epidermal Cell Renewal
Grove, G. L., & Kligman, A. M. (1983) · Journal of Gerontology · doi:10.1093/geronj/38.2.137 · Cited by 234 · see citing works
Enhanced Elastin and Fibrillin Gene Expression in Chronically Photodamaged Skin
Chen, Y. Q., Bernstein, E. F., Tamai, K., Shepley, K. J., Resnik, K. S., Zhang, H., Tuan, R. S., Mauviel, A., & Uitto, J. (1994) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12392693 · Cited by 234 · see citing works
Effect of Chronologic Aging and Ultraviolet Irradiation on Langerhans Cells in Human Epidermis
Gilchrest, B. A., Murphy, G. F., & Soter, N. A. (1982) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12500031 · Cited by 232 · see citing works
Why Some Women Look Young for Their Age
Gunn, D. A., Rexbye, H., Griffiths, C. E. M., Murray, P., Fereday, A., Catt, S. D., Tomlin, C. C., Strongitharm, B. H., Perrett, D. I., Catt, M., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0008021 · Cited by 225 · see citing works
Stratum Corneum Acidification Is Impaired in Moderately Aged Human and Murine Skin
Choi, E., Man, M., Xu, P., Xin, S., Liu, Z., Crumrine, D. A., Jiang, Y. J., Fluhr, J. W., Feingold, K. R., Elias, P. M., et al. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700913 · Cited by 216 · see citing works
Facial wrinkling in men and women, by smoking status.
Ernster, V. L., Grady, D., Miike, R., Black, D., Selby, J. V., & Kerlikowske, K. M. (1995) · American Journal of Public Health · doi:10.2105/ajph.85.1.78 · Cited by 209 · see citing works
Water and Protein Structure in Photoaged and Chronically Aged Skin
Gniadecka, M., Wessel, S., Heidenheim, M., Wulf, H. C., Nielsen, O. F., & Christensen, D. H. (1998) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.1998.00430.x · Cited by 200 · see citing works
A histological study of human wrinkle structures: comparison between sun-exposed areas of the face, with or without wrinkles, and sun-protected areas
Contet-Audonneau, Jeanmaire, & Pauly (1999) · British Journal of Dermatology · doi:10.1046/j.1365-2133.1999.02901.x · Cited by 199 · see citing works
The role of telomeres in skin aging/photoaging
Kosmadaki, M., & Gilchrest, B. A. (2003) · Micron · doi:10.1016/j.micron.2003.11.002 · Cited by 198 · see citing works
Alterations of extracellular matrix induced by tobacco smoke extract
Yin, L., Morita, A., & Tsuji, T. (2000) · Archives of Dermatological Research · doi:10.1007/s004030050476 · Cited by 196 · see citing works
Human hair greying is linked to a specific depletion of hair follicle melanocytes affecting both the bulb and the outer root sheath
Commo, S., Gaillard, O., & Bernard, B. A. (2004) · British Journal of Dermatology · doi:10.1046/j.1365-2133.2004.05787.x · Cited by 196 · see citing works
Histology of sun-damaged human skin
Montagna, W., Kirchner, S. J., & Carlisle, K. S. (1989) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(89)70276-0 · Cited by 193 · see citing works
Impaired delayed hypersensitivity in an aging population. Association with antinuclear reactivity and rheumatoid factor
Waldorf, D. S. (1968) · JAMA · doi:10.1001/jama.203.10.831 · Cited by 186 · see citing works
Fibrillin-Rich Microfibrils are Reduced in Photoaged Skin. Distribution at the Dermal–Epidermal Junction
Watson, R. E. B., Griffiths, C. E. M., Craven, N. M., Shuttleworth, C. A., & Kielty, C. M. (1999) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.1999.00562.x · Cited by 185 · see citing works
Quantitative evaluation of chronological ageing and photoageing in vivo : studies on skin echogenicity and thickness
Gniadecka, & Jemec, G. B. E. (1998) · British Journal of Dermatology · doi:10.1046/j.1365-2133.1998.02506.x · Cited by 179 · see citing works
Damage to Skin Extracellular Matrix Induced by UV Exposure
Watson, R. E. B., Gibbs, N. K., Griffiths, C. E. M., & Sherratt, M. J. (2014) · Antioxidants & Redox Signaling · doi:10.1089/ars.2013.5653 · Cited by 179 · see citing works
Skin collagen changes in postmenopausal women receiving different regimens of estrogen therapy.
