The DOI matches its Crossref record, with a small difference in title or year; 73 of the 73 references it cites were found in a registry or an index.
The role of myelin damage in Alzheimer’s disease pathology
Open accessAbstract
Although Alois Alzheimer described myelin disruption in Alzheimer's disease (AD) as early as in 1911, his observation has escaped the attention of researchers since that time. Alzheimer's disease has been mainly considered as a grey matter disorder; nevertheless, recent evidence suggests that myelin impairment may play an important role in AD pathology. Classical neuropathological changes in AD, e.g. the accumulation of aggregated Aβ 42 and the presence of neurofibrillary tangles, are responsible for neuronal loss, but they may also induce death of oligodendrocytes and myelin damage. There is also evidence that myelin pathology may even precede Aβ and tau pathologies in AD. The state of the art does not allow us to determine whether myelin damage is a primary or a secondary injury in AD subjects. The article presents an overview of current knowledge on the role of myelin in AD pathology and its interactions with Aβ and tau pathologies.
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“This is notable because myelin damage likely precedes and contributes to amyloid plaque buildup in early AD.55–57”
From TET2-mutant myeloid cells mitigate Alzheimer’s disease progression via CNS infiltration and enhanced phagocytosis in mice (2025) · cites this paper as [56]
Experimental — accuracy not yet measuredIn the citing paper
“Several studies have shown that demyelination can be mainly found in the proximity of Aβ plaques within the neocortex,69”
From A spatial imaging-transcriptomics paradigm for deciphering the molecular basis of microscopic MRI in the normal brain and Alzheimer’s disease (2025) · cites this paper as [69]
In the citing paper
“The main AD pathology of Aβ is also related to myelin damage.”
From A spatial imaging-transcriptomics paradigm for deciphering the molecular basis of microscopic MRI in the normal brain and Alzheimer’s disease (2025) · cites this paper as [69]
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Cites
The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics
Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864
Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy
Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359
Shankar, G. M., Li, S., Mehta, T. H., Garcia-Munoz, A., Shepardson, N. E., Smith, I., Brett, F. M., Farrell, M. A., Rowan, M. J., Lemere, C. A., et al. (2008) · Nature Medicine · doi:10.1038/nm1782 · Cited by 3,685
Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity
DeKosky, S. T., & Scheff, S. W. (1990) · Annals of Neurology · doi:10.1002/ana.410270502 · Cited by 2,376
Cognitive impairment in multiple sclerosis
Chiaravalloti, N. D., & DeLuca, J. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(08)70259-x · Cited by 2,088
Biology of Oligodendrocyte and Myelin in the Mammalian Central Nervous System
Baumann, N., & Pham-Dinh, D. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.871 · Cited by 1,828
Axonopathy and Transport Deficits Early in the Pathogenesis of Alzheimer’s Disease
Stokin, G. B., Lillo, C., Falzone, T. L., Brusch, R. G., Rockenstein, E., Mount, S. L., Raman, R., Davies, P., Masliah, E., Williams, D. S., et al. (2005) · Science · doi:10.1126/science.1105681 · Cited by 1,214
Motor skill learning requires active central myelination
McKenzie, I. A., Ohayon, D., Li, H., Paes de Faria, J., Emery, B., Tohyama, K., & Richardson, W. D. (2014) · Science · doi:10.1126/science.1254960 · Cited by 1,177
Age-related myelin breakdown: a developmental model of cognitive decline and Alzheimer’s disease
Bartzokis, G. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.03.001 · Cited by 968
