The DOI matches its Crossref record; 69 of the 69 references it cites were found in a registry or an index.
The clinical impact of bacterial biofilms
Open accessAbstract
Bacteria survive in nature by forming biofilms on surfaces and probably most, if not all, bacteria (and fungi) are capable of forming biofilms. A biofilm is a structured consortium of bacteria embedded in a self-produced polymer matrix consisting of polysaccharide, protein and extracellular DNA. Bacterial biofilms are resistant to antibiotics, disinfectant chemicals and to phagocytosis and other components of the innate and adaptive inflammatory defense system of the body. It is known, for example, that persistence of staphylococcal infections related to foreign bodies is due to biofilm formation. Likewise, chronic Pseudomonas aeruginosa lung infections in cystic fibrosis patients are caused by biofilm growing mucoid strains. Gradients of nutrients and oxygen exist from the top to the bottom of biofilms and the bacterial cells located in nutrient poor areas have decreased metabolic activity and increased doubling times. These more or less dormant cells are therefore responsible for some of the tolerance to antibiotics. Biofilm growth is associated with an increased level of mutations. Bacteria in biofilms communicate by means of molecules, which activates certain genes responsible for production of virulence factors and, to some extent, biofilm structure. This phenomenon is called quorum sensing and depends upon the concentration of the quorum sensing molecules in a certain niche, which depends on the number of the bacteria. Biofilms can be prevented by antibiotic prophylaxis or early aggressive antibiotic therapy and they can be treated by chronic suppressive antibiotic therapy. Promising strategies may include the use of compounds which can dissolve the biofilm matrix and quorum sensing inhibitors, which increases biofilm susceptibility to antibiotics and phagocytosis.
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Cites
Bacterial Biofilms: A Common Cause of Persistent Infections
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The Involvement of Cell-to-Cell Signals in the Development of a Bacterial Biofilm
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Antibiotic resistance of bacterial biofilms
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Self-citationQuorum-sensing signals indicate that cystic fibrosis lungs are infected with bacterial biofilms
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Cited by
Strategies for combating bacterial biofilm infections
Wu, H., Moser, C., Wang, H.-Z., Høiby, N., & Song, Z.-J. (2015) · International Journal of Oral Science · doi:10.1038/ijos.2014.65 · Cited by 925
Self-citationNew approaches for treating staphylococcal biofilm infections
Kiedrowski, M. R., & Horswill, A. R. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06281.x · Cited by 288
Rendueles, O., Kaplan, J. B., & Ghigo, J. (2013) · Environmental Microbiology · doi:10.1111/j.1462-2920.2012.02810.x · Cited by 271
The Battle of Probiotics and Their Derivatives Against Biofilms
Barzegari, A., Kheyrolahzadeh, K., Hosseiniyan Khatibi, S. M., Sharifi, S., Memar, M. Y., & Zununi Vahed, S. (2020) · Infection and Drug Resistance · doi:10.2147/idr.s232982 · Cited by 263
Current developments in antimicrobial surface coatings for biomedical applications
Swartjes, J. J. T. M., Sharma, P. K., Kooten, T. G., Mei, H. C., Mahmoudi, M., Busscher, H. J., & Rochford, E. T. J. (2015) · Current Medicinal Chemistry · doi:10.2174/0929867321666140916121355 · Cited by 149
Metadata
- Authors
- Høiby, N., Ciofu, O., Johansen, H. K., Song, Z., Moser, C., Jensen, P. Ø., Molin, S., Givskov, M., Tolker‐Nielsen, T., & Bjarnsholt, T.
- Venue
- International Journal of Oral Science
- Published
- 2011-04
- Volume
- 3
- Issue
- 2
- Pages
- 55-65
- ISSN
- 1674-2818 (ISSN-L)
- 2049-3169
- OpenAlex
- W2166359904
- Cited by
- 894
- References
- 69
- FWCI
- 16.93
- Type
- journal article
- Language
- en
- Open access
- gold
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