Antidepressant-Induced Sexual Dysfunction among Newer Antidepressants in a Naturalistic Setting
Open accessAbstract
OBJECTIVE: Antidepressants used to treat depression are frequently associated with sexual dysfunction. Sexual side effects affect the patient's quality of life and, in long-term treatment, can lead to non-compliance and relapse. However, studies covering many antidepressants with differing mechanisms of action were scarce. The present study assessed and compared the incidence of sexual dysfunction among different antidepressants in a naturalistic setting. METHODS: Participants were married patients diagnosed with depression, per DSM-IV diagnostic criteria, who had been taking antidepressants for more than 1 month. We assessed the participants via the Arizona Sexual Experiences Scale (ASEX), Beck Depression Inventory (BDI), and State-Trait Anxiety Inventory (STAI), and assessed their demographic variables, types and dosages of antidepressants, and duration of antidepressant use via their medical records. RESULTS: One hundred and one patients (46 male, 55 female, age 42.2+/-7 years) completed the instruments. Thirteen were taking fluoxetine (mean dose 21.3+/-8.5 mg/day), 24 were taking paroxetine (mean dose 20.4+/-7.2 mg/day), 20 taking citalopram (mean dose 22.1+/-6.5 mg/day), 22, venlafaxine (mean dose 115.7+/-53.2 mg/day) and 22, mirtazapine (mean dose 18+/-8.7 mg/day). Mean ages, sex ratios, and BDI and STAI scores did not differ significantly across antidepressants. A substantial number of participants (46.5%, n=47) experienced sexual dysfunction. The prevalence of sexual dysfunction differed across drugs: citalopram 60% (n=12), venlafaxine 54.5% (n=12), paroxetine 54.2% (n=13), fluoxetine 46.2% (n=6), and mirtazapine 18.2% (n=4). Regression analyses revealed the significant factors for sexual dysfunction were being female, total scores on the BDI and SAI, and type of antidepressant (F=4.92, p<0.0001). Of the antidepressants, the mirtarzapine group's total ASEX score was significantly lower than the scores of the citalopram, fluoxetine, and paroxetine groups. CONCLUSION: The incidence of sexual dysfunction was substantially high during antidepressant treatment. The incidence of sexual dysfunction differed among antidepressants having different mechanisms of action. Our study suggests the need for clinicians to consider the impact of pharmacotherapy on patients' sexual functioning in the course of treatment with antidepressants.
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Antidepressant therapy (except for mirtazapine, nefazodone and bupropion) frequently induces or exacerbates sexual dysfunction, which occurs in approximately 50% of patients.
“AD therapy (except for mirtazapine, nefazodone and bupropion) frequently induces or exacerbates sexual dysfunction, which occurs in approximately 50% of patients (548).”
From Physical illness in patients with severe mental disorders. I. Prevalence, impact of medications and disparities in health care (2011) · cites this paper as [548]
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- Authors
- Lee, K.-U., Lee, Y. M., Nam, J.-M., Lee, H.-K., Kweon, Y.-S., Lee, C. T., & Jun, T.-Y.
- Affiliations
- Catholic University of Korea (KR)
- Pusan National University (KR)
- Corresponding author
- Kweon, Yong-Sil
- Venue
- Psychiatry Investigation
- Publisher
- Korean Neuropsychiatric Association
- Published
- 2010
- Volume
- 7
- Issue
- 1
- Pages
- 55
- ISSN
- 1738-3684 (ISSN-L)
- PMC
- PMC2848770
- OpenAlex
- W2115411118
- Cited by
- 63
- References
- 29
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 2 · 2022: 6 · 2021: 2 · 2020: 2 · 2019: 6 · 2017: 2 · 2016: 5 · 2015: 5 · 2014: 4 · 2013: 10 · 2012: 6
- FWCI
- 5.68
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Psychiatry Investigation (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- antidepressant-induced sexual dysfunction, newer antidepressants, depression, sexual side effects, citalopram, venlafaxine, paroxetine, fluoxetine, mirtazapine, sex differences, depression severity, anxiety, naturalistic settings, Arizona Sexual Experience Scale, medication adherence, quality of life, married patients, long-term antidepressant use
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Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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