Case Report: Ischemic Colitis in Severe COVID-19 Pneumonia: An Unforeseen Gastrointestinal Complication
Open accessAbstract
Clinical manifestations and complications of SARS-CoV-2 are still emerging and variant. Gastrointestinal (GI) manifestations and complications are hugely under-recognized. The presence of angiotensin converting enzyme-2 receptors in the intestinal enterocytes, the receptors primarily involved in the pathogenesis of COVID-19 pneumonia, maybe the key factor contributing to the pathogenesis of GI manifestations. Ischemic colitis, although the most common ischemic pathology of the GI tract, is relatively rare, occurring as a result of colonic hypoperfusion. The innumerable causes of colonic ischemia are categorized into occlusive and nonocclusive pathologies. Here, we have discussed a case of severe COVID-19 pneumonia, developing ischemic colitis, as a rare GI complication. The cause of ischemia in COVID-19 pneumonia is multifactorial, including hypercoagulable state, coagulopathy leading to thromboembolic complications, and use of vasopressors in severely ill patients with hemodynamic compromise.
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- Authors
- Paul, T., Joy, A. R., Alsoub, H. A. R. S., & Parambil, J. V.
- Affiliations
- Hamad Medical Corporation (QA)
- Corresponding author
- Paul, Theresa
- Venue
- The American Journal of Tropical Medicine and Hygiene
- Published
- 2021-01-06
- Volume
- 104
- Issue
- 1
- Pages
- 63-65
- ISSN
- 0002-9637 (ISSN-L)
- 1476-1645
- PMC
- PMC7790084
- OpenAlex
- W3096423353
- Cited by
- 26
- References
- 22
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 6 · 2022: 6 · 2021: 11
- FWCI
- 5.25
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- American Journal of Tropical Medicine and Hygiene (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Hamad Medical Corporation
- Qatar National Library
- Topics
- Health Sciences › Medicine › Surgery › Abdominal vascular conditions and treatments
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Ophthalmology › Retinal and Optic Conditions
- Keywords
- ischemic colitis, COVID-19 pneumonia, SARS-CoV-2, gastrointestinal complications, ACE2 receptor, hypercoagulability, coagulopathy, thromboembolism, vasopressors, hemodynamic instability
- MeSH terms
- COVID-19, SARS-CoV-2, Aged, Gastrointestinal Hemorrhage, Humans, Male, Colitis, Ischemic
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