Impact of amino-acid coating on the synthesis and characteristics of iron-oxide nanoparticles (IONs)
Open accessAbstract
Iron-oxide nanoparticles (IONs) with biocompatible coatings are the only nanostructural materials which have been approved by the FDA for clinical use. Common biocompatible coatings such as hydrocarbons, polymers, and silica have profound influences on critical characteristics of IONs. Recently, amino acids were introduced as a novel biocompatible coating. In the present study, the effects of amino acids on IONs synthesis and characteristics have been evaluated. Magnetite nanoparticles with L-arginine and L-lysine coatings were synthesised by a coprecipitation reaction in aqueous solvent and their characteristics were compared with naked magnetite nanoparticles. The results showed that amino acids can be a perfect coating for IONs and would increase particle stability without any significant effects on the critical properties of nanoparticles such as particle size and magnetization saturation value.
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Prototypic examples of materials used to coat iron oxide nanoparticles are polymers, fatty acids, amino acids, metals, and oxides.
“Prototypic examples of materials used to coat iron oxide nanoparticles are polymers [28, 47, 50], fatty acids (like oleic acid, stearic acid, lauric acid and dodecylphosphonic acid) [51–55], amino acids (like phenyl alanine, tyrosine, arginine, lysine and cysteine) [56–58],_metals (like gold, gadolinium and silver) [59–61] and oxides (like silica and TiO2) [62–64].”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [56]
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Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications
Dadfar, S. M., Roemhild, K., Drude, N. I., von Stillfried, S., Knüchel, R., Kiessling, F., & Lammers, T. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.01.005 · Cited by 1,181 · see citing works
- Authors
- Ebrahiminezhad, A., Ghasemi, Y., Rasoul-Amini, S., Barar, J., & Davaran, S.
- Affiliations
- Tabriz University of Medical Sciences (IR)
- Shiraz University of Medical Sciences (IR)
- Venue
- Bulletin of the Korean Chemical Society
- Publisher
- Korean Chemical Society
- Published
- 2012-12-20
- Volume
- 33
- Issue
- 12
- Pages
- 3957-3962
- ISSN
- 0253-2964 (ISSN-L)
- OpenAlex
- W2070857970
- Cited by
- 172
- References
- 37
- Citations by year
- 2026: 12 · 2025: 12 · 2024: 10 · 2023: 14 · 2022: 17 · 2021: 20 · 2020: 19 · 2019: 18 · 2018: 14 · 2017: 18 · 2016: 11 · 2015: 5 · 2014: 2
- FWCI
- 1.27
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Bulletin of the Korean Chemical Society (publishedVersion)
- Funders
- Shiraz University of Medical Sciences
- Tabriz University of Medical Sciences
- Shiraz University
- University of Tabriz
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
- Physical Sciences › Materials Science › Materials Chemistry › Magnetic Properties and Synthesis of Ferrites
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- iron oxide nanoparticles, L-arginine, L-lysine, magnetite, biocompatible coatings, co-precipitation synthesis, particle stability, saturation magnetization, particle size
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