A new mechanism of nervous system plasticity: activity-dependent myelination
Fields, R. D. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn4023 · Cited by 794
Molecular pathways to neurodegeneration
Bossy-Wetzel, E., Schwarzenbacher, R., & Lipton, S. A. (2004) · Nature Medicine · doi:10.1038/nm1067 · Cited by 740
Han, X., M. Holtzman, D., W. McKeel, D., Kelley, J., & Morris, J. C. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00997.x · Cited by 626
Fibrillar amyloid deposition leads to local synaptic abnormalities and breakage of neuronal branches
Tsai, J., Grutzendler, J., Duff, K., & Gan, W.-B. (2004) · Nature Neuroscience · doi:10.1038/nn1335 · Cited by 561
Alzheimer's disease as homeostatic responses to age-related myelin breakdown
Bartzokis, G. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.08.007 · Cited by 546
Dynamics of Oligodendrocyte Generation and Myelination in the Human Brain
Yeung, M. S. Y., Zdunek, S., Bergmann, O., Bernard, S., Salehpour, M., Alkass, K., Perl, S., Tisdale, J., Possnert, G., Brundin, L., et al. (2014) · Cell · doi:10.1016/j.cell.2014.10.011 · Cited by 541
The preclinical phase of the pathological process underlying sporadic Alzheimer’s disease
Braak, H., & Del Tredici, K. (2015) · Brain · doi:10.1093/brain/awv236 · Cited by 540
Motor skill learning induces changes in white matter microstructure and myelination
Sampaio-Baptista, C., Khrapitchev, A. A., Foxley, S., Schlagheck, T., Scholz, J., Jbabdi, S., DeLuca, G. C., Miller, K. L., Taylor, A., Thomas, N., et al. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.3048-13.2013 · Cited by 417
Braak, H., & Braak, E. (1996) · Acta Neuropathologica · doi:10.1007/s004010050508 · Cited by 406
Bartzokis, G., Sultzer, D., Lu, P. H., Nuechterlein, K. H., Mintz, J., & Cummings, J. L. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.09.005 · Cited by 363
Wilkins, A., Majed, H., Layfield, R., Compston, A., & Chandran, S. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-12-04967.2003 · Cited by 337
Demyelination causes synaptic alterations in hippocampi from multiple sclerosis patients
Dutta, R., Chang, A., Doud, M. K., Kidd, G. J., Ribaudo, M. V., Young, E. A., Fox, R. J., Staugaitis, S. M., & Trapp, B. D. (2010) · Annals of Neurology · doi:10.1002/ana.22337 · Cited by 320
Stricker, N. H., Schweinsburg, B. C., Delano‐Wood, L., Wierenga, C. E., Bangen, K. J., Haaland, K. Y., Frank, L. R., Salmon, D. P., & Bondi, M. W. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.11.027 · Cited by 318
Extensive Hippocampal Demyelination in Multiple Sclerosis
Geurts, J. J. G., Bø, L., Roosendaal, S. D., Hazes, T., Daniëls, R., Barkhof, F., Witter, M. P., Huitinga, I., & van der Valk, P. (2007) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181461f54 · Cited by 286
Lee, J.-T., Xu, J., Lee, J.-M., Ku, G., Han, X., Yang, D.-I., Chen, S., & Hsu, C. Y. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200307017 · Cited by 280
Desai, M. K., Sudol, K. L., Janelsins, M. C., Mastrangelo, M. A., Frazer, M. E., & Bowers, W. J. (2009) · Glia · doi:10.1002/glia.20734 · Cited by 266
The case described by Alois Alzheimer in 1911
Møller, H. J., & Graeber, M. B. (1998) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s004060050027 · Cited by 261
Association of Amyloid Pathology With Myelin Alteration in Preclinical Alzheimer Disease
Dean, D. C., Hurley, S. A., Kecskemeti, S. R., O’Grady, J. P., Canda, C., Davenport-Sis, N. J., Carlsson, C. M., Zetterberg, H., Blennow, K., Asthana, S., et al. (2017) · JAMA Neurology · doi:10.1001/jamaneurol.2016.3232 · Cited by 252 · cited 9×
“Although there exists evidence for myelin damage in the normal aging brain [9, 13, 31], recent data suggest that AD pathology is influenced by myelin damage [9].”
