Cited by 93Malaria Research and ControlBird parasitology and diseasesHemoglobinopathies and Related Disorders

High incidence of asymptomatic malara infections in a birth cohort of children less than one year of age in Ghana, detected by multicopy gene polymerase chain reaction

Wagner, G, Koram, K, McGuinness, D, Bennett, S, Nkrumah, F, Riley, E·1998·The American journal of tropical medicine and hygiene

Abstract

The incidence of Plasmodium falciparum infection has been followed in a birth cohort of 71 infants in southern Ghana, an area of perennial malaria transmission. Parasite DNA detection established the presence of a high rate of infection in newborns (13.6%), a low level of infection from two to 26 weeks (1.5-9.7%) and a steadily increasing parasite rate from 26 weeks of age. The median age to first infection was 42 weeks. Five cases of fever (temperature > or = 37.5 degrees C) and parasite density greater than 1,000 parasites/microl of blood, all in children more than 18 weeks of age, were considered possible cases of clinical malaria. The risk of infection was almost three times higher in the wet season than in the dry season and increased significantly from the age of 18 weeks. The level of malaria-specific IgG at birth was positively correlated with risk of infection in children 6-12 months of age, indicating that maternally derived anti-malarial IgG is correlated with exposure to malaria infection. There was no association between malaria-specific IgG at birth and risk of infection in children 0-6 months of age. However, infants do appear to possess mechanisms to limit parasite growth and a role for maternal antibody cannot be ruled out.

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Crossref · 10.4269/ajtmh.1998.59.115

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Authors
Wagner, G., Koram, K., McGuinness, D., Bennett, S., Nkrumah, F., & Riley, E.
Affiliations
University of Edinburgh (GB)
Venue
The American journal of tropical medicine and hygiene
Published
1998-07
Volume
59
Issue
1
Pages
115-123
ISSN
0002-9637 (ISSN-L)
OpenAlex
W2102561764
Cited by
93
References
42
Citations by year
2023: 2 · 2022: 11 · 2021: 9 · 2020: 4 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 4 · 2015: 5 · 2014: 4 · 2013: 5 · 2012: 2
FWCI
5.80
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Tropical Medicine and Hygiene (publishedVersion)
  • PubMed (publishedVersion)
Funders
Wellcome Trust
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
  • Life Sciences › Immunology and Microbiology › Parasitology › Bird parasitology and diseases
  • Health Sciences › Medicine › Genetics › Hemoglobinopathies and Related Disorders
Keywords
Plasmodium falciparum, asymptomatic malaria, infants, birth cohort, malaria incidence, seasonal variation, maternal antibodies, parasite density, malaria transmission, Ghana
MeSH terms
Adult, Age Factors, Animals, Antibodies, Protozoan, Female, Ghana, Humans, Immunoglobulin G, Immunity, Maternally-Acquired, Infant, Infant, Newborn, Longitudinal Studies, Male, Plasmodium falciparum, Pregnancy, Prospective Studies, Risk Factors, Seasons, Cohort Studies, Pregnancy Complications, Parasitic, Incidence, Prevalence, DNA, Protozoan, Polymerase Chain Reaction, Malaria, Falciparum

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