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Cited by 11Probiotics and Fermented FoodsNosocomial Infections in ICUSepsis Diagnosis and Treatment

Probiotics in critically ill patients: An umbrella review

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Mahmoodpoor, Ata, Sanaie, Sarvin, Naseri, Amirreza, Seyedi-Sahebari, Sepideh·2022·Indian Journal of Critical Care Medicine
DOI 10.5005/jp-journals-10071-24129PMC PMC9015916
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Abstract

Objectives: Probiotics are live microorganisms which when administered in adequate amounts confer a health benefit on the host. Because of the wide usage of antibiotics, acute changes in diet, and the stress of illness, critically ill patients' homeostasis of the gut microbiome can be disrupted during intensive care unit (ICU) confinement; probiotics are suggested as a beneficial intervention in critically ill patients. We tried to give an overview of the effects of probiotic supplements in critically ill patients based on published systematic reviews (SRs) and meta-analyses (MAs). Data sources: A systematic search was performed in four databases as well as hand searching. Study selection: The results were independently screened in two title/abstracts and full-text stages. Data extraction: Any reported outcomes in each study were extracted, using a data extraction table. Data synthesis: A wide range of outcomes of using probiotic supplements in critically ill patients have been reported in 20 included studies. Based on the current knowledge, we can say that probiotics may reduce the rate of ventilator-associated pneumonia, nosocomial pneumonia, the overall infection rate, duration of mechanical ventilation, and antibiotic use in critically ill patients, but there is not a significant association between using the probiotics and mortality, length of hospitalization, and incidence of diarrhea. Conclusion: Despite the various beneficial effects of probiotics in critically ill patients, there is not yet much evidence supporting the routine use of these supplements and further well-designed multicenter trials are needed to provide "evidence-based" recommendations. How to cite this article: Naseri A, Seyedi-Sahebari S, Mahmoodpoor A, Sanaie S. Probiotics in Critically Ill Patients: An Umbrella Review. Indian J Crit Care Med 2022;26(3):339-360.

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  • The clinical implications of sex differences in probiotic studies are unclear.

    “The clinical implications of this issue are unclear [15,136].”

    From Current Concepts in Probiotic Safety and Efficacy (2026) · cites this paper as [136]

    The Discussion identifies uncertainty about probiotic use in critically ill patients, but does not discuss sex differences or their clinical implications. Searches for sex differences and sex- or gender-specific probiotic effects found no passage addressing that point. (LLM, conf=0.74)

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Cited by

Sorted by citations

Authors
Mahmoodpoor, A., Sanaie, S., Naseri, A., & Seyedi-Sahebari, S.
Affiliations
Tabriz University of Medical Sciences (IR)
Corresponding author
Sanaie, Sarvin
ORCID
Venue
Indian Journal of Critical Care Medicine
Publisher
Jaypee Brothers Medical Publishing
Published
2022-03-30
Volume
26
Issue
3
Pages
339-360
ISSN
  • 0972-5229 (ISSN-L)
  • 1998-359X
DOI
10.5005/jp-journals-10071-24129
PMC
PMC9015916
OpenAlex
W4214490320
Cited by
11
References
3
Citations by year
2026: 2 · 2025: 3 · 2024: 3 · 2023: 1 · 2022: 2
FWCI
1.20
Type
journal article
Language
en
Open access
Locations
  • Indian Journal of Critical Care Medicine (publishedVersion)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
Funders
  • Tabriz University of Medical Sciences
  • University of Tabriz
  • Student Research Committee, Tabriz University of Medical Sciences
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Nosocomial Infections in ICU
  • Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
Keywords
probiotics, critically ill patients, intensive care unit, gut microbiota, ventilator-associated pneumonia, nosocomial pneumonia, infection rate, mechanical ventilation duration, antibiotic use, mortality, length of hospital stay, diarrhea

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