Brincat, M., Versi, E., Cf, M., Magos, A. L., de Trafford, J., & Jw, S. (1987) · PubMed · Cited by 178 · see citing works
Does Hormonal Skin Aging Exist? A Study of the Influence of Different Hormone Therapy Regimens on the Skin of Postmenopausal Women Using Non-Invasive Measurement Techniques
Caliens, A., Vaillant, L., Lecomte, P., Berson, M., Gall, Y., & Lorette, G. (2009) · Dermatology · doi:10.1159/000246272 · Cited by 178 · see citing works
Characteristics and Pathomechanisms of Endogenously Aged Skin
Makrantonaki, E., & Zouboulis, C. C. (2007) · Dermatology · doi:10.1159/000100890 · Cited by 177 · see citing works
Chronic sun exposure alters both the content and distribution of dermal glycosaminoglycans
Bernstein, E. F., Underhill, C. B., HAHN, P. J., Brown, D. B., & Uitto, J. (1996) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1996.tb01156.x · Cited by 174 · see citing works
Skin aging induced by ultraviolet exposure and tobacco smoking: evidence from epidemiological and molecular studies
Yin, L., Morita, A., & Tsuji, T. (2001) · Photodermatology, Photoimmunology & Photomedicine · doi:10.1034/j.1600-0781.2001.170407.x · Cited by 172 · see citing works
Does estrogen prevent skin aging? Results from the First National Health and Nutrition Examination Survey (NHANES I)
Dunn, L. B. (1997) · Archives of Dermatology · doi:10.1001/archderm.133.3.339 · Cited by 172 · see citing works
Effects of postmenopausal hypoestrogenism on skin collagen
Affinito, P., Palomba, S., Sorrentino, C., Carlo, C. D., Bifulco, G., Arienzo, M., & Nappi, C. (1999) · Maturitas · doi:10.1016/s0378-5122(99)00077-8 · Cited by 171 · see citing works
Hormone replacement therapy and the skin
Brincat, M. (2000) · Maturitas · doi:10.1016/s0378-5122(00)00097-9 · Cited by 170 · see citing works
The influence of hormone replacement therapy on skin ageing
Sator, P. G., Schmidt, J. B., Sator, M. O., Huber, J., & Hönigsmann, H. (2001) · Maturitas · doi:10.1016/s0378-5122(00)00225-5 · Cited by 162 · see citing works
Evidence that exposure of the telomere 3′ overhang sequence induces senescence
Li, G., Eller, M. S., Firoozabadi, R., & Gilchrest, B. A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0235444100 · Cited by 155 · see citing works
Clinical features of ageing skin
LEYDEN, J. J. (1990) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1990.tb16118.x · Cited by 154 · see citing works
Influence of age on the wrinkling capacities of skin
Batisse, D., Bazin, R., Baldeweck, T., Querleux, B., & Lévêque, J. (2002) · Skin Research and Technology · doi:10.1034/j.1600-0846.2002.10308.x · Cited by 149 · see citing works
Aspartic acid racemization: evidence for marked longevity of elastin in human skin
Ritz‐Timme, S., Laumeier, I., & Collins, M. J. (2003) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2003.05618.x · Cited by 149 · see citing works
The Effect of Aging and Chronic Sun Exposure on Human Langerhans Cell Populations
THIERS, B. H., Maize, J. C., Spicer, S. S., & Cantor, A. B. (1984) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12260055 · Cited by 147 · see citing works
The Role of the Epidermal Endothelin Cascade in the Hyperpigmentation Mechanism of Lentigo Senilis
Kadono, S., Manaka, I., Kawashima, M., Kobayashi, T., & Imokawa, G. (2001) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2001.01296.x · Cited by 147 · see citing works
Photodamage to human skin by suberythemal exposure to solar ultraviolet radiation can be attenuated by sunscreens: a review: Suberythemal exposure of human skin
Seité, S., Fourtanier, A., Moyal, D., & Young, A. R. (2010) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2010.10018.x · Cited by 142 · see citing works
Chronologic Aging Alters the Response to Ultraviolet-induced Inflammation in Human Skin
Gilchrest, B. A., Stoff, J. S., & Soter, N. A. (1982) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12510417 · Cited by 140 · see citing works
Wound Healing and Aging
Goodson, W. H., & Hunt, T. K. (1979) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12532775 · Cited by 140 · see citing works
Ultrasound Structure and Digital Image Analysis of the Subepidermal Low Echogenic Band in Aged Human Skin: Diurnal Changes and Interindividual Variability
Gniadecka, M., Gniadecki, R., Serup, J. V., et al. (1994) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12371796 · Cited by 139 · see citing works
Does Estrogen Prevent Skin Aging?
