Improvement of memory deficits via acetylcholinesterase inhibitory activity of Nepeta nuda ssp. nuda essential oil in rats
Open accessAbstract
Nepeta L. (Lamiaceae) species are belonging to aromatic and medicinal plants. Many biological activities of Nepeta species have been reported. In this study, memory-enhancing activities of Nepeta nuda ssp. nuda essential oil was aimed to be evaluated in laboratory rats treated with scopolamine. GC-MS/GC-FID system was used to identify oil composition. Memory performances of the rats were tested using Y-maze and radial-arm maze. Acetylcholinesterase enzyme activity and molecular docking analysis were also performed in this study. In total, 44 different compounds were identified in Nepeta nuda ssp. nuda essential oil. Trans-cis nepetalactone was showed to be the most abundant constituent in the oil. In the Y-maze test, the oil improved the performances of the animals on spontaneous alternation. Besides, in the radial-arm maze test, the oil improved working and reference memory significantly impaired in the rats subjected to scopolamine. The oil also showed acetylcholinesterase inhibitory activity in vitro. The molecular docking method, in the meantime, revealed that some of the compounds in the oil could interact with the acetylcholinesterase enzyme, theoretically. Nepeta nuda ssp. nuda essential oil improved spatial memory of scopolamine-induced rats. Neuroprotective effects of the oil are probably related to the anti-cholinesterase activity of the oil. Therefore, Nepeta nuda ssp. nuda essential oil could be used as a complementary therapy to improve memory in Alzheimer’s and related diseases.
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Extracts from Nepeta nuda, Indigofera sessiliflora, Dendropanax morbifera, Pinus densiflora, Dichrocephala integrifolia, Alnus rugosa, Salvia moorcroftiana, and Sanguisorba minor reduced AChE activity and enhanced cognitive function in scopolamine-induced memory impairment models.
“Other studies on plant extracts like Nepeta nuda, Indigofera sessiliflora, Dendropanax morbifera, Pinus densiflora, Dichrocephala integrifolia, Alnus rugosa, Salvia moorcroftiana, and Sanguisorba minor have similarly reported reduced AChE activity and enhanced cognitive function in SCO-induced memory impairment models [40,41,42,43,44,45,46,47].”
From Cholinesterase Inhibitors from Plants and Their Potential in Alzheimer’s Treatment: Systematic Review (2025) · cites this paper as [40]
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Cited by
Sorted by citations
ALNasser, M. N., Alboraiy, G. M., Alsowig, E. M., & Alqattan, F. M. (2025) · Brain Sciences · doi:10.3390/brainsci15020215 · Cited by 35 · see citing works
“…Nepeta nuda, Indigofera sessiliflora, Dendropanax morbifera , Pinus densiflora , Dichrocephala integrifolia , Alnus rugosa , Salvia moorcroftiana , and Sanguisorba minor have similarly reported reduced AChE activity and enhanced cognitive function in SCO-induced memory impairment models [40–47].”
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Akbaba, E., Karataş, D., Gönel, A., Soylu, E., Kiraz, B., & Almahdi, Y. A. (2025) · Cumhuriyet Science Journal · doi:10.17776/csj.1599148
- Authors
- Dept. of Biology, F. O. S., Akbaba, E., Bagci, E., Dept. of Biology, F. O. S., Hritcu, L., Dept. of Biology, A. I. C. U. O. I., Maniu, C., & Dept. of Biology, A. I. C. U. O. I.
- Affiliations
- Fırat University (TR)
- ORCID
- Akbaba, Emel
- Venue
- Kuwait Journal of Science
- Publisher
- Elsevier BV
- Published
- 2021-06-25
- Volume
- 48
- Issue
- 3
- ISSN
- 2307-4108 (ISSN-L)
- 2307-4116
- OpenAlex
- W3177173299
- Cited by
- 10
- References
- 44
- Citations by year
- 2025: 4 · 2024: 3 · 2023: 1 · 2022: 2
- FWCI
- 1.69
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Kuwait Journal of Science (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- DSpace - FIRAT (Fırat University) (submittedVersion, cc-by-nc-nd)
- Funders
- Firat Üniversitesi (FF.15.18)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plant Extracts Effects
- Keywords
- Nepeta nuda, essential oils, memory enhancement, acetylcholinesterase inhibition, scopolamine-induced amnesia, spatial memory, working memory, reference memory, neuroprotection, Alzheimer's disease, complementary therapy, essential oil composition
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