Gastrointestinal motility enhancing effect of ginger and its active constituents.
Open accessAbstract
The effect of ginger root (Zingiberis Rhizoma) on gastrointestinal motility was examined based on its ability to enhance charcoal meal transport in mice. Oral administrations of the acetone extract of ginger (which contains volatile oils and bitter substances) at 75 mg/kg, [6]-shogaol at 2.5 mg/kg, or a [6]-, [8]- or [10]-gingerol at 5 mg/kg enhanced the transport of a charcoal meal. The effects of these substances were similar to or slightly weaker than those of metoclopramide and donperidone.
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Ginger consumption accelerates gastrointestinal motility and reduces food transit time, which may alleviate constipation.
“Also, ginger consumption has been reported to accelerate GI motility and reduce food transit time, which may alleviate constipation [15, 16].”
From The effects of ginger supplementation on common gastrointestinal symptoms in patients with relapsing-remitting multiple sclerosis: a double-blind randomized placebo-controlled trial (2023) · cites this paper as [15]
The opening summary (p. 1) reports that orally administered ginger extract and constituents increased charcoal-meal transport in mice, supporting an effect on gastrointestinal motility. The methods (p. 1) measured distance travelled by charcoal, not food transit time; the paper does not establish that consuming ginger reduces transit time or alleviates constipation. (LLM, conf=0.88)
Experimental — accuracy not yet measuredThe mechanism of ginger's beneficial effect on constipation may be related to its ability to increase GI motility.
“The mechanism of this beneficial effect may be related to the ability of ginger to increase GI motility [15].”
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- Authors
- YAMAHARA, J., HUANG, Q., LI, Y., XU, L., & FUJIMURA, H.
- Affiliations
- Kyoto Pharmaceutical University (JP)
- Venue
- Chemical and Pharmaceutical Bulletin
- Publisher
- Pharmaceutical Society of Japan
- Published
- 1990
- Volume
- 38
- Issue
- 2
- Pages
- 430-431
- ISSN
- 0009-2363 (ISSN-L)
- 1347-5223
- OpenAlex
- W2037992963
- Cited by
- 138
- References
- 0
- Citations by year
- 2025: 2 · 2024: 4 · 2023: 3 · 2022: 4 · 2021: 7 · 2020: 6 · 2019: 9 · 2018: 3 · 2017: 4 · 2016: 11 · 2015: 8 · 2014: 4 · 2013: 8 · 2012: 3
- FWCI
- 0.81
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Chemical and Pharmaceutical Bulletin (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Ginger and Zingiberaceae research
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ginseng Biological Effects and Applications
- Keywords
- ginger, Zingiberis Rhizoma, gastrointestinal motility, 6-shogaol, gingerol, essential oils, bitter compounds, metoclopramide, prokinetic agents
- MeSH terms
- Animals, Catechols, Condiments, Fatty Alcohols, Gastrointestinal Motility, Male, Plant Extracts, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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