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Metformin Treatment Was Associated with Decreased Mortality in COVID-19 Patients with Diabetes in a Retrospective Analysis
Open accessAbstract
Metformin was proposed to be a candidate for host-directed therapy for COVID-19. However, its efficacy remains to be validated. In this study, we compared the outcome of metformin users and nonusers in hospitalized COVID-19 patients with diabetes. Hospitalized diabetic patients with confirmed COVID-19 in the Tongji Hospital of Wuhan, China, from January 27, 2020 to March 24, 2020, were grouped into metformin and no-metformin groups according to the diabetic medications used. The demographics, characteristics, laboratory parameters, treatments, and clinical outcome in these patients were retrospectively assessed. A total of 283 patients (104 in the metformin and 179 in the no-metformin group) were included in this study. There were no significant differences between the two groups in gender, age, underlying diseases, clinical severity, and oxygen-support category at admission. The fasting blood glucose level of the metformin group was higher than that of the no-metformin group at admission and was under effective control in both groups after admission. Other laboratory parameters at admission and treatments after admission were not different between the two groups. The length of hospital stay did not differ between the two groups (21.0 days for metformin versus 19.5 days for no metformin, P = 0.74). However, in-hospital mortality was significantly lower in the metformin group (3/104 (2.9%) versus 22/179 (12.3%), P = 0.01). Antidiabetic treatment with metformin was associated with decreased mortality compared with diabetics not receiving metformin. This retrospective analysis suggests that metformin may offer benefits in patients with COVID-19 and that further study is indicated.
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“Aside from its anti-hyperglycemic effects, metformin has an additional benefit for conditions like polycystic ovary syndrome, atherosclerosis, cancer, coronavirus disease 2019 (COVID-19), and obesity (7–14).”
From GDF-15 as a Weight Watcher for Diabetic and Non-Diabetic People Treated With Metformin (2020) · cites this paper as [13]
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Fan, G., Xu, J., Gu, X., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30183-5 · Cited by 48,884
Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Qiu, Y., Wang, J., Liu, Y., Wei, Y., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30211-7 · Cited by 21,415
COVID-19 infection: the perspectives on immune responses
Shi, Y., Wang, Y., Shao, C., Huang, J., Gan, J., Huang, X., Bucci, E. M., Piacentini, M., Ippolito, G., & Melino, G. (2020) · Cell Death and Differentiation · doi:10.1038/s41418-020-0530-3 · Cited by 1,602
Immune responses in COVID-19 and potential vaccines: Lessons learned from SARS and MERS epidemic
(2020) · Asian Pacific Journal of Allergy and Immunology · doi:10.12932/ap-200220-0772 · Cited by 1,537
Metformin improves healthspan and lifespan in mice
Martin-Montalvo, A., Mercken, E. M., Mitchell, S. J., Palacios, H. H., Mote, P. L., Scheibye-Knudsen, M., Gomes, A. P., Ward, T. M., Minor, R. K., Blouin, M.-J., et al. (2013) · Nature Communications · doi:10.1038/ncomms3192 · Cited by 1,445
COVID-19: Melatonin as a potential adjuvant treatment
Zhang, R., Wang, X., Ni, L., Di, X., Ma, B., Niu, S., Liu, C., & Reiter, R. J. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117583 · Cited by 629
Burgos‐Morón, E., Abad‐Jiménez, Z., Marañón, A., Iannantuoni, F., Escribano‐López, I., López‐Domènech, S., Salom, C., Jover, A., Llabata, V. M., Torres, I. R., et al. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8091385 · Cited by 612
Reducing mortality from 2019-nCoV: host-directed therapies should be an option.
