The DOI matches its Crossref record, with a small difference in title or year; 73 of the 73 references it cites were found in a registry or an index.
The role of myelin damage in Alzheimer’s disease pathology
Open accessAbstract
Although Alois Alzheimer described myelin disruption in Alzheimer's disease (AD) as early as in 1911, his observation has escaped the attention of researchers since that time. Alzheimer's disease has been mainly considered as a grey matter disorder; nevertheless, recent evidence suggests that myelin impairment may play an important role in AD pathology. Classical neuropathological changes in AD, e.g. the accumulation of aggregated Aβ 42 and the presence of neurofibrillary tangles, are responsible for neuronal loss, but they may also induce death of oligodendrocytes and myelin damage. There is also evidence that myelin pathology may even precede Aβ and tau pathologies in AD. The state of the art does not allow us to determine whether myelin damage is a primary or a secondary injury in AD subjects. The article presents an overview of current knowledge on the role of myelin in AD pathology and its interactions with Aβ and tau pathologies.
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In the citing paper
“This is notable because myelin damage likely precedes and contributes to amyloid plaque buildup in early AD.55–57”
From TET2-mutant myeloid cells mitigate Alzheimer’s disease progression via CNS infiltration and enhanced phagocytosis in mice (2025) · cites this paper as [56]
Experimental — accuracy not yet measuredIn the citing paper
“Several studies have shown that demyelination can be mainly found in the proximity of Aβ plaques within the neocortex,69”
From A spatial imaging-transcriptomics paradigm for deciphering the molecular basis of microscopic MRI in the normal brain and Alzheimer’s disease (2025) · cites this paper as [69]
In the citing paper
“The main AD pathology of Aβ is also related to myelin damage.”
From A spatial imaging-transcriptomics paradigm for deciphering the molecular basis of microscopic MRI in the normal brain and Alzheimer’s disease (2025) · cites this paper as [69]
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Citations
Cites
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Biology of Oligodendrocyte and Myelin in the Mammalian Central Nervous System
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Axonopathy and Transport Deficits Early in the Pathogenesis of Alzheimer’s Disease
Stokin, G. B., Lillo, C., Falzone, T. L., Brusch, R. G., Rockenstein, E., Mount, S. L., Raman, R., Davies, P., Masliah, E., Williams, D. S., et al. (2005) · Science · doi:10.1126/science.1105681 · Cited by 1,214
Motor skill learning requires active central myelination
McKenzie, I. A., Ohayon, D., Li, H., Paes de Faria, J., Emery, B., Tohyama, K., & Richardson, W. D. (2014) · Science · doi:10.1126/science.1254960 · Cited by 1,177
Age-related myelin breakdown: a developmental model of cognitive decline and Alzheimer’s disease
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Fields, R. D. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn4023 · Cited by 794
Flagged first, then by citations
Research works printed but not linked: 2
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Lau, V. Z., Ramer, L. M., & Tremblay, M. (2023) · Nature Communications · doi:10.1038/s41467-023-37304-3 · Cited by 175
Fast-spiking parvalbumin-positive interneurons in brain physiology and Alzheimer’s disease
Hijazi, S., Smit, A. B., & van Kesteren, R. E. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02168-y · Cited by 157
Transgenic Mouse Models of Alzheimer’s Disease: An Integrative Analysis
Sanchez-Varo, R. M., Mejias‐Ortega, M., Fernandez-Valenzuela, J. J., Nuñez‐Diaz, C., Cáceres-Palomo, L., Vegas‐Gomez, L., Sánchez‐Mejías, E., Trujillo‐Estrada, L., García‐León, J. A., Moreno‐González, I., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105404 · Cited by 136
Qiu, S., Palavicini, J. P., Wang, J., Gonzalez, N. S., He, S., Dustin, E., Zou, C., Ding, L., Bhattacharjee, A., Skike, C. E. V., et al. (2021) · Molecular Neurodegeneration · doi:10.1186/s13024-021-00488-7 · Cited by 126
COVID-19 and Alzheimer’s Disease
Ciaccio, M., Sasso, B. L., Scazzone, C., Gambino, C. M., Ciaccio, A. M., Bivona, G., Piccoli, T., Giglio, R. V., & Agnello, L. (2021) · Brain Sciences · doi:10.3390/brainsci11030305 · Cited by 116
Metadata
- Authors
- Papuć, E., & Rejdak, K.
- Affiliations
- Medical University of Lublin (PL)
- Corresponding author
- Papuć, Ewa
- Venue
- Archives of Medical Science
- Publisher
- Termedia Sp. z.o.o.
- Published
- 2020
- Volume
- 16
- Issue
- 2
- Pages
- 345-341
- ISSN
- 1734-1922 (ISSN-L)
- PMC
- PMC7069444
- OpenAlex
- W2898142024
- Cited by
- 188
- References
- 73
- Citations by year
- 2026: 22 · 2025: 33 · 2024: 31 · 2023: 33 · 2022: 40 · 2021: 20 · 2020: 8
- FWCI
- 5.67
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- Archives of Medical Science (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, myelin damage, oligodendrocyte death, amyloid-beta, tau pathology, neurofibrillary tangles, myelin pathology, grey matter
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