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Cited by 29Wound Healing and TreatmentsDiabetic Foot Ulcer Assessment and ManagementDermatologic Treatments and Research

Polydeoxyribonucleotides Improve Diabetic Wound Healing in Mouse Animal Model for Experimental Validation

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Kwon, Tae-Rin, Han, Sung Won, Kim, Jong Hwan, Lee, Byung Chul, Kim, Jae Min, Hong, Ji Yeon, Kim, Beom Joon·2019·Annals of Dermatology
DOI 10.5021/ad.2019.31.4.403PMC PMC7992745
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Abstract

BACKGROUND: Wound healing mechanisms is believed to have effects similar to wound healing disorders in diabetic patients, including abnormal inflammatory cells, angiogenesis disorders, and reduced collagen synthesis. Therefore, reestablishment of structural and promoted angiogenesis could be beneficial to promote wound healing process. OBJECTIVE: Therefore, we investigated whether the polydeoxyribonucleotide (PDRN) that was self-production in Korea, could be useful as an intradermal injection for promoting wound healing. Also, we validate for wound healing effect of PDRN using healing-impaired (db/db) mice. METHODS: wound healing assay, we observed that PDRN stimulated closure of wounded monolayers of human fibroblast cells. PDRN (8.25 mg/ml) or phosphate-buffered saline (0.9% NaCl) was injected once daily into the dermis adjacent to the wound for 12 days after skin injury. RESULTS: Time course observations revealed that mice treated with PDRN showed accelerated wound closure and epidermal and dermal regeneration, enhanced angiogenesis. The wound area and depth decreased at 3, 6, 9, and 12 days after skin injury. Histological evaluation showed an increase of vascular endothelial growth factor, CD31, and collagen fibers in the PDRN group compared with the control group, indicating that PDRN was effective in the treatment of delayed wound healing caused by diabetes. CONCLUSION: This study suggests that our PDRN has a wound healing effect in transgenic animal models with cells and diabetes through angiogenesis.

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  • A2A receptor activation by PDRN reduces inflammatory cell infiltration, promotes proliferation and migration of reparative cells, stimulates VEGF production, and facilitates fibroblast differentiation and maturation.

    “A2A receptor activation by PDRN reduces inflammatory cell infiltration, promotes proliferation and migration of reparative cells, stimulates vascular endothelial growth factor (VEGF) production, and facilitates fibroblast differentiation and maturation, thereby accelerating the reparative cascade [112,113].”

    From Comparison of Polynucleotide and Polydeoxyribonucleotide in Dermatology: Molecular Mechanisms and Clinical Perspectives (2025) · cites this paper as [112]

    The Discussion (page not supplied) links PDRN to A2A-receptor stimulation and increased VEGF expression; the Results report increased fibroblast proliferation. The paper does not report reduced inflammatory-cell infiltration or fibroblast differentiation and maturation, and its observed increase in fibroblast migration was not statistically significant. (LLM, conf=0.87)

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Research works printed but not linked: 26

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Cited by

Sorted by citations

Authors
Kwon, T.-R., Han, S. W., Kim, J. H., Lee, B. C., Kim, J. M., Hong, J. Y., & Kim, B. J.
Affiliations
Chung-Ang University Hospital (KR)
Corresponding author
Kim, Beom Joon
ORCID
Venue
Annals of Dermatology
Publisher
XMLink
Published
2019
Volume
31
Issue
4
Pages
403
ISSN
  • 1013-9087 (ISSN-L)
  • 2005-3894
DOI
10.5021/ad.2019.31.4.403
PMC
PMC7992745
OpenAlex
W2956669871
Cited by
29
References
0
Citations by year
2026: 4 · 2025: 9 · 2024: 3 · 2023: 4 · 2022: 3 · 2021: 3 · 2020: 3
FWCI
1.52
Type
journal article
Language
en
Open access
Licence
Locations
  • Annals of Dermatology (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetic Foot Ulcer Assessment and Management
  • Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
Keywords
polydeoxyribonucleotide, diabetic wound healing, angiogenesis, db/db mice, intradermal injection, vascular endothelial growth factor, collagen synthesis, epidermal regeneration, delayed wound healing

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