Cited by 158Colorectal Cancer Treatments and StudiesProtein Kinase Regulation and GTPase SignalingGenetic factors in colorectal cancer

RAS signaling pathways, mutations and their role in colorectal cancer

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Zenonos, Kypros·2013·World Journal of Gastrointestinal Oncology

Abstract

Two of the main cellular pathways in which the RAS protein operates are the mitogen-activated protein kinases (MAPK) and phosphoinositide-3 kinase (PI3K) pathways. In a normal cell, these are important in controlling several functions, such as cell growth and survival. It becomes self-evident that these events will be disrupted in a malignant cell with a deregulated MAPK or PI3K pathway. Mutations in genes involved in these pathways and interacting with RAS, as well as RAS itself will be discussed. The second part of this review concentrates on how crucial RAS signaling is in colorectal cancer progression, with references to treatment response and prognosis when RAS or other related mutations are present.

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Authors
Zenonos, K.
Affiliations
University of Birmingham (GB)
Corresponding author
Zenonos, Kypros
Venue
World Journal of Gastrointestinal Oncology
Published
2013
Volume
5
Issue
5
Pages
97
ISSN
1948-5204 (ISSN-L)
OpenAlex
W2080354187
Cited by
156
References
32
Citations by year
2026: 7 · 2025: 10 · 2024: 11 · 2023: 15 · 2022: 27 · 2021: 19 · 2020: 15 · 2019: 13 · 2018: 15 · 2017: 12 · 2016: 4 · 2015: 4 · 2014: 3 · 2013: 1
FWCI
2.14
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • World Journal of Gastrointestinal Oncology (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Oncology › Colorectal Cancer Treatments and Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
Keywords
Ras signaling, colorectal cancer, RAS mutations, MAPK signaling, PI3K signaling, tumor progression, treatment response, prognosis, cell growth and survival

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