The Impact of Opioid Treatment on Regional Gastrointestinal Transit
Open accessAbstract
BACKGROUND/AIMS: To employ an experimental model of opioid-induced bowel dysfunction in healthy human volunteers, and evaluate the impact ofopioid treatment compared to placebo on gastrointestinal (GI) symptoms and motility assessed by questionnaires and regional GItransit times using the 3-dimensional (3D)-Transit system. METHODS: Twenty-five healthy males were randomly assigned to oxycodone or placebo for 5 days in a double blind, crossover design. AdverseGI effects were measured with the bowel function index, gastrointestinal symptom rating scale, patient assessment of constipationsymptom questionnaire, and Bristol stool form scale. Regional GI transit times were determined using the 3D-Transit system, and segmental transit times in the colon were determined using a custom Matlab(®) graphical user interface. RESULTS: GI symptom scores increased significantly across all applied GI questionnaires during opioid treatment. Oxycodone increased median total GI transit time from 22.2 to 43.9 hours (P < 0.001), segmental transit times in the cecum and ascending colon from 5.7 to 9.9 hours (P = 0.012), rectosigmoid colon transit from 2.7 to 9.0 hours (P = 0.044), and colorectal transit time from 18.6 to 38.6 hours (P= 0.001). No associations between questionnaire scores and segmental transit times were detected. CONCLUSIONS: Self-assessed GI adverse effects and increased GI transit times in different segments were induced during oxycodone treatment. This detailed information about segmental changes in motility has great potential for future interventional head-to-head trials of different laxative regimes for prevention and treatment of constipation.
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Several papers have addressed opioid-related GI concerns, yet no authors make any specific nutrition recommendations.
“Several papers have addressed opioid-related GI concerns, yet no authors make any specific nutrition recommendations (174, 175).”
From A Biopsychosocial Overview of the Opioid Crisis: Considering Nutrition and Gastrointestinal Health (2019) · cites this paper as [175]
GI transit times are prolonged in the cecum and ascending colon, but not in the transverse or descending colon.
“It has been shown that GI transit times are prolonged in the cecum and ascending colon, but not in the transverse or descending colon (175).”
From A Biopsychosocial Overview of the Opioid Crisis: Considering Nutrition and Gastrointestinal Health (2019) · cites this paper as [175]
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Okdahl, T., Mark, E. B., Nedergaard, R. B., Knoph, C. S., Cook, M. E., Krogh, K., & Drewes, A. M. (2023) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.13850 · Cited by 7 · see citing works
Mark, E. B., Okdahl, T., Kahlke, D. G., Hansen, L. E. M., Krogh, K., Frøkjær, J. B., & Drewes, A. M. (2024) · Neurogastroenterology & Motility · doi:10.1111/nmo.14941 · Cited by 6 · see citing works
The influence of tramadol on bowel function: A randomised, placebo‐controlled trial
Larsen, I. M., Okdahl, T., Mark, E. B., Frøkjær, J. B., & Drewes, A. M. (2024) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.14067 · Cited by 5 · see citing works
Gourcerol, G., & Lemaire, A. (2020) · Douleurs Évaluation - Diagnostic - Traitement · doi:10.1016/j.douler.2020.07.001 · Cited by 4 · see citing works
An update on the use of pharmacotherapy for opioid-induced bowel dysfunction
Mousavi, T., Nikfar, S., & Abdollahi, M. R. (2022) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2022.2161883 · Cited by 4 · see citing works
Clinical Efficacy of Mesenteric Lift to Relieve Constipation in Traumatic Brain Injury Patients
Berry, J. A. D., Ogunlade, J. I., Kashyap, S., Berry, D. K., Wacker, M. R., Miulli, D. E., & Saini, H. (2020) · Journal of Osteopathic Medicine · doi:10.7556/jaoa.2020.094 · Cited by 4 · see citing works
Opioid trail: Tracking contributions to opioid use disorder from host genetics to the gut microbiome
Duffy, E. P., Bachtell, R. K., & Ehringer, M. A. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105487 · Cited by 3 · see citing works
Hale, M. E., Wild, J. E., Yamada, T., Yokota, T., Tack, J. F., Andresen, V., & Drewes, A. M. (2021) · Therapeutic Advances in Gastroenterology · doi:10.1177/17562848211032320 · Cited by 3 · see citing works
Methylnaltrexone: Peripherally Acting μ-Opioid Receptor Antagonist
Tanya J. Urtisky, P. (2019) · Journal of the Advanced Practitioner in Oncology · doi:10.6004/jadpro.2019.10.1.5 · Cited by 3 · see citing works
Constipation induite par les opioïdes : état des lieux et modalités de prise en charge
Boilève, A., Desprez, C., Scotté, F., Coffin, B., Gervais, C., & Soliman, H. (2025) · Bulletin du Cancer · doi:10.1016/j.bulcan.2025.01.007 · Cited by 1 · see citing works
Sieg, M., Mark, E. B., Drewes, A. M., & Vase, L. (2021) · Scandinavian Journal of Pain · doi:10.1515/sjpain-2021-0115 · Cited by 1 · see citing works
A Novel Approach to Assess Opioid-Induced Bowel Dysfunction
Nilsson, M. (2015) · Aalborg University Library · doi:10.5278/vbn.phd.med.00040
López, B. S. (2019) · Open Journal of Pain Medicine · doi:10.17352/ojpm.000015
Nors, J., Klinge, M. W., Sommer, T., Laurberg, S., Krogh, K., & Funder, J. A. (2020) · BMJ Innovations · doi:10.1136/bmjinnov-2019-000396
- Authors
- Poulsen, J. L., Nilsson, M., Brock, C., Sandberg, T. H., Krogh, K., & Drewes, A. M.
- Affiliations
- Aalborg University Hospital (DK)
- University of Copenhagen (DK)
- Aarhus University Hospital (DK)
- Corresponding author
- Drewes, Asbjørn M
- Venue
- Journal of Neurogastroenterology and Motility
- Published
- 2016-04-30
- Volume
- 22
- Issue
- 2
- Pages
- 282-291
- ISSN
- 2093-0879 (ISSN-L)
- 2093-0887
- PMC
- PMC4819867
- OpenAlex
- W2333283069
- Cited by
- 53
- References
- 48
- Citations by year
- 2025: 1 · 2024: 4 · 2023: 6 · 2022: 3 · 2021: 9 · 2020: 6 · 2019: 9 · 2018: 9 · 2017: 5 · 2015: 1
- FWCI
- 8.39
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc
- Locations
- Journal of Neurogastroenterology and Motility (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- VBN Forskningsportal (Aalborg Universitet) (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
- Health Sciences › Medicine › Surgery › Enhanced Recovery After Surgery
- Keywords
- opioid-induced bowel dysfunction, oxycodone, gastrointestinal transit time, constipation, gastrointestinal adverse effects, laxative therapy, healthy volunteers
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