Dunn, L. B. (1997) · Archives of Dermatology · doi:10.1001/archderm.1997.03890390077010 · Cited by 135 · see citing works
Tumour necrosis factor-α-induced migration of human Langerhans cells: the influence of ageing: TNF-Α and LANGERHANS CELLS
Bhushan, M., Cumberbatch, M., Dearman, R. J., Andrew, S. M., Kimber, I., & Griffiths, C. E. M. (2002) · British Journal of Dermatology · doi:10.1046/j.1365-2133.2002.04549.x · Cited by 126 · see citing works
Rate of Greying of Human Hair
Keogh, E. V., & Walsh, R. J. (1965) · Nature · doi:10.1038/207877a0 · Cited by 126 · see citing works
Greying of the human hair: a worldwide survey, revisiting the ‘50’ rule of thumb
Panhard, S., Lozano, I., & Loussouarn, G. (2012) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2012.11095.x · Cited by 125 · see citing works
The Effect of Aging on the Rate of Linear Nail Growth
Orentreich∥, N., Markofsky, J., & Vogelman∥, J. H. (1979) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12532799 · Cited by 123 · see citing works
Physiological changes in ageing skin
Cerimele, D., Celleno, L., & Serri, F. (1990) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1990.tb16120.x · Cited by 123 · see citing works
Alterations in the epidermal-dermal melanin axis and factor XIIIa melanophages in senile lentigo and ageing skin
Ünver, N., Freyschmidt‐Paul, P., Horster, S., Wenck, H., Stäb, F., Blatt, T., & Elsässer, H. P. (2006) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2006.07210.x · Cited by 119 · see citing works
The aging of skin: chronoaging versus photoaging.
Oikarinen, A. (1990) · PubMed · Cited by 114 · see citing works
Skin ageing
Calleja‐Agius, J., Muscat-Baron, Y., & Brincat, M. (2007) · Menopause international · doi:10.1258/175404507780796325 · Cited by 112 · see citing works
Skin changes in menopause
Bolognia, J. L., Braverman, I. M., Rousseau, M. E., & Sarrel, P. M. (1989) · Maturitas · doi:10.1016/0378-5122(89)90026-1 · Cited by 110 · see citing works
Photoageing shows histological features of chronic skin inflammation without clinical and molecular abnormalities
Bosset, S., Bonnet, M., Barre, P., Chalon, A., Kurfürst, R., Bonté, F., Schnebert, S., Varlet, B. L., & Nicolas, J. (2003) · British Journal of Dermatology · doi:10.1046/j.1365-2133.2003.05456.x · Cited by 107 · see citing works
Population differences in skin structure and physiology and the susceptibility to irritant and allergic contact dermatitis: implications for skin safety testing and risk assessment
Robinson, M. K. (1999) · Contact Dermatitis · doi:10.1111/j.1600-0536.1999.tb06229.x · Cited by 101 · see citing works
Host Resistance and The Immune System
Ben‐Yehuda, A., & Weksler, M. E. (1992) · Clinics in Geriatric Medicine · doi:10.1016/s0749-0690(18)30438-5 · Cited by 101 · see citing works
Proliferative Activity of the Sebaceous Glands of the Aged
Plewig, G., & Kligman, A. M. (1978) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12543478 · Cited by 99 · see citing works
The Human Apocrine Sweat Gland in Health and Disease
(1960) · Archives of Dermatology · doi:10.1001/archderm.1960.01580050190035 · Cited by 98 · see citing works
Skin collagen changes in postmenopausal women receiving different regimens of estrogen therapy
Brincat, M., Versi, E., & Cf, M. (1988) · Maturitas · doi:10.1016/0378-5122(88)90119-3 · Cited by 95 · see citing works
Percutaneous absorption and inflammation in aged skin: A review
Harvell, J. D., & Maibach, H. I. (1994) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(94)70273-x · Cited by 93 · see citing works
Exogenous factors in skin aging
Landau, M. (2007) · Current problems in dermatology · doi:10.1159/000106405 · Cited by 90 · cited 3× · see citing works
“Essentially intrinsic skin aging can only be seen in quite old age and is characterized by unblemished, smooth, pale(r), drier, less elastic skin with fine wrinkles [12,13].”
