The Effects of Ginger on Gallbladder Motility in Healthy Male Humans
Open accessAbstract
BACKGROUND/AIMS: Ginger has been used to treat a number of diseases including those affecting the digestive tract. This study was aimed to investigate the effects of ginger on gallbladder volume and gastrointestinal sensation in healthy male subjects. METHODS: Nineteen healthy male volunteers (age 21.3 ± 3.9 years, body mass index 21.6 ± 1.9 kg/m(2)) were studied on 2 occasions in a double blind randomized crossover design. After ingesting ginger (1,200 mg) or placebo capsules (starch), abdominal ultrasound was used to measure the gallbladder volume (calculated from gallbladder width, depth and diameter) and ejection fraction following a standard test meal. Gastrointestinal symptoms were also recorded at regular intervals by visual analogue scales. RESULTS: There were no differences in gallbladder volume or ejection fraction between ginger and placebo. Abdominal symptoms of bloating, fullness, nausea, discomfort and hunger was not different between the 2 occasions. CONCLUSIONS: Ginger (1,200 mg) may not affect gallbladder ejection fraction and possible relevant abdominal symptoms in healthy male human subjects.
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Some trials showed no effect of ginger on any dyspepsia symptoms.
“some trials showed no effect of ginger on any dyspepsia symptoms [43–45].”
From The effects of ginger supplementation on common gastrointestinal symptoms in patients with relapsing-remitting multiple sclerosis: a double-blind randomized placebo-controlled trial (2023) · cites this paper as [44]
The Results report no significant difference between ginger and placebo in measured abdominal symptoms, including bloating, fullness, nausea and discomfort. But the Discussion specifies that participants were healthy volunteers without dyspeptic syndromes, so the study does not establish a lack of effect on symptoms in people with dyspepsia. (LLM, conf=0.84)
Experimental — accuracy not yet measuredShort-term studies (i.e., 1 day) did not find significant beneficial effects of ginger on dyspepsia symptoms.
“short-term studies (i.e., 1 day) did not [43–45].”
From The effects of ginger supplementation on common gastrointestinal symptoms in patients with relapsing-remitting multiple sclerosis: a double-blind randomized placebo-controlled trial (2023) · cites this paper as [44]
The Results report no significant difference in bloating, fullness, nausea, or abdominal discomfort between the ginger and placebo study days. However, the Discussion says the participants were healthy volunteers without dyspeptic syndromes, so the study does not establish a lack of benefit for people with dyspepsia. (LLM, conf=0.88)
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- Authors
- Chuah, S.-K., Wu, K.-L., Tai, W.-C., & Changchien, C.-S.
- Affiliations
- Chang Gung University (TW)
- Corresponding author
- Wu, Keng-Liang
- Venue
- Journal of Neurogastroenterology and Motility
- Published
- 2011-10-31
- Volume
- 17
- Issue
- 4
- Pages
- 411-415
- ISSN
- 2093-0879 (ISSN-L)
- 2093-0887
- PMC
- PMC3228982
- OpenAlex
- W2017527057
- Cited by
- 5
- References
- 22
- Citations by year
- 2025: 1 · 2023: 1 · 2020: 1 · 2017: 1 · 2014: 1
- FWCI
- 0.34
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- Journal of Neurogastroenterology and Motility (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Ginger and Zingiberaceae research
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Gallbladder and Bile Duct Disorders
- Keywords
- ginger, gallbladder motility, gallbladder ejection fraction, gallbladder volume, gastrointestinal symptoms, bloating, nausea, hunger, healthy men, herbal medicine
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