Zumla, A., Hui, D. S., Azhar, E. I., Memish, Z. A., & Maeurer, M. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30305-6 · Cited by 429
Commentary: COVID-19 in patients with diabetes
Hill, M. A., Mantzoros, C. S., & Sowers, J. R. (2020) · Metabolism · doi:10.1016/j.metabol.2020.154217 · Cited by 183
The Role of Metformin in Controlling Oxidative Stress in Muscle of Diabetic Rats
Vilela, D. D., Peixoto, L. G., Teixeira, R. R., Baptista, N. B., Caixeta, D. C., de Souza, A. V., Machado, H. L., Pereira, M. N., Silva, R. S., & Espíndola, F. S. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/6978625 · Cited by 134
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Lim, S. K., Bae, J. H., Kwon, H., & Nauck, M. A. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-00435-4 · Cited by 1,061
The IL-1β, IL-6, and TNF cytokine triad is associated with post-acute sequelae of COVID-19
Schultheiß, C., Willscher, E., Paschold, L., Gottschick, C., Klee, B., Henkes, S.-S., Henkes, S.-S., Bosurgi, L., Sedding, D., Sedding, D., et al. (2022) · Cell Reports Medicine · doi:10.1016/j.xcrm.2022.100663 · Cited by 487
Xian, H., Liu, Y., Nilsson, A. R., Gatchalian, R., Crother, T. R., Tourtellotte, W. G., Zhang, Y., Alemán-Muench, G. R., Lewis, G. M., Chen, W., et al. (2021) · Immunity · doi:10.1016/j.immuni.2021.05.004 · Cited by 412
Bramante, C. T., Ingraham, N. E., Murray, T. A., Marmor, S., Hovertsen, S., Gronski, J., McNeil, C., Feng, R., Guzman, G., Abdelwahab, N., et al. (2020) · The Lancet Healthy Longevity · doi:10.1016/s2666-7568(20)30033-7 · Cited by 285
Randomized trial of metformin, ivermectin, and fluvoxamine for Covid-19.
Bramante, C. T., Huling, J. D., Tignanelli, C. J., Buse, J. B., Liebovitz, D. M., Nicklas, J. M., Cohen, K., Puskarich, M. A., Belani, H. K., Proper, J. L., et al. (2022) · New England Journal of Medicine · doi:10.1056/nejmoa2201662 · Cited by 242
COVID-19 and pulmonary fibrosis: a potential role for lung epithelial cells and fibroblasts
John, A. E., Joseph, C., Jenkins, G., & Tatler, A. L. (2021) · Immunological Reviews · doi:10.1111/imr.12977 · Cited by 219
Crouse, A. B., Grimes, T., Li, P., Might, M., Ovalle, F., & Shalev, A. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.600439 · Cited by 194
Khunti, K., Knighton, P., Zaccardi, F., Bakhai, C., Barron, E., Holman, N., Kar, P. S., Meace, C., Sattar, N. A., Sharp, S. J., et al. (2021) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(21)00050-4 · Cited by 190
Metformin in aging and aging-related diseases: clinical applications and relevant mechanisms
Chen, S., Gan, D., Lin, S., Zhong, Y., Chen, M., Zou, X., Shao, Z., & Xiao, G. (2022) · Theranostics · doi:10.7150/thno.71360 · Cited by 205
Neutrophil Extracellular Traps (NETs) and Covid-19: A new frontiers for therapeutic modality
Al-Kuraishy, H. M., Al-Gareeb, A. I., Al-Hussaniy, H. A., Al-Harcan, N. A. H., Alexiou, A. T., & Batiha, G. E. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2021.108516 · Cited by 201
Metformin and COVID-19: From cellular mechanisms to reduced mortality
Scheen, A. J. (2020) · Diabetes & Metabolism · doi:10.1016/j.diabet.2020.07.006 · Cited by 176
Cheng, X., Liu, Y.-M., Li, H., Zhang, X., Lei, F., Qin, J., Chen, Z., Deng, K., Lin, L., Chen, M., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.08.013 · Cited by 159
Yu, B., Li, C., Sun, Y., & Wang, D. W. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2020.11.014 · Cited by 148
The Role of Nutrition in COVID-19 Susceptibility and Severity of Disease: A Systematic Review
James, P. T., Ali, Z., Armitage, A. E., Bonell, A., Cerami, C., Drakesmith, H., Jobe, M., Jones, K. S., Liew, Z., Moore, S. E., et al. (2021) · The Journal of Nutrition · doi:10.1093/jn/nxab059 · Cited by 147
“Metformin use, however, was associated with better outcomes in diabetics compared with those not receiving it (103).”
