Cited by 43Malaria Research and ControlMosquito-borne diseases and controlInsect Pest Control Strategies

Long-Lasting Permethrin-Impregnated Clothing Protects Against Mosquito Bites in Outdoor Workers

Open access
Londono-Renteria, Berlin, Patel, Jaymin C., Vaughn, Meagan, Funkhauser, Sheana, Ponnusamy, Loganathan, Grippin, Crystal, Jameson, Sam B., Apperson, Charles +4 more·2015·The American Society of Tropical Medicine and Hygiene

Abstract

Outdoor exposure to mosquitoes is a risk factor for many diseases, including malaria and dengue. We have previously shown that long-lasting permethrin-impregnated clothing protects against tick and chigger bites in a double-blind randomized controlled trial in North Carolina outdoor workers. Here, we evaluated whether this clothing is protective against mosquito bites by measuring changes in antibody titers to mosquito salivary gland extracts. On average, there was a 10-fold increase in titer during the spring and summer when mosquito exposure was likely to be the highest. During the first year of the study, the increase in titer in subjects wearing treated uniforms was 2- to 2.5-fold lower than that of control subjects. This finding suggests that long-lasting permethrin-impregnated clothing provided protection against mosquito bites.

Integrity signals

Registry

Crossref · 10.4269/ajtmh.15-0130

Cites

35 of 35 references verified0 citation errors · 0 not checkable

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  • The efficacy of permethrin-treated clothing against mosquitoes has been demonstrated in many laboratory studies and short-duration field trials.

    “The efficacy of permethrin-treated clothing against mosquitoes has been demonstrated in many laboratory studies and short-duration field trials.[4,6,7,44,45,47–60]”
  • A US-based study in park rangers documented a significant difference in antibody titer to Aedes spp. salivary antigen between treated and control groups, suggesting that this clothing did exert a sizable protective effect against mosquito biting.

    “A US-based study in park rangers documented a significant difference in antibody titer to Aedes spp. salivary antigen between treated and control groups, suggesting that this clothing did exert a sizable protective effect against mosquito biting.[50]”

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Authors
Londono-Renteria, B., Patel, J. C., Vaughn, M., Funkhauser, S., Ponnusamy, L., Grippin, C., Jameson, S. B., Apperson, C., Mores, C. N., Wesson, D. M., Colpitts, T. M., & Meshnick, S. R.
Affiliations
Tulane University (US)
Corresponding author
Londono-Renteria, Berlin
Venue
The American Society of Tropical Medicine and Hygiene
Published
2015-10-07
Volume
93
Issue
4
Pages
869-874
ISSN
  • 0002-9637 (ISSN-L)
  • 1476-1645
OpenAlex
W2292300898
Cited by
43
References
40
Citations by year
2026: 3 · 2025: 3 · 2024: 4 · 2023: 3 · 2022: 3 · 2021: 4 · 2020: 7 · 2019: 3 · 2018: 5 · 2017: 5 · 2016: 3
FWCI
4.65
Type
journal article
Language
en
Open access
Locations
  • American Journal of Tropical Medicine and Hygiene (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute of General Medical Sciences (P20GM103641)
  • National Institute of Allergy and Infectious Diseases (K22AI103067)
  • National Institute for Occupational Safety and Health (5r01oh009874-03, R01 OH009874)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Mosquito-borne diseases and control
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Insect Pest Control Strategies
Keywords
long-lasting insecticidal nets, mosquito bite prevention, outdoor workers, antibody titers, malaria, dengue
MeSH terms
Aedes, Animals, Antibodies, Electrophoresis, Polyacrylamide Gel, Enzyme-Linked Immunosorbent Assay, Female, Humans, Insect Bites and Stings, Insecticides, Protective Clothing, Saliva, Blotting, Western, Permethrin

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