Background
Comparative Analysis of Telomere Lengths and Erosion with Age in Human Epidermis and Lingual Epithelium
Nakamura, K., Izumiyama‐Shimomura, N., Takubo, K., Sawabe, M., Arai, T., Aoyagi, Y., Fujiwara, M., Tsuchiya, E., Kobayashi, Y., Kato, M., et al. (2002) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2002.19523.x · Cited by 90 · see citing works
Physiologic Changes in Older Skin
Grove, G. L. (1989) · Clinics in Geriatric Medicine · doi:10.1016/s0749-0690(18)30699-2 · Cited by 88 · see citing works
DEMOGRAPHICS AND PSYCHOLOGICAL IMPLICATIONS FOR THE AGING POPULATION
Kligman, A. M., & Koblenzer, C. (1997) · Dermatologic Clinics · doi:10.1016/s0733-8635(05)70464-2 · Cited by 80 · see citing works
A Short-Term Screening Protocol, Using Fibrillin-1 as a Reporter Molecule, for Photoaging Repair Agents
Watson, R. E. B., Craven, N. M., Griffiths, C. E. M., Kang, S., Jones, C. J. P., & Kielty, C. M. (2001) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2001.01322.x · Cited by 79 · see citing works
Histopathologic characteristics and ultrastructure of aging skin.
Smith, L. T. (1989) · PubMed · Cited by 74 · see citing works
Male pattern hair loss: current understanding
Whiting, D. A. (1998) · International Journal of Dermatology · doi:10.1046/j.1365-4362.1998.00542.x · Cited by 73 · see citing works
Age-related changes in human dermal elastic fibres
Tsuji, T., & Hamada, T. (1981) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1981.tb00882.x · Cited by 72 · see citing works
Effect of ageing on the blistering of human skin with ammonium hydroxide
Grove, G. L., DUNCAN, S., & Kligman, A. M. (1982) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1982.tb00382.x · Cited by 68 · see citing works
Human Hair Follicle and Epidermal Melanocytes Exhibit Striking Differences in Their Aging Profile which Involves Catalase
Kauser, S., Westgate, G. E., Green, M. R., & Tobin, D. J. (2010) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.397 · Cited by 66 · see citing works
Self-citation
Noninvasive measurement of the effect of lifetime exposure to the sun on the aged skin.
Richard, S., de Rigal, J., de Lacharrière, O., et al. (1994) · PubMed · Cited by 66 · see citing works
Skin collagen changes in post-menopausal women receiving oestradiol gel
Brincat, M., Versi, E., O'Dowd, T., Moniz, C. F., Magos, A. L., Kabalan, S. N., & Studd, J. W. W. (1987) · Maturitas · doi:10.1016/0378-5122(87)90045-4 · Cited by 65 · see citing works
Age-Associated Changes in Stratum corneum Lipids and Their Relation to Dryness
Léger, S., François, A. M., Lévêque, J. L., Stoudemayer, T., Grove, G. L., & Kligman, A. M. (2009) · Dermatologica · doi:10.1159/000248535 · Cited by 62 · see citing works
Chronic and Acute Effects of Cigarette Smoking on Skin Blood Flow
Tur, E., Yosipovitch, G., & Oren-Vulfs, S. (1992) · Angiology · doi:10.1177/000331979204300407 · Cited by 61 · see citing works