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Bai, B., & Chen, H. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.622262 · Cited by 149
Hariyanto, T. I., & Kurniawan, A. (2020) · Obesity Medicine · doi:10.1016/j.obmed.2020.100290 · Cited by 132
COVID-19 in people living with diabetes: An international consensus
Caballero, A. E., Ceriello, A., Misra, A., Aschner, P., McDonnell, M. E., Hassanein, M., Ji, L., Mbanya, J. C., & Fonseca, V. A. (2020) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2020.107671 · Cited by 132
Cholesterol-Rich Lipid Rafts as Platforms for SARS-CoV-2 Entry
Palacios-Rápalo, S. N., Jesús‐González, L. A. D., Cordero‐Rivera, C. D., Farfán-Morales, C. N., Osuna‐Ramos, J. F., Martínez-Mier, G., Quistián-Galván, J., Muñoz-Pérez, A., Bernal-Dolores, V., del Ángel, R. M., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.796855 · Cited by 125
Metformin in cardiovascular diabetology: a focused review of its impact on endothelial function
Ding, Y., Zhou, Y., Ling, P., Feng, X., Luo, S., Zheng, X., Little, P. J., Xu, S., & Weng, J. (2021) · Theranostics · doi:10.7150/thno.64706 · Cited by 121
The PI3K/Akt/mTOR pathway: A potential pharmacological target in COVID-19
Basile, M. S., Cavalli, E., McCubrey, J. A., Hernández‐Bello, J., Muñóz-Valle, J. F., Fagone, P., & Nicoletti, F. (2021) · Drug Discovery Today · doi:10.1016/j.drudis.2021.11.002 · Cited by 114
COVID-19, cytokines, inflammation, and spices: How are they related?
Kunnumakkara, A. B., Rana, V., Parama, D., Banik, K., Girisa, S., Henamayee, S., Thakur, K. K., Dutta, U., Garodia, P., Gupta, S. C., et al. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119201 · Cited by 107
Kim, M. K., Jeon, J., Kim, S.-W., Moon, J. S., Cho, N. H., Han, E., You, J. H., Lee, J. Y., Hyun, M., Park, J. S., et al. (2020) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2020.0146 · Cited by 102
Singh, A. K., & Khunti, K. (2021) · Annual Review of Medicine · doi:10.1146/annurev-med-042220-011857 · Cited by 108
The geroscience agenda: Toxic stress, hormetic stress, and the rate of aging
Epel, E. S. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101167 · Cited by 110
Lukito, A. A., Pranata, R., Henrina, J., Lim, M. A., Lawrensia, S., & Suastika, K. (2020) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2020.11.006 · Cited by 101
Preparing for the next viral threat with broad-spectrum antivirals
Karim, M., Lo, C.-W., & Einav, S. (2023) · Journal of Clinical Investigation · doi:10.1172/jci170236 · Cited by 81
Schlesinger, S., Neuenschwander, M., Lang, A., Pafili, K., Kuß, O., Herder, C., & Roden, M. (2021) · Diabetologia · doi:10.1007/s00125-021-05458-8 · Cited by 100
Lalau, J., Al‐Salameh, A., Hadjadj, S., Goronflot, T., Wiernsperger, N. F., Pichelin, M., Allix, I., Amadou, C., Bourron, O., Duriez, T., et al. (2020) · Diabetes & Metabolism · doi:10.1016/j.diabet.2020.101216 · Cited by 98
Effects of Metformin in Heart Failure: From Pathophysiological Rationale to Clinical Evidence
Salvatore, T., Galiero, R., Caturano, A., Vetrano, E., Rinaldi, L., Coviello, F., Martino, A. D., Albanese, G., Marfella, R., Sardu, C., et al. (2021) · Biomolecules · doi:10.3390/biom11121834 · Cited by 99
mTOR inhibition in COVID‐19: A commentary and review of efficacy in RNA viruses
Karam, B. S., Morris, R., Bramante, C. T., Puskarich, M. A., Zolfaghari, E. J., Lotfi‐Emran, S., Ingraham, N. E., Charles, A. G., Odde, D. J., & Tignanelli, C. J. (2020) · Journal of Medical Virology · doi:10.1002/jmv.26728 · Cited by 94
