Long-Lasting Permethrin-Impregnated Clothing Protects Against Mosquito Bites in Outdoor Workers
Open accessAbstract
Outdoor exposure to mosquitoes is a risk factor for many diseases, including malaria and dengue. We have previously shown that long-lasting permethrin-impregnated clothing protects against tick and chigger bites in a double-blind randomized controlled trial in North Carolina outdoor workers. Here, we evaluated whether this clothing is protective against mosquito bites by measuring changes in antibody titers to mosquito salivary gland extracts. On average, there was a 10-fold increase in titer during the spring and summer when mosquito exposure was likely to be the highest. During the first year of the study, the increase in titer in subjects wearing treated uniforms was 2- to 2.5-fold lower than that of control subjects. This finding suggests that long-lasting permethrin-impregnated clothing provided protection against mosquito bites.
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The efficacy of permethrin-treated clothing against mosquitoes has been demonstrated in many laboratory studies and short-duration field trials.
“The efficacy of permethrin-treated clothing against mosquitoes has been demonstrated in many laboratory studies and short-duration field trials.[4,6,7,44,45,47–60]”
From Pyrethroid insecticides maintain repellent effect on knock-down resistant populations of Aedes aegypti mosquitoes (2018) · cites this paper as [50]
A US-based study in park rangers documented a significant difference in antibody titer to Aedes spp. salivary antigen between treated and control groups, suggesting that this clothing did exert a sizable protective effect against mosquito biting.
“A US-based study in park rangers documented a significant difference in antibody titer to Aedes spp. salivary antigen between treated and control groups, suggesting that this clothing did exert a sizable protective effect against mosquito biting.[50]”
From Pyrethroid insecticides maintain repellent effect on knock-down resistant populations of Aedes aegypti mosquitoes (2018) · cites this paper as [50]
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- Authors
- Londono-Renteria, B., Patel, J. C., Vaughn, M., Funkhauser, S., Ponnusamy, L., Grippin, C., Jameson, S. B., Apperson, C., Mores, C. N., Wesson, D. M., Colpitts, T. M., & Meshnick, S. R.
- Affiliations
- Tulane University (US)
- Corresponding author
- Londono-Renteria, Berlin
- ORCID
- Venue
- The American Society of Tropical Medicine and Hygiene
- Published
- 2015-10-07
- Volume
- 93
- Issue
- 4
- Pages
- 869-874
- ISSN
- 0002-9637 (ISSN-L)
- 1476-1645
- PMC
- PMC4596613
- OpenAlex
- W2292300898
- Cited by
- 43
- References
- 40
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 4 · 2023: 3 · 2022: 3 · 2021: 4 · 2020: 7 · 2019: 3 · 2018: 5 · 2017: 5 · 2016: 3
- FWCI
- 4.65
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Tropical Medicine and Hygiene (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of General Medical Sciences (P20GM103641)
- National Institute of Allergy and Infectious Diseases (K22AI103067)
- National Institute for Occupational Safety and Health (5r01oh009874-03, R01 OH009874)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Mosquito-borne diseases and control
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Insect Pest Control Strategies
- Keywords
- long-lasting insecticidal nets, mosquito bite prevention, outdoor workers, antibody titers, malaria, dengue
- MeSH terms
- Aedes, Animals, Antibodies, Electrophoresis, Polyacrylamide Gel, Enzyme-Linked Immunosorbent Assay, Female, Humans, Insect Bites and Stings, Insecticides, Protective Clothing, Saliva, Blotting, Western, Permethrin
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