In vitro anti-cholinesterase and cognitive enhancing properties of essential oils from Piper nigrum L. and Monodora myristica (Gaertn) dunal
Open accessAbstract
Aging in humans generally is associated with deterioration of cognitive abilities, particularly of learning and memory leading to dementia, including Alzheimer’s disease. A number of herbal medicines are reported to improve brain function and intelligence. In the present study, the ameliorating effects of essential oil extracted from Piper nigrum and Monodora myristica on learning and memory in Scopolamine induced amnesic mice were determined using two cognitive behavioural paradigms: the Step-Through Passive Avoidance and Morris-Water Maze test. Essential oils were obtained by hydro-distillation using a Clavenger-type apparatus and their profiles analyzed by GC-MS. Inhibitory effects on AChE and BuChE were investigated by Ellman’s method. The animals were assessed for performance by measuring the Step-Through Latency Time (SLT) and Escape Latency Time (ELT). Brain cholinesterase activities were assayed in brain tissues from the mice. The results showed that M. myristica and P. nigrum oils were characterized by 51 (94.76%) and 61 (90.65%) components, respectively. M. myristica is dominated by α-phellandrene (18.13%), while P. nigrum is dominated by β-pinene (5.92%) and caryophyllene (4.55%). Both oils at 416 µg/ml elicited significant inhibitory (p>0.05) activity with M. myristica exhibiting a stronger inhibition against AChE and BuChE than P. nigrum. This trend was also exhibited significantly (p>0.05) in both ELT and the SLT when compared to scopolamine-treated group. In conclusion, the seeds of M. myristica and P. nigrum are potential sources of active metabolites with anti-cholinesterase and cognition enhancing properties, but M. myristica exhibited a higher activity.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Monodora myristica and Piper nigrum seed oils showed significant AChE and BChE inhibitory activity (p < 0.05) in a dose-dependent manner at 416 μg/mL.
“Both the oils showed significant AChE and BChE inhibitory activity (p < 0.05) in a dose-dependent manner at the concentration of 416 µg/mL.”
From Acetylcholinesterase Inhibitory Potential of Various Sesquiterpene Analogues for Alzheimer’s Disease Therapy (2021) · cites this paper as [96]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
A new and rapid colorimetric determination of acetylcholinesterase activity
Ellman, G. L., Courtney, K. D., Andres, V., & Featherstone, R. M. (1961) · Biochemical Pharmacology · doi:10.1016/0006-2952(61)90145-9 · Cited by 27,221 · see citing works
Developments of a water-maze procedure for studying spatial learning in the rat
Morris, R. (1984) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(84)90007-4 · Cited by 7,180 · see citing works
Tau-mediated neurodegeneration in Alzheimer’s disease and related disorders
Ballatore, C., Lee, V. M.-Y., & Trojanowski, J. Q. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2194 · Cited by 2,174 · see citing works
Intracellular amyloid-β in Alzheimer's disease
LaFerla, F. M., Green, K. N., & Oddo, S. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2168 · Cited by 1,942 · see citing works
Oxidative stress in neurodegeneration: Cause or consequence?
Andersen, J. K. (2004) · Nature Medicine · doi:10.1038/nrn1434 · Cited by 1,869 · see citing works
Caughey, B., & Lansbury, P. T. (2003) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.26.010302.081142 · Cited by 1,650 · see citing works
Acetylcholinesterase — new roles for an old actor
Soreq, H., & Seidman, S. (2001) · Nature reviews. Neuroscience · doi:10.1038/35067589 · Cited by 1,397 · see citing works
Microglial Activation and its Implications in the Brain Diseases
Dheen, S. T., Kaur, C., & Ling, E. (2007) · Current Medicinal Chemistry · doi:10.2174/092986707780597961 · Cited by 954 · see citing works
Bartus, R. T. (2000) · Experimental Neurology · doi:10.1006/exnr.2000.7397 · Cited by 829 · see citing works
The role of inflammation in Alzheimer’s disease
Tuppo, E. E., & Arias, H. R. (2005) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2004.07.009 · Cited by 734 · see citing works