The Fatty Acid Lipid Metabolism Nexus in COVID-19
Tanner, J. E., & Alfieri, C. (2021) · Viruses · doi:10.3390/v13010090 · Cited by 87
Therapeutic Potential of Metformin in COVID-19: Reasoning for Its Protective Role
Samuel, S. M., Varghese, E., & Büsselberg, D. (2021) · Trends in Microbiology · doi:10.1016/j.tim.2021.03.004 · Cited by 86
Kastora, S. L., Patel, M., Carter, B., Delibegović, M., & Myint, P. K. (2022) · Endocrinology Diabetes & Metabolism · doi:10.1002/edm2.338 · Cited by 87
Kow, C. S., & Hasan, S. S. (2020) · Journal of Medical Virology · doi:10.1002/jmv.26498 · Cited by 85
Metformin in therapeutic applications in human diseases: its mechanism of action and clinical study
Du, Y., Zhu, Y., Zhou, Y., Ding, J., & Liu, J. (2022) · Molecular Biomedicine · doi:10.1186/s43556-022-00108-w · Cited by 84
Chen, P., Wu, M., He, Y., Jiang, B., & He, M. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01510-8 · Cited by 89
Nguyen, N. N., Ho, D. S., Nguyen, H. S., Ho, D. K. N., Li, H., Lin, C.-Y., Chiu, H., & Chen, Y. (2022) · Metabolism · doi:10.1016/j.metabol.2022.155196 · Cited by 78
Chen, X., Guo, H., Li, Q., Zhang, C., Deng, Q., & Leng, Q. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.02056 · Cited by 77
Regulation of the immune system by the insulin receptor in health and disease
Makhijani, P., Basso, P. J., Chan, Y. T., Chen, N., Baechle, J. J., Khan, S. M., Furman, D., Tsai, S. J., & Winer, D. A. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1128622 · Cited by 79
Understanding Long COVID; Mitochondrial Health and Adaptation—Old Pathways, New Problems
Nunn, A. V. W., Guy, G. W., Brysch, W., & Bell, J. D. (2022) · Biomedicines · doi:10.3390/biomedicines10123113 · Cited by 74
High-mobility group box 1 (HMGB1) in COVID-19: extrapolation of dangerous liaisons
Al-Kuraishy, H. M., Al-Gareeb, A. I., Alkazmi, L. M., Habotta, O. A., & Batiha, G. E. (2022) · Inflammopharmacology · doi:10.1007/s10787-022-00988-y · Cited by 73
Lally, M., Tsoukas, P., Halladay, C. W., O’Neill, E., Gravenstein, S., & Rudolph, J. L. (2020) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2020.10.031 · Cited by 75
Understanding Immune Responses to Viruses—Do Underlying Th1/Th2 Cell Biases Predict Outcome?
Howard, F. H. N., Kwan, A., Winder, N., Mughal, A., Collado‐Rojas, C., & Muthana, M. (2022) · Viruses · doi:10.3390/v14071493 · Cited by 71
Cell deaths: Involvement in the pathogenesis and intervention therapy of COVID-19
Li, X., Zhang, Z., Wang, Z., Gutiérrez-Castrellón, P., & Shi, H. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01043-6 · Cited by 67
Kan, C., Zhang, Y., Han, F., Xu, Q., Ye, T., Hou, N., & Sun, X. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.708494 · Cited by 67
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Ibrahim, S. M., Lowe, J. R., Bramante, C. T., Shah, S., Klatt, N. R., Sherwood, N. E., Aronne, L. J., Puskarich, M. A., Tamariz, L. J., Palacio, A., et al. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.587801 · Cited by 61
Geetha, R. G., & Ramachandran, S. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13081170 · Cited by 66
Malhotra, A., Hepokoski, M., McCowen, K. C., & Shyy, J. Y.-J. (2020) · iScience · doi:10.1016/j.isci.2020.101425 · Cited by 65
Wee, A. K. H. (2020) · Medical Hypotheses · doi:10.1016/j.mehy.2020.110374 · Cited by 62
Improved COVID‐19 Outcomes following Statin Therapy: An Updated Systematic Review and Meta‐analysis
Vahedian‐Azimi, A., Mohammadi, S. M., Banach, M., Heidari‐Beni, F., Guest, P. C., Al‐Rasadi, K., Jamialahmadi, T., & Sahebkar, A. (2021) · BioMed Research International · doi:10.1155/2021/1901772 · Cited by 61
