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Cited by 84Sexual function and dysfunction studiesTreatment of Major DepressionSexuality, Behavior, and Technology

Sexual dysfunction associated with antidepressant drugs

Baldwin, David S·2004·Expert Opinion on Drug Safety
DOI 10.1517/14740338.3.5.457
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Abstract

The term 'sexual dysfunction' describes a disturbance in sexual desire and the psychophysiological changes that characterise the normal sexual response cycle, and cause marked personal distress and interpersonal difficulty. Epidemiological studies indicate that sexual dysfunction is common in the general population, but more common in depressed individuals in community settings and clinical samples. Most antidepressant drugs have adverse effects on sexual function, but accurate identification of the incidence of treatment-emergent dysfunction has proved troublesome. Futhermore, investigations of sexual dysfunction associated with antidepressants have one or more methodological flaws. There may be some advantages for bupropion, moclobemide, nefazodone and reboxetine over other antidepressants. Many approaches have been adopted for management of patients with sexual dysfunction associated with antidepressant treatment, including waiting for the problem to resolve, behavioural strategies to modify sexual technique, individual and couple psychotherapy, delaying the intake of antidepressants until after sexual activity, reduction in daily dosage, 'drug holidays', use of adjuvant treatments, and switching to a different antidepressant.

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Authors
Baldwin, D. S.
Affiliations
Royal South Hants Hospital (GB)
Corresponding author
Baldwin, David S
ORCID
Baldwin, David S
Venue
Expert Opinion on Drug Safety
Publisher
Informa Healthcare
Published
2004-09
Volume
3
Issue
5
Pages
457-470
ISSN
  • 1474-0338 (ISSN-L)
  • 1744-764X
DOI
10.1517/14740338.3.5.457
OpenAlex
W1994717858
Cited by
84
References
65
Citations by year
2026: 2 · 2025: 1 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 4 · 2017: 2 · 2016: 2 · 2015: 7 · 2014: 4 · 2013: 7 · 2012: 4
FWCI
4.18
Type
journal article
Language
en
Open access
closed
Locations
  • Expert Opinion on Drug Safety (publishedVersion)
  • PubMed (publishedVersion)
  • ePrints Soton (University of Southampton) (submittedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Social Sciences › Psychology › Clinical Psychology › Sexuality, Behavior, and Technology
Keywords
sexual dysfunction, antidepressant side effects, depression, sexual desire, sexual response cycle, bupropion, moclobemide, nefazodone, reboxetine, drug holidays, antidepressant switching, couple therapy, behavioral strategies
MeSH terms
Adolescent, Adult, Antidepressive Agents, Depression, Depressive Disorder, Double-Blind Method, Drug Administration Schedule, Ejaculation, Female, Humans, Erectile Dysfunction, Libido, Male, Phytotherapy, Orgasm, Prospective Studies, Sexual Behavior, Sexual Dysfunction, Physiological, Prevalence, Case-Control Studies, Randomized Controlled Trials as Topic, Cross-Over Studies

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