BackgroundInfluentialEngvig, A., Fjell, A. M., Westlye, L. T., Moberget, T., Sundseth, Ø., Larsen, V. A., & Walhovd, K. B. (2012) · Human Brain Mapping · doi:10.1002/hbm.21370 · Cited by 250
β‐amyloid burden is not associated with rates of brain atrophy
Josephs, K. A., Whitwell, J. L., Ahmed, Z., Shiung, M. M., Weigand, S. D., Knopman, D. S., Boeve, B. F., Parisi, J. E., Petersen, R. C., Dickson, D. W., et al. (2007) · Annals of Neurology · doi:10.1002/ana.21223 · Cited by 240
WHITE MATTER CHANGES IN DEMENTIA OF ALZHEIMER'S TYPE: BIOCHEMICAL AND NEUROPATHOLOGICAL CORRELATES
ENGLUND, E., BRUN, A., & ALLING, C. (1988) · Brain · doi:10.1093/brain/111.6.1425 · Cited by 228
Behrendt, G., Baer, K., Buffo, A., Curtis, M. A., Faull, R. L., Rees, M. I., Götz, M., & Dimou, L. (2013) · Glia · doi:10.1002/glia.22432 · Cited by 219
Cognitive impairment in multiple sclerosis – a review of current knowledge and recent research
Grzegorski, T., & Losy, J. (2017) · Reviews in the Neurosciences · doi:10.1515/revneuro-2017-0011 · Cited by 206
A role for oligodendrocyte‐derived IGF‐1 in trophic support of cortical neurons
Wilkins, A., Chandran, S., & Compston, A. (2001) · Glia · doi:10.1002/glia.1094 · Cited by 191
Hippocampal CA1 atrophy and synaptic loss during experimental autoimmune encephalomyelitis, EAE
Ziehn, M. O., Avedisian, A., Tiwari-Woodruff, S., & Voskuhl, R. (2010) · Laboratory Investigation · doi:10.1038/labinvest.2010.6 · Cited by 190
Focal demyelination in Alzheimer’s disease and transgenic mouse models
Mitew, S., Kirkcaldie, M. T. K., Halliday, G. M., Shepherd, C. E., Vickers, J. C., & Dickson, T. C. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0657-2 · Cited by 186
The node of Ranvier in CNS pathology
Arancibia-Carcamo, I. L., & Attwell, D. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1305-z · Cited by 177
Multiple Brain Markers are Linked to Age-Related Variation in Cognition
Hedden, T., Schultz, A. P., Rieckmann, A., Mormino, E. C., Johnson, K. A., Sperling, R. A., & Buckner, R. L. (2014) · Cerebral Cortex · doi:10.1093/cercor/bhu238 · Cited by 172
Human brain myelination and amyloid beta deposition in Alzheimer's disease
Bartzokis, G., Lu, P. H., & Mintz, J. (2007) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2007.01.019 · Cited by 162
Amyloid‐ß‐directed immunotherapy for Alzheimer's disease
Lannfelt, L., Relkin, N. R., & Siemers, E. (2014) · Journal of Internal Medicine · doi:10.1111/joim.12168 · Cited by 161
Kohama, S. G., Rosene, D. L., & Sherman, L. S. (2011) · AGE · doi:10.1007/s11357-011-9357-7 · Cited by 142
Anderson, J. M., Hampton, D. W., Patani, R., Pryce, G., Crowther, R. A., Reynolds, R., Franklin, R. J. M., Giovannoni, G., Compston, D. A. S., Baker, D., et al. (2008) · Brain · doi:10.1093/brain/awn119 · Cited by 141
Benitez, A. M., Fieremans, E., Jensen, J. H., Falangola, M. F., Tabesh, A., Ferris, S. H., & Helpern, J. A. (2013) · NeuroImage Clinical · doi:10.1016/j.nicl.2013.11.001 · Cited by 134
Diffusion tensor MRI tractography and cognitive impairment in multiple sclerosis
Mesaroš, Š., Rocca, M. A., Kac̆ar, K., Kostić, J., Copetti, M., Stošić-Opinćal, T., Preziosa, P., Sala, S., Riccitelli, G. C., Horsfield, M. A., et al. (2012) · Neurology · doi:10.1212/wnl.0b013e31824d5859 · Cited by 121
Apolipoprotein E and cholesterol metabolism in the pathogenesis and treatment of Alzheimer's disease
Poirier, J. (2003) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(03)00007-8 · Cited by 116
Ihara, M., Tomimoto, H., Kinoshita, M., Oh, J., Noda, M., Wakita, H., Akiguchi, I., & Shibasaki, H. (2001) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200107000-00008 · Cited by 115
