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Cited by 1,537SARS-CoV-2 and COVID-19 ResearchImmune responses and vaccinationsCOVID-19 Clinical Research Studies

Immune responses in COVID-19 and potential vaccines: Lessons learned from SARS and MERS epidemic

Open access
Eakachai Prompetchara, Chutitorn Ketloy, Tanapat Palaga·2020·Asian Pacific Journal of Allergy and Immunology
DOI 10.12932/ap-200220-0772
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Abstract

As the world is witnessing the epidemic of COVID-19, a disease caused by a novel coronavirus, SARS-CoV-2, emerging genetics and clinical evidences suggest a similar path to those of SARS and MERS. The rapid genomic sequencing and open access data, together with advanced vaccine technology, are expected to give us more knowledge on the pathogen itself, including the host immune response as well as the plan for therapeutic vaccines in the near future. This review aims to provide a comparative view among SARS-CoV, MERS-CoV and the newly epidemic SARS-CoV-2, in the hope to gain a better understanding of the host-pathogen interaction, host immune responses, and the pathogen immune evasion strategies. This predictive view may help in designing an immune intervention or preventive vaccine for COVID-19 in the near future.

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  • Protection from subsequent coronavirus infections is largely mediated by humoral immunity.

    “protection from subsequent coronavirus infections is largely mediated by humoral immunity (16, 17).”

    From Development of an inactivated vaccine candidate for SARS-CoV-2 (2020) · cites this paper as [16]

    The 'Adaptive Immune Responses' section says that humoral immunity, especially neutralizing antibodies, helps prevent future reinfection. It does not say that protection is largely mediated by humoral immunity; the same section describes Th1 responses as dominant in adaptive antiviral immunity. Page numbers are unavailable in our copy. (LLM, conf=0.85)

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Cited by

Sorted by citations

Authors
Prompetchara, E., Ketloy, C., & Palaga, T.
Affiliations
Chulalongkorn University (TH)
Corresponding author
Tanapat Palaga
ORCID
Venue
Asian Pacific Journal of Allergy and Immunology
Publisher
Allergy, Asthma, and Immunology Association of Thailand
Published
2020
Volume
38
Issue
1
Pages
1-9
ISSN
  • 0125-877X (ISSN-L)
  • 2228-8694
DOI
10.12932/ap-200220-0772
OpenAlex
W3009582878
Cited by
1,537
References
6
Citations by year
2026: 3 · 2025: 21 · 2024: 53 · 2023: 116 · 2022: 195 · 2021: 459 · 2020: 687 · 2019: 2 · 2018: 1
FWCI
17.11
Type
journal article
Language
en
Open access
Licence
other-oa
Locations
  • Asian Pacific Journal of Allergy and Immunology (publishedVersion, other-oa)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
  • Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
  • Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
Keywords
COVID-19 pandemic, SARS-CoV-2, SARS-CoV, MERS-CoV, host immune response, host-pathogen interaction, COVID-19 vaccines, therapeutic vaccines
MeSH terms
Betacoronavirus, COVID-19, SARS-CoV-2, COVID-19 Vaccines, Humans, Immunity, Innate, Pneumonia, Viral, Viral Vaccines, Coronavirus Infections, Severe Acute Respiratory Syndrome, Severe acute respiratory syndrome-related coronavirus, Host-Pathogen Interactions, Adaptive Immunity, Immune Evasion, Epidemics, Middle East Respiratory Syndrome Coronavirus

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