Impact of Age and Body Site on Adult Female Skin Surface pH
Schreml, S., Zeller, V., Meier, R. J., Körting, H. C., Behm, B., Landthaler, M., & Babilas, P. (2012) · Dermatology · doi:10.1159/000337029 · Cited by 60 · see citing works
Decreased expression of keratinocyte beta1 integrins in chronically sun-exposed skin in vivo
Bosset, S., Bonnet, M., Barré, P., Chalon, A., Lazou, K., Kurfürst, R., Bonté, F., Schnebert, S., Disant, F., Varlet, B. L., et al. (2003) · British Journal of Dermatology · doi:10.1046/j.1365-2133.2003.05159.x · Cited by 59 · see citing works
Effect of ethnicity, gender and age on the amount and composition of residual skin surface components derived from sebum, sweat and epidermal lipids
Shetage, S. S., Traynor, M. J., Brown, M. B., Raji, M., Graham-Kalio, D., & Chilcott, R. P. (2013) · Skin Research and Technology · doi:10.1111/srt.12091 · Cited by 57 · see citing works
Ageing of the Skin: Study of Elastic Fiber Network Modifications by Computerized Image Analysis
Robert, C., Lesty, C., & Robert, A. M. (2009) · Gerontology · doi:10.1159/000212969 · Cited by 56 · see citing works
Pubertal Induction of Sweat Gland Activity
Rees, J., & Shuster, S. (1981) · Clinical Science · doi:10.1042/cs0600689 · Cited by 54 · see citing works
Age and Sex Variation in Lipid Composition of Human Fingernail Plates1
Helmdach, M., Thielitz, A., Röpke, E.-M., & Gollnick, H. P. M. (2000) · Skin Pharmacology and Physiology · doi:10.1159/000029915 · Cited by 53 · see citing works
Biological effects of simulated ultraviolet daylight: a new approach to investigate daily photoprotection
Seité, S., Medaisko, C., Christiaens, F., Bredoux, C., Compan, D., Zucchi, H., Lombard, D., & Fourtanier, A. M. (2006) · Photodermatology Photoimmunology & Photomedicine · doi:10.1111/j.1600-0781.2006.00209.x · Cited by 53 · see citing works
SCALP THICKNESS AND THE FAT-LOSS THEORY OF BALDING
Garn, S. M. (1954) · Archives of Dermatology · doi:10.1001/archderm.1954.01540230051006 · Cited by 50 · see citing works
Microarray analysis of androgenetic and senescent alopecia: Comparison of gene expression shows two distinct profiles
Karnik, P. S., Shah, S., Dvorkin-Wininger, Y., et al. (2013) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2013.06.017 · Cited by 42 · see citing works
Morphological alterations of epidermal melanocytes in photoageing: an ultrastructural and cytomorphometric study
Toyoda, & Morohashi (1998) · British Journal of Dermatology · doi:10.1046/j.1365-2133.1998.02408.x · Cited by 39 · see citing works
The immune system: Functions and therapy of dysfunction
Roser, B. J. (1980) · Molecular Immunology · doi:10.1016/0161-5890(80)90187-x · Cited by 37 · see citing works
The limit to human longevity: an approach through a stress theory of ageing
Parsons, P. A. (1996) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(96)01710-1 · Cited by 35 · see citing works
The lives of pigment cells.