Metformin in Patients With COVID-19: A Systematic Review and Meta-Analysis
Li, Y., Yang, X., Yan, P., Sun, T., Zeng, Z., & Li, S. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.704666 · Cited by 64
Kamyshnyi, O., Matskevych, V. M., Lenchuk, T., Strilbytska, O. M., Storey, K. B., & Lushchak, O. V. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112230 · Cited by 62
SARS-CoV-2 and mitochondrial health: implications of lifestyle and ageing
Nunn, A. V. W., Guy, G. W., Brysch, W., Botchway, S. W., Frasch, W. D., Calabrese, E. J., & Bell, J. D. (2020) · Immunity & Ageing · doi:10.1186/s12979-020-00204-x · Cited by 60
Zangiabadian, M., Nejadghaderi, S. A., Zahmatkesh, M. M., Hajikhani, B., Mirsaeidi, M. S., & Nasiri, M. J. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.645194 · Cited by 58
Altered gut microbial metabolites could mediate the effects of risk factors in Covid‐19
Chen, J., Hall, S., & Vitetta, L. (2021) · Reviews in Medical Virology · doi:10.1002/rmv.2211 · Cited by 55
Inhibition of HECT E3 ligases as potential therapy for COVID-19
Novelli, G., Liu, J., Biancolella, M., Alonzi, T., Novelli, A., Patten, J. J., Cocciadiferro, D., Agolini, E., Colona, V. L., Rizzacasa, B., et al. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03513-1 · Cited by 58
McCarty, M. F., Assanga, S. B. I., Luján, L. M. L., O’Keefe, J. H., & DiNicolantonio, J. J. (2020) · Nutrients · doi:10.3390/nu13010047 · Cited by 55
Justice, J. N., Gubbi, S., Kulkarni, A. S., Bartley, J. M., Kuchel, G. A., & Barzilai, N. (2020) · GeroScience · doi:10.1007/s11357-020-00261-6 · Cited by 53
Bramante, C. T., Buse, J. B., Tamaritz, L., Palacio, A., Cohen, K., Vojta, D. D., Liebovitz, D., Mitchell, N. S., Nicklas, J. M., Lingvay, I., et al. (2021) · Journal of Medical Virology · doi:10.1002/jmv.26873 · Cited by 48
Han, T., Ma, S., Sun, C., Zhang, H., Qu, G., Chen, Y., Cheng, C., Chen, E. L., Ahmed, M. A., Kim, K. Y., et al. (2021) · Archives of Medical Research · doi:10.1016/j.arcmed.2021.08.002 · Cited by 53
COVID‐19: A systematic review and update on prevention, diagnosis, and treatment
Aliabadi, H. A. M., Eivazzadeh‐Keihan, R., Parikhani, A. B., Mehraban, S. F., Maleki, A. R., Fereshteh, S., Bazaz, M., Zolriasatein, A., Bozorgnia, B., Rahmati, S., et al. (2022) · MedComm · doi:10.1002/mco2.115 · Cited by 50
G6PD deficiency, redox homeostasis, and viral infections: implications for SARS-CoV-2 (COVID-19)
Yang, H., Ma, T., Tjong, W.-Y., Stern, A., & Chiu, D. T.-Y. (2021) · Free Radical Research · doi:10.1080/10715762.2020.1866757 · Cited by 48
The effect of metformin on mortality and severity in COVID-19 patients with diabetes mellitus
Yang, W., Sun, X., Zhang, J., & Zhang, K. (2021) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2021.108977 · Cited by 48
Repurposing existing drugs for COVID-19: an endocrinology perspective
Cadegiani, F. (2020) · BMC Endocrine Disorders · doi:10.1186/s12902-020-00626-0 · Cited by 46
Metformin suppresses SARS-CoV-2 in cell culture
Parthasarathy, H., Tandel, D., Siddiqui, A. H., & Harshan, K. H. (2022) · Virus Research · doi:10.1016/j.virusres.2022.199010 · Cited by 46
Parikhani, A. B., Bazaz, M., Bamehr, H., Fereshteh, S., Amiri, S., Salehi-Vaziri, ., Arashkia, A., & Azadmanesh, K. (2021) · Current Microbiology · doi:10.1007/s00284-021-02396-x · Cited by 47
Ganesh, A., & Randall, M. D. (2022) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.15258 · Cited by 43