Agosta, F., Dalla Libera, D., Spinelli, E. G., Finardi, A., Canu, E., Bergami, A., Bocchio Chiavetto, L., Baronio, M., Comi, G., Martino, G., et al. (2014) · Annals of Neurology · doi:10.1002/ana.24235 · Cited by 113
Zhan, X., Jickling, G. C., Ander, B. P., Stamova, B. S., Liu, D., Kao, P. F., Zelin, M. A., Jin, L., DeCarli, C. S., & Sharp, F. R. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-142013 · Cited by 109
On certain peculiar diseases of old age
Alzheimer, A., Förstl, H., & Levy, R. (1991) · History of Psychiatry · doi:10.1177/0957154x9100200505 · Cited by 105
Couttas, T. A., Kain, N., Suchowerska, A. K., Quek, L., Turner, N. A., Fath, T., Garner, B., & Don, A. S. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.03.027 · Cited by 99
Ziehn, M. O., Avedisian, A., Dervin, S., Umeda, E., O'Dell, T., & Voskuhl, R. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2796-12.2012 · Cited by 98
Cognitive impairment in multiple sclerosis
Hoffmann, S., Tittgemeyer, M., & von Cramon, D. Y. (2007) · Current Opinion in Neurology · doi:10.1097/wco.0b013e32810c8e87 · Cited by 93
Myelin breakdown mediates age-related slowing in cognitive processing speed in healthy elderly men
Lu, P. H., Lee, G. J., Tishler, T. A., Meghpara, M., Thompson, P. M., & Bartzokis, G. (2012) · Brain and Cognition · doi:10.1016/j.bandc.2012.09.006 · Cited by 92
Bendlin, B. B., Carlsson, C. M., Johnson, S. C., Zetterberg, H., Blennow, K., Willette, A. A., Okonkwo, O. C., Sodhi, A., Ries, M. L., Birdsill, A. C., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037720 · Cited by 91
Fornari, E., Maeder, P. P., Meuli, R. A., Ghika, J. A., & Knyazeva, M. G. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.11.014 · Cited by 88
Contribution of changes in ubiquitin and myelin basic protein to age-related cognitive decline
Wang, D.-S., Bennett, D. A., Mufson, E. J., Mattila, P. M., Cochran, E. J., & Dickson, D. W. (2003) · Neuroscience Research · doi:10.1016/j.neures.2003.10.002 · Cited by 72
Llorens, F., Gil, V., & del Río, J. A. (2010) · The FASEB Journal · doi:10.1096/fj.10-162792 · Cited by 72
Autophagy is involved in oligodendroglial precursor-mediated clearance of amyloid peptide
Li, W., Tang, Y., Fan, Z., Meng, Y. J., Yang, G., Luo, J., & Ke, Z. (2013) · Molecular Neurodegeneration · doi:10.1186/1750-1326-8-27 · Cited by 65
Association of apolipoprotein (Apo)E genotype with plasma apo E levels
Larson, I. A., Ordovás, J. M., DeLuca, C., Barnard, J. R., Feussner, G., & Schaefer, E. J. (2000) · Atherosclerosis · doi:10.1016/s0021-9150(99)00280-4 · Cited by 64
Degradation of Amyloid β Protein by Purified Myelin Basic Protein
Liao, M.-C., Ahmed, M., Smith, S. O., & Nostrand, W. E. V. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.050856 · Cited by 64
Shindo, A., Liang, A. C., Maki, T., Miyamoto, N., Tomimoto, H., Lo, E. H., & Arai, K. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2015.80 · Cited by 58
Hippocampal function is compromised in an animal model of multiple sclerosis
Novkovic, T., Shchyglo, O., Gold, R., & Manahan‐Vaughan, D. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.03.008 · Cited by 56
Alzheimer disease immunotherapeutics: Then and now
Jindal, H., Bhatt, B., Shashikantha, S. K., & Malik, J. S. (2014) · Human Vaccines & Immunotherapeutics · doi:10.4161/21645515.2014.970959 · Cited by 52
Maat–Schieman, M. L. C., Yamaguchi, H., Hegeman-Kleinn, I. M., Welling‐Graafland, C., Natté, R., Roos, R. A. C., & van Duinen, S. G. (2004) · Acta Neuropathologica · doi:10.1007/s00401-004-0824-4 · Cited by 45
Mortamais, M., Reynès, C., Brickman, A. M., Provenzano, F. A., Muraskin, J., Portet, F., Berr, C., Touchon, J., Bonafé, A., Bars, E. L., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056972 · Cited by 41
