Effect of probiotics on symptoms in Korean adults with irritable bowel syndrome
Open accessAbstract
BACKGROUND/AIMS: Irritable bowel syndrome (IBS) is a troublesome disease. Some strains of probiotics reportedly exert remarkable immunomodulatory effects, and so we designed a prospective double-blind randomized placebo-controlled clinical study to assess their effects in Korean adults with IBS. METHODS: IBS patients who met Rome III criteria were randomly assigned to receive composite probiotics or placebo. A total of 20 billion lyophilized bacteria were administered twice daily for 8 weeks. Primary outcome variables were symptom scores consisting of abdominal pain, flatulence, defecation discomfort, and sum of symptom scores. A visual analogue scale was used to quantify the severity. Secondary outcome variables consisted of the quality of life and bowel habits including defecation frequency and stool form. RESULTS: Thirty-six and 34 patients were randomized to the probiotics and placebo groups, respectively. Intention-to-treat analysis showed significant reductions in pain after 8 weeks of treatment: -31.9 and -17.7 in the probiotics and placebo groups, respectively (p=0.045). The reductions in abdominal pain, defecation discomfort, and sum of scores were more significant in 58 patients with a score of at least 3 on the baseline stool-form scale. CONCLUSIONS: Composite probiotics containing Bifidobacterium bifidum BGN4, Lactobacillus acidophilus AD031, and other species are safe and effective, especially in patients who excrete normal or loose stools.
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All three studies that examined flatus as a primary end point, and four of seven studies in which flatus was a secondary end point only, showed no significant difference between seven specific probiotic treatments and control.
“all three studies that examined flatus as a primary end point,30,57 and four of seven studies in which flatus was a secondary end point only,28–38 showed no significant difference between seven specific probiotic treatments and control.”
From Systematic review: probiotics in the management of lower gastrointestinal symptoms in clinical practice - an evidence-based international guide (2013) · cites this paper as [57]
Probiotics tested to date do not help reduce flatus in patients with IBS, with low grade of evidence.
“Probiotics tested to date do not help reduce flatus in patients with IBS Low [147,149-150,156,168,174-175, 178-179,184]”
From Gut microbiota role in irritable bowel syndrome: New therapeutic strategies (2016) · cites this paper as [184]
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Kim, N. Y., & Ji, G. E. (2012)
Self-citationGut Microbiota in Health and Probiotics in Functional Bowel Disease
Rhyou, J. H. (2017) · Ewha Medical Journal · doi:10.12771/emj.2017.40.1.22
Wen, B. (2015) · TSpace (University of Toronto)
Evaluation of the effect of probiotics on celiac patients
Çalışır, B., Adiloğlu, A. K., & Berkem, R. (2022) · Kastamonu Medical Journal · doi:10.51271/kmj-0083
Lim, J.-S., Oh, B., Lee, H., Shin, E., Kim, J. Y., Park, M., Ji, G. E., & Cho, B. (2024) · Research Square · doi:10.21203/rs.3.rs-4141489/v1
Self-citation
- Authors
- Hong, K. S., Kang, H. W., Im, J. P., Ji, G. E., Kim, S. G., Jung, H. C., Song, I. S., & Kim, J. S.
- Affiliations
- Seoul National University (KR)
- Corresponding author
- Kim, Joo Sung
- ORCID
- Venue
- Gut and Liver
- Published
- 2009-06-30
- Volume
- 3
- Issue
- 2
- Pages
- 101-107
- ISSN
- 1976-2283 (ISSN-L)
- 2005-1212
- PMC
- PMC2852694
- OpenAlex
- W2108226288
- Cited by
- 75
- References
- 22
- Citations by year
- 2024: 3 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 3 · 2019: 4 · 2018: 8 · 2017: 3 · 2016: 8 · 2015: 5 · 2014: 5 · 2013: 4 · 2012: 12
- FWCI
- 8.15
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc
- Locations
- Gut and Liver (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Seoul National University Open Repository (Seoul National University) (submittedVersion)
- Funders
- Seoul National University
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- irritable bowel syndrome, probiotics, abdominal pain, flatulence, quality of life, bowel habits, stool consistency, Bifidobacterium bifidum, Lactobacillus acidophilus, immunomodulation, Korean adults
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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