Jiang, N., Chen, Z., Liu, L., Yin, X., Yang, H., Tan, X., Wang, J., Li, H., Tian, M., Lu, Z., et al. (2020) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2020.108619 · Cited by 44
Targeting immunometabolism to treat COVID-19
O’Carroll, S. M., & O'Neill, L. A. J. (2021) · Immunotherapy Advances · doi:10.1093/immadv/ltab013 · Cited by 44
Singh, A. K., & Singh, R. (2020) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2020.108268 · Cited by 42
Geroscience in the Age of COVID-19
Barzilai, N., Appleby, J. C., Austad, S. N., Cuervo, A. M., Kaeberlein, M. R., González-Billault, C. E., Lederman, S., Stambler, I., & Sierra, F. (2020) · Aging and Disease · doi:10.14336/ad.2020.0629 · Cited by 41
Bailey, C. J., & Gwilt, M. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.784459 · Cited by 42
Chen, Y., Lv, X., Lin, S., Arshad, M., & Dai, M. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.895458 · Cited by 42
Shoshan‐Barmatz, V., Anand, U., Crystal, E. N., Carlo, M. D., & Shteinfer‐Kuzmine, A. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.730048 · Cited by 42
Hariyanto, T. I., & Kurniawan, A. (2021) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2021.02.020 · Cited by 41
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Yang, S., Ling, Y., Zhao, F., Li, W., Song, Z., Wang, L., Li, Q., Liu, M., Tong, Y., Chen, L., et al. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00952-w · Cited by 40
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Ouyang, J., Isnard, S., Lin, J., Fombuena, B., Peng, X., Chen, Y., & Routy, J.-P. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.581839 · Cited by 39
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You, J. H., Lee, S. A., Chun, S., Song, S. O., Lee, B., Kim, D. J., & Boyko, E. J. (2020) · Endocrinology and Metabolism · doi:10.3803/enm.2020.787 · Cited by 38
Kow, C. S., & Hasan, S. S. (2021) · American Journal of Cardiovascular Drugs · doi:10.1007/s40256-021-00490-w · Cited by 38
Ghany, R. A., Palacio, A., Dawkins, E., Chen, G., McCarter, D. F., Forbes, E., Chung, B., & Tamariz, L. J. (2021) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2021.02.022 · Cited by 37
Singh, A. K., Singh, R., Saboo, B., & Misra, A. (2020) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2020.12.026 · Cited by 36
Metformin Use in Diabetes Prior to Hospitalization: Effects on Mortality in Covid-19
Li, J., Wei, Q., Li, W. X., McCowen, K. C., Xiong, W., Liu, J., Jiang, W., Marin, T., Thomas, R. L., He, M., et al. (2020) · Endocrine Practice · doi:10.4158/ep-2020-0466 · Cited by 38
Perspectives of Antidiabetic Drugs in Diabetes With Coronavirus Infections
Sun, B., Huang, S., & Zhou, J. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.592439 · Cited by 37
Mbara, K. C., Mato, P. E. M., Driver, C., Nzuza, S., Mkhombo, N. T., Gcwensa, S. K., Mcobothi, E. N., & Owira, P. M. O. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.173934 · Cited by 36
Metformin in Antiviral Therapy: Evidence and Perspectives
Halabitska, I., Petakh, P., Lushchak, O. V., Kamyshna, I. I., Oksenych, V., & Kamyshnyi, O. (2024) · Viruses · doi:10.3390/v16121938 · Cited by 37
Krishnamoorthy, P., Raj, A. S., Roy, S., Kumar, N. S., & Kumar, H. (2020) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2020.104123 · Cited by 33
Genetic and phenotypic analysis of the causal relationship between aging and COVID-19
Ying, K., Zhai, R., Pyrkov, T. V., Shindyapina, A. V., Mariotti, M., Fedichev, P. O., Shen, X., & Gladyshev, V. N. (2021) · Communications Medicine · doi:10.1038/s43856-021-00033-z · Cited by 37
Metformin Suppresses Monocyte Immunometabolic Activation by SARS-CoV-2 Spike Protein Subunit 1
Cory, T. J., Emmons, R. S., Yarbro, J. R., Davis, K. L., & Pence, B. D. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.733921 · Cited by 34
Ma, Z., Patel, N., Vemparala, P., & Krishnamurthy, M. (2022) · Scientific Reports · doi:10.1038/s41598-022-09639-2 · Cited by 32
Do, J. Y., Kim, S. W., Park, J. W., Cho, K. H., & Kang, S. H. (2020) · Diabetes & Metabolism · doi:10.1016/j.diabet.2020.10.006 · Cited by 30
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Damiano, S., Sozio, C., Rosa, G. L., & Santillo, M. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.608435 · Cited by 31
Association of Metformin with Susceptibility to COVID-19 in People with Type 2 Diabetes
Wang, J., Cooper, J. M., Gokhale, K. M., Acosta, D., Dhalla, S., Byne, N., Chandan, J. S., Anand, A., Okoth, K., Subramanian, A., et al. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab067 · Cited by 35
Sharifi, Y., Payab, M., Mohammadi‐Vajari, E., Aghili, S. M. M., Sharifi, F., Mehrdad, N., Kashani, E., Shadman, Z., Larijani, B. A., & Ebrahimpur, M. (2021) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-021-00822-2 · Cited by 32
Oh, T. K., & Song, I. (2021) · Acta Diabetologica · doi:10.1007/s00592-020-01666-7 · Cited by 29
Tamura, R. E., Said, S. M., de Freitas, L. M., & Rubio, I. G. S. (2021) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-021-00695-8 · Cited by 30
Afzal, O., Altamimi, A. S. A., Mubeen, B., Alzarea, S. I., Almalki, W. H., Al-Qahtani, S. D., Atiya, E. M., Al-Abbasi, F. A., Ali, F., Ullah, I., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232012470 · Cited by 36
Cheng, X., Xin, S., Chen, Y., Li, L., Chen, W., Li, W., Zhou, B., Li, C., Gong, Y., Li, F., et al. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119371 · Cited by 29
Dave, J. A., Tamuhla, T., Tiffin, N., Levitt, N. S., Ross, I. L., Toet, W., Davies, M., Boulle, A., Coetzee, A., & Raubenheimer, P. J. (2021) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2021.108925 · Cited by 29
Xie, L., Zhang, Z., Wang, Q., Chen, Y., Lu, D., & Wu, W. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.772865 · Cited by 30
Metadata
- Authors
- Luo, P., Qiu, L., Liu, Y., Liu, X.-L., Zheng, J.-L., Xue, H.-Y., Liu, W.-H., Liu, D., & Li, J.
- Affiliations
- Tongji Hospital (CN)
- Clinical Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Corresponding author
- Liu, Yi
- Liu, Xiu-lan
- Liu, Dong
- Li, Juan
- Venue
- The American Journal of Tropical Medicine and Hygiene
- Published
- 2020-07-08
- Volume
- 103
- Issue
- 1
- Pages
- 69-72
- ISSN
- 0002-9637 (ISSN-L)
- 1476-1645
- PMC
- PMC7356425
- OpenAlex
- W3027187955
- Cited by
- 259
- References
- 16
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 17 · 2023: 32 · 2022: 62 · 2021: 83 · 2020: 55
- FWCI
- 7.61
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- American Journal of Tropical Medicine and Hygiene (publishedVersion)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- metformin, COVID-19 pandemic, diabetes mellitus, in-hospital mortality, antidiabetic therapy, hospitalized patients, host-directed therapy, length of hospital stay
- MeSH terms
- Betacoronavirus, COVID-19, SARS-CoV-2, Aged, China, Diabetes Mellitus, Type 2, Female, Humans, Hypoglycemic Agents, Length of Stay, Male, Metformin, Middle Aged, Pneumonia, Viral, Retrospective Studies, Hospital Mortality, Coronavirus Infections, Pandemics
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