Myelin Basic Protein Binds to and Inhibits the Fibrillar Assembly of Aβ42 in Vitro
Hoos, M. D., Ahmed, M., Smith, S. O., & Nostrand, W. E. V. (2009) · Biochemistry · doi:10.1021/bi900037s · Cited by 37
Papuć, E., Kurys-Denis, E., Krupski, W., Tatara, M. R., & Rejdak, K. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-150309 · Cited by 35
Self-citationC. Schmued, L., Raymick, J., G. Paule, M., Dumas, M., & Sarkar, S. (2013) · Current Alzheimer Research · doi:10.2174/1567205011310010005 · Cited by 35
Diffusion Tensor Imaging Abnormalities in Cognitively Impaired Multiple Sclerosis Patients
Akbar, N., Lobaugh, N. J., O'Connor, P. W., Moradzadeh, L., Scott, C. J. M., & Feinstein, A. (2010) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100010775 · Cited by 28
Long, P. T., & Corfas, G. (2014) · Science · doi:10.1126/science.1261127 · Cited by 23
Age-Related Changes in Frontal and Temporal Lobe Volumes in Men: A Magnetic Resonance Imaging Study
Bartzokis, G., Beckson, M., Lu, P. H., Nuechterlein, K. H., Edwards, N., & Mintz, J. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.5.461 · Cited by 14
An Emerging Role for Imaging White Matter in the Preclinical Risk for Alzheimer Disease
Alexander, G. E. (2016) · JAMA Neurology · doi:10.1001/jamaneurol.2016.4123 · Cited by 10
Alzheimer disease immunotherapeutics: Then and now
Jindal, H., Bhatt, B., Shashikantha, S. K., & Malik, J. S. (2014) · Human Vaccines & Immunotherapeutics · doi:10.4161/hv.29437 · Cited by 4
Flagged first, then by citations
Research works printed but not linked: 2
- [70]Ziehn MO Avedisian AA Tiwari-Woodruff S Voskuhl RR Hippocampal CA1 atrophy and synaptic loss during experimental autoimmune encephalomyelitis, EAE Lab Invest 2010 90 774 86 20157291 PMC3033772
- [71]Kohama SG Rosene DL Sherman LS Age-related changes in human and non-human primate white matter: from myelination disturbances to cognitive decline Age (Dordr) 2012 34 1093 110 22203458 PMC3448998
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Hijazi, S., Smit, A. B., & van Kesteren, R. E. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02168-y · Cited by 157
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Sanchez-Varo, R. M., Mejias‐Ortega, M., Fernandez-Valenzuela, J. J., Nuñez‐Diaz, C., Cáceres-Palomo, L., Vegas‐Gomez, L., Sánchez‐Mejías, E., Trujillo‐Estrada, L., García‐León, J. A., Moreno‐González, I., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105404 · Cited by 136
Qiu, S., Palavicini, J. P., Wang, J., Gonzalez, N. S., He, S., Dustin, E., Zou, C., Ding, L., Bhattacharjee, A., Skike, C. E. V., et al. (2021) · Molecular Neurodegeneration · doi:10.1186/s13024-021-00488-7 · Cited by 126
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Ciaccio, M., Sasso, B. L., Scazzone, C., Gambino, C. M., Ciaccio, A. M., Bivona, G., Piccoli, T., Giglio, R. V., & Agnello, L. (2021) · Brain Sciences · doi:10.3390/brainsci11030305 · Cited by 116
Metadata
- Authors
- Papuć, E., & Rejdak, K.
- Affiliations
- Medical University of Lublin (PL)
- Corresponding author
- Papuć, Ewa
- Venue
- Archives of Medical Science
- Publisher
- Termedia Sp. z.o.o.
- Published
- 2020
- Volume
- 16
- Issue
- 2
- Pages
- 345-341
- ISSN
- 1734-1922 (ISSN-L)
- PMC
- PMC7069444
- OpenAlex
- W2898142024
- Cited by
- 188
- References
- 73
- Citations by year
- 2026: 22 · 2025: 33 · 2024: 31 · 2023: 33 · 2022: 40 · 2021: 20 · 2020: 8
- FWCI
- 5.67
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- Archives of Medical Science (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, myelin damage, oligodendrocyte death, amyloid-beta, tau pathology, neurofibrillary tangles, myelin pathology, grey matter
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