The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
The Success of Natural Products in Drug Discovery
Open accessAbstract
Drug discovery leading to robust and viable lead candidates’ remains a challenging scientific task, which is the transition from a screening hit to a drug candidate, requires expertise and experience. Natural products and their derivatives have been recognized for many years as a source of therapeutic agents and of structural diversity. However, in addition to their chemical structure diversity and their biodiversity, the development of new technologies has revolutionized the screening of natural products in discovering new drugs. Applying these technologies compensates for the inherent limitations of natural products and offers a unique opportunity to re-establish natural products as a major source for drug discovery. The present article attempts to describe the utilization of compounds derived from natural resources as drug candidates, with a focus on the success of these resources in the process of finding and discovering new and effective drug compounds, an approach commonly referred to as “natural product drug discovery”.
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Citations
Cites
The evolving role of natural products in drug discovery
Koehn, F. E., & Carter, G. T. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1657 · Cited by 2,572
The value of plants used in traditional medicine for drug discovery.
Fabricant, D. S., & Farnsworth, N. R. (2001) · Environmental Health Perspectives · doi:10.1289/ehp.01109s169 · Cited by 2,038
The role of natural product chemistry in drug discovery
Butler, M. S. (2004) · Journal of Natural Products · doi:10.1021/np040106y · Cited by 1,381
Drug discovery from natural sources
Chin, Y.-W., Balunas, M. J., Chai, H. B., & Kinghorn, A. D. (2006) · The AAPS Journal · doi:10.1007/bf02854894 · Cited by 662
Ayurveda and natural products drug discovery
Patwardhan, B., Vaidya, A. D. B., & Chorghade, M. S. (2004) · Cited by 450
Medicines from nature: are natural products still relevant to drug discovery?
Harvey, A. (1999) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(99)01346-2 · Cited by 186
Screening of natural products for drug discovery
Lahlou, M. (2007) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2.5.697 · Cited by 121
Self-citationWill natural products remain an important source of drug research for the future?
Nisbet, L. J., & Moore, M. J. (1997) · Current Opinion in Biotechnology · doi:10.1016/s0958-1669(97)80124-3 · Cited by 85
Cited by
Tungmunnithum, D., Thongboonyou, A., Pholboon, A., & Yangsabai, A. (2018) · Medicines · doi:10.3390/medicines5030093 · Cited by 1,969
Plant-Derived Natural Products: A Source for Drug Discovery and Development
Chaachouay, N., & Zidane, L. (2024) · Drugs and Drug Candidates · doi:10.3390/ddc3010011 · Cited by 1,081
Patil, K. R., Mahajan, U. B., Unger, B. S., Goyal, S. N., Belemkar, S., Surana, S. J., Ojha, S., & Patil, C. R. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20184367 · Cited by 403
Karthikeyan, A., Joseph, A., & Nair, B. G. (2022) · Journal of Genetic Engineering and Biotechnology · doi:10.1186/s43141-021-00290-4 · Cited by 336
Chemistry and Pharmacology of Citrus sinensis
Favela-Hernández, J., González-Santiago, O., Ramírez-Cabrera, M., Esquivel-Ferriño, P., & Camacho-Corona, M. (2016) · Molecules · doi:10.3390/molecules21020247 · Cited by 264
Metadata
- Authors
- Lahlou, M.
- Venue
- Pharmacology & Pharmacy
- Publisher
- Scientific Research Publishing, Inc.
- Published
- 2013
- Volume
- 04
- Issue
- 03
- Pages
- 17-31
- ISSN
- 2157-9423 (ISSN-L)
- 2157-9431
- OpenAlex
- W2041301244
- Cited by
- 577
- References
- 8
- FWCI
- 16.29
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