Celone, K., Calhoun, V. D., Dickerson, B. C., Atri, A., Chua, E. F., Miller, S. L., DePeau, K. M., Rentz, D., Selkoe, D. J., Blacker, D., et al. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2250-06.2006 · Cited by 733 · see citing works
Auld, D. S., Kornecook, T. J., Bastianetto, S., & Quirion, R. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(02)00079-5 · Cited by 669 · see citing works
Targeting acetylcholinesterase and butyrylcholinesterase in dementia
Lane, R. M., Potkin, S. G., & Enz, A. (2005) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145705005833 · Cited by 654 · see citing works
The chemistry of Alzheimer’s disease
Rauk, A. (2009) · Chemical Society Reviews · doi:10.1039/b807980n · Cited by 417 · see citing works
Perry, N. S. L., Bollen, C. S. C., Perry, E. K., & Ballard, C. G. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(03)00108-4 · Cited by 384 · see citing works
Reassessing the amyloid cascade hypothesis of Alzheimer's disease
Pimplikar, S. W. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2008.12.015 · Cited by 373 · see citing works
Savelev, S. U., Okello, E. J., Perry, N. S. L., Wilkins, R. M., & Perry, E. K. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(03)00125-4 · Cited by 366 · see citing works
Memory enhancing activity of Glycyrrhiza glabra in mice
Dhingra, D., Parle, M., & Kulkarni, S. K. (2004) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2004.01.016 · Cited by 307 · see citing works
A comparative study in rodents of standardized extracts of Bacopa monniera and Ginkgo biloba
Das, A., Shanker, G., Nath, C., Pal, R., Singh, S., & Singh, H. K. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(02)00940-1 · Cited by 264 · see citing works
Intracellular Aβ and cognitive deficits precede β-amyloid deposition in transgenic arcAβ mice
Knobloch, M., Konietzko, U., Krebs, D. C., & Nitsch, R. M. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.06.019 · Cited by 259 · see citing works
Jirovetz, L., Buchbauer, G., Ngassoum, M. B., & Geißler, M. (2002) · Journal of Chromatography A · doi:10.1016/s0021-9673(02)00376-x · Cited by 237 · see citing works
Current drug targets for Alzheimer's disease treatment
Lahiri, D. K., Farlow, M. R., Greig, N. H., & Sambamurti, K. (2002) · Drug Development Research · doi:10.1002/ddr.10081 · Cited by 220 · see citing works
Hriţcu, L., Cioancă, O., & Hăncianu, M. (2012) · Phytomedicine · doi:10.1016/j.phymed.2012.02.002 · Cited by 197 · see citing works
Can herbs provide a new generation of drugs for treating Alzheimer’s disease?
Anekonda, T. S., & Reddy, P. H. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2005.09.001 · Cited by 140 · cited 1× · see citing works
“Aromatherapy, non-pharmacological therapy, is currently used worldwide in the management of chronic pain, depression, anxiety as well as cognitive, sleep and stress–related disorders (Savelev et al., 2004; Anekonda and Reddy, 2005; Hritcu et al., 2012; Natarajan et al., 2013).”
BackgroundHăncianu, M., Cioancă, O., Mihăşan, M., & Hriţcu, L. (2013) · Phytomedicine · doi:10.1016/j.phymed.2012.12.005 · Cited by 135 · see citing works
Wang, Q., Sun, L., Jia, W. W.-G., Liu, X., Dang, H., Mai, W., Wang, N., Steinmetz, A. A., Yu-qin, W., & Xu, C. (2010) · Phytotherapy Research · doi:10.1002/ptr.3130 · Cited by 115 · see citing works
Ustun, O., Şenol, F. S., Kürkçüoğlu, M., Orhan, İ. E., Kartal, M., & Başer, K. H. C. (2012) · Industrial Crops and Products · doi:10.1016/j.indcrop.2012.01.016 · Cited by 104 · see citing works
Arruda, M., Viana, H., Rainha, N., Neng, N. R., Rosa, J. S., Nogueira, J. M. F., & Barreto, M. D. C. (2012) · Molecules · doi:10.3390/molecules17033082 · Cited by 81 · see citing works
Kashani, M. S., Rezaei–Tavirani, M., Talaei, S. A., & Salami, M. (2011) · Neuroscience Bulletin · doi:10.1007/s12264-011-1149-7 · Cited by 78 · see citing works
Sun, X.-L., Ito, H., Masuoka, T., Kamei, C., & Hatano, T. (2007) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.30.1727 · Cited by 76 · see citing works
Majlessi, N., Choopani, S., Kamalinejad, M., & Azizi, Z. (2011) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2011.00237.x · Cited by 61 · see citing works
Nicotinic receptors and Alzheimer's disease
Bourin, M., Ripoll, N., & Dailly, É. (2003) · Current Medical Research and Opinion · doi:10.1185/030079903125001631 · Cited by 61 · see citing works
Plants traditionally used in age-related brain disorders (dementia): an ethanopharmacological survey
Suganthy, N., Pandian, S. K., & Kasi, P. D. (2013) · Pharmaceutical Biology · doi:10.3109/13880209.2012.738423 · Cited by 53 · see citing works
Molecular and cellular mediators of Alzheimer's disease inflammation
Strohmeyer, R., & Rogers, J. (2001) · Journal of Alzheimer s Disease · doi:10.3233/jad-2001-3118 · Cited by 51 · see citing works
Essential Oil and Methanolic Extract of Zataria multiflora Boiss with Anticholinesterase Effect
Sharififar, F., Mirtajadin, M., Azampour, M. J., & Zamani, E. (2011) · Pakistan Journal of Biological Sciences · doi:10.3923/pjbs.2012.49.53 · Cited by 42 · see citing works
Hefco, V., Yamada, K., Hefco, A., Hriţcu, L., Tiron, A., Olariu, A., & Nabeshima, T. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)02034-x · Cited by 41 · see citing works
Syad, A. N., Pandian, S. K., & Kasi, P. D. (2012) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2012/497242 · Cited by 41 · see citing works
Figueiró, M., Ilha, J., Linck, V. M., Herrmann, A. P., Nardin, P., Menezes, C. B., Achaval, M., Gonçalves, C. A., Porciúncula, L. O., Nunes, D. S., et al. (2010) · Phytomedicine · doi:10.1016/j.phymed.2010.07.013 · Cited by 29 · see citing works
Comparative study of the essential oils of Monodora myristica from Nigeria
Owokotomo, I. A., & Ekundayo, O. (2012) · European Chemical Bulletin · doi:10.17628/ecb.2012.1.263-265 · Cited by 15 · see citing works
Flagged first, then by citations
1 of the 40 references couldn’t be matched to a known paper.
Research works printed but not linked: 5
- Ali, N A. A., Crouch, R. A., Al-Fatimi, M., Arnold, N., Teichert, A., Setzer, W. N. and Wessjohann, L. (2012). Chemical composition, antimicrobial, antiradical and anticholinesterase activity of the essen- tial oil of Pulicariastephanocarpa from Soqotra. Natural Product Communications.7 (1): 113-116.
- El-Hela, A. and Abdullah, A. (2010). Chemical Composition and Bi- ological Activities of Essential Oil of Salvia acetabulosa L. Grown in Egypt. Journal of Applied Sciences Research. 6(6): 690-695.
- Obuotor, E. M. (2004). The mode of action of Ichthtotoxic principles in Raphia hookeri fruit. Ph.D Thesis. Obafemi Awolowo University, Ile-Ife.
- Sennuga, A. T. (2007). A Comparative Study of the Anti-cholines- terase and Cognitive Enhancing Properties of Morinda lucida Benth and Croton zambesicus Muell. Arg. in Adult Mice. M.Sc Thesis. Obafemi Awolowo University, Ile-Ife.
- Tchoumbougnang, F., Jazet, D. P. M., Sameza, L. M., Fombotioh, N., Wouatsa, N. A. V., Amvam, Z. P. H. and Menut, C. (2009). Com- parative essential oils composition and insecticidal effect of different tissues of Piper capense L. Piper guineense Schum. Et Thonn., Piper nigrum L. and Piperumbellatum L. grown in Cameroun. African Journal of Biotechnology.8 (3):424-431.
Cited by
Sorted by citations
Arya, A., Chahal, R., Rao, R., Rahman, M. H., Kaushik, D., Akhtar, M. F., Saleem, A., Khalifa, S. M. A., El-Seedi, H. R., Kamel, M., et al. (2021) · Biomolecules · doi:10.3390/biom11030350 · Cited by 111 · see citing works
“[96] extracted the essential oils of Monodora myristica and Piper nigrum Linn.”
Santoso, V. J., & Azminah, A. (2024) · Eduvest - Journal Of Universal Studies · doi:10.59188/eduvest.v4i10.1692
- Authors
- I J, O., S A, N., E E, E., F S, B., & E M, O.
- Venue
- International Journal of Pharmacology and Toxicology
- Publisher
- Science Publishing Corporation
- Published
- 2018-08-23
- Volume
- 6
- Issue
- 2
- Pages
- 34-41
- ISSN
- 2310-2985 (ISSN-L)
- OpenAlex
- W2921427565
- Cited by
- 2
- References
- 40
- Citations by year
- 2024: 1 · 2021: 1
- FWCI
- 0.34
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by
- Locations
- International Journal of Pharmacology and Toxicology (publishedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Piperaceae Chemical and Biological Studies
- Keywords
- black pepper, Monodora myristica, essential oils, anticholinesterase activity, acetylcholinesterase inhibition, butyrylcholinesterase inhibition, cognitive enhancement, learning and memory, scopolamine-induced amnesia, Alzheimer's disease, brain cholinesterase activity, essential oil composition, α-phellandrene, β-pinene, caryophyllene
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
