Potential Role of Natural Compounds Against Skin Aging
Abstract
Skin aging is an inevitable biological phenomenon of human life. Advancing age brings changes to all components of the integumentary system with consequent signs on the skin. Skin aging is mainly due to intrinsic (chronologic) and extrinsic aging (photo-aging). Photo-aging is a consequence of exposure to ultraviolet radiations. Despite variable economic conditions, the skin care market based on natural products continues to see strong growth. In this context, the research of naturally occurring anti-aging agents is greatly expanding and in recent years numerous plant-derived products have been investigated. This review article focuses on highlighting recent advances in current knowledge on anti-aging natural products grouped and presented according to their family origin. Plants from 35 families were reviewed. A variety of phytomolecules, derived in particular from polyphenols, triterpenes and sterols classes, demonstrated a promising activity. Among them carnosic acid, curculigoside, curcumin, glycyrrhizic acid, mangiferin, mirkoin, asiaticoside, rosmarinic acid, tectorigenin, tyrosol etc., able to inhibit tyrosinase, hyaluronidase, elastase, and collagenase, to scavenge free radicals from skin cells, to prevent trans-epidermal water loss, and to contribute to protect skin from wrinkles, were largely investigated and herein discussed. Extracts and pure compounds from Fabaceae, Asperaceae and Zingiberaceae families have shown particular interest and appear most promising in t…
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Different extracts of C. asiatica as well as its individual triterpene constituents asiaticoside, madecassoside, asiatic acid and madecassic acid have shown significant applications in the treatment of dermatoses and skin lesions such as excoriations, burn injuries, cutaneous scars, eczema, and in the healing process of skin wounds.
“Different extracts (TECA, TTFCA, ethanolic and methanolic) of C. asiatica as well as its individual triterpene constituents asiaticoside, madecassoside, asiatic and madecassic acid, have shown significant applications in the treatment of dermatoses and skin lesions such as excoriations, burn injuries, cutaneous scars (hypertrophic scars and keloid scars), eczema, as well as in the healing process”
From Therapeutic Properties and Pharmacological Activities of Asiaticoside and Madecassoside: A Review (2023) · cites this paper as [80]
Cited by
Sorted by citations
The gut-skin axis in health and disease: A paradigm with therapeutic implications
O'Neill, C. A., Monteleone, G., McLaughlin, J. T., & Paus, R. (2016) · BioEssays · doi:10.1002/bies.201600008 · Cited by 449 · see citing works
Plant extracts and natural compounds used against UVB-induced photoaging
Cavinato, M., Waltenberger, B., Baraldo, G., Grade, C. V. C., Stuppner, H., & Jansen-Dürr, P. (2017) · Biogerontology · doi:10.1007/s10522-017-9715-7 · Cited by 218 · see citing works
Therapeutic Properties and Pharmacological Activities of Asiaticoside and Madecassoside: A Review
Bandopadhyay, S., Mandal, S., Ghorai, M., Jha, N. K., Kumar, M., Radha, Ghosh, A., Proćków, J., Pérez de la Lastra, J. M., & Dey, A. (2023) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17635 · Cited by 220 · see citing works
Profiling of Tyrosinase Inhibitors in Mango Leaves for a Sustainable Agro-Industry
Shi, F., Xie, L., Lin, Q., Tong, C., Fu, Q., Xu, J., Xiao, J., & Shi, S. (2020) · Food Chemistry · doi:10.1016/j.foodchem.2019.126042 · Cited by 47 · see citing works
Son, D. J., Jung, J. C., Choi, Y. M., Ryu, H. Y., Lee, S., & Davis, B. A. (2020) · Nutrients · doi:10.3390/nu12020300 · Cited by 26 · see citing works
Fan, L., Li, X., & Liu, T. (2020) · Journal of Molecular Neuroscience · doi:10.1007/s12031-020-01601-z · Cited by 20 · see citing works
Effects of Plant Meristem-Cell-Based Cosmetics on Menopausal Skin: Clinical Data and Mechanisms
Korkina, L., Kharaeva, Z., Shokarova, A., Barokova, E., Mayer, W., Trakhtman, I., Dal Toso, R., & De Luca, C. (2024) · Biomolecules · doi:10.3390/biom14091176 · Cited by 3 · see citing works
- Authors
- Tundis, R., Loizzo, M. R., Bonesi, M., & Menichini, F.
- Affiliations
- University of Calabria (IT)
- Venue
- Current Medicinal Chemistry
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2015-03-26
- Volume
- 22
- Issue
- 12
- Pages
- 1515-1538
- ISSN
- 0929-8673 (ISSN-L)
- OpenAlex
- W2144003426
- Cited by
- 119
- References
- 0
- Citations by year
- 2026: 4 · 2025: 13 · 2024: 9 · 2023: 8 · 2022: 16 · 2021: 13 · 2020: 16 · 2019: 11 · 2018: 10 · 2017: 10 · 2016: 8 · 2015: 1
- FWCI
- 10.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Medicinal Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Archive of Doctoral Theses and Digital Collections (University of Calabria) (submittedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioactive natural compounds
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Keywords
- skin aging, phytochemicals, polyphenols, triterpenoids, sterols, carnosic acid, curcumin, mangiferin, rosmarinic acid, tyrosinase inhibition, collagenase inhibition, elastase inhibition, hyaluronidase inhibition, free radical scavenging, transepidermal water loss, photoaging, Fabaceae, Zingiberaceae, skin care products
- MeSH terms
- Biological Products, Flavonoids, Humans, Plant Extracts, Plants, Medicinal, Ultraviolet Rays, Skin Aging, Oxidative Stress, Magnoliopsida, Polyphenols
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