Nordlund, J. J. (1986) · PubMed · Cited by 34 · see citing works
Degenerative Changes in Aging Skin
Farage, M. A., Miller, K. W., & Maibach, H. I. (2015) · Springer eBooks · doi:10.1007/978-3-642-27814-3_4-2 · Cited by 32 · see citing works
The Lives of Pigment Cells
Nordlund, J. J. (1986) · Dermatologic Clinics · doi:10.1016/s0733-8635(18)30803-9 · Cited by 32 · see citing works
Aging
Gilchrest, B. A. (1984) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(84)80026-2 · Cited by 9 · see citing works
Gerontobiology of the Hair Follicle
Tobin, D. J. (2010) · Springer eBooks · doi:10.1007/978-3-642-02636-2_1 · Cited by 4 · see citing works
Self-citation

Flagged first, then by citations

Sorted by citations

Hydroxycinnamic Acids and Their Derivatives: Cosmeceutical Significance, Challenges and Future Perspectives, a Review
Taofiq, O., González-Paramás, A., Barreiro, M., & Ferreira, I. (2017) · Molecules · doi:10.3390/molecules22020281 · Cited by 411 · see citing works
Skin Senescence: Mechanisms and Impact on Whole-Body Aging
Franco, A. C., Aveleira, C., & Cavadas, C. (2022) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2021.12.003 · Cited by 321 · see citing works
Skin collagen through the lifestages: importance for skin health and beauty
Reilly, D. M., & Lozano, J. (2021) · Plastic and Aesthetic Research · doi:10.20517/2347-9264.2020.153 · Cited by 241 · see citing works
Review of the safety of application of cosmetic products containing parabens
Matwiejczuk, N., Galicka, A., & Brzóska, M. M. (2020) · Journal of Applied Toxicology · doi:10.1002/jat.3917 · Cited by 166 · see citing works
Photoaging: a Review of Current Literature
Huang, A. H., & Chien, A. L. (2020) · Current Dermatology Reports · doi:10.1007/s13671-020-00288-0 · Cited by 131 · see citing works
Collagen peptides and the related synthetic peptides: A review on improving skin health
Zhao, X., Zhang, X., & Liu, D. (2021) · Journal of Functional Foods · doi:10.1016/j.jff.2021.104680 · Cited by 133 · see citing works
Coffee Silverskin: A Review on Potential Cosmetic Applications
Bessada, S., C. Alves, R., & P. P. Oliveira, M. (2018) · Cosmetics · doi:10.3390/cosmetics5010005 · Cited by 126 · see citing works
Boosting the Photoaged Skin: The Potential Role of Dietary Components
Geng, R., Kang, S.-G., Huang, K., & Tong, T. (2021) · Nutrients · doi:10.3390/nu13051691 · Cited by 116 · see citing works
Aging in skin of color
Venkatesh, S., Maymone, M. B. C., & Vashi, N. A. (2019) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2019.04.010 · Cited by 95 · see citing works
Human skin aging is associated with increased expression of the histone variant H2A.J in the epidermis
Rübe, C. E., Bäumert, C., Schuler, N., Isermann, A., Schmal, Z., Glanemann, M., Mann, C., & Scherthan, H. (2021) · npj Aging and Mechanisms of Disease · doi:10.1038/s41514-021-00060-z · Cited by 76 · see citing works
Persistent JunB activation in fibroblasts disrupts stem cell niche interactions enforcing skin aging
Maity, P., Singh, K., Krug, L., Koroma, A., Hainzl, A., Bloch, W., Kochanek, S., Wlaschek, M., Schorpp-Kistner, M., Angel, P., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109634 · Cited by 56 · see citing works
Effects of Tenascin C on the Integrity of Extracellular Matrix and Skin Aging
Choi, Y. E., Song, M. J., Hara, M., Imanaka-Yoshida, K., Lee, D. H., Chung, J. H., & Lee, S.-T. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228693 · Cited by 58 · see citing works
Topical tretinoin for treating photoaging: A systematic review of randomized controlled trials
Sitohang, I. B. S., Makes, W. I., Sandora, N., & Suryanegara, J. (2022) · International Journal of Women’s Dermatology · doi:10.1097/jw9.0000000000000003 · Cited by 32 · see citing works
Protective effects of tyndallized Lactobacillus�acidophilus IDCC 3302 against UVB‑induced photodamage to epidermal keratinocytes cells
Im, A., Lee, B., Kang, D., & Chae, S. (2019) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2019.4161 · Cited by 32 · see citing works
A Frog Peptide Ameliorates Skin Photoaging Through Scavenging Reactive Oxygen Species
Feng, G., Wei, L., Che, H., Shen, Y., Yang, J., Mi, K., Liu, J., Wu, J., Yang, H., & Mu, L. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.761011 · Cited by 30 · see citing works
Lymphatic Capillaries in Aging
Jakic, B., Kerjaschki, D., & Wick, G. (2020) · Gerontology · doi:10.1159/000508459 · Cited by 28 · see citing works
Asiaticoside delays senescence and attenuate generation of ROS in UV‑exposure cells through regulates TGF‑β1/Smad pathway
Jiang, H., Zhou, X., & Chen, L. (2022) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2022.11603 · Cited by 27 · see citing works
Anti-Aging and Anti-Inflammatory Effects of Compounds from Fresh Panax ginseng Roots: A Study on TNF-α/IFN-γ-Induced Skin Cell Damage
Kang, M., Park, S., Son, S.-R., Noh, Y., Jang, D. S., & Lee, S. (2024) · Molecules · doi:10.3390/molecules29225479 · Cited by 23 · see citing works
Research on the Correlation Between Skin Elasticity Evaluation Parameters and Age
Chen, D., Yin, S., Lu, X., Fu, H., Gao, H., & Zhang, S. (2024) · Cosmetics · doi:10.3390/cosmetics11060205 · Cited by 22 · see citing works
Role of Autophagy in Skin Photoaging: A Narrative Review
Zhong, X., Deng, Y., Yang, H., Du, X., Liu, P., & Du, Y. (2024) · Medicine · doi:10.1097/md.0000000000037178 · Cited by 18 · see citing works
Comparison of Polynucleotide and Polydeoxyribonucleotide in Dermatology: Molecular Mechanisms and Clinical Perspectives
Kim, S. T. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17081024 · Cited by 18 · see citing works
Organotypic cultures as aging associated disease models
Sanchez, M. M., Bagdasarian, I. A., Darch, W., & Morgan, J. T. (2022) · Aging · doi:10.18632/aging.204361 · Cited by 12 · see citing works
The Impact of Sunlight on Skin Aging
Kaddurah, H., Braunberger, T. L., Vellaichamy, G., Nahhas, A. F., Lim, H. W., & Hamzavi, I. H. (2018) · Current Geriatrics Reports · doi:10.1007/s13670-018-0262-0 · Cited by 11 · see citing works

TRF1 is a critical trans-acting factor required for de novo telomere formation in human cells
Okabe, J. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.18.2639 · Cited by 35 · see citing works
Molecular Manifestations and Molecular Determinants of Telomere CappingPreprint
Blackburn, E. H., Chan, S. R. W. L., Chang, J., Fulton, T. B., Krauskopf, A., McEachern, M. J., Prescott, J. C., Roy, J., Smith, C. J., & WANG, H. (2000) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2000.65.253 · Cited by 70 · see citing works
Tankyrase 1 as a target for telomere-directed molecular cancer therapeutics
Seimiya, H., Muramatsu, Y., Ohishi, T., & Tsuruo, T. (2005) · Cancer Cell · doi:10.1016/j.ccr.2004.11.021 · Cited by 166 · see citing works
Analysis of Telomere Length and Telomerase Activity
Hathcock, K. S., Hodes, R. J., & Weng, N. (2004) · Current Protocols in Immunology · doi:10.1002/0471142735.im1030s62 · Cited by 20 · see citing works
[Relationship between telomere length and clinical and biological characteristics of the cancers with telomerase reactivation].
Hiyama, E., Yokoyama, T., Hiyama, K., et al. (1998) · PubMed · Cited by 3 · see citing works

Authors: Tobin, D. J.
Affiliations: University of Bradford (GB)
Corresponding author: Tobin, Desmond J.
ORCID: Tobin, Desmond J.
Venue: Journal of Tissue Viability
Publisher: Elsevier BV
Published: 2017-02
Volume: 26
Issue: 1
Pages: 37-46
ISSN: 0268-0009 (ISSN-L)
0965-206X
DOI: 10.1016/j.jtv.2016.03.002
OpenAlex: W2299859137
Cited by: 701
References: 121
Citations by year: 2026: 43 · 2025: 92 · 2024: 123 · 2023: 108 · 2022: 75 · 2021: 100 · 2020: 52 · 2019: 61 · 2018: 23 · 2017: 19 · 2016: 5
FWCI: 5.09
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Tissue Viability (publishedVersion)
PubMed (publishedVersion)
Bradford Scholars (University of Bradford) (submittedVersion, cc-by-nc-nd)
Topics: Health Sciences › Medicine › Dermatology › Skin Protection and Aging
Health Sciences › Medicine › Urology › Hair Growth and Disorders
Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
Keywords: skin aging, extrinsic aging, intrinsic aging, reactive oxygen species, mitochondrial DNA mutations, telomere shortening, hormonal changes, skin stem cells, hair follicle stem cells, skin regeneration, wound healing, quality of life in old age
MeSH terms: Hair, Humans, Nails, Skin, Skin Physiological Phenomena, Sunlight, Skin Aging

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Introduction to Skin Aging

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks