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Cited by 189Probiotics and Fermented FoodsDermatology and Skin DiseasesGut microbiota and health

Targeting the gut‐skin axis—Probiotics as new tools for skin disorder management?

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Szántó, Magdolna, Dózsa, Anikó, Antal, Dóra, Szabó, Kornélia, Kemény, Lajos, Bai, Péter·2019·Experimental Dermatology
DOI 10.1111/exd.14016
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Abstract

The existence of a gut-skin axis is supported by increasing evidence, but its translational potential is not widely recognized. Studies linked inflammatory skin diseases to an imbalanced gut microbiome; hence, the modulation of the gut microbiota to improve skin condition seems to be a feasible approach. Today, there is a growing interest in natural products as alternatives to synthetic drugs. In this respect, oral probiotics could be a simple, safe and cheap modality in the therapeutic management of skin inflammation. Unfortunately, very few studies have looked into how probiotic supplementation influences inflammatory skin disorders. The result, though promising, are difficult to implement in clinical practice due to the heterogeneity of the applied supplemental regimen in the different studies. In this Viewpoint, we aim to encourage the conduction of more research in that direction to explore unambiguously the therapeutic potential of oral probiotics in dermatology. We focus on the most common inflammatory skin diseases (atopic dermatitis, psoriasis, rosacea, acne vulgaris) with an associated gut dysbiosis, but we also discuss some less common, but very serious skin pathologies (eg erythema nodosum, pyoderma gangrenosum, hidradenitis suppurativa) that are possibly linked to a disturbed gut flora composition. We dissect the possible mechanisms along the gut-skin axis and highlight novel points where probiotics could interfere in this communication in the diseased state.

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Authors
Szántó, M., Dózsa, A., Antal, D., Szabó, K., Kemény, L., & Bai, P.
Affiliations
  • University of Debrecen (HU)
  • Borsod-Abaúj-Zemplén Megyei Kórház és Egyetemi Oktató Kórház (HU)
  • University of Szeged (HU)
Corresponding author
  • Szántó, Magdolna
  • Bai, Péter
ORCID
Venue
Experimental Dermatology
Publisher
Wiley
Published
2019-08-28
Volume
28
Issue
11
Pages
1210-1218
ISSN
  • 0906-6705 (ISSN-L)
  • 1600-0625
DOI
10.1111/exd.14016
OpenAlex
W2965164867
Cited by
189
References
118
Citations by year
2026: 19 · 2025: 30 · 2024: 27 · 2023: 29 · 2022: 37 · 2021: 30 · 2020: 14 · 2019: 3
FWCI
16.20
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Experimental Dermatology (publishedVersion)
  • PubMed (publishedVersion)
  • SZTE Publicatio Repozitórium (University of Szeged) (acceptedVersion)
  • Repository of the Academy's Library (Library of the Hungarian Academy of Sciences) (acceptedVersion)
  • University of Debrecen Electronic Archive (University of Debrecen) (submittedVersion)
Funders
Nemzeti Kutatási Fejlesztési és Innovációs Hivatal (K123975, PD121138, GINOP‐2.3.2‐15‐2016‐00006, GINOP‐2.3.2‐15‐2016‐00015, EFOP_363_VEKOP_16201700009)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords
gut-skin axis, oral probiotics, gut microbiota, inflammatory skin diseases, atopic dermatitis, psoriasis, rosacea, acne, erythema nodosum, pyoderma gangrenosum, hidradenitis suppurativa, gut dysbiosis, probiotic mechanisms of action
MeSH terms
Gastrointestinal Microbiome, Humans, Skin Diseases, Probiotics

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