Cited by 67Cell death mechanisms and regulationAutophagy in Disease and TherapySARS-CoV-2 and COVID-19 Research

Cell deaths: Involvement in the pathogenesis and intervention therapy of COVID-19

Open access
Li, Xue, Zhang, Ziqi, Wang, Zhenling, Gutiérrez-Castrellón, Pedro, Shi, Huashan·2022·Signal Transduction and Targeted Therapy

Abstract

The current pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has dramatically influenced various aspects of the world. It is urgent to thoroughly study pathology and underlying mechanisms for developing effective strategies to prevent and treat this threatening disease. It is universally acknowledged that cell death and cell autophagy are essential and crucial to maintaining host homeostasis and participating in disease pathogenesis. At present, more than twenty different types of cell death have been discovered, some parts of which have been fully understood, whereas some of which need more investigation. Increasing studies have indicated that cell death and cell autophagy caused by coronavirus might play an important role in virus infection and pathogenicity. However, the knowledge of the interactions and related mechanisms of SARS-CoV-2 between cell death and cell autophagy lacks systematic elucidation. Therefore, in this review, we comprehensively delineate how SARS-CoV-2 manipulates diverse cell death (including apoptosis, necroptosis, pyroptosis, ferroptosis, and NETosis) and cell autophagy for itself benefits, which is simultaneously involved in the occurrence and progression of COVID-19, aiming to provide a reasonable basis for the existing interventions and further development of novel therapies.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1038/s41392-022-01043-6

Cites

329 of 329 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Certain cytokines such as IL-1β and IL-6 have clearly emerged as key to promoting inflammaging.

    “Certain cytokines, such as IL-1β and IL-6, have clearly emerged as key to promoting inflammaging.83,229–232”

    From Inflammation and aging: signaling pathways and intervention therapies (2023) · cites this paper as [229]

    In “Pyroptosis during SARS-CoV-2 infection” (page not provided), the paper identifies IL-1β and IL-6 as pro-inflammatory cytokines and says these mediators intensify inflammation and tissue damage. That discussion concerns COVID-19, not inflammaging, so it does not establish their claimed role in promoting inflammaging. (LLM, conf=0.82)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

2 retracted

Flagged first, then by citations

Research works printed but not linked: 1

  1. [295]Gorshkov, K. et al. The SARS-CoV-2 cytopathic effect is blocked with autophagy modulators. bioRxiv.10.1101/2020.05.16.091520 (2020). · DOI

Cited by

Sorted by citations

Authors
Li, X., Zhang, Z., Wang, Z., Gutiérrez-Castrellón, P., & Shi, H.
Affiliations
Sichuan University (CN)
Venue
Signal Transduction and Targeted Therapy
Published
2022-06-13
Volume
7
Issue
1
Pages
186-186
ISSN
2059-3635 (ISSN-L)
OpenAlex
W4282575739
Cited by
67
References
327
Citations by year
2026: 6 · 2025: 14 · 2024: 18 · 2023: 24 · 2022: 4
FWCI
1.56
Type
journal article
Language
en
Open access
Locations
  • Signal Transduction and Targeted Therapy (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
National Natural Science Foundation of China (81201788)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
  • Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
Keywords
COVID-19 pandemic, SARS-CoV-2, cell death, autophagy, apoptosis, necroptosis, pyroptosis, ferroptosis, NETosis, viral pathogenesis, antiviral therapy
MeSH terms
COVID-19, SARS-CoV-2, Autophagy, Humans, Apoptosis